Increased expression of the Akt/PKB inhibitor TRB3 in osteoarthritic chondrocytes inhibits insulin-like growth factor 1-mediated cell survival and proteoglycan synthesis

Arthritis and Rheumatism

Volumn 60, Issue 2, 2009, Pages 492-500

  Cravero, John D ^a   Carlson, Cathy S ^b   Im, Hee Jeong ^c   Yammani, Raghunatha R ^a   Long, David ^a   Loeser, Richard F ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE; PROTEIN TRB3; SOMATOMEDIN C; THAPSIGARGIN; TUNICAMYCIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CARTILAGE CELL; CELL SURVIVAL; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEOGLYCAN SYNTHESIS;

ADULT; AGED, 80 AND OVER; ANKLE JOINT; CARTILAGE, ARTICULAR; CELL CYCLE PROTEINS; CELL SURVIVAL; CHILD; CHONDROCYTES; ENZYME INHIBITORS; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MIDDLE AGED; OSTEOARTHRITIS, KNEE; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTEOGLYCANS; PROTO-ONCOGENE PROTEINS C-AKT; REPRESSOR PROTEINS; THAPSIGARGIN; TUNICAMYCIN; YOUNG ADULT;

EID: 59649084411     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.24225     Document Type: Article

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