Synoviocyte innate immune responses: II. Pivotal role of IFN regulatory factor 3

Journal of Immunology

Volumn 184, Issue 12, 2010, Pages 7162-7168

  Sweeney, Susan E ^a   Kimbler, Trevor B ^a   Firestein, Gary S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GELATINASE B; INTERFERON; INTERFERON REGULATORY FACTOR 3; INTERFERON REGULATORY FACTOR 5; INTERFERON REGULATORY FACTOR 7; INTERLEUKIN 18; INTERLEUKIN 6; LUCIFERASE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; POLYINOSINIC POLYCYTIDYLIC ACID; PROTEIN C JUN; RANTES; SMALL INTERFERING RNA; STROMELYSIN; IRF3 PROTEIN, HUMAN; IRF7 PROTEIN, HUMAN;

ARTICLE; CONTROLLED STUDY; ENZYME ASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBROBLAST; GENE ACTIVATION; GENE ACTIVITY; GENE CONSTRUCT; GENE CONTROL; GENE EXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOSTIMULATION; INNATE IMMUNITY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REPORTER GENE; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SYNOVIOCYTE; WESTERN BLOTTING; CYTOLOGY; DNA RESPONSIVE ELEMENT; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SYNOVIUM;

ARTHRITIS, RHEUMATOID; BLOTTING, WESTERN; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMANS; IMMUNITY, INNATE; INTERFERON REGULATORY FACTOR-3; INTERFERON REGULATORY FACTOR-7; POLY I-C; PROMOTER REGIONS, GENETIC; RESPONSE ELEMENTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SYNOVIAL MEMBRANE; TRANSFECTION;

EID: 77953633063     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0903944     Document Type: Article

References (30)

1. Brentano, F., D. Kyburz, O. Schorr, R. Gay, and S. Gay. 2005. The role of Toll-like receptor signalling in the pathogenesis of arthritis. Cell. Immunol. 233: 90-96.
2. van Holten, J., T. J. Smeets, P. Blankert, and P. P. Tak. 2005. Expression of interferon β in synovial tissue from patients with rheumatoid arthritis: comparison with patients with osteoarthritis and reactive arthritis. Ann. Rheum. Dis. 64: 1780-1782.
3. Haringman, J. J., T. J. Smeets, P. Reinders-Blankert, and P. P. Tak. 2006. Chemokine and chemokine receptor expression in paired peripheral blood mononuclear cells and synovial tissue of patients with rheumatoid arthritis, osteoarthritis, and reactive arthritis. Ann. Rheum. Dis. 65: 294-300.
4. García-Vicuña, R., M. V. Gómez-Gaviro, M. J. Domínguez-Luis, M. K. Pec, I. González-Alvaro, J. M. Alvaro-Gracia, and F. Díaz-González. 2004. CC and CXC chemokine receptors mediate migration, proliferation, and matrix metalloproteinase production by fibroblast-like synoviocytes from rheumatoid arthritis patients. Arthritis Rheum. 50: 3866-3877. (Pubitemid 39643933)
5. Koch, A. E., S. L. Kunkel, L. A. Harlow, B. Johnson, H. L. Evanoff, G. K. Haines, M. D. Burdick, R. M. Pope, and R. M. Strieter. 1992. Enhanced production of monocyte chemoattractant protein-1 in rheumatoid arthritis. J. Clin. Invest. 90: 772-779.
6. Sweeney, S. E., L. Mo, and G. S. Firestein. 2007. Antiviral gene expression in rheumatoid arthritis: role of IKKepsilon and interferon regulatory factor 3. Arthritis Rheum. 56: 743-752.
7. Kim, T. K., T. H. Kim, and T. Maniatis. 1998. Efficient recruitment of TFIIB and CBP-RNA polymerase II holoenzyme by an interferon-β enhanceosome in vitro. Proc. Natl. Acad. Sci. USA 95: 12191-12196.
8. Malmgaard, L. 2004. Induction and regulation of IFNs during viral infections. J. Interferon Cytokine Res. 24: 439-454. (Pubitemid 39120592)
9. Honda, K., H. Yanai, H. Negishi, M. Asagiri, M. Sato, T. Mizutani, N. Shimada, Y. Ohba, A. Takaoka, N. Yoshida, and T. Taniguchi. 2005. IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature 434: 772-777. (Pubitemid 44739521)
10. Lundberg, A. M., S. K. Drexler, C. Monaco, L. M. Williams, S. M. Sacre, M. Feldmann, and B. M. Foxwell. 2007. Key differences in TLR3/poly I:C signaling and cytokine induction by human primary cells: a phenomenon absent from murine cell systems. Blood 110: 3245-3252.
11. Alvaro-Gracia, J. M., N. J. Zvaifler, and G. S. Firestein. 1990. Cytokines in chronic inflammatory arthritis. V. Mutual antagonism between interferon-γ and tumor necrosis factor-a on HLA-DR expression, proliferation, collagenase production, and granulocyte macrophage colony-stimulating factor production by rheumatoid arthritis synoviocytes. J. Clin. Invest. 86: 1790-1798.
12. Arnett, F. C., S. M. Edworthy, D. A. Bloch, D. J. McShane, J. F. Fries, N. S. Cooper, L. A. Healey, S. R. Kaplan, M. H. Liang, H. S. Luthra, et al. 1988. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 31: 315-324.
13. Hammaker, D. R., D. L. Boyle, M. Chabaud-Riou, and G. S. Firestein. 2004. Regulation of c-Jun N-terminal kinase by MEKK-2 and mitogen-activated protein kinase kinase kinases in rheumatoid arthritis. J. Immunol. 172: 1612-1618.
14. Boyle, D. L., S. Rosengren, W. Bugbee, A. Kavanaugh, and G. S. Firestein. 2003. Quantitative biomarker analysis of synovial gene expression by real-time PCR. Arthritis Res. Ther. 5: R352-R360.
15. Sweeney, S. E., D. Hammaker, D. L. Boyle, and G. S. Firestein. 2005. Regulation of c-Jun phosphorylation by the I kappa B kinase-ε complex in fibroblastlike synoviocytes. J. Immunol. 174: 6424-6430.
16. Tenoever, B. R., S. L. Ng, M. A. Chua, S. M. McWhirter, A. García-Sastre, and T. Maniatis. 2007. Multiple functions of the IKK-related kinase IKKε in interferon- mediated antiviral immunity. Science 315: 1274-1278.
17. Olsen, N., T. Sokka, C. L. Seehorn, B. Kraft, K. Maas, J. Moore, and T. M. Aune. 2004. A gene expression signature for recent onset rheumatoid arthritis in peripheral blood mononuclear cells. Ann. Rheum. Dis. 63: 1387-1392.
18. Corr, M., D. L. Boyle, L. Ronacher, N. Flores, and G. S. Firestein. 2009. Synergistic benefit in inflammatory arthritis by targeting I κB kinase ε and interferon β. Ann. Rheum. Dis. 68: 257-263.
19. Zare, F., M. Bokarewa, N. Nenonen, T. Bergström, L. Alexopoulou, R. A. Flavell, and A. Tarkowski. 2004. Arthritogenic properties of double-stranded (viral) RNA. J. Immunol. 172: 5656-5663. (Pubitemid 38542069)
20. Roelofs, M. F., L. A. Joosten, S. Abdollahi-Roodsaz, A. W. van Lieshout, T. Sprong, F. H. van den Hoogen, W. B. van den Berg, and T. R. Radstake. 2005. The expression of Toll-like receptors 3 and 7 in rheumatoid arthritis synovium is increased and costimulation of Toll-like receptors 3, 4, and 7/8 results in synergistic cytokine production by dendritic cells. Arthritis Rheum. 52: 2313-2322.
21. Brentano, F., O. Schorr, R. E. Gay, S. Gay, and D. Kyburz. 2005. RNA released from necrotic synovial fluid cells activates rheumatoid arthritis synovial fibroblasts via Toll-like receptor 3. Arthritis Rheum. 52: 2656-2665. (Pubitemid 41369093)
22. Fitzgerald, K. A., S. M. McWhirter, K. L. Faia, D. C. Rowe, E. Latz, D. T. Golenbock, A. J. Coyle, S. M. Liao, and T. Maniatis. 2003. IKKε and TBK1 are essential components of the IRF3 signaling pathway. Nat. Immunol. 4: 491-496.
23. Sharma, S., B. R. tenOever, N. Grandvaux, G. P. Zhou, R. Lin, and J. Hiscott. 2003. Triggering the interferon antiviral response through an IKK-related pathway. Science 300: 1148-1151.
24. Borden, E. C., G. C. Sen, G. Uze, R. H. Silverman, R. M. Ransohoff, G. R. Foster, and G. R. Stark. 2007. Interferons at age 50: past, current and future impact on biomedicine. Nat. Rev. Drug Discov. 6: 975-990.
25. Smeets, T. J., J. M. Dayer, M. C. Kraan, J. Versendaal, R. Chicheportiche, F. C. Breedveld, and P. P. Tak. 2000. The effects of interferon-β treatment of synovial inflammation and expression of metalloproteinases in patients with rheumatoid arthritis. Arthritis Rheum. 43: 270-274.
26. van Holten, J., K. Reedquist, P. Sattonet-Roche, T. J. Smeets, C. Plater-Zyberk, M. J. Vervoordeldonk, and P. P. Tak. 2004. Treatment with recombinant interferon-β reduces inflammation and slows cartilage destruction in the collagen-induced arthritis model of rheumatoid arthritis. Arthritis Res. Ther. 6: R239-R249.
27. van Holten, J., K. Pavelka, J. Vencovsky, H. Stahl, B. Rozman, M. Genovese, A. J. Kivitz, J. Alvaro, G. Nuki, D. E. Furst, et al. 2005. A multicentre, randomised, double blind, placebo controlled phase II study of subcutaneous interferon β-1a in the treatment of patients with active rheumatoid arthritis. Ann. Rheum. Dis. 64: 64-69.
28. Graham, R. R., S. V. Kozyrev, E. C. Baechler, M. V. Reddy, R. M. Plenge, J. W. Bauer, W. A. Ortmann, T. Koeuth, M. F. González Escribano, B. Pons- Estel, et al. 2006. A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus. Nat. Genet. 38: 550-555.
29. Dieguez-Gonzalez, R., M. Calaza, E. Perez-Pampin, A. R. de la Serna, B. Fernandez-Gutierrez, S. Castañeda, R. Largo, B. Joven, J. Narvaez, F. Navarro, et al. 2008. Association of interferon regulatory factor 5 haplotypes, similar to that found in systemic lupus erythematosus, in a large subgroup of patients with rheumatoid arthritis. Arthritis Rheum. 58: 1264-1274. (Pubitemid 351705915)
30. Sigurdsson, S., L. Padyukov, F. A. Kurreeman, U. Liljedahl, A. C. Wiman, L. Alfredsson, R. Toes, J. Rönnelid, L. Klareskog, T. W. Huizinga, et al. 2007. Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis. Arthritis Rheum. 56: 2202-2210. (Pubitemid 47173567)