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Volumn 2 S, Issue 3, 2010, Pages 1169-1188

Important roles of Akt/PKB signaling in the aging process

Author keywords

Adipose tissue; Aging; Akt protein kinase B; Alzheimer's disease; Bone; Cardiovascular system; Digestive system; Immune system; Neuronal system; PKB; Respiratory system; Review; Skeletal muscle; Urinary system

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

EID: 77956638875     PISSN: 19450516     EISSN: 19450524     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (19)

References (228)
  • 1
    • 38949104188 scopus 로고    scopus 로고
    • The coming acceleration of global population ageing
    • DOI 10.1038/nature06516, PII NATURE06516
    • W. Lutz, W. Sanderson and S. Scherbov: The coming acceleration of global population ageing. Nature, 451(7179), 716-9 (2008) (Pubitemid 351220565)
    • (2008) Nature , vol.451 , Issue.7179 , pp. 716-719
    • Lutz, W.1    Sanderson, W.2    Scherbov, S.3
  • 2
    • 38949185369 scopus 로고    scopus 로고
    • U.S. health spending by age, selected years through 2004
    • DOI 10.1377/hlthaff.27.1.w1
    • M. Hartman, A. Catlin, D. Lassman, J. Cylus and S. Heffler: U.S. Health spending by age, selected years through 2004. Health Aff (Millwood), 27(1), w1-w12 (2008) (Pubitemid 351222403)
    • (2008) Health Affairs , vol.27 , Issue.1
    • Hartman, M.1    Catlin, A.2    Lassman, D.3    Cylus, J.4    Heffler, S.5
  • 4
    • 0035661501 scopus 로고    scopus 로고
    • Total body mass, fat mass, fat-free mass, and skeletal muscle in older people: Cross-sectional differences in 60-year-old persons
    • DOI 10.1046/j.1532-5415.2001.t01-1-49272.x
    • U. G. Kyle, L. Genton, D. Hans, V. L. Karsegard, J. P. Michel, D. O. Slosman and C. Pichard: Total body mass, fat mass, fat-free mass, and skeletal muscle in older people: cross-sectional differences in 60-year-old persons. J Am Geriatr Soc, 49(12), 1633-40 (2001) (Pubitemid 34007989)
    • (2001) Journal of the American Geriatrics Society , vol.49 , Issue.12 , pp. 1633-1640
    • Kyle, U.G.1    Genton, L.2    Hans, D.3    Karsegard, V.L.4    Michel, J.-P.5    Slosman, D.O.6    Pichard, C.7
  • 5
    • 0035252433 scopus 로고    scopus 로고
    • Age-dependent variation in contractility of adult cardiac myocytes
    • DOI 10.1016/S1357-2725(00)00077-7, PII S1357272500000777
    • R. R. Nair and P. Nair: Age-dependent variation in contractility of adult cardiac myocytes. Int J Biochem Cell Biol, 33(2), 119-25 (2001) (Pubitemid 32193773)
    • (2001) International Journal of Biochemistry and Cell Biology , vol.33 , Issue.2 , pp. 119-125
    • Nair, R.R.1    Nair, P.2
  • 8
    • 34249025187 scopus 로고    scopus 로고
    • Changes in the structural complexity of the aged brain
    • DOI 10.1111/j.1474-9726.2007.00289.x
    • D. L. Dickstein, D. Kabaso, A. B. Rocher, J. I. Luebke, S. L. Wearne and P. R. Hof: Changes in the structural complexity of the aged brain. Aging Cell, 6(3), 275-84 (2007) (Pubitemid 46785133)
    • (2007) Aging Cell , vol.6 , Issue.3 , pp. 275-284
    • Dickstein, D.L.1    Kabaso, D.2    Rocher, A.B.3    Luebke, J.I.4    Wearne, S.L.5    Hof, P.R.6
  • 9
    • 34447316702 scopus 로고    scopus 로고
    • Genetics of alzheimer's disease: A centennial review
    • DOI 10.1016/j.ncl.2007.03.009, PII S0733861907000552, Dementia
    • N. Ertekin-Taner: Genetics of Alzheimer's disease: a centennial review. Neurol Clin, 25(3), 611-67, v (2007) (Pubitemid 47058875)
    • (2007) Neurologic Clinics , vol.25 , Issue.3 , pp. 611-667
    • Ertekin-Taner, N.1
  • 12
    • 34249775503 scopus 로고    scopus 로고
    • Altered innate immune functioning of dendritic cells in elderly humans: A role of phosphoinositide 3-kinase-signaling pathway
    • A. Agrawal, S. Agrawal, J. N. Cao, H. Su, K. Osann and S. Gupta: Altered innate immune functioning of dendritic cells in elderly humans: a role of phosphoinositide 3-kinase-signaling pathway. J Immunol, 178(11), 6912-22 (2007) (Pubitemid 46847417)
    • (2007) Journal of Immunology , vol.178 , Issue.11 , pp. 6912-6922
    • Agrawal, A.1    Agrawal, S.2    Cao, J.-N.3    Su, H.4    Osann, K.5    Gupta, S.6
  • 13
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: Navigating downstream
    • DOI 10.1016/j.cell.2007.06.009, PII S0092867407007751
    • B. D. Manning and L. C. Cantley: AKT/PKB signaling: navigating downstream. Cell, 129(7), 1261-74 (2007) (Pubitemid 46962095)
    • (2007) Cell , vol.129 , Issue.7 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 14
    • 0035499454 scopus 로고    scopus 로고
    • Ten years of protein kinase B signalling: A hard Akt to follow
    • DOI 10.1016/S0968-0004(01)01958-2, PII S0968000401019582
    • D. P. Brazil and B. A. Hemmings: Ten years of protein kinase B signalling: a hard Akt to follow. Trends Biochem Sci, 26(11), 657-64 (2001) (Pubitemid 33042488)
    • (2001) Trends in Biochemical Sciences , vol.26 , Issue.11 , pp. 657-664
    • Brazil, D.P.1    Hemmings, B.A.2
  • 16
    • 53049104850 scopus 로고    scopus 로고
    • Age-related differences in skeletal muscle insulin signaling: The role of stress kinases and heat shock proteins
    • A. A. Gupte, G. L. Bomhoff and P. C. Geiger: Age-related differences in skeletal muscle insulin signaling: the role of stress kinases and heat shock proteins. J Appl Physiol, 105(3), 839-48 (2008)
    • (2008) J Appl Physiol , vol.105 , Issue.3 , pp. 839-848
    • Gupte, A.A.1    Bomhoff, G.L.2    Geiger, P.C.3
  • 17
    • 65649139145 scopus 로고    scopus 로고
    • Acetaminophen prevents aging-associated hyperglycemia in aged rats: Effect of aging-associated hyperactivation of p38-MAPK and ERK1/2
    • M. Wu, D. H. Desai, S. K. Kakarla, A. Katta, S. Paturi, A. K. Gutta, K. M. Rice, E. M. Walker Jr., and E. R. Blough: Acetaminophen prevents aging-associated hyperglycemia in aged rats: effect of aging-associated hyperactivation of p38-MAPK and ERK1/2. Diabetes Metab Res Rev, 25(3), 279-286 (2009)
    • (2009) Diabetes Metab Res Rev , vol.25 , Issue.3 , pp. 279-286
    • Wu, M.1    Desai, D.H.2    Kakarla, S.K.3    Katta, A.4    Paturi, S.5    Gutta, A.K.6    Rice, K.M.7    Walker Jr., E.M.8    Blough, E.R.9
  • 19
    • 48649088560 scopus 로고    scopus 로고
    • Intracellular signaling by akt: Bound to be specific
    • T. F. Franke: Intracellular signaling by Akt: bound to be specific. Sci Signal, 1(24), pe29 (2008)
    • (2008) Sci Signal , vol.1 , Issue.24
    • Franke, T.F.1
  • 20
    • 34447644976 scopus 로고    scopus 로고
    • Protein kinase B/Akt: A nexus of growth factor and cytokine signaling in determining muscle mass
    • DOI 10.1152/japplphysiol.00089.2007
    • R. A. Frost and C. H. Lang: Protein kinase B/Akt: a nexus of growth factor and cytokine signaling in determining muscle mass. J Appl Physiol, 103(1), 378-87 (2007) (Pubitemid 47092315)
    • (2007) Journal of Applied Physiology , vol.103 , Issue.1 , pp. 378-387
    • Frost, R.A.1    Lang, C.H.2
  • 23
    • 65649154065 scopus 로고    scopus 로고
    • Lean and obese zucker rats exhibit different patterns of p70s6 kinase regulation in the tibialis anterior muscle in response to high-force muscle contraction
    • A. Katta, S. K. Karkala, M. Wu, S. Meduru, D. H. Desai, K. M. Rice and E. R. Blough: Lean and obese Zucker rats exhibit different patterns of p70s6 kinase regulation in the tibialis anterior muscle in response to high-force muscle contraction. Muscle Nerve, 39(4), 503-11 (2009)
    • (2009) Muscle Nerve , vol.39 , Issue.4 , pp. 503-511
    • Katta, A.1    Karkala, S.K.2    Wu, M.3    Meduru, S.4    Desai, D.H.5    Rice, K.M.6    Blough, E.R.7
  • 24
    • 70350560575 scopus 로고    scopus 로고
    • Current perspectives on akt akt-ivation and akt-ions
    • R. W. Matheny Jr., and M. L. Adamo: Current perspectives on Akt Akt-ivation and Akt-ions. Exp Biol Med (Maywood), 234(11), 1264-70 (2009)
    • (2009) Exp Biol Med (Maywood) , vol.234 , Issue.11 , pp. 1264-1270
    • Matheny Jr., R.W.1    Adamo, M.L.2
  • 25
    • 0036849331 scopus 로고    scopus 로고
    • PKB binding proteins: Getting in on the Akt
    • DOI 10.1016/S0092-8674(02)01083-8
    • D. P. Brazil, J. Park and B. A. Hemmings: PKB binding proteins. Getting in on the Akt. Cell, 111(3), 293-303 (2002) (Pubitemid 35341386)
    • (2002) Cell , vol.111 , Issue.3 , pp. 293-303
    • Brazil, D.P.1    Park, J.2    Hemmings, B.A.3
  • 27
    • 0028826421 scopus 로고
    • Cloning, chromosomal localization and expression analysis of the mouse akt2 oncogene
    • D. A. Altomare, K. Guo, J. Q. Cheng, G. Sonoda, K. Walsh and J. R. Testa: Cloning, chromosomal localization and expression analysis of the mouse Akt2 oncogene. Oncogene, 11(6), 1055-60 (1995)
    • (1995) Oncogene , vol.11 , Issue.6 , pp. 1055-1060
    • Altomare, D.A.1    Guo, K.2    Cheng, J.Q.3    Sonoda, G.4    Walsh, K.5    Testa, J.R.6
  • 28
    • 0032493105 scopus 로고    scopus 로고
    • Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin
    • D. A. Altomare, G. E. Lyons, Y. Mitsuuchi, J. Q. Cheng and J. R. Testa: Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin. Oncogene, 16(18), 2407-11 (1998) (Pubitemid 28226889)
    • (1998) Oncogene , vol.16 , Issue.18 , pp. 2407-2411
    • Altomare, D.A.1    Lyons, G.E.2    Mitsuuchi, Y.3    Cheng, J.Q.4    Testa, J.R.5
  • 29
    • 0033515625 scopus 로고    scopus 로고
    • A human protein kinase bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain
    • D. Brodbeck, P. Cron and B. A. Hemmings: A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain. J Biol Chem, 274(14), 9133-6 (1999)
    • (1999) J Biol Chem , vol.274 , Issue.14 , pp. 9133-9136
    • Brodbeck, D.1    Cron, P.2    Hemmings, B.A.3
  • 30
    • 0033591008 scopus 로고    scopus 로고
    • Identification of a human Akt3 (Protein kinase B γ) which contains the regulatory serine phosphorylation site
    • DOI 10.1006/bbrc.1999.0559
    • K. Nakatani, H. Sakaue, D. A. Thompson, R. J. Weigel and R. A. Roth: Identification of a human Akt3 (protein kinase B gamma) which contains the regulatory serine phosphorylation site. Biochem Biophys Res Commun, 257(3), 906-10 (1999) (Pubitemid 29301540)
    • (1999) Biochemical and Biophysical Research Communications , vol.257 , Issue.3 , pp. 906-910
    • Nakatani, K.1    Sakaue, H.2    Thompson, D.A.3    Weigel, R.J.4    Roth, R.A.5
  • 33
    • 0035914388 scopus 로고    scopus 로고
    • Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice
    • H. Cho, J. L. Thorvaldsen, Q. Chu, F. Feng and M. J. Birnbaum: Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. J Biol Chem, 276(42), 38349-52 (2001)
    • (2001) J Biol Chem , vol.276 , Issue.42 , pp. 38349-38352
    • Cho, H.1    Thorvaldsen, J.L.2    Chu, Q.3    Feng, F.4    Birnbaum, M.J.5
  • 34
    • 33745668478 scopus 로고    scopus 로고
    • SiRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle
    • DOI 10.1016/j.cmet.2006.04.008, PII S1550413106001276
    • K. Bouzakri, A. Zachrisson, L. Al-Khalili, B. B. Zhang, H. A. Koistinen, A. Krook and J. R. Zierath: siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle. Cell Metab, 4(1), 89-96 (2006) (Pubitemid 43964475)
    • (2006) Cell Metabolism , vol.4 , Issue.1 , pp. 89-96
    • Bouzakri, K.1    Zachrisson, A.2    Al-Khalili, L.3    Zhang, B.B.4    Koistinen, H.A.5    Krook, A.6    Zierath, J.R.7
  • 35
    • 0035368548 scopus 로고    scopus 로고
    • Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBβ)
    • DOI 10.1126/science.292.5522.1728
    • H. Cho, J. Mu, J. K. Kim, J. L. Thorvaldsen, Q. Chu, E. B. Crenshaw, 3rd, K. H. Kaestner, M. S. Bartolomei, G. I. Shulman and M. J. Birnbaum: Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Science, 292(5522), 1728-31 (2001) (Pubitemid 32506248)
    • (2001) Science , vol.292 , Issue.5522 , pp. 1728-1731
    • Cho, H.1    Mu, J.2    Kim, J.K.3    Thorvaldsen, J.L.4    Chu, Q.5    Crenshaw III, E.B.6    Kaestner, K.H.7    Bartolomei, M.S.8    Shulman, G.I.9    Birnbaum, M.J.10
  • 38
    • 27944493875 scopus 로고    scopus 로고
    • Dosage-dependent effects of Akt1/protein kinase Bα (PKBα) and Akt3/PKBγ on thymus, skin, and cardiovascular and nervous system development in mice
    • DOI 10.1128/MCB.25.23.10407-10418.2005
    • Z. Z. Yang, O. Tschopp, N. Di-Poi, E. Bruder, A. Baudry, B. Dummler, W. Wahli and B. A. Hemmings: Dosage-dependent effects of Akt1/protein kinase Balpha (PKBalpha) and Akt3/PKBgamma on thymus, skin, and cardiovascular and nervous system development in mice. Mol Cell Biol, 25(23), 10407-18 (2005) (Pubitemid 41681964)
    • (2005) Molecular and Cellular Biology , vol.25 , Issue.23 , pp. 10407-10418
    • Yang, Z.-Z.1    Tschopp, O.2    Di-Poi, N.3    Bruder, E.4    Baudry, A.5    Dummler, B.6    Wahli, W.7    Hemmings, B.A.8
  • 39
    • 33750380920 scopus 로고    scopus 로고
    • Life with a single isoform of Akt: Mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies
    • DOI 10.1128/MCB.00722-06
    • B. Dummler, O. Tschopp, D. Hynx, Z. Z. Yang, S. Dirnhofer and B. A. Hemmings: Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies. Mol Cell Biol, 26(21), 8042-51 (2006) (Pubitemid 44631003)
    • (2006) Molecular and Cellular Biology , vol.26 , Issue.21 , pp. 8042-8051
    • Dummler, B.1    Tschopp, O.2    Hynx, D.3    Yang, Z.-Z.4    Dirnhofer, S.5    Hemmings, B.A.6
  • 40
    • 62149108988 scopus 로고    scopus 로고
    • Distinct actions of akt1 and akt2 in skeletal muscle differentiation
    • P. Rotwein and E. M. Wilson: Distinct actions of Akt1 and Akt2 in skeletal muscle differentiation. J Cell Physiol, 219(2), 503-11 (2009)
    • (2009) J Cell Physiol , vol.219 , Issue.2 , pp. 503-511
    • Rotwein, P.1    Wilson, E.M.2
  • 41
    • 17844401269 scopus 로고    scopus 로고
    • Akt2 Is essential for the full effect of calorie restriction on insulin-stimulated glucose uptake in skeletal muscle
    • DOI 10.2337/diabetes.54.5.1349
    • C. E. McCurdy and G. D. Cartee: Akt2 is essential for the full effect of calorie restriction on insulin-stimulated glucose uptake in skeletal muscle. Diabetes, 54(5), 1349-56 (2005) (Pubitemid 40586663)
    • (2005) Diabetes , vol.54 , Issue.5 , pp. 1349-1356
    • McCurdy, C.E.1    Cartee, G.D.2
  • 42
    • 0032752063 scopus 로고    scopus 로고
    • Cellular survival: A play in three akts
    • S. R. Datta, A. Brunet and M. E. Greenberg: Cellular survival: a play in three Akts. Genes Dev, 13(22), 2905-27 (1999)
    • (1999) Genes Dev , vol.13 , Issue.22 , pp. 2905-2927
    • Datta, S.R.1    Brunet, A.2    Greenberg, M.E.3
  • 43
    • 36248985545 scopus 로고    scopus 로고
    • G protein-coupled receptor-induced Akt activity in cellular proliferation and apoptosis
    • DOI 10.1111/j.1742-4658.2007.06116.x
    • D. C. New, K. Wu, A. W. Kwok and Y. H. Wong: G protein-coupled receptor-induced Akt activity in cellular proliferation and apoptosis. Febs J, 274(23), 6025-36 (2007) (Pubitemid 350135324)
    • (2007) FEBS Journal , vol.274 , Issue.23 , pp. 6025-6036
    • New, D.C.1    Wu, K.2    Kwok, A.W.S.3    Wong, Y.H.4
  • 45
  • 47
    • 34447097272 scopus 로고    scopus 로고
    • Stimulation of phosphoinositide 3-kinase/Akt signaling by copper and zinc ions: Mechanisms and consequences
    • DOI 10.1016/j.abb.2007.04.015, PII S0003986107002044
    • A. Barthel, E. A. Ostrakhovitch, P. L. Walter, A. Kampkotter and L. O. Klotz: Stimulation of phosphoinositide 3-kinase/Akt signaling by copper and zinc ions: mechanisms and consequences. Arch Biochem Biophys, 463(2), 175-82 (2007) (Pubitemid 47030342)
    • (2007) Archives of Biochemistry and Biophysics , vol.463 , Issue.2 , pp. 175-182
    • Barthel, A.1    Ostrakhovitch, E.A.2    Walter, P.L.3    Kampkotter, A.4    Klotz, L.-O.5
  • 48
    • 27844601539 scopus 로고    scopus 로고
    • Regulation of the Akt kinase by interacting proteins
    • DOI 10.1038/sj.onc.1209099, PII 1209099
    • K. Du and P. N. Tsichlis: Regulation of the Akt kinase by interacting proteins. Oncogene, 24(50), 7401-9 (2005) (Pubitemid 41637980)
    • (2005) Oncogene , vol.24 , Issue.50 , pp. 7401-7409
    • Du, K.1    Tsichlis, P.N.2
  • 49
    • 34547795824 scopus 로고    scopus 로고
    • Proto-oncogene TCL1: More than just a coactivator for Akt
    • DOI 10.1096/fj.06-7684com
    • M. Noguchi, V. Ropars, C. Roumestand and F. Suizu: Proto-oncogene TCL1: more than just a coactivator for Akt. Faseb J, 21(10), 2273-84 (2007) (Pubitemid 47230657)
    • (2007) FASEB Journal , vol.21 , Issue.10 , pp. 2273-2284
    • Noguchi, M.1    Ropars, V.2    Roumestand, C.3    Suizu, F.4
  • 50
    • 0035850916 scopus 로고    scopus 로고
    • Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane
    • DOI 10.1126/science.1062030
    • S. M. Maira, I. Galetic, D. P. Brazil, S. Kaech, E. Ingley, M. Thelen and B. A. Hemmings: Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane. Science, 294(5541), 374-80 (2001) (Pubitemid 32963405)
    • (2001) Science , vol.294 , Issue.5541 , pp. 374-380
    • Maira, S.-M.1    Galetic, I.2    Brazil, D.P.3    Kaech, S.4    Ingley, E.5    Thelen, M.6    Hemmings, B.A.7
  • 51
    • 34047095297 scopus 로고    scopus 로고
    • The two torcs and akt
    • DOI 10.1016/j.devcel.2007.03.020, PII S1534580707001207
    • P. T. Bhaskar and N. Hay: The two TORCs and Akt. Dev Cell, 12(4), 487-502 (2007) (Pubitemid 46523652)
    • (2007) Developmental Cell , vol.12 , Issue.4 , pp. 487-502
    • Bhaskar, P.T.1    Hay, N.2
  • 52
    • 4644359805 scopus 로고    scopus 로고
    • Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase
    • DOI 10.1074/jbc.M406731200
    • J. Feng, J. Park, P. Cron, D. Hess and B. A. Hemmings: Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase. J Biol Chem, 279(39), 41189-96 (2004) (Pubitemid 39287721)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.39 , pp. 41189-41196
    • Feng, J.1    Park, J.2    Cron, P.3    Hess, D.4    Hemmings, B.A.5
  • 53
    • 0036333737 scopus 로고    scopus 로고
    • Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B
    • DOI 10.1128/MCB.22.17.6247-6260.2002
    • M. P. Scheid, P. A. Marignani and J. R. Woodgett: Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B. Mol Cell Biol, 22(17), 6247-60 (2002) (Pubitemid 34857843)
    • (2002) Molecular and Cellular Biology , vol.22 , Issue.17 , pp. 6247-6260
    • Scheid, M.P.1    Marignani, P.A.2    Woodgett, J.R.3
  • 54
    • 0033545393 scopus 로고    scopus 로고
    • Intracellular signalling: PDK1 - A kinase at the hub of things
    • DOI 10.1016/S0960-9822(99)80058-X
    • C. Belham, S. Wu and J. Avruch: Intracellular signalling: PDK1 - a kinase at the hub of things. Curr Biol, 9(3), R93-6 (1999) (Pubitemid 29087534)
    • (1999) Current Biology , vol.9 , Issue.3
    • Belham, C.1    Shilan, W.2    Avruch, J.3
  • 55
    • 17844371042 scopus 로고    scopus 로고
    • Regulation of phosphoinositide metabolism, Akt phosphorylation, and glucose transport by PTEN (phosphatase and tensin homolog deleted on chromosome 10) in 3T3-L1 adipocytes
    • DOI 10.1210/me.15.8.1411
    • H. Ono, H. Katagiri, M. Funaki, M. Anai, K. Inukai, Y. Fukushima, H. Sakoda, T. Ogihara, Y. Onishi, M. Fujishiro, M. Kikuchi, Y. Oka and T. Asano: Regulation of phosphoinositide metabolism, Akt phosphorylation, and glucose transport by PTEN (phosphatase and tensin homolog deleted on chromosome 10) in 3T3-L1 adipocytes. Mol Endocrinol, 15(8), 1411-22 (2001) (Pubitemid 32703487)
    • (2001) Molecular Endocrinology , vol.15 , Issue.8 , pp. 1411-1422
    • Ono, H.1    Katagiri, H.2    Funaki, M.3    Anai, M.4    Inukai, K.5    Fukushima, Y.6    Sakoda, H.7    Ogihara, T.8    Onishi, Y.9    Fujishiro, M.10    Kikuchi, M.11    Oka, Y.12    Asano, T.13
  • 56
  • 57
    • 0033429554 scopus 로고    scopus 로고
    • Mammalian target of rapamycin is a direct target for protein kinase B: Identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation
    • DOI 10.1042/0264-6021:3440427
    • B. T. Nave, M. Ouwens, D. J. Withers, D. R. Alessi and P. R. Shepherd: Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation. Biochem J, 344 Pt 2, 427-31 (1999) (Pubitemid 30011599)
    • (1999) Biochemical Journal , vol.344 , Issue.2 , pp. 427-431
    • Nave, B.T.1    Ouwens, D.M.2    Withers, D.J.3    Alessi, D.R.4    Shepherd, P.R.5
  • 58
    • 0036713778 scopus 로고    scopus 로고
    • TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
    • DOI 10.1038/ncb839
    • K. Inoki, Y. Li, T. Zhu, J. Wu and K. L. Guan: TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol, 4(9), 648-57 (2002) (Pubitemid 34993700)
    • (2002) Nature Cell Biology , vol.4 , Issue.9 , pp. 648-657
    • Inoki, K.1    Li, Y.2    Zhu, T.3    Wu, J.4    Guan, K.-L.5
  • 59
    • 0032543578 scopus 로고    scopus 로고
    • The Kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136
    • P. Blume-Jensen, R. Janknecht and T. Hunter: The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136. Curr Biol, 8(13), 779-82 (1998) (Pubitemid 28301165)
    • (1998) Current Biology , vol.8 , Issue.13 , pp. 779-782
    • Blume-Jensen, P.1    Janknecht, R.2    Hunter, T.3
  • 63
    • 0029587224 scopus 로고
    • Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    • DOI 10.1038/378785a0
    • D. A. Cross, D. R. Alessi, P. Cohen, M. Andjelkovich and B. A. Hemmings: Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature, 378(6559), 785-9 (1995) (Pubitemid 26004411)
    • (1995) Nature , vol.378 , Issue.6559 , pp. 785-789
    • Cross, D.A.E.1    Alessi, D.R.2    Cohen, P.3    Andjelkovich, M.4    Hemmings, B.A.5
  • 64
    • 0032557646 scopus 로고    scopus 로고
    • Essential role for protein kinase B (PKB) in insulin-induced glycogen synthase kinase 3 inactivation. Characterization of dominant-negative mutant of PKB
    • DOI 10.1074/jbc.273.21.13150
    • P. C. van Weeren, K. M. de Bruyn, A. M. de Vries-Smits, J. van Lint and B. M. Burgering: Essential role for protein kinase B (PKB) in insulin-induced glycogen synthase kinase 3 inactivation. Characterization of dominant-negative mutant of PKB. J Biol Chem, 273(21), 13150-6 (1998) (Pubitemid 28246883)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.21 , pp. 13150-13156
    • Van Weeren, P.C.1    De Bruyn, K.M.T.2    De Vries-Smits, A.M.M.3    Van Lint, J.4    Burgering, B.M.T.5
  • 65
    • 33644855216 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1
    • DOI 10.1016/j.molcel.2006.02.009, PII S1097276506001110
    • U. Maurer, C. Charvet, A. S. Wagman, E. Dejardin and D. R. Green: Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Mol Cell, 21(6), 749-60 (2006) (Pubitemid 43376126)
    • (2006) Molecular Cell , vol.21 , Issue.6 , pp. 749-760
    • Maurer, U.1    Charvet, C.2    Wagman, A.S.3    Dejardin, E.4    Green, D.R.5
  • 66
    • 0033542476 scopus 로고    scopus 로고
    • Activation of nitric oxide synthase in endothelial cells by akt-dependent phosphorylation
    • S. Dimmeler, I. Fleming, B. Fisslthaler, C. Hermann, R. Busse and A. M. Zeiher: Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature, 399(6736), 601-5 (1999)
    • (1999) Nature , vol.399 , Issue.6736 , pp. 601-605
    • Dimmeler, S.1    Fleming, I.2    Fisslthaler, B.3    Hermann, C.4    Busse, R.5    Zeiher, A.M.6
  • 67
    • 46149086585 scopus 로고    scopus 로고
    • Central control of thermogenesis in mammals
    • DOI 10.1113/expphysiol.2007.041848
    • S. F. Morrison, K. Nakamura and C. J. Madden: Central control of thermogenesis in mammals. Exp Physiol, 93(7), 773-97 (2008) (Pubitemid 351904256)
    • (2008) Experimental Physiology , vol.93 , Issue.7 , pp. 773-797
    • Morrison, S.F.1    Nakamura, K.2    Madden, C.J.3
  • 68
    • 0026635733 scopus 로고
    • Skeletal muscle tone and the misunderstood stretch reflex
    • R. A. Davidoff: Skeletal muscle tone and the misunderstood stretch reflex. Neurology, 42(5), 951-63 (1992)
    • (1992) Neurology , vol.42 , Issue.5 , pp. 951-963
    • Davidoff, R.A.1
  • 69
  • 70
    • 57349126137 scopus 로고    scopus 로고
    • Caloric restriction optimizes the proteasome pathway with aging in rat plantaris muscle: Implications for sarcopenia
    • R. T. Hepple, M. Qin, H. Nakamoto and S. Goto: Caloric restriction optimizes the proteasome pathway with aging in rat plantaris muscle: implications for sarcopenia. Am J Physiol Regul Integr Comp Physiol, 295(4), R1231-7 (2008)
    • (2008) Am J Physiol Regul Integr Comp Physiol , vol.295 , Issue.4
    • Hepple, R.T.1    Qin, M.2    Nakamoto, H.3    Goto, S.4
  • 71
    • 58149172075 scopus 로고    scopus 로고
    • Aortic aging in the fischer 344 / NNiaHSd x brown Norway / BiNia rat
    • K. M. Rice, M. Wu and E. R. Blough: Aortic aging in the Fischer 344 / NNiaHSd x Brown Norway / BiNia Rat. J Pharmacol Sci, 108(4), 393-8 (2008)
    • (2008) J Pharmacol Sci , vol.108 , Issue.4 , pp. 393-398
    • Rice, K.M.1    Wu, M.2    Blough, E.R.3
  • 73
    • 33646474863 scopus 로고    scopus 로고
    • Age-associated decrease in contraction-induced activation of downstream targets of akt/mTor signaling in skeletal muscle
    • K. Funai, J. D. Parkington, S. Carambula and R. A. Fielding: Age-associated decrease in contraction-induced activation of downstream targets of Akt/mTor signaling in skeletal muscle. Am J Physiol Regul Integr Comp Physiol, 290(4), R1080-6 (2006)
    • (2006) Am J Physiol Regul Integr Comp Physiol , vol.290 , Issue.4
    • Funai, K.1    Parkington, J.D.2    Carambula, S.3    Fielding, R.A.4
  • 74
    • 33646357762 scopus 로고    scopus 로고
    • Aging-sensitive cellular and molecular mechanisms associated with skeletal muscle hypertrophy
    • DOI 10.1152/japplphysiol.01227.2005
    • F. Haddad and G. R. Adams: Aging-sensitive cellular and molecular mechanisms associated with skeletal muscle hypertrophy. J Appl Physiol, 100(4), 1188-203 (2006) (Pubitemid 43671476)
    • (2006) Journal of Applied Physiology , vol.100 , Issue.4 , pp. 1188-1203
    • Haddad, F.1    Adams, G.R.2
  • 75
    • 9444290436 scopus 로고    scopus 로고
    • Impaired anabolic response of muscle protein synthesis is associated with S6K1 dysregulation in elderly humans
    • DOI 10.1096/fj.03-1341fje
    • C. Guillet, M. Prod'homme, M. Balage, P. Gachon, C. Giraudet, L. Morin, J. Grizard and Y. Boirie: Impaired anabolic response of muscle protein synthesis is associated with S6K1 dysregulation in elderly humans. Faseb J, 18(13), 1586-7 (2004) (Pubitemid 39561641)
    • (2004) FASEB Journal , vol.18 , Issue.13 , pp. 1586-1587
    • Guillet, C.1    Prod'homme, M.2    Balage, M.3    Gachon, P.4    Giraudet, C.5    Morin, L.6    Grizard, J.7    Boirie, Y.8
  • 76
    • 0347363477 scopus 로고    scopus 로고
    • Responsiveness of cell signaling pathways during the failed 15-day regrowth of aged skeletal muscle
    • DOI 10.1152/japplphysiol.00454.2003
    • R. T. Morris, E. E. Spangenburg and F. W. Booth: Responsiveness of cell signaling pathways during the failed 15-day regrowth of aged skeletal muscle. J Appl Physiol, 96(1), 398-404 (2004) (Pubitemid 38032026)
    • (2004) Journal of Applied Physiology , vol.96 , Issue.1 , pp. 398-404
    • Morris, R.T.1    Spangenburg, E.E.2    Booth, F.W.3
  • 77
    • 66149120589 scopus 로고    scopus 로고
    • Age-related deficit in load-induced skeletal muscle growth
    • D. T. Hwee and S. C. Bodine: Age-related deficit in load-induced skeletal muscle growth. J Gerontol A Biol Sci Med Sci, 64(6), 618-28 (2009)
    • (2009) J Gerontol a Biol Sci Med Sci , vol.64 , Issue.6 , pp. 618-628
    • Hwee, D.T.1    Bodine, S.C.2
  • 78
    • 70350135233 scopus 로고    scopus 로고
    • Effects of PI3K catalytic subunit and akt isoform deficiency on mTOR and p70S6K activation in myoblasts
    • R. W. Matheny Jr., and M. L. Adamo: Effects of PI3K catalytic subunit and Akt isoform deficiency on mTOR and p70S6K activation in myoblasts. Biochem Biophys Res Commun, 390(2), 252-7 (2009)
    • (2009) Biochem Biophys Res Commun , vol.390 , Issue.2 , pp. 252-257
    • Matheny Jr., R.W.1    Adamo, M.L.2
  • 79
    • 0028670343 scopus 로고
    • S6 phosphorylation and the p70s6k/p85s6k
    • S. Ferrari and G. Thomas: S6 phosphorylation and the p70s6k/p85s6k. Crit Rev Biochem Mol Biol, 29(6), 385-413 (1994)
    • (1994) Crit Rev Biochem Mol Biol , vol.29 , Issue.6 , pp. 385-413
    • Ferrari, S.1    Thomas, G.2
  • 80
    • 0032520009 scopus 로고    scopus 로고
    • 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway
    • A. C. Gingras, S. G. Kennedy, M. A. O'Leary, N. Sonenberg and N. Hay: 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway. Genes Dev, 12(4), 502-13 (1998) (Pubitemid 28101013)
    • (1998) Genes and Development , vol.12 , Issue.4 , pp. 502-513
    • Gingras, A.-C.1    Kennedy, S.G.2    O'Leary, M.A.3    Sonenberg, N.4    Hay, N.5
  • 81
    • 38949179820 scopus 로고    scopus 로고
    • Involvement of phosphoinositide 3-kinase and Akt in the induction of muscle protein degradation by proteolysis-inducing factor
    • DOI 10.1042/BJ20070688
    • S. T. Russell, H. L. Eley, S. M. Wyke and M. J. Tisdale: Involvement of phosphoinositide 3-kinase and Akt in the induction of muscle protein degradation by proteolysis-inducing factor. Biochem J, 409(3), 751-9 (2008) (Pubitemid 351214201)
    • (2008) Biochemical Journal , vol.409 , Issue.3 , pp. 751-759
    • Russell, S.T.1    Eley, H.L.2    Wyke, S.M.3    Tisdale, M.J.4
  • 82
    • 2042425906 scopus 로고    scopus 로고
    • The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors
    • DOI 10.1016/S1097-2765(04)00211-4, PII S1097276504002114
    • T. N. Stitt, D. Drujan, B. A. Clarke, F. Panaro, Y. Timofeyva, W. O. Kline, M. Gonzalez, G. D. Yancopoulos and D. J. Glass: The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors. Mol Cell, 14(3), 395-403 (2004) (Pubitemid 38591410)
    • (2004) Molecular Cell , vol.14 , Issue.3 , pp. 395-403
    • Stitt, T.N.1    Drujan, D.2    Clarke, B.A.3    Panaro, F.4    Timofeyva, Y.5    Kline, W.O.6    Gonzalez, M.7    Yancopoulos, G.D.8    Glass, D.J.9
  • 83
    • 33748526240 scopus 로고    scopus 로고
    • Atrophy-related ubiquitin ligases, atrogin-1 and MuRF1 are up-regulated in aged rat Tibialis Anterior muscle
    • DOI 10.1016/j.mad.2006.07.005, PII S0047637406001709
    • S. Clavel, A. S. Coldefy, E. Kurkdjian, J. Salles, I. Margaritis and B. Derijard: Atrophy-related ubiquitin ligases, atrogin-1 and MuRF1 are up-regulated in aged rat Tibialis Anterior muscle. Mech Ageing Dev, 127(10), 794-801 (2006) (Pubitemid 44374662)
    • (2006) Mechanisms of Ageing and Development , vol.127 , Issue.10 , pp. 794-801
    • Clavel, S.1    Coldefy, A.-S.2    Kurkdjian, E.3    Salles, J.4    Margaritis, I.5    Derijard, B.6
  • 84
    • 0037381535 scopus 로고    scopus 로고
    • Defective signaling through Akt-2 and -3 but not Akt-1 in insulin-resistant human skeletal muscle: Potential role in insulin resistance
    • DOI 10.2337/diabetes.52.4.935
    • J. T. Brozinick Jr., B. R. Roberts and G. L. Dohm: Defective signaling through Akt-2 and -3 but not Akt-1 in insulin-resistant human skeletal muscle: potential role in insulin resistance. Diabetes, 52(4), 935-41 (2003) (Pubitemid 36384263)
    • (2003) Diabetes , vol.52 , Issue.4 , pp. 935-941
    • Brozinick Jr., J.T.1    Roberts, B.R.2    Dohm, G.L.3
  • 85
    • 2342428466 scopus 로고    scopus 로고
    • Tumor Necrosis Factor α Produces Insulin Resistance in Skeletal Muscle by Activation of Inhibitor κB Kinase in a p38 MAPK-dependent Manner
    • DOI 10.1074/jbc.M312021200
    • C. de Alvaro, T. Teruel, R. Hernandez and M. Lorenzo: Tumor necrosis factor alpha produces insulin resistance in skeletal muscle by activation of inhibitor kappaB kinase in a p38 MAPK-dependent manner. J Biol Chem, 279(17), 17070-8 (2004) (Pubitemid 38560462)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.17 , pp. 17070-17078
    • De Alvaro, C.1    Teruel, T.2    Hernandez, R.3    Lorenzo, M.4
  • 86
    • 39049172652 scopus 로고    scopus 로고
    • Isoform-specific defects of insulin stimulation of akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients
    • D. Cozzone, S. Frojdo, E. Disse, C. Debard, M. Laville, L. Pirola and H. Vidal: Isoform-specific defects of insulin stimulation of Akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients. Diabetologia, 51(3), 512-21 (2008)
    • (2008) Diabetologia , vol.51 , Issue.3 , pp. 512-521
    • Cozzone, D.1    Frojdo, S.2    Disse, E.3    Debard, C.4    Laville, M.5    Pirola, L.6    Vidal, H.7
  • 88
    • 33748597111 scopus 로고    scopus 로고
    • Protein kinase Cδ participates in insulin-induced activation of PKB via PDK1
    • DOI 10.1016/j.bbrc.2006.08.100, PII S0006291X06019243
    • C. Brand, M. Cipok, V. Attali, A. Bak and S. R. Sampson: Protein kinase Cdelta participates in insulin-induced activation of PKB via PDK1. Biochem Biophys Res Commun, 349(3), 954-62 (2006) (Pubitemid 44380192)
    • (2006) Biochemical and Biophysical Research Communications , vol.349 , Issue.3 , pp. 954-962
    • Brand, C.1    Cipok, M.2    Attali, V.3    Bak, A.4    Sampson, S.R.5
  • 89
    • 33646258495 scopus 로고    scopus 로고
    • Spatial and temporal regulation of GLUT4 translocation by flotillin-1 and caveolin-3 in skeletal muscle cells
    • DOI 10.1096/fj.05-4661fje
    • K. Fecchi, D. Volonte, M. P. Hezel, K. Schmeck and F. Galbiati: Spatial and temporal regulation of GLUT4 translocation by flotillin-1 and caveolin-3 in skeletal muscle cells. Faseb J, 20(6), 705-7 (2006) (Pubitemid 46671188)
    • (2006) FASEB Journal , vol.20 , Issue.6 , pp. 705-707
    • Fecchi, K.1    Volonte, D.2    Hezel, M.P.3    Schmeck, K.4    Galbiati, F.5
  • 90
    • 59049097003 scopus 로고    scopus 로고
    • The effect of aging on insulin signalling pathway is tissue dependent: Central role of adipose tissue in the insulin resistance of aging
    • R. Serrano, M. Villar, N. Gallardo, J. M. Carrascosa, C. Martinez and A. Andres: The effect of aging on insulin signalling pathway is tissue dependent: central role of adipose tissue in the insulin resistance of aging. Mech Ageing Dev, 130(3), 189-97 (2009)
    • (2009) Mech Ageing Dev , vol.130 , Issue.3 , pp. 189-197
    • Serrano, R.1    Villar, M.2    Gallardo, N.3    Carrascosa, J.M.4    Martinez, C.5    Andres, A.6
  • 91
    • 33749684748 scopus 로고    scopus 로고
    • Calorie restriction initiated at middle age improved glucose tolerance without affecting age-related impairments of insulin signaling in rat skeletal muscle
    • DOI 10.1016/j.exger.2006.06.055, PII S0531556506002427
    • S. Park, T. Komatsu, H. Hayashi, H. Yamaza, T. Chiba, Y. Higami, K. Kuramoto and I. Shimokawa: Calorie restriction initiated at middle age improved glucose tolerance without affecting age-related impairments of insulin signaling in rat skeletal muscle. Exp Gerontol, 41(9), 837-45 (2006) (Pubitemid 44557025)
    • (2006) Experimental Gerontology , vol.41 , Issue.9 , pp. 837-845
    • Park, S.1    Komatsu, T.2    Hayashi, H.3    Yamaza, H.4    Chiba, T.5    Higami, Y.6    Kuramoto, K.7    Shimokawa, I.8
  • 92
    • 43049107547 scopus 로고    scopus 로고
    • A potential role for skeletal muscle caveolin-1 as an insulin sensitivity modulator in ageing-dependent non-obese type 2 diabetes: Studies in a new mouse model
    • Y. S. Oh, L. Y. Khil, K. A. Cho, S. J. Ryu, M. K. Ha, G. J. Cheon, T. S. Lee, J. W. Yoon, H. S. Jun and S. C. Park: A potential role for skeletal muscle caveolin-1 as an insulin sensitivity modulator in ageing-dependent non-obese type 2 diabetes: studies in a new mouse model. Diabetologia, 51(6), 1025-34 (2008)
    • (2008) Diabetologia , vol.51 , Issue.6 , pp. 1025-1034
    • Oh, Y.S.1    Khil, L.Y.2    Cho, K.A.3    Ryu, S.J.4    Ha, M.K.5    Cheon, G.J.6    Lee, T.S.7    Yoon, J.W.8    Jun, H.S.9    Park, S.C.10
  • 93
    • 4344581405 scopus 로고    scopus 로고
    • Disruption of the SH2-B gene causes age-dependent insulin resistance and glucose intolerance
    • DOI 10.1128/MCB.24.17.7435-7443.2004
    • C. Duan, H. Yang, M. F. White and L. Rui: Disruption of the SH2-B gene causes age-dependent insulin resistance and glucose intolerance. Mol Cell Biol, 24(17), 7435-43 (2004) (Pubitemid 39121472)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.17 , pp. 7435-7443
    • Duan, C.1    Yang, H.2    White, M.F.3    Rui, L.4
  • 94
    • 77952419746 scopus 로고    scopus 로고
    • Chronic 17beta-estradiol treatment improves skeletal muscle insulin signaling pathway components in insulin resistance associated with aging
    • M. Moreno, P. Ordonez, A. Alonso, F. Diaz, J. Tolivia and C. Gonzalez: Chronic 17beta-estradiol treatment improves skeletal muscle insulin signaling pathway components in insulin resistance associated with aging. Age (Dordr) (2009)
    • (2009) Age (Dordr)
    • Moreno, M.1    Ordonez, P.2    Alonso, A.3    Diaz, F.4    Tolivia, J.5    Gonzalez, C.6
  • 95
    • 0142106463 scopus 로고    scopus 로고
    • Age-related differences in the des IGF-I-mediated activation of Akt-1 and p70 S6K in mouse skeletal muscle
    • DOI 10.1016/S0047-6374(03)00124-6
    • M. Li, C. Li and W. S. Parkhouse: Age-related differences in the des IGF-I-mediated activation of Akt-1 and p70 S6K in mouse skeletal muscle. Mech Ageing Dev, 124(7), 771-8 (2003) (Pubitemid 37279135)
    • (2003) Mechanisms of Ageing and Development , vol.124 , Issue.7 , pp. 771-778
    • Li, M.1    Li, C.2    Parkhouse, W.S.3
  • 96
    • 39449100832 scopus 로고    scopus 로고
    • Human sarcopenia reveals an increase in SOCS-3 and myostatin and a reduced efficiency of akt phosphorylation
    • B. Leger, W. Derave, K. De Bock, P. Hespel and A. P. Russell: Human sarcopenia reveals an increase in SOCS-3 and myostatin and a reduced efficiency of Akt phosphorylation. Rejuvenation Res, 11(1), 163-175B (2008)
    • (2008) Rejuvenation Res , vol.11 , Issue.1
    • Leger, B.1    Derave, W.2    De Bock, K.3    Hespel, P.4    Russell, A.P.5
  • 99
    • 67650309019 scopus 로고    scopus 로고
    • Bone modeling and remodeling
    • E. Seeman: Bone modeling and remodeling. Crit Rev Eukaryot Gene Expr, 19(3), 219-33 (2009)
    • (2009) Crit Rev Eukaryot Gene Expr , vol.19 , Issue.3 , pp. 219-233
    • Seeman, E.1
  • 100
    • 65949087872 scopus 로고    scopus 로고
    • Developments in the scientific understanding of osteoporosis
    • N. E. Lane and W. Yao: Developments in the scientific understanding of osteoporosis. Arthritis Res Ther, 11(3), 228 (2009)
    • (2009) Arthritis Res Ther , vol.11 , Issue.3 , pp. 228
    • Lane, N.E.1    Yao, W.2
  • 101
    • 59249084680 scopus 로고    scopus 로고
    • Expression of the longevity proteins by both red and white wines and their cardioprotective components, resveratrol, tyrosol, and hydroxytyrosol
    • S. Mukherjee, I. Lekli, N. Gurusamy, A. A. Bertelli and D. K. Das: Expression of the longevity proteins by both red and white wines and their cardioprotective components, resveratrol, tyrosol, and hydroxytyrosol. Free Radic Biol Med, 46(5), 573-8 (2009)
    • (2009) Free Radic Biol Med , vol.46 , Issue.5 , pp. 573-578
    • Mukherjee, S.1    Lekli, I.2    Gurusamy, N.3    Bertelli, A.A.4    Das, D.K.5
  • 104
    • 55849107783 scopus 로고    scopus 로고
    • European guidance for the diagnosis and management of osteoporosis in postmenopausal women - What is the current message for clinical practice?
    • J. A. Kanis and J. Y. Reginster: European guidance for the diagnosis and management of osteoporosis in postmenopausal women - what is the current message for clinical practice? Pol Arch Med Wewn, 118(10), 538-40 (2008)
    • (2008) Pol Arch Med Wewn , vol.118 , Issue.10 , pp. 538-540
    • Kanis, J.A.1    Reginster, J.Y.2
  • 106
    • 59649084411 scopus 로고    scopus 로고
    • Increased expression of the akt/PKB inhibitor TRB3 in osteoarthritic chondrocytes inhibits insulin-like growth factor 1-mediated cell survival and proteoglycan synthesis
    • J. D. Cravero, C. S. Carlson, H. J. Im, R. R. Yammani, D. Long and R. F. Loeser: Increased expression of the Akt/PKB inhibitor TRB3 in osteoarthritic chondrocytes inhibits insulin-like growth factor 1-mediated cell survival and proteoglycan synthesis. Arthritis Rheum, 60(2), 492-500 (2009)
    • (2009) Arthritis Rheum , vol.60 , Issue.2 , pp. 492-500
    • Cravero, J.D.1    Carlson, C.S.2    Im, H.J.3    Yammani, R.R.4    Long, D.5    Loeser, R.F.6
  • 107
    • 0033304161 scopus 로고    scopus 로고
    • Cardiovascular risks related to increased diastolic, systolic and pulse pressure. An epidemiologist's point of view
    • S. S. Franklin: Cardiovascular risks related to increased diastolic, systolic and pulse pressure. An epidemiologist's point of view. Pathol Biol (Paris), 47(6), 594-603 (1999)
    • (1999) Pathol Biol (Paris) , vol.47 , Issue.6 , pp. 594-603
    • Franklin, S.S.1
  • 108
    • 10644227035 scopus 로고    scopus 로고
    • Systolic blood pressure it's time to take control
    • S. S. Franklin: Systolic blood pressure It's time to take control. Am J Hypertens, 17(12 Pt 2), S49-54 (2004)
    • (2004) Am J Hypertens , vol.17 , Issue.12 PART 2
    • Franklin, S.S.1
  • 109
    • 0028051464 scopus 로고
    • Aging effects on the vasculature in health: Risk factors for cardiovascular disease
    • E. Lakatta: Aging Effects on the Vasculature in Health: Risk Factors for Cardiovascular Disease. Am J Geriatr Cardiol, 3(6), 11-17 (1994)
    • (1994) Am J Geriatr Cardiol , vol.3 , Issue.6 , pp. 11-17
    • Lakatta, E.1
  • 110
    • 0029126538 scopus 로고
    • Arterial wall hypertrophy and stiffness in essential hypertensive patients
    • S. Laurent: Arterial wall hypertrophy and stiffness in essential hypertensive patients. Hypertension, 26(2), 355-62 (1995)
    • (1995) Hypertension , vol.26 , Issue.2 , pp. 355-362
    • Laurent, S.1
  • 111
    • 0031791380 scopus 로고    scopus 로고
    • Cardiovascular aging: Perspectives from humans to rodents
    • E. G. Lakatta: Cardiovascular Aging: Perspectives From Humans to Rodents. Am J Geriatr Cardiol, 7(6), 32-45 (1998) (Pubitemid 28538496)
    • (1998) American Journal of Geriatric Cardiology , vol.7 , Issue.6 , pp. 32-45
    • Lakatta, E.G.1
  • 112
    • 0031852988 scopus 로고    scopus 로고
    • Aging and cardiovascular structure and function in healthy sedentary humans
    • E. G. Lakatta: Aging and cardiovascular structure and function in healthy sedentary humans. Aging (Milano), 10(2), 162-4 (1998) (Pubitemid 28318511)
    • (1998) Aging - Clinical and Experimental Research , vol.10 , Issue.2 , pp. 162-164
    • Lakatta, E.G.1
  • 114
    • 39049192580 scopus 로고    scopus 로고
    • Role of akt in cardiac growth and metabolism
    • discussion 126-31, 152-5, 272-6
    • A. J. Muslin and B. DeBosch: Role of Akt in cardiac growth and metabolism. Novartis Found Symp, 274, 118-26; discussion 126-31, 152-5, 272-6 (2006)
    • (2006) Novartis Found Symp , vol.274 , pp. 118-126
    • Muslin, A.J.1    DeBosch, B.2
  • 120
    • 0034517548 scopus 로고    scopus 로고
    • Intracoronary, adenovirus-mediated Akt gene transfer in heart limits infarct size following ischemia-reperfusion injury in vivo
    • DOI 10.1006/jmcc.2000.1283
    • W. Miao, Z. Luo, R. N. Kitsis and K. Walsh: Intracoronary, adenovirus-mediated Akt gene transfer in heart limits infarct size following ischemia-reperfusion injury in vivo. J Mol Cell Cardiol, 32(12), 2397-402 (2000) (Pubitemid 32039789)
    • (2000) Journal of Molecular and Cellular Cardiology , vol.32 , Issue.12 , pp. 2397-2402
    • Miao, W.1    Luo, Z.2    Kitsis, R.N.3    Walsh, K.4
  • 122
    • 0034651983 scopus 로고    scopus 로고
    • Akt promotes survival of cardiomyocytes in vitro and protects against lschemia-reperfusion injury in mouse heart
    • Y. Fujio, T. Nguyen, D. Wencker, R. N. Kitsis and K. Walsh: Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart. Circulation, 101(6), 660-7 (2000) (Pubitemid 30094738)
    • (2000) Circulation , vol.101 , Issue.6 , pp. 660-667
    • Fujio, Y.1    Nguyen, T.2    Wencker, D.3    Kitsis, R.N.4    Walsh, K.5
  • 124
    • 0041920901 scopus 로고    scopus 로고
    • TSC2 regulates VEGF through mTOR-dependent and -independent pathways
    • DOI 10.1016/S1535-6108(03)00187-9
    • J. B. Brugarolas, F. Vazquez, A. Reddy, W. R. Sellers and W. G. Kaelin Jr.,: TSC2 regulates VEGF through mTOR-dependent and -independent pathways. Cancer Cell, 4(2), 147-58 (2003) (Pubitemid 37045363)
    • (2003) Cancer Cell , vol.4 , Issue.2 , pp. 147-158
    • Brugarolas, J.B.1    Vazquez, F.2    Reddy, A.3    Sellers, W.R.4    Kaelin Jr., W.G.5
  • 128
    • 23644446462 scopus 로고    scopus 로고
    • Akt1 in the cardiovascular system: Friend or foe?
    • DOI 10.1172/JCI25900
    • B. T. O'Neill and E. D. Abel: Akt1 in the cardiovascular system: friend or foe? J Clin Invest, 115(8), 2059-64 (2005) (Pubitemid 41134142)
    • (2005) Journal of Clinical Investigation , vol.115 , Issue.8 , pp. 2059-2064
    • O'Neill, B.T.1    Abel, E.D.2
  • 129
    • 41449088342 scopus 로고    scopus 로고
    • Regulation of cardiomyocyte proliferation and myocardial growth during development by FOXO transcription factors
    • DOI 10.1161/CIRCRESAHA.107.163428
    • H. J. Evans-Anderson, C. M. Alfieri and K. E. Yutzey: Regulation of cardiomyocyte proliferation and myocardial growth during development by FOXO transcription factors. Circ Res, 102(6), 686-94 (2008) (Pubitemid 351457856)
    • (2008) Circulation Research , vol.102 , Issue.6 , pp. 686-694
    • Evans-Anderson, H.J.1    Alfieri, C.M.2    Yutzey, K.E.3
  • 130
    • 51449118038 scopus 로고    scopus 로고
    • Age-related differences in insulin-like growth factor-1 receptor signaling regulates akt/FOXO3a and ERK/Fos pathways in vascular smooth muscle cells
    • M. Li, J. F. Chiu, J. Gagne and N. K. Fukagawa: Age-related differences in insulin-like growth factor-1 receptor signaling regulates Akt/FOXO3a and ERK/Fos pathways in vascular smooth muscle cells. J Cell Physiol, 217(2), 377-87 (2008)
    • (2008) J Cell Physiol , vol.217 , Issue.2 , pp. 377-387
    • Li, M.1    Chiu, J.F.2    Gagne, J.3    Fukagawa, N.K.4
  • 131
    • 0034705239 scopus 로고    scopus 로고
    • Regulation of protien kinase B and 4E-BP1 by oxidative stress in cardiac myocytes
    • F. H. Pham, P. H. Sugden and A. Clerk: Regulation of protein kinase B and 4E-BP1 by oxidative stress in cardiac myocytes. Circ Res, 86(12), 1252-8 (2000) (Pubitemid 30436666)
    • (2000) Circulation Research , vol.86 , Issue.12 , pp. 1252-1258
    • Pham, F.H.1    Sugden, P.H.2    Clerk, A.3
  • 132
    • 0035116179 scopus 로고    scopus 로고
    • Down-regulation of Akt/PKB in senescent cardiac fibroblasts impairs PDGF-induced cell proliferation
    • DOI 10.1016/S0008-6363(00)00296-0, PII S0008636300002960
    • C. Diez, M. Nestler, U. Friedrich, M. Vieth, M. Stolte, K. Hu, J. Hoppe and A. Simm: Down-regulation of Akt/PKB in senescent cardiac fibroblasts impairs PDGF-induced cell proliferation. Cardiovasc Res, 49(4), 731-40 (2001) (Pubitemid 32178376)
    • (2001) Cardiovascular Research , vol.49 , Issue.4 , pp. 731-740
    • Diez, C.1    Nestler, M.2    Friedrich, U.3    Vieth, M.4    Stolte, M.5    Hu, K.6    Hoppe, J.7    Simm, A.8
  • 133
    • 50449083011 scopus 로고    scopus 로고
    • Deficiency of insulin-like growth factor 1 reduces sensitivity to aging-associated cardiomyocyte dysfunction
    • Q. Li, A. F. Ceylan-Isik, J. Li and J. Ren: Deficiency of insulin-like growth factor 1 reduces sensitivity to aging-associated cardiomyocyte dysfunction. Rejuvenation Res, 11(4), 725-33 (2008)
    • (2008) Rejuvenation Res , vol.11 , Issue.4 , pp. 725-733
    • Li, Q.1    Ceylan-Isik, A.F.2    Li, J.3    Ren, J.4
  • 136
    • 30744432102 scopus 로고    scopus 로고
    • Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo
    • DOI 10.1038/nm1307, PII NM1307
    • J. Chen, P. R. Somanath, O. Razorenova, W. S. Chen, N. Hay, P. Bornstein and T. V. Byzova: Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo. Nat Med, 11(11), 1188-96 (2005) (Pubitemid 43093666)
    • (2005) Nature Medicine , vol.11 , Issue.11 , pp. 1188-1196
    • Chen, J.1    Somanath, P.R.2    Razorenova, O.3    Chen, W.S.4    Hay, N.5    Bornstein, P.6    Byzova, T.V.7
  • 137
  • 138
    • 0036851826 scopus 로고    scopus 로고
    • Vascular proliferation and atherosclerosis: New perspectives and therapeutic strategies
    • DOI 10.1038/nm1102-1249
    • V. J. Dzau, R. C. Braun-Dullaeus and D. G. Sedding: Vascular proliferation and atherosclerosis: new perspectives and therapeutic strategies. Nat Med, 8(11), 1249-56 (2002) (Pubitemid 35373556)
    • (2002) Nature Medicine , vol.8 , Issue.11 , pp. 1249-1256
    • Dzau, V.J.1    Braun-Dullaeus, R.C.2    Sedding, D.G.3
  • 140
    • 73849128842 scopus 로고    scopus 로고
    • Absence of akt1 reduces vascular smooth muscle cell migration and survival and induces features of plaque vulnerability and cardiac dysfunction during atherosclerosis
    • C. Fernandez-Hernando, L. Jozsef, D. Jenkins, A. Di Lorenzo and W. C. Sessa: Absence of Akt1 reduces vascular smooth muscle cell migration and survival and induces features of plaque vulnerability and cardiac dysfunction during atherosclerosis. Arterioscler Thromb Vasc Biol, 29(12), 2033-40 (2009)
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , Issue.12 , pp. 2033-2040
    • Fernandez-Hernando, C.1    Jozsef, L.2    Jenkins, D.3    Di Lorenzo, A.4    Sessa, W.C.5
  • 141
    • 0842263745 scopus 로고    scopus 로고
    • Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway
    • DOI 10.1038/sj.emboj.7600045
    • H. Miyauchi, T. Minamino, K. Tateno, T. Kunieda, H. Toko and I. Komuro: Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway. Embo J, 23(1), 212-20 (2004) (Pubitemid 38165761)
    • (2004) EMBO Journal , vol.23 , Issue.1 , pp. 212-220
    • Miyauchi, H.1    Minamino, T.2    Tateno, K.3    Kunieda, T.4    Toko, H.5    Komuro, I.6
  • 144
    • 0035937503 scopus 로고    scopus 로고
    • Pro-atherogenic factors induce telomerase inactivation in endothelial cells through an Akt-dependent mechanism
    • DOI 10.1016/S0014-5793(01)02272-4, PII S0014579301022724
    • K. Breitschopf, A. M. Zeiher and S. Dimmeler: Pro-atherogenic factors induce telomerase inactivation in endothelial cells through an Akt-dependent mechanism. FEBS Lett, 493(1), 21-5 (2001) (Pubitemid 32241169)
    • (2001) FEBS Letters , vol.493 , Issue.1 , pp. 21-25
    • Breitschopf, K.1    Zeiher, A.M.2    Dimmeler, S.3
  • 146
    • 9344232808 scopus 로고    scopus 로고
    • Mathematical modeling of vascular endothelial layer maintenance: The role of endothelial cell division, progenitor cell homing, and telomere shortening
    • DOI 10.1152/ajpheart.00332.2004
    • J. Op den Buijs, M. Musters, T. Verrips, J. A. Post, B. Braam and N. van Riel: Mathematical modeling of vascular endothelial layer maintenance: the role of endothelial cell division, progenitor cell homing, and telomere shortening. Am J Physiol Heart Circ Physiol, 287(6), H2651-8 (2004) (Pubitemid 39557136)
    • (2004) American Journal of Physiology - Heart and Circulatory Physiology , vol.287 , Issue.6
    • Den Buijs, J.O.1    Musters, M.2    Verrips, T.3    Post, J.A.4    Braam, B.5    Van Riel, N.6
  • 147
    • 28444481339 scopus 로고    scopus 로고
    • Effect of estrogen on differentiation and senescence in endothelial progenitor cells derived from bone marrow in spontaneously hypertensive rats
    • DOI 10.1291/hypres.28.763
    • T. Imanishi, K. Kobayashi, T. Hano and I. Nishio: Effect of estrogen on differentiation and senescence in endothelial progenitor cells derived from bone marrow in spontaneously hypertensive rats. Hypertens Res, 28(9), 763-72 (2005) (Pubitemid 41723536)
    • (2005) Hypertension Research , vol.28 , Issue.9 , pp. 763-772
    • Imanishi, T.1    Kobayashi, K.2    Hano, T.3    Nishio, I.4
  • 148
    • 0034672560 scopus 로고    scopus 로고
    • Analysis of FAK-associated signaling pathways in the regulation of cell cycle progression
    • H. R. Reiske, J. Zhao, D. C. Han, L. A. Cooper and J. L. Guan: Analysis of FAK-associated signaling pathways in the regulation of cell cycle progression. FEBS Lett, 486(3), 275-80 (2000)
    • (2000) FEBS Lett , vol.486 , Issue.3 , pp. 275-280
    • Reiske, H.R.1    Zhao, J.2    Han, D.C.3    Cooper, L.A.4    Guan, J.L.5
  • 149
    • 37349026906 scopus 로고    scopus 로고
    • HDL slowing down endothelial progenitor cells senescence: A novel anti-atherogenic property of HDL
    • DOI 10.1016/j.mehy.2007.05.025, PII S0306987707003696
    • D. R. Pu and L. Liu: HDL slowing down endothelial progenitor cells senescence: a novel anti-atherogenic property of HDL. Med Hypotheses, 70(2), 338-42 (2008) (Pubitemid 350297601)
    • (2008) Medical Hypotheses , vol.70 , Issue.2 , pp. 338-342
    • Pu, D.-R.1    Liu, L.2
  • 151
    • 0034626735 scopus 로고    scopus 로고
    • Oxidants, oxidative stress and the biology of ageing
    • T. Finkel and N. J. Holbrook: Oxidants, oxidative stress and the biology of ageing. Nature, 408(6809), 239-47 (2000)
    • (2000) Nature , vol.408 , Issue.6809 , pp. 239-247
    • Finkel, T.1    Holbrook, N.J.2
  • 153
    • 40149101710 scopus 로고    scopus 로고
    • FoxO transcription factors in oxidative stress response and ageing - A new fork on the way to longevity?
    • DOI 10.1515/BC.2008.033
    • D. G. Sedding: FoxO transcription factors in oxidative stress response and ageing - a new fork on the way to longevity? Biol Chem, 389(3), 279-83 (2008) (Pubitemid 351329031)
    • (2008) Biological Chemistry , vol.389 , Issue.3 , pp. 279-283
    • Sedding, D.G.1
  • 154
    • 38049059990 scopus 로고    scopus 로고
    • The activation of NF-kappaB through akt-induced FOXO1 phosphorylation during aging and its modulation by calorie restriction
    • D. H. Kim, J. Y. Kim, B. P. Yu and H. Y. Chung: The activation of NF-kappaB through Akt-induced FOXO1 phosphorylation during aging and its modulation by calorie restriction. Biogerontology, 9(1), 33-47 (2008)
    • (2008) Biogerontology , vol.9 , Issue.1 , pp. 33-47
    • Kim, D.H.1    Kim, J.Y.2    Yu, B.P.3    Chung, H.Y.4
  • 155
    • 33845967865 scopus 로고    scopus 로고
    • Down-regulation of manganese-superoxide dismutase through phosphorylation of FOXO3a by Akt in explanted vascular smooth muscle cells from old rats
    • DOI 10.1074/jbc.M606596200
    • M. Li, J. F. Chiu, B. T. Mossman and N. K. Fukagawa: Down-regulation of manganese-superoxide dismutase through phosphorylation of FOXO3a by Akt in explanted vascular smooth muscle cells from old rats. J Biol Chem, 281(52), 40429-39 (2006) (Pubitemid 46041846)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.52 , pp. 40429-40439
    • Li, M.1    Chiu, J.-F.2    Mossman, B.T.3    Fukagawa, N.K.4
  • 156
    • 0035975586 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor type-1 in cardiovascular disease. Status report 2001
    • K. Huber, G. Christ, J. Wojta and D. Gulba: Plasminogen activator inhibitor type-1 in cardiovascular disease. Status report 2001. Thromb Res, 103 Suppl 1, S7-19 (2001)
    • (2001) Thromb Res , vol.103 , Issue.SUPPL. 1
    • Huber, K.1    Christ, G.2    Wojta, J.3    Gulba, D.4
  • 157
    • 0033376209 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor type-1 (PAI-1) and its role in cardiovascular disease
    • T. K. Nordt, K. Peter, J. Ruef, W. Kubler and C. Bode: Plasminogen activator inhibitor type-1 (PAI-1) and its role in cardiovascular disease. Thromb Haemost, 82 Suppl 1, 14-8 (1999) (Pubitemid 30093624)
    • (1999) Thrombosis and Haemostasis , vol.82 , Issue.SUPPL. 1 , pp. 14-18
    • Nordt, T.K.1    Peter, K.2    Ruef, J.3    Kubler, W.4    Bode, C.5
  • 158
    • 0034660437 scopus 로고    scopus 로고
    • Plasminogen-activator inhibitor type 1 and coronary artery disease
    • DOI 10.1056/NEJM200006153422406
    • H. P. Kohler and P. J. Grant: Plasminogen-activator inhibitor type 1 and coronary artery disease. N Engl J Med, 342(24), 1792-801 (2000) (Pubitemid 30390240)
    • (2000) New England Journal of Medicine , vol.342 , Issue.24 , pp. 1792-1801
    • Kohler, H.P.1    Grant, P.J.2
  • 160
    • 0029089162 scopus 로고
    • Senescence-dependent regulation of type 1 plasminogen activator inhibitor in human vascular endothelial cells
    • P. Comi, R. Chiaramonte and J. A. Maier: Senescence-dependent regulation of type 1 plasminogen activator inhibitor in human vascular endothelial cells. Exp Cell Res, 219(1), 304-8 (1995)
    • (1995) Exp Cell Res , vol.219 , Issue.1 , pp. 304-308
    • Comi, P.1    Chiaramonte, R.2    Maier, J.A.3
  • 161
    • 0029806684 scopus 로고    scopus 로고
    • Altered expression of gelatinase and surface-associated plasminogen activator activity by trophoblast cells isolated from placentas of preeclamptic patients
    • C. H. Graham and K. R. McCrae: Altered expression of gelatinase and surface-associated plasminogen activator activity by trophoblast cells isolated from placentas of preeclamptic patients. Am J Obstet Gynecol, 175(3 Pt 1), 555-62 (1996)
    • (1996) Am J Obstet Gynecol , vol.175 , Issue.3 PART 1 , pp. 555-562
    • Graham, C.H.1    McCrae, K.R.2
  • 162
    • 34147145253 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase/protein kinase Akt negatively regulates plasminogen activator inhibitor type 1 expression in vascular endothelial cells
    • DOI 10.1152/ajpheart.00868.2006
    • Y. Mukai, C. Y. Wang, Y. Rikitake and J. K. Liao: Phosphatidylinositol 3-kinase/protein kinase Akt negatively regulates plasminogen activator inhibitor type 1 expression in vascular endothelial cells. Am J Physiol Heart Circ Physiol, 292(4), H1937-42 (2007) (Pubitemid 46572419)
    • (2007) American Journal of Physiology - Heart and Circulatory Physiology , vol.292 , Issue.4
    • Mukai, Y.1    Wang, C.-Y.2    Rikitake, Y.3    Liao, J.K.4
  • 163
    • 0034721883 scopus 로고    scopus 로고
    • Reversal of angiogenesis in vitro, induction of apoptosis, and inhibition of AKT phosphorylation in endothelial cells by thromboxane A(2)
    • Y. Gao, R. Yokota, S. Tang, A. W. Ashton and J. A. Ware: Reversal of angiogenesis in vitro, induction of apoptosis, and inhibition of AKT phosphorylation in endothelial cells by thromboxane A(2). Circ Res, 87(9), 739-45 (2000)
    • (2000) Circ Res , vol.87 , Issue.9 , pp. 739-745
    • Gao, Y.1    Yokota, R.2    Tang, S.3    Ashton, A.W.4    Ware, J.A.5
  • 165
    • 0027417262 scopus 로고
    • Cardiovascular regulatory mechanisms in advanced age
    • E. G. Lakatta: Cardiovascular regulatory mechanisms in advanced age. Physiol Rev, 73(2), 413-67 (1993)
    • (1993) Physiol Rev , vol.73 , Issue.2 , pp. 413-467
    • Lakatta, E.G.1
  • 166
    • 0020578305 scopus 로고
    • Effects of aging on changing arterial compliance and left ventricular load in a northern Chinese urban community
    • A. P. Avolio, S. G. Chen, R. P. Wang, C. L. Zhang, M. F. Li and M. F. O'Rourke: Effects of aging on changing arterial compliance and left ventricular load in a northern Chinese urban community. Circulation, 68(1), 50-8 (1983) (Pubitemid 13058209)
    • (1983) Circulation , vol.68 , Issue.1 , pp. 50-58
    • Avolio, A.P.1    Chen, S.G.2    Wang, R.P.3
  • 167
    • 0026443019 scopus 로고
    • Aortic compliance in young patients with heterozygous familial hypercholesterolaemia
    • E. D. Lehmann, G. F. Watts, B. Fatemi-Langroudi and R. G. Gosling: Aortic compliance in young patients with heterozygous familial hypercholesterolaemia. Clin Sci (Lond), 83(6), 717-21 (1992)
    • (1992) Clin Sci (Lond) , vol.83 , Issue.6 , pp. 717-721
    • Lehmann, E.D.1    Watts, G.F.2    Fatemi-Langroudi, B.3    Gosling, R.G.4
  • 169
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell- intrinsic death machinery
    • DOI 10.1016/S0092-8674(00)80405-5
    • S. R. Datta, H. Dudek, X. Tao, S. Masters, H. Fu, Y. Gotoh and M. E. Greenberg: Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell, 91(2), 231-41 (1997) (Pubitemid 27456390)
    • (1997) Cell , vol.91 , Issue.2 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Xu, T.3    Masters, S.4    Haian, F.5    Gotoh, Y.6    Greenberg, M.E.7
  • 170
    • 0031931414 scopus 로고    scopus 로고
    • Characterization of the p53-dependent postmitotic checkpoint following spindle disruption
    • J. S. Lanni and T. Jacks: Characterization of the p53-dependent postmitotic checkpoint following spindle disruption. Mol Cell Biol, 18(2), 1055-64 (1998) (Pubitemid 28063440)
    • (1998) Molecular and Cellular Biology , vol.18 , Issue.2 , pp. 1055-1064
    • Lanni, J.S.1    Jacks, T.2
  • 171
    • 0037119925 scopus 로고    scopus 로고
    • Deaths: Leading causes for 2000
    • R. N. Anderson: Deaths: leading causes for 2000. Natl Vital Stat Rep, 50(16), 1-85 (2002)
    • (2002) Natl Vital Stat Rep , vol.50 , Issue.16 , pp. 1-85
    • Anderson, R.N.1
  • 172
    • 0346158343 scopus 로고    scopus 로고
    • Vascular endothelial dysfunction in aging: Loss of Akt-dependent endothelial nitric oxide synthase phosphorylation and partial restoration by (R)-α-lipoic acid
    • A. R. Smith and T. M. Hagen: Vascular endothelial dysfunction in aging: loss of Akt-dependent endothelial nitric oxide synthase phosphorylation and partial restoration by (R)-alpha-lipoic acid. Biochem Soc Trans, 31 (Pt 6), 1447-9 (2003) (Pubitemid 38030998)
    • (2003) Biochemical Society Transactions , vol.31 , Issue.6 , pp. 1447-1449
    • Smith, A.R.1    Hagen, T.M.2
  • 175
    • 65949121134 scopus 로고    scopus 로고
    • Oxidative stress and neurodegenerative diseases: A review of upstream and downstream antioxidant therapeutic options
    • B. Uttara, A. V. Singh, P. Zamboni and R. T. Mahajan: Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options. Curr Neuropharmacol, 7(1), 65-74 (2009)
    • (2009) Curr Neuropharmacol , vol.7 , Issue.1 , pp. 65-74
    • Uttara, B.1    Singh, A.V.2    Zamboni, P.3    Mahajan, R.T.4
  • 176
    • 34748826699 scopus 로고    scopus 로고
    • 4 expression and induction of the phosphorylation of PKB/Akt and ERK1/2 by aging in rat brain
    • DOI 10.1016/j.phrs.2007.07.005, PII S104366180700134X
    • G. Y. Song, J. S. Kang, S. Y. Lee and C. S. Myung: Region-specific reduction of Gbeta4 expression and induction of the phosphorylation of PKB/Akt and ERK1/2 by aging in rat brain. Pharmacol Res, 56(4), 295-302 (2007) (Pubitemid 47488897)
    • (2007) Pharmacological Research , vol.56 , Issue.4 , pp. 295-302
    • Song, G.Y.1    Kang, J.S.2    Lee, S.Y.3    Myung, C.-S.4
  • 177
    • 56949087435 scopus 로고    scopus 로고
    • Age-related decrease in constructive activation of akt/PKB in SAMP10 hippocampus
    • K. Nie, J. C. Yu, Y. Fu, H. Y. Cheng, F. Y. Chen, Y. Qu and J. X. Han: Age-related decrease in constructive activation of Akt/PKB in SAMP10 hippocampus. Biochem Biophys Res Commun, 378(1), 103-7 (2009)
    • (2009) Biochem Biophys Res Commun , vol.378 , Issue.1 , pp. 103-107
    • Nie, K.1    Yu, J.C.2    Fu, Y.3    Cheng, H.Y.4    Chen, F.Y.5    Qu, Y.6    Han, J.X.7
  • 179
    • 55149116095 scopus 로고    scopus 로고
    • Age-related changes of calcineurin and akt1/protein kinase balpha (Akt1/PKBalpha) immunoreactivity in the mouse hippocampal CA1 sector: An immunohistochemical study
    • R. Eto, M. Abe, N. Hayakawa, H. Kato and T. Araki: Age-related changes of calcineurin and Akt1/protein kinase Balpha (Akt1/PKBalpha) immunoreactivity in the mouse hippocampal CA1 sector: an immunohistochemical study. Metab Brain Dis, 23(4), 399-409 (2008)
    • (2008) Metab Brain Dis , vol.23 , Issue.4 , pp. 399-409
    • Eto, R.1    Abe, M.2    Hayakawa, N.3    Kato, H.4    Araki, T.5
  • 180
    • 60849109194 scopus 로고    scopus 로고
    • Regional hippocampal differences in AKT survival signaling across the lifespan: Implications for CA1 vulnerability with aging
    • T. C. Jackson, A. Rani, A. Kumar and T. C. Foster: Regional hippocampal differences in AKT survival signaling across the lifespan: implications for CA1 vulnerability with aging. Cell Death Differ, 16(3), 439-48 (2009)
    • (2009) Cell Death Differ , vol.16 , Issue.3 , pp. 439-448
    • Jackson, T.C.1    Rani, A.2    Kumar, A.3    Foster, T.C.4
  • 181
    • 65249113325 scopus 로고    scopus 로고
    • The insulin/Akt signaling pathway is targeted by intracellular beta-amyloid
    • H. K. Lee, P. Kumar, Q. Fu, K. M. Rosen and H. W. Querfurth: The insulin/Akt signaling pathway is targeted by intracellular beta-amyloid. Mol Biol Cell, 20(5), 1533-44 (2009)
    • (2009) Mol Biol Cell , vol.20 , Issue.5 , pp. 1533-1544
    • Lee, H.K.1    Kumar, P.2    Fu, Q.3    Rosen, K.M.4    Querfurth, H.W.5
  • 182
    • 33747425620 scopus 로고    scopus 로고
    • GSK-3 is essential in the pathogenesis of Alzheimer's disease
    • A. Takashima: GSK-3 is essential in the pathogenesis of Alzheimer's disease. J Alzheimers Dis, 9(3 Suppl), 309-17 (2006) (Pubitemid 44253325)
    • (2006) Journal of Alzheimer's Disease , vol.9 , Issue.SUPPL. 3 , pp. 309-317
    • Takashima, A.1
  • 183
    • 28044446528 scopus 로고    scopus 로고
    • Intraneuronal β-amyloid expression downregulates the Akt survival pathway and blunts the stress response
    • DOI 10.1523/JNEUROSCI.1723-05.2005
    • J. Magrane, K. M. Rosen, R. C. Smith, K. Walsh, G. K. Gouras and H. W. Querfurth: Intraneuronal beta-amyloid expression downregulates the Akt survival pathway and blunts the stress response. J Neurosci, 25(47), 10960-9 (2005) (Pubitemid 41692626)
    • (2005) Journal of Neuroscience , vol.25 , Issue.47 , pp. 10960-10969
    • Magrane, J.1    Rosen, K.M.2    Smith, R.C.3    Walsh, K.4    Gouras, G.K.5    Querfurth, H.W.6
  • 185
    • 16244391770 scopus 로고    scopus 로고
    • Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology
    • DOI 10.1111/j.1471-4159.2004.02949.x
    • R. J. Griffin, A. Moloney, M. Kelliher, J. A. Johnston, R. Ravid, P. Dockery, R. O'Connor and C. O'Neill: Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology. J Neurochem, 93(1), 105-17 (2005) (Pubitemid 40463520)
    • (2005) Journal of Neurochemistry , vol.93 , Issue.1 , pp. 105-117
    • Griffin, R.J.1    Moloney, A.2    Kelliher, M.3    Johnston, J.A.4    Ravid, R.5    Dockery, P.6    O'Connor, R.7    O'Neill, C.8
  • 187
    • 41949089154 scopus 로고    scopus 로고
    • FOXO transcription factors are mechanosensitive and their regulation is altered with aging in the respiratory pump
    • DOI 10.1152/ajpcell.00270.2007
    • P. S. Pardo, M. A. Lopez and A. M. Boriek: FOXO transcription factors are mechanosensitive and their regulation is altered with aging in the respiratory pump. Am J Physiol Cell Physiol, 294(4), C1056-66 (2008) (Pubitemid 351507908)
    • (2008) American Journal of Physiology - Cell Physiology , vol.294 , Issue.4
    • Pardo, P.S.1    Lopez, M.A.2    Boriek, A.M.3
  • 189
    • 33646794381 scopus 로고    scopus 로고
    • Senescent fibroblasts induce moderate stress in lung epithelial cells in vitro
    • DOI 10.1016/j.exger.2006.02.006, PII S0531556506000416
    • B. Bartling, G. Rehbein, R. E. Silber and A. Simm: Senescent fibroblasts induce moderate stress in lung epithelial cells in vitro. Exp Gerontol, 41(5), 532-9 (2006) (Pubitemid 43765893)
    • (2006) Experimental Gerontology , vol.41 , Issue.5 , pp. 532-539
    • Bartling, B.1    Rehbein, G.2    Silber, R.-E.3    Simm, A.4
  • 190
    • 0032977315 scopus 로고    scopus 로고
    • Deterioration of esophageal motility with age: A manometric study of 79 healthy subjects
    • DOI 10.1111/j.1572-0241.1999.01208.x, PII S0002927099002646
    • L. Grande, G. Lacima, E. Ros, M. Pera, C. Ascaso, J. Visa and C. Pera: Deterioration of esophageal motility with age: a manometric study of 79 healthy subjects. Am J Gastroenterol, 94(7), 1795-801 (1999) (Pubitemid 29315888)
    • (1999) American Journal of Gastroenterology , vol.94 , Issue.7 , pp. 1795-1801
    • Grande, L.1    Lacima, G.2    Ros, E.3    Pera, M.4    Ascaso, C.5    Visa, J.6    Pera, C.7
  • 191
    • 0032838741 scopus 로고    scopus 로고
    • Effects of aging and gastric lipolysis on gastric emptying of lipid in liquid meal
    • DOI 10.1007/s005350050294
    • Y. Nakae, H. Onouchi, M. Kagaya and T. Kondo: Effects of aging and gastric lipolysis on gastric emptying of lipid in liquid meal. J Gastroenterol, 34(4), 445-9 (1999) (Pubitemid 29408168)
    • (1999) Journal of Gastroenterology , vol.34 , Issue.4 , pp. 445-449
    • Nakae, Y.1    Onouchi, H.2    Kagaya, M.3    Kondo, T.4
  • 192
    • 0036976301 scopus 로고    scopus 로고
    • 13C-acetate breath test
    • DOI 10.1159/000065500
    • C. Shimamoto, I. Hirata, Y. Hiraike, N. Takeuchi, T. Nomura and K. Katsu: Evaluation of gastric motor activity in the elderly by electrogastrography and the (13)C-acetate breath test. Gerontology, 48(6), 381-6 (2002) (Pubitemid 36152989)
    • (2002) Gerontology , vol.48 , Issue.6 , pp. 381-386
    • Shimamoto, C.1    Hirata, I.2    Hiraike, Y.3    Takeuchi, N.4    Nomura, T.5    Katsu, K.-I.6
  • 193
    • 1542359600 scopus 로고    scopus 로고
    • Effects of ageing on gastrointestinal motor function
    • DOI 10.1093/ageing/afh040
    • J. L. Madsen and J. Graff: Effects of ageing on gastrointestinal motor function. Age Ageing, 33(2), 154-9 (2004) (Pubitemid 38313114)
    • (2004) Age and Ageing , vol.33 , Issue.2 , pp. 154-159
    • Madsen, J.L.1    Graff, J.2
  • 194
    • 0028837092 scopus 로고
    • Nerve cell loss in the myenteric plexus of the human esophagus in relation to age: A preliminary investigation
    • J. Meciano Filho, V. C. Carvalho and R. R. de Souza: Nerve cell loss in the myenteric plexus of the human esophagus in relation to age: a preliminary investigation. Gerontology, 41(1), 18-21 (1995)
    • (1995) Gerontology , vol.41 , Issue.1 , pp. 18-21
    • Meciano Filho, J.1    Carvalho, V.C.2    De Souza, R.R.3
  • 195
    • 0038488561 scopus 로고    scopus 로고
    • Aging of the myenteric plexus: Neuronal loss is specific to cholinergic neurons
    • DOI 10.1016/S1566-0702(03)00072-9
    • R. J. Phillips, E. J. Kieffer and T. L. Powley: Aging of the myenteric plexus: neuronal loss is specific to cholinergic neurons. Auton Neurosci, 106(2), 69-83 (2003) (Pubitemid 36870909)
    • (2003) Autonomic Neuroscience: Basic and Clinical , vol.106 , Issue.2 , pp. 69-83
    • Phillips, R.J.1    Kieffer, E.J.2    Powley, T.L.3
  • 196
    • 0030739407 scopus 로고    scopus 로고
    • A preliminary investigation of the effects of aging on the nerve cell number in the myenteric ganglia of the human colon
    • O. A. Gomes, R. R. de Souza and E. A. Liberti: A preliminary investigation of the effects of aging on the nerve cell number in the myenteric ganglia of the human colon. Gerontology, 43(4), 210-7 (1997) (Pubitemid 27285469)
    • (1997) Gerontology , vol.43 , Issue.4 , pp. 210-217
    • Gomes, O.A.1    De Souza, R.R.2    Liberti, E.A.3
  • 197
    • 0034634464 scopus 로고    scopus 로고
    • Decreased expression of nitric oxide synthase in the colonic myenteric plexus of aged rats
    • T. Takahashi, A. Qoubaitary, C. Owyang and J. W. Wiley: Decreased expression of nitric oxide synthase in the colonic myenteric plexus of aged rats. Brain Res, 883(1), 15-21 (2000)
    • (2000) Brain Res , vol.883 , Issue.1 , pp. 15-21
    • Takahashi, T.1    Qoubaitary, A.2    Owyang, C.3    Wiley, J.W.4
  • 198
    • 0035977073 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor-stimulated phosphatidylinositol 3-kinase and akt activities exert opposing effects on the ERK pathway: Importance for the rescue of neuroectodermic cells
    • B. Mograbi, R. Bocciardi, I. Bourget, R. Busca, N. Rochet, D. Farahi-Far, T. Juhel and B. Rossi: Glial cell line-derived neurotrophic factor-stimulated phosphatidylinositol 3-kinase and Akt activities exert opposing effects on the ERK pathway: importance for the rescue of neuroectodermic cells. J Biol Chem, 276(48), 45307-19 (2001)
    • (2001) J Biol Chem , vol.276 , Issue.48 , pp. 45307-45319
    • Mograbi, B.1    Bocciardi, R.2    Bourget, I.3    Busca, R.4    Rochet, N.5    Farahi-Far, D.6    Juhel, T.7    Rossi, B.8
  • 199
    • 70349666889 scopus 로고    scopus 로고
    • Loss of enteric neurons accompanied by decreased expression of GDNF and PI3K/Akt pathway in diabetic rats
    • F. Du, L. Wang, W. Qian and S. Liu: Loss of enteric neurons accompanied by decreased expression of GDNF and PI3K/Akt pathway in diabetic rats. Neurogastroenterol Motil, 21(11), 1229-e114 (2009)
    • (2009) Neurogastroenterol Motil , vol.21 , Issue.11
    • Du, F.1    Wang, L.2    Qian, W.3    Liu, S.4
  • 200
    • 0029901727 scopus 로고    scopus 로고
    • Renal agenesis and the absence of enteric neurons in mice lacking GDNF
    • DOI 10.1038/382070a0
    • M. P. Sanchez, I. Silos-Santiago, J. Frisen, B. He, S. A. Lira and M. Barbacid: Renal agenesis and the absence of enteric neurons in mice lacking GDNF. Nature, 382(6586), 70-3 (1996) (Pubitemid 26243359)
    • (1996) Nature , vol.382 , Issue.6586 , pp. 70-73
    • Sanchez, M.P.1    Silos-Santiago, I.2    Frisen, J.3    He, B.4    Lira, S.A.5    Barbacid, M.6
  • 201
    • 18044362169 scopus 로고    scopus 로고
    • Enteric neuroblasts require the phosphatidylinositol 3-kinase/Akt/ Forkhead pathway for GDNF-stimulated survival
    • DOI 10.1016/j.mcn.2005.02.005
    • S. Srinivasan, M. Anitha, S. Mwangi and R. O. Heuckeroth: Enteric neuroblasts require the phosphatidylinositol 3-kinase/Akt/Forkhead pathway for GDNF-stimulated survival. Mol Cell Neurosci, 29(1), 107-19 (2005) (Pubitemid 40603885)
    • (2005) Molecular and Cellular Neuroscience , vol.29 , Issue.1 , pp. 107-119
    • Srinivasan, S.1    Anitha, M.2    Mwangi, S.3    Heuckeroth, R.O.4
  • 203
    • 0027509745 scopus 로고
    • Gastrointestinal proliferation and aging
    • E. Atillasoy and P. R. Holt: Gastrointestinal proliferation and aging. J Gerontol, 48(2), B43-9 (1993) (Pubitemid 23084170)
    • (1993) Journals of Gerontology , vol.48 , Issue.2
    • Atillasoy, E.1    Holt, P.R.2
  • 204
    • 0023901132 scopus 로고
    • Altered controls of proliferation in proximal small intestine of the senescent rat
    • P. R. Holt, K. Y. Yeh and D. P. Kotler: Altered controls of proliferation in proximal small intestine of the senescent rat. Proc Natl Acad Sci U S A, 85(8), 2771-5 (1988)
    • (1988) Proc Natl Acad Sci U S A , vol.85 , Issue.8 , pp. 2771-2775
    • Holt, P.R.1    Yeh, K.Y.2    Kotler, D.P.3
  • 205
    • 0032939325 scopus 로고    scopus 로고
    • Multiple positive and negative regulators of signaling by the EGF-receptor
    • DOI 10.1016/S0955-0674(99)80025-8
    • N. Moghal and P. W. Sternberg: Multiple positive and negative regulators of signaling by the EGF-receptor. Curr Opin Cell Biol, 11(2), 190-6 (1999) (Pubitemid 29164033)
    • (1999) Current Opinion in Cell Biology , vol.11 , Issue.2 , pp. 190-196
    • Moghal, N.1    Sternberg, P.W.2
  • 206
    • 0030913673 scopus 로고    scopus 로고
    • Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway
    • DOI 10.1093/emboj/16.10.2783
    • A. Khwaja, P. Rodriguez-Viciana, S. Wennstrom, P. H. Warne and J. Downward: Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway. Embo J, 16(10), 2783-93 (1997) (Pubitemid 27226215)
    • (1997) EMBO Journal , vol.16 , Issue.10 , pp. 2783-2793
    • Khwaja, A.1    Rodriguez-Viciana, P.2    Wennstrom, S.3    Warne, P.H.4    Downward, J.5
  • 209
    • 69849096465 scopus 로고    scopus 로고
    • Age-related decline of immune function and age-related diseases
    • K. Isobe, N. Nishio and S. Ito: [Age-related decline of immune function and age-related diseases]. Nippon Rinsho, 67(7), 1327-31 (2009)
    • (2009) Nippon Rinsho , vol.67 , Issue.7 , pp. 1327-1331
    • Isobe, K.1    Nishio, N.2    Ito, S.3
  • 210
    • 0033787565 scopus 로고    scopus 로고
    • Ageing of lymphocytes and lymphocytes in the aged
    • A. Globerson and R. B. Effros: Ageing of lymphocytes and lymphocytes in the aged. Immunol Today, 21(10), 515-21 (2000)
    • (2000) Immunol Today , vol.21 , Issue.10 , pp. 515-521
    • Globerson, A.1    Effros, R.B.2
  • 211
    • 0030860733 scopus 로고    scopus 로고
    • The aging immune system: Primary and secondary alterations of immune reactivity in the elderly
    • DOI 10.1016/S0531-5565(96)00152-0, PII S0531556596001520
    • G. Wick and B. Grubeck-Loebenstein: The aging immune system: primary and secondary alterations of immune reactivity in the elderly. Exp Gerontol, 32(4-5), 401-13 (1997) (Pubitemid 27366479)
    • (1997) Experimental Gerontology , vol.32 , Issue.4-5 , pp. 401-413
    • Wick, G.1    Grubeck-Loebenstein, B.2
  • 212
    • 33645102374 scopus 로고    scopus 로고
    • Differential role of lipid rafts in the functions of CD4+ and CD8+ human T lymphocytes with aging
    • A. Larbi, G. Dupuis, A. Khalil, N. Douziech, C. Fortin and T. Fulop Jr.,: Differential role of lipid rafts in the functions of CD4+ and CD8+ human T lymphocytes with aging. Cell Signal, 18(7), 1017-30 (2006)
    • (2006) Cell Signal , vol.18 , Issue.7 , pp. 1017-1030
    • Larbi, A.1    Dupuis, G.2    Khalil, A.3    Douziech, N.4    Fortin, C.5    Fulop Jr., T.6
  • 213
    • 0027712654 scopus 로고
    • Renal physiology and pathophysiology of aging
    • R. D. Lindeman: Renal physiology and pathophysiology of aging. Contrib Nephrol, 105, 1-12 (1993)
    • (1993) Contrib Nephrol , vol.105 , pp. 1-12
    • Lindeman, R.D.1
  • 214
    • 69949098489 scopus 로고    scopus 로고
    • Proteasome inactivation promotes p38 mitogen-activated protein kinase-dependent phosphatidylinositol 3-kinase activation and increases interleukin-8 production in retinal pigment epithelial cells
    • A. F. Fernandes, Q. Bian, J. K. Jiang, C. J. Thomas, A. Taylor, P. Pereira and F. Shang: Proteasome inactivation promotes p38 mitogen-activated protein kinase-dependent phosphatidylinositol 3-kinase activation and increases interleukin-8 production in retinal pigment epithelial cells. Mol Biol Cell, 20(16), 3690-9 (2009)
    • (2009) Mol Biol Cell , vol.20 , Issue.16 , pp. 3690-3699
    • Fernandes, A.F.1    Bian, Q.2    Jiang, J.K.3    Thomas, C.J.4    Taylor, A.5    Pereira, P.6    Shang, F.7
  • 216
    • 59049097132 scopus 로고    scopus 로고
    • Obesity and hypertension have differing oxidant handling molecular pathways in age-related chronic kidney disease
    • C. J. Percy, L. Brown, D. A. Power, D. W. Johnson and G. C. Gobe: Obesity and hypertension have differing oxidant handling molecular pathways in age-related chronic kidney disease. Mech Ageing Dev, 130(3), 129-38 (2009)
    • (2009) Mech Ageing Dev , vol.130 , Issue.3 , pp. 129-138
    • Percy, C.J.1    Brown, L.2    Power, D.A.3    Johnson, D.W.4    Gobe, G.C.5
  • 217
    • 43049120704 scopus 로고    scopus 로고
    • Obesity in old age
    • I. M. Chapman: Obesity in old age. Front Horm Res, 36, 97-106 (2008)
    • (2008) Front Horm Res , vol.36 , pp. 97-106
    • Chapman, I.M.1
  • 218
    • 66149107054 scopus 로고    scopus 로고
    • Obesity increases vascular senescence and susceptibility to ischemic injury through chronic activation of akt and mTOR
    • ra11
    • C. Y. Wang, H. H. Kim, Y. Hiroi, N. Sawada, S. Salomone, L. E. Benjamin, K. Walsh, M. A. Moskowitz and J. K. Liao: Obesity increases vascular senescence and susceptibility to ischemic injury through chronic activation of Akt and mTOR. Sci Signal, 2(62), ra11 (2009)
    • (2009) Sci Signal , vol.2 , Issue.62
    • Wang, C.Y.1    Kim, H.H.2    Hiroi, Y.3    Sawada, N.4    Salomone, S.5    Benjamin, L.E.6    Walsh, K.7    Moskowitz, M.A.8    Liao, J.K.9
  • 219
    • 0023035033 scopus 로고
    • Subcutaneous and visceral fat distribution according to sex, age, and overweight, evaluated by computed tomography
    • G. Enzi, M. Gasparo, P. R. Biondetti, D. Fiore, M. Semisa and F. Zurlo: Subcutaneous and visceral fat distribution according to sex, age, and overweight, evaluated by computed tomography. Am J Clin Nutr, 44(6), 739-46 (1986) (Pubitemid 17208993)
    • (1986) American Journal of Clinical Nutrition , vol.44 , Issue.6 , pp. 739-746
    • Enzi, G.1    Gasparo, M.2    Raimondo Biondetti, P.3
  • 221
    • 0041976087 scopus 로고    scopus 로고
    • Development and differentiation of adipose tissue
    • T. Ivkovic-Lazar: [Development and differentiation of adipose tissue]. Med Pregl, 56(3-4), 142-5 (2003)
    • (2003) Med Pregl , vol.56 , Issue.3-4 , pp. 142-145
    • Ivkovic-Lazar, T.1
  • 222
    • 33644982433 scopus 로고    scopus 로고
    • Altered subcellular distribution of IRS-1 and IRS-3 is associated with defective akt activation and GLUT4 translocation in insulin-resistant old rat adipocytes
    • M. Villar, R. Serrano, N. Gallardo, J. M. Carrascosa, C. Martinez and A. Andres: Altered subcellular distribution of IRS-1 and IRS-3 is associated with defective Akt activation and GLUT4 translocation in insulin-resistant old rat adipocytes. Biochim Biophys Acta, 1763(2), 197-206 (2006)
    • (2006) Biochim Biophys Acta , vol.1763 , Issue.2 , pp. 197-206
    • Villar, M.1    Serrano, R.2    Gallardo, N.3    Carrascosa, J.M.4    Martinez, C.5    Andres, A.6
  • 223
    • 0034055787 scopus 로고    scopus 로고
    • Insulin resistance in fat cells from obese Zucker rats - Evidence for an impaired activation and translocation of protein kinase B and glucose transporter 4
    • E. Carvalho, C. Rondinone and U. Smith: Insulin resistance in fat cells from obese Zucker rats - evidence for an impaired activation and translocation of protein kinase B and glucose transporter 4. Mol Cell Biochem, 206(1-2), 7-16 (2000) (Pubitemid 30246501)
    • (2000) Molecular and Cellular Biochemistry , vol.206 , Issue.1-2 , pp. 7-16
    • Carvalho, E.1    Rondinone, C.2    Smith, U.3
  • 224
    • 56749170729 scopus 로고    scopus 로고
    • Calorie restriction initiated at a young age activates the akt/PKC zeta/lambda-glut4 pathway in rat white adipose tissue in an insulin-independent manner
    • S. Park, T. Komatsu, H. Hayashi, H. Yamaza, T. Chiba, Y. Higami, K. Kuramoto and I. Shimokawa: Calorie restriction initiated at a young age activates the Akt/PKC zeta/lambda-Glut4 pathway in rat white adipose tissue in an insulin-independent manner. Age (Dordr), 30(4), 293-302 (2008)
    • (2008) Age (Dordr) , vol.30 , Issue.4 , pp. 293-302
    • Park, S.1    Komatsu, T.2    Hayashi, H.3    Yamaza, H.4    Chiba, T.5    Higami, Y.6    Kuramoto, K.7    Shimokawa, I.8
  • 226
    • 38649091396 scopus 로고    scopus 로고
    • Fast/glycolytic muscle fiber growth reduces fat mass and improves metabolic parameters in obese mice
    • DOI 10.1016/j.cmet.2007.11.003, PII S1550413107003385
    • Y. Izumiya, T. Hopkins, C. Morris, K. Sato, L. Zeng, J. Viereck, J. A. Hamilton, N. Ouchi, N. K. LeBrasseur and K. Walsh: Fast/Glycolytic muscle fiber growth reduces fat mass and improves metabolic parameters in obese mice. Cell Metab, 7(2), 159-72 (2008) (Pubitemid 351168553)
    • (2008) Cell Metabolism , vol.7 , Issue.2 , pp. 159-172
    • Izumiya, Y.1    Hopkins, T.2    Morris, C.3    Sato, K.4    Zeng, L.5    Viereck, J.6    Hamilton, J.A.7    Ouchi, N.8    LeBrasseur, N.K.9    Walsh, K.10


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