Significant inhibition of TRAIL-mediated fibroblast-like synovial cell apoptosis by IFN-γ through JAK/STAT pathway by translational regulation

Journal of Laboratory and Clinical Medicine

Volumn 147, Issue 4, 2006, Pages 182-190

  Tamai, Mami ^a   Kawakami, Atsushi ^a   Tanaka, Fumiko ^a   Miyashita, Taiichiro ^b   Nakamura, Hideki ^a   Iwanaga, Nozomi ^a   Izumi, Yasumori ^a   Arima, Kazuhiko ^a   Aratake, Kouichiro ^a   Huang, Mingguo ^a   Kamachi, Makoto ^a   Ida, Hiroaki ^a   Origuchi, Tomoki ^a   Eguchi, Katsumi ^a  

^a NAGASAKI UNIVERSITY   (Japan)

^b NATIONAL HOSPITAL ORGANIZATION NAGASAKI MEDICAL CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CASPASE 8; CYCLOHEXIMIDE; DEATH RECEPTOR; FLICE INHIBITORY PROTEIN; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE B; SILENCER OF DEATH DOMAIN PROTEIN; STAT PROTEIN; STAT1 PROTEIN; STAT3 PROTEIN; STAT6 PROTEIN; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL DEATH; CELL DISRUPTION; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CONTROLLED STUDY; DIPLOIDY; ENZYME ACTIVITY; FIBROBLAST CULTURE; HUMAN; HUMAN CELL; HUMAN TISSUE; MITOCHONDRIAL MEMBRANE; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SYNOVIOCYTE; SYNOVIUM; TRANSLATION REGULATION;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; FIBROBLASTS; HUMANS; INTERFERON-GAMMA, RECOMBINANT; MAP KINASE SIGNALING SYSTEM; MEMBRANE GLYCOPROTEINS; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; STAT TRANSCRIPTION FACTORS; STAT1 TRANSCRIPTION FACTOR; SYNOVIAL MEMBRANE; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33645871828     PISSN: 00222143     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lab.2005.12.001     Document Type: Article

References (28)

1. van der Pouw Kraan T.C., van Gaalen F.A., Kasperkovitz P.V., Verbeet N.L., Smeets T.J., Kraan M.C., et al. Rheumatoid arthritis is a heterogenous disease. evidence for differences in the activation of the STAT-1 pathway between rheumatoid tissues. Arthritis Rheum 48 (2003) 2132-2145
2. Ivashkiv L.B., and Hu X. The JAK/STAT pathways in rheumatoid arthritis. pathogenic or protective?. Arthritis Rheum 48 (2003) 2092-2096
3. Kisseleva T., Bhattacharya S., Braunstein J., and Schindler C.W. Signaling through the JAK/STAT pathway, recent advances and future challenges. Gene 285 (2002) 1-24
4. Kawakami A., Matsuoka N., Tsuboi M., Urayama S., Nakashima T., Kawabe Y., et al. CD4+ T-cell-mediated cytotoxicity against staphylococcal enterotoxin B-pulsed synovial cells. Immunology 95 (1998) 38-46
5. Kawakami A., Tsuboi M., Urayama S., Matsuoka N., Yamasaki S., Hida A., et al. Inhibitory effect of a new anti-rheumatic drug T-614 on costimulatory molecule expression, cytokine production, and antigen presentation by synovial cells. J Lab Clin Med 133 (1999) 566-574
6. Davis L.S., Sackler M., Brezinschek R.I., Lightfoot E., Bailey J.L., Oppenheimer-Marks N., et al. Inflammation, immune reactivity, and angiogenesis in a severe combined immunodeficiency model of rheumatoid arthritis. Am J Pathol 160 (2002) 357-367
7. Kawakami A., and Eguchi K. Involvement of apoptotic cell death in autoimmune diseases. Med Electron Microsc 35 (2002) 1-8
8. Baier A., Meineckel I., Gay S., and Pap T. Apoptosis in rheumatoid arthritis. Curr Opin Rheumatol 15 (2003) 274-279
9. Liu H., and Pope R.M. The role of apoptosis in rheumatoid arthritis. Curr Opin Pharmacol 3 (2003) 317-322
10. Yamasaki S., Kawakami A., Nakashima T., Nakamura H., Kamachi M., Honda S., et al. Importance of NF-kappaB in rheumatoid synovial tissues. in situ NF-kappaB expression and in vitro study using cultured synovial cells. Ann Rheu Dis 60 (2001) 678-684
11. Song K., Chen Y., Goke R., Wilmen A., Seidel C., Goke A., et al. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an inhibitor of autoimmune inflammation and cell cycle progression. J Exp Med 191 (2000) 1095-1104
12. -/- mice. Nat Immunol 10 (2003) 255-260
13. Alexandru A., and Ashkenazi A. Apo2L/TRAIL. apoptosis signaling, biology, and potential for cancer therapy. Cytokine Growth Factor Rev 14 (2003) 337-348
14. LeBlanc H.N., and Ashkenazi A. Apo2L/TRAIL and its death and decoy receptors. Cell Death Differ 10 (2003) 66-75
15. Miyashita T., Kawakami A., Tamai M., Izumi Y., Mingguo H., Tanaka F., et al. Akt is an endogenous inhibitor toward tumor necrosis factor-related apoptosis inducing ligand-mediated apoptosis in rheumatoid synovial cells. Biochem Biophys Res Commun 312 (2003) 397-404
16. Miyashita T., Kawakami A., Nakashima T., Yamasaki S., Tamai M., Tanaka F., et al. Osteoprotegerin (OPG) acts as an endogenous decoy receptor in tumour necrosis factor-related apoptosis of fibroblast-like synovial cells. Clin Exp Immunol 137 (2004) 430-436
17. Ichikawa K., Liu W., Fleck M., Zhang H., Zhao L., Ohtsuka T., et al. TRAIL-R2 (DR5) mediates apoptosis of synovial fibroblasts in rheumatoid arthritis. J Immunol 171 (2003) 1061-1069
18. Chen C.W., Chao Y., Chang Y.H., Hsu M.J., and Lin W.W. Inhibition of cytokine-induced JAK-STAT signaling pathways by an endonuclease inhibitor aurintricarboxylic acid. Br J Pharmacol 137 (2002) 1011-1020
19. Scaffidi C., Schmitz I., Zha J., Korsmeyer S.J., Krammer P.H., and Peter M.E. Differential modulation of apoptosis sensitivity in CD95 type I and type II cells. J Biol Chem 274 (1999) 22532-22538
20. Ozoren W.S., and El-Deiry W.S. Defining characteristics of type I and type II apoptotic cells in response to TRAIL. Neoplasia 4 (2002) 551-557
21. MacFarlane M. TRAIL-induced signaling and apoptosis. Toxicol Lett 139 (2003) 89-97
22. Frisch S.M. Evidence for a function of death-receptor-related, death-domain-containing proteis in anoikis. Curr Biol 9 (1999) 1047-1049
23. Land K.J., Moll J.S., Kaplan M.H., and Seetharamaiah G.S. Signal transducer and activator of transcription (Stat)-6-dependent, but not Stat4-dependent, immunity is required for the development of autoimmunity in Graves' hyperthyroidism. Endocrinology 145 (2004) 3724-3730
24. Jarug A.B., Hong F., Sun R., Radaeva S., and Gao B. Crucial role of IL-4/STAT6 in T cell-mediated hepatitis. up-regulating eotaxins and IL-5 and recruiting leukocytes. J Immunol 171 (2003) 3233-3244
25. Stephanou A., and Latchman D.S. STAT-1. a novel regulator of apoptosis. Int J Exp Pathol 84 (2003) 239-244
26. Terui K., Haga S., Enosawa S., Ohnuma N., and Ozaki M. Hypoxia/re-oxygenation-induced, redox-dependent activation of STAT1 (signal transducer and activator of transcription 1) confers resistance to apoptotic cell death via hsp 70 induction. Biochem J 380 (2004) 203-209
27. Morris S.C., Dragula N.L., and Finkelman F.D. IL-4 promotes STAT6-dependent survival of autoreactive B cells in vivo without inducing autoantibody production. J Immunol 169 (2002) 1696-1704
28. Bailey D.P., Kashyap M., Mirmonsef P., Bouton L.A., Domen J., Zhu J., et al. Interleukin-4 elicits apoptosis of developing mast cells via a Stat6-dependent mitochondrial pathway. Exp Hematol 32 (2004) 52-59