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Volumn 11, Issue 11, 2005, Pages 1188-1196

Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo

Author keywords

[No Author keywords available]

Indexed keywords

NITRIC OXIDE SYNTHASE; PROTEIN KINASE B; THROMBOSPONDIN 1; THROMBOSPONDIN 2;

EID: 30744432102     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm1307     Document Type: Article
Times cited : (380)

References (45)
  • 1
    • 0030952289 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis
    • Risau, W. Mechanisms of angiogenesis. Nature 386, 671-674 (1997).
    • (1997) Nature , vol.386 , pp. 671-674
    • Risau, W.1
  • 2
    • 0028929803 scopus 로고
    • Angiogenesis in cancer, vascular, rheumatoid and other disease
    • Folkman, J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat. Med. 1, 27-31 (1995).
    • (1995) Nat. Med. , vol.1 , pp. 27-31
    • Folkman, J.1
  • 3
    • 0037699955 scopus 로고    scopus 로고
    • Angiogenesis in health and disease
    • Carmeliet, P. Angiogenesis in health and disease. Nat. Med. 9, 653-660 (2003).
    • (2003) Nat. Med. , vol.9 , pp. 653-660
    • Carmeliet, P.1
  • 4
    • 0034652392 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells
    • Jiang, B.H., Zheng, J.Z., Aoki, M. & Vogt, P.K. Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells. Proc. Natl. Acad. Sci. USA 97, 1749-1753 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 1749-1753
    • Jiang, B.H.1    Zheng, J.Z.2    Aoki, M.3    Vogt, P.K.4
  • 5
    • 0033604585 scopus 로고    scopus 로고
    • The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB
    • Kandel, E.S. & Hay, N. The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. Exp. Cell Res. 253, 210-229 (1999).
    • (1999) Exp. Cell Res. , vol.253 , pp. 210-229
    • Kandel, E.S.1    Hay, N.2
  • 6
    • 0035448879 scopus 로고    scopus 로고
    • Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene
    • Chen, W.S. et al. Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes Dev. 15, 2203-2208 (2001).
    • (2001) Genes Dev. , vol.15 , pp. 2203-2208
    • Chen, W.S.1
  • 7
    • 0038624395 scopus 로고    scopus 로고
    • Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2
    • Peng, X.D. et al. Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. Genes Dev. 17, 1352-1365 (2003).
    • (2003) Genes Dev. , vol.17 , pp. 1352-1365
    • Peng, X.D.1
  • 8
    • 23644446462 scopus 로고    scopus 로고
    • Akt1 in the cardiovascular system: Friend or foe?
    • O'neill, B.T. & Abel, E.D. Akt1 in the cardiovascular system: friend or foe? J. Clin. Invest. 115, 2059-2064 (2005).
    • (2005) J. Clin. Invest. , vol.115 , pp. 2059-2064
    • O'Neill, B.T.1    Abel, E.D.2
  • 9
    • 23644439061 scopus 로고    scopus 로고
    • Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure
    • Shiojima, I. et al. Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure. J. Clin. Invest. 115, 2108-2118 (2005).
    • (2005) J. Clin. Invest. , vol.115 , pp. 2108-2118
    • Shiojima, I.1
  • 10
    • 0033636606 scopus 로고    scopus 로고
    • A mechanism for modulation of cellular responses to VEGF: Activation of the integrins
    • Byzova, T.V. et al. A mechanism for modulation of cellular responses to VEGF: activation of the integrins. Mol. Cell 6, 851-860 (2000).
    • (2000) Mol. Cell , vol.6 , pp. 851-860
    • Byzova, T.V.1
  • 11
    • 0030944931 scopus 로고    scopus 로고
    • Integrins and vascular extracellular matrix assembly
    • Ruoslahti, E. & Engvall, E. Integrins and vascular extracellular matrix assembly. J. Clin. Invest. 99, 1149-1152 (1997).
    • (1997) J. Clin. Invest. , vol.99 , pp. 1149-1152
    • Ruoslahti, E.1    Engvall, E.2
  • 12
    • 19244379078 scopus 로고    scopus 로고
    • Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions
    • Carmeliet, P. et al. Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions. Nat. Med. 7, 575-583 (2001).
    • (2001) Nat. Med. , vol.7 , pp. 575-583
    • Carmeliet, P.1
  • 13
    • 0037097816 scopus 로고    scopus 로고
    • Adenovirus encoding vascular endothelial growth factor-D induces tissue-specific vascular patterns in vivo
    • Byzova, T.V. et al. Adenovirus encoding vascular endothelial growth factor-D induces tissue-specific vascular patterns in vivo. Blood 99, 4434-4442 (2002).
    • (2002) Blood , vol.99 , pp. 4434-4442
    • Byzova, T.V.1
  • 15
    • 0033601357 scopus 로고    scopus 로고
    • Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1
    • Thurston, G. et al. Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1. Science 286, 2511-2514 (1999).
    • (1999) Science , vol.286 , pp. 2511-2514
    • Thurston, G.1
  • 16
    • 0036731861 scopus 로고    scopus 로고
    • The lack of thrombospondin-1 (TSP1) dictates the course of wound healing in double-TSP1/TSP2-null mice
    • Agah, A., Kyriakides, T.R., Lawler, J. & Bornstein, P. The lack of thrombospondin-1 (TSP1) dictates the course of wound healing in double-TSP1/TSP2-null mice. Am. J. Pathol. 161, 831-839 (2002).
    • (2002) Am. J. Pathol. , vol.161 , pp. 831-839
    • Agah, A.1    Kyriakides, T.R.2    Lawler, J.3    Bornstein, P.4
  • 17
    • 0035049231 scopus 로고    scopus 로고
    • Thrombospondins as matricellular modulators of cell function
    • Bornstein, P. Thrombospondins as matricellular modulators of cell function. J. Clin. Invest. 107, 929-934 (2001).
    • (2001) J. Clin. Invest. , vol.107 , pp. 929-934
    • Bornstein, P.1
  • 18
    • 4444269330 scopus 로고    scopus 로고
    • Impaired platelet responses to thrombin and collagen in AKT-1 deficient mice
    • Chen, J. et al. Impaired platelet responses to thrombin and collagen in AKT-1 deficient mice. Blood 104, 1703-1710 (2004).
    • (2004) Blood , vol.104 , pp. 1703-1710
    • Chen, J.1
  • 19
    • 23644446866 scopus 로고    scopus 로고
    • Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis
    • Ackah, E. et al. Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis. J. Clin. Invest. 115, 2119-2127 (2005).
    • (2005) J. Clin. Invest. , vol.115 , pp. 2119-2127
    • Ackah, E.1
  • 20
    • 0030869787 scopus 로고    scopus 로고
    • Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element
    • Mazure, N.M., Chen, E.Y., Laderoute, K.R. & Giaccia, A.J. Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element. Blood 90, 3322-3331 (1997).
    • (1997) Blood , vol.90 , pp. 3322-3331
    • Mazure, N.M.1    Chen, E.Y.2    Laderoute, K.R.3    Giaccia, A.J.4
  • 21
    • 2442669295 scopus 로고    scopus 로고
    • Akt and hypoxia-inducible factor-1 independently enhance tumor growth and angiogenesis
    • Arsham, A.M., Plas, D.R., Thompson, C.B. & Simon, M.C. Akt and hypoxia-inducible factor-1 independently enhance tumor growth and angiogenesis. Cancer Res. 64, 3500-3507 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 3500-3507
    • Arsham, A.M.1    Plas, D.R.2    Thompson, C.B.3    Simon, M.C.4
  • 22
    • 23344452702 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase is critical for ischemic remodeling, mural cell recruitment, and blood flow reserve
    • Yu, J. et al. Endothelial nitric oxide synthase is critical for ischemic remodeling, mural cell recruitment, and blood flow reserve. Proc. Natl. Acad. Sci. USA 102, 10999-11004 (2005).
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 10999-11004
    • Yu, J.1
  • 24
    • 0345276632 scopus 로고    scopus 로고
    • Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells
    • Aicher, A. et al. Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells. Nat. Med. 9, 1370-1376 (2003).
    • (2003) Nat. Med. , vol.9 , pp. 1370-1376
    • Aicher, A.1
  • 25
    • 0038784546 scopus 로고    scopus 로고
    • Membrane type I matrix metalloproteinase usurps tumor growth control imposed by the three-dimensional extracellular matrix
    • Hotary, K.B. et al. Membrane type I matrix metalloproteinase usurps tumor growth control imposed by the three-dimensional extracellular matrix. Cell 114, 33-45 (2003).
    • (2003) Cell , vol.114 , pp. 33-45
    • Hotary, K.B.1
  • 26
    • 3543090480 scopus 로고    scopus 로고
    • Enhanced growth of pancreatic tumors in SPARC-null mice is associated with decreased deposition of extracellular matrix and reduced tumor cell apoptosis
    • Puolakkainen, P.A., Brekken, R.A., Muneer, S. & Sage, E.H. Enhanced growth of pancreatic tumors in SPARC-null mice is associated with decreased deposition of extracellular matrix and reduced tumor cell apoptosis. Mol. Cancer Res. 2, 215-224 (2004).
    • (2004) Mol. Cancer Res. , vol.2 , pp. 215-224
    • Puolakkainen, P.A.1    Brekken, R.A.2    Muneer, S.3    Sage, E.H.4
  • 27
    • 0037693895 scopus 로고    scopus 로고
    • Matrix metalloproteinases and tissue inhibitors of metalloproteinases: Structure, function, and biochemistry
    • Visse, R. & Nagase, H. Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Circ. Res. 92, 827-839 (2003).
    • (2003) Circ. Res. , vol.92 , pp. 827-839
    • Visse, R.1    Nagase, H.2
  • 28
    • 4344701559 scopus 로고    scopus 로고
    • CD36: A critical anti-angiogenic receptor
    • Simantov, R. & Silverstein, R.L. CD36: a critical anti-angiogenic receptor. Front. Biosci. 8, s874-s882 (2003).
    • (2003) Front. Biosci. , vol.8
    • Simantov, R.1    Silverstein, R.L.2
  • 29
    • 0035940429 scopus 로고    scopus 로고
    • Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor
    • Rodriguez-Manzaneque, J.C. et al. Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor. Proc. Natl. Acad. Sci. USA 98, 12485-12490 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 12485-12490
    • Rodriguez-Manzaneque, J.C.1
  • 30
    • 0035985164 scopus 로고    scopus 로고
    • Thrombospondin 2 inhibits microvascular endothelial cell proliferation by a caspase-independent mechanism
    • Armstrong, L.C. et al. Thrombospondin 2 inhibits microvascular endothelial cell proliferation by a caspase-independent mechanism. Mol. Biol. Cell 13, 1893-1905 (2002).
    • (2002) Mol. Biol. Cell , vol.13 , pp. 1893-1905
    • Armstrong, L.C.1
  • 31
    • 0037079702 scopus 로고    scopus 로고
    • Increased and prolonged inflammation and angiogenesis in delayed-type hypersensitivity reactions elicited in the skin of thrombospondin-2-deficient mice
    • Lange-Asschenfeldt, B. et al. Increased and prolonged inflammation and angiogenesis in delayed-type hypersensitivity reactions elicited in the skin of thrombospondin-2-deficient mice. Blood 99, 538-545 (2002).
    • (2002) Blood , vol.99 , pp. 538-545
    • Lange-Asschenfeldt, B.1
  • 32
    • 11844298904 scopus 로고    scopus 로고
    • The role of thrombospondins 1 and 2 in the regulation of cell-matrix interactions, collagen fibril formation, and the response to injury
    • Bornstein, P., Agah, A. & Kyriakides, T.R. The role of thrombospondins 1 and 2 in the regulation of cell-matrix interactions, collagen fibril formation, and the response to injury. Int. J. Biochem. Cell Biol. 36, 1115-1125 (2004).
    • (2004) Int. J. Biochem. Cell Biol. , vol.36 , pp. 1115-1125
    • Bornstein, P.1    Agah, A.2    Kyriakides, T.R.3
  • 33
    • 0037188941 scopus 로고    scopus 로고
    • Role of Akt signaling in vascular homeostasis and angiogenesis
    • Shiojima, I. & Walsh, K. Role of Akt signaling in vascular homeostasis and angiogenesis. Circ. Res. 90, 1243-1250 (2002).
    • (2002) Circ. Res. , vol.90 , pp. 1243-1250
    • Shiojima, I.1    Walsh, K.2
  • 34
    • 19944426515 scopus 로고    scopus 로고
    • Microvascular patterning is controlled by fine-tuning the Akt signal
    • Sun, J.F. et al. Microvascular patterning is controlled by fine-tuning the Akt signal. Proc. Natl. Acad. Sci. USA 102, 128-133 (2005).
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 128-133
    • Sun, J.F.1
  • 35
    • 23644442091 scopus 로고    scopus 로고
    • PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury
    • Nagoshi, T. et al. PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury. J. Clin. Invest. 115, 2128-2138 (2005).
    • (2005) J. Clin. Invest. , vol.115 , pp. 2128-2138
    • Nagoshi, T.1
  • 36
    • 0036152857 scopus 로고    scopus 로고
    • Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins
    • Reynolds, L.E. et al. Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins. Nat. Med. 8, 27-34 (2002).
    • (2002) Nat. Med. , vol.8 , pp. 27-34
    • Reynolds, L.E.1
  • 37
    • 1842360394 scopus 로고    scopus 로고
    • A general strategy for isolation of endothelial cells from murine tissues. Characterization of two endothelial cell lines from the murine lung and subcutaneous sponge implants
    • Dong, Q.G. et al. A general strategy for isolation of endothelial cells from murine tissues. Characterization of two endothelial cell lines from the murine lung and subcutaneous sponge implants. Arterioscler. Thromb. Vasc. Biol. 17, 1599-1604 (1997).
    • (1997) Arterioscler. Thromb. Vasc. Biol. , vol.17 , pp. 1599-1604
    • Dong, Q.G.1
  • 38
    • 0034142057 scopus 로고    scopus 로고
    • Activation of integrin alpha(V)beta(3) regulates cell adhesion and migration to bone sialoprotein
    • Byzova, T.V., Kim, W., Midura, R.J. & Plow, E.F. Activation of integrin alpha(V)beta(3) regulates cell adhesion and migration to bone sialoprotein. Exp. Cell Res. 254, 299-308 (2000).
    • (2000) Exp. Cell Res. , vol.254 , pp. 299-308
    • Byzova, T.V.1    Kim, W.2    Midura, R.J.3    Plow, E.F.4
  • 39
    • 0141643144 scopus 로고    scopus 로고
    • Molecular pathway for cancer metastasis to bone
    • De, S. et al. Molecular pathway for cancer metastasis to bone. J. Biol. Chem. 278, 39044-39050 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 39044-39050
    • De, S.1
  • 40
    • 21744434375 scopus 로고    scopus 로고
    • Thrombospondin-1 up-regulates expression of cell adhesion molecules and promotes monocyte binding to endothelium
    • Narizhneva, N.V. et al. Thrombospondin-1 up-regulates expression of cell adhesion molecules and promotes monocyte binding to endothelium. FASEB J. 19, 1158-1160 (2005).
    • (2005) FASEB J. , vol.19 , pp. 1158-1160
    • Narizhneva, N.V.1
  • 41
    • 19644367119 scopus 로고    scopus 로고
    • VEGF-integrin interplay controls tumor growth and vascularization
    • De, S. et al. VEGF-integrin interplay controls tumor growth and vascularization. Proc. Natl. Acad. Sci. USA 102, 7589-7594 (2005).
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 7589-7594
    • De, S.1
  • 42
    • 0032945433 scopus 로고    scopus 로고
    • Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization
    • Takahashi, T. et al. Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization. Nat. Med. 5, 434-438 (1999).
    • (1999) Nat. Med. , vol.5 , pp. 434-438
    • Takahashi, T.1
  • 43
    • 0036122075 scopus 로고    scopus 로고
    • Increased vascular permeability in C1 inhibitor-deficient mice mediated by the bradykinin type 2 receptor
    • Han, E.D., MacFarlane, R.C., Mulligan, A.N., Scafidi, J. & Davis, A.E., III. Increased vascular permeability in C1 inhibitor-deficient mice mediated by the bradykinin type 2 receptor. J. Clin. Invest. 109, 1057-1063 (2002).
    • (2002) J. Clin. Invest. , vol.109 , pp. 1057-1063
    • Han, E.D.1    MacFarlane, R.C.2    Mulligan, A.N.3    Scafidi, J.4    Davis III, A.E.5
  • 44
    • 8744274131 scopus 로고    scopus 로고
    • p21-activated kinase regulates endothelial permeability through modulation of contractility
    • Stockton, R.A., Schaefer, E. & Schwartz, M.A. p21-activated kinase regulates endothelial permeability through modulation of contractility. J. Biol. Chem. 279, 46621-46630 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 46621-46630
    • Stockton, R.A.1    Schaefer, E.2    Schwartz, M.A.3
  • 45
    • 13544272732 scopus 로고    scopus 로고
    • The tumor suppressor PTEN inhibits EGF-induced TSP-1 and TIMP-1 expression in FTC-133 thyroid carcinoma cells
    • Soula-Rothhut, M. et al. The tumor suppressor PTEN inhibits EGF-induced TSP-1 and TIMP-1 expression in FTC-133 thyroid carcinoma cells. Exp. Cell Res. 304, 187-201 (2005).
    • (2005) Exp. Cell Res. , vol.304 , pp. 187-201
    • Soula-Rothhut, M.1


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