The effect of aging on insulin signalling pathway is tissue dependent: Central role of adipose tissue in the insulin resistance of aging

Mechanisms of Ageing and Development

Volumn 130, Issue 3, 2009, Pages 189-197

  Serrano, Rosario ^a   Villar, Margarita ^a   Gallardo, Nilda ^a   Carrascosa, José M ^b   Martinez, Carmen ^a   Andrés, Antonio ^a  

^a UNIVERSITY OF CASTILLA LA MANCHA   (Spain)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

Adipose tissue; Aging; Insulin resistance; Insulin signalling; Liver; Skeletal muscle

Indexed keywords

FATTY ACID; GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; PROTEIN KINASE B;

ADIPOSE TISSUE; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHOSPHORYLATION; CELL MEMBRANE; CELLULAR DISTRIBUTION; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME ACTIVATION; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; INSULIN RESISTANCE; INSULIN SENSITIVITY; INTRACELLULAR SPACE; LIVER; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; QUADRICEPS FEMORIS MUSCLE; RAT; SKELETAL MUSCLE; WHITE ADIPOSE TISSUE;

ADIPOSE TISSUE, WHITE; AGE FACTORS; AGING; ANIMALS; GLUCOSE TRANSPORTER TYPE 4; INJECTIONS, INTRAVENOUS; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN RESISTANCE; LIVER; MALE; PHOSPHORYLATION; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-AKT; QUADRICEPS MUSCLE; RATS; RATS, WISTAR; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION;

ANIMALIA; RATTUS;

EID: 59049097003     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mad.2008.11.005     Document Type: Article

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