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Volumn 287, Issue 1 50-1, 2004, Pages

Impaired expression and insulin-stimulated phosphorylation of Akt-2 in muscle of obese patients with atypical diabetes

Author keywords

Akt 1; Glucose transporter 4; Hyperglycemia; Insulin receptor; Insulin receptor substrate

Indexed keywords

GLUCOSE TRANSPORTER 4; INSULIN; INSULIN RECEPTOR; PROTEIN AKT1; PROTEIN KINASE B; PROTEIN KINASE B BETA; SERINE; THREONINE; UNCLASSIFIED DRUG;

EID: 3042697259     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00485.2003     Document Type: Article
Times cited : (45)

References (50)
  • 1
    • 0030046606 scopus 로고    scopus 로고
    • Long-term normoglycemic remission in black newly diagnosed NIDDM subjects
    • Banerji MA, Chaiken RL, and Lebovitz HE. Long-term normoglycemic remission in black newly diagnosed NIDDM subjects. Diabetes 45: 337-341, 1996.
    • (1996) Diabetes , vol.45 , pp. 337-341
    • Banerji, M.A.1    Chaiken, R.L.2    Lebovitz, H.E.3
  • 2
    • 0035499454 scopus 로고    scopus 로고
    • Ten years of protein kinase B signalling: A hard Akt to follow
    • Brazil DP and Hemmings BA. Ten years of protein kinase B signalling: a hard Akt to follow. Trends Biochem Sci 26: 657-664, 2001.
    • (2001) Trends Biochem Sci , vol.26 , pp. 657-664
    • Brazil, D.P.1    Hemmings, B.A.2
  • 3
    • 0037381535 scopus 로고    scopus 로고
    • Defective signaling through Akt-2 and -3 but not Akt-1 in insulin-resistant human skeletal muscle: Potential role in insulin resistance
    • Brozinick JT Jr, Roberts BR, and Dohm GL. Defective signaling through Akt-2 and -3 but not Akt-1 in insulin-resistant human skeletal muscle: potential role in insulin resistance. Diabetes 52: 935-941, 2003.
    • (2003) Diabetes , vol.52 , pp. 935-941
    • Brozinick Jr., J.T.1    Roberts, B.R.2    Dohm, G.L.3
  • 5
    • 0035914388 scopus 로고    scopus 로고
    • Aktl/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice
    • Cho H, Thorvaldsen JL, Chu Q, Feng F, and Birnbaum MJ. Aktl/ PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. J Biol Chem 276: 38349-38352, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 38349-38352
    • Cho, H.1    Thorvaldsen, J.L.2    Chu, Q.3    Feng, F.4    Birnbaum, M.J.5
  • 6
    • 0033304583 scopus 로고    scopus 로고
    • Glucosamine regulation of glucose metabolism in cultured human skeletal muscle cells: Divergent effects on glucose transport/phosphorylation and glycogen synthase in non-diabetic and type 2 diabetic subjects
    • Ciaraldi TP, Carter L, Nikoulina S, Mudaliar S, McClain DA, and Henry RR. Glucosamine regulation of glucose metabolism in cultured human skeletal muscle cells: divergent effects on glucose transport/ phosphorylation and glycogen synthase in non-diabetic and type 2 diabetic subjects. Endocrinology 140: 3971-3980, 1999.
    • (1999) Endocrinology , vol.140 , pp. 3971-3980
    • Ciaraldi, T.P.1    Carter, L.2    Nikoulina, S.3    Mudaliar, S.4    McClain, D.A.5    Henry, R.R.6
  • 7
    • 0030841793 scopus 로고    scopus 로고
    • PDK1, one of the missing links in insulin signal transduction?
    • Cohen P, Alessi DR, and Cross DA. PDK1, one of the missing links in insulin signal transduction? FEBS Lett 410: 3-10, 1997.
    • (1997) FEBS Lett , vol.410 , pp. 3-10
    • Cohen, P.1    Alessi, D.R.2    Cross, D.A.3
  • 9
    • 0037219409 scopus 로고    scopus 로고
    • Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?
    • Evans JL, Goldfine ID, Maddux BA, and Grodsky GM. Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction? Diabetes 52: 1-8, 2003.
    • (2003) Diabetes , vol.52 , pp. 1-8
    • Evans, J.L.1    Goldfine, I.D.2    Maddux, B.A.3    Grodsky, G.M.4
  • 10
    • 0026577332 scopus 로고
    • Restoration of insulin responsiveness in skeletal muscle of morbidly obese patients after weight loss. Effect on muscle glucose transport and glucose transporter GLUT4
    • Friedman JE, Dohm GL, Leggett-Frazier N, Elton CW, Tapscott EB, Pories WP, and Caro JF. Restoration of insulin responsiveness in skeletal muscle of morbidly obese patients after weight loss. Effect on muscle glucose transport and glucose transporter GLUT4. J Clin Invest 89: 701-705, 1992.
    • (1992) J Clin Invest , vol.89 , pp. 701-705
    • Friedman, J.E.1    Dohm, G.L.2    Leggett-Frazier, N.3    Elton, C.W.4    Tapscott, E.B.5    Pories, W.P.6    Caro, J.F.7
  • 11
    • 0035187238 scopus 로고    scopus 로고
    • Effects of insulin on regional blood flow and glucose uptake in Wistar and Sprague-Dawley rats
    • Gaudreault N, Santure M, Pitre M, Nadeau A, Marette A, and Bachelard H. Effects of insulin on regional blood flow and glucose uptake in Wistar and Sprague-Dawley rats. Metabolism 50: 65-73, 2001.
    • (2001) Metabolism , vol.50 , pp. 65-73
    • Gaudreault, N.1    Santure, M.2    Pitre, M.3    Nadeau, A.4    Marette, A.5    Bachelard, H.6
  • 12
    • 0037341708 scopus 로고    scopus 로고
    • NKCC activity restores muscle water during hyperosmotic challenge independent of insulin, ERK, and p38 MAPK
    • Gosmanov AR, Schneider EG, and Thomason DB. NKCC activity restores muscle water during hyperosmotic challenge independent of insulin, ERK, and p38 MAPK. Am J Physiol Regul Integr Comp Physiol 284: R655-R665, 2003.
    • (2003) Am J Physiol Regul Integr Comp Physiol , vol.284
    • Gosmanov, A.R.1    Schneider, E.G.2    Thomason, D.B.3
  • 13
    • 0036310137 scopus 로고    scopus 로고
    • Insulin and isoproterenol differentially regulate mitogen-activated protein kinase-dependent Na(+)-K(+)-2Cl(-) cotransporter activity in skeletal muscle
    • Gosmanov AR and Thomason DB. Insulin and isoproterenol differentially regulate mitogen-activated protein kinase-dependent Na(+)-K(+)-2Cl(-) cotransporter activity in skeletal muscle. Diabetes 51: 615-623, 2002.
    • (2002) Diabetes , vol.51 , pp. 615-623
    • Gosmanov, A.R.1    Thomason, D.B.2
  • 14
    • 0031782480 scopus 로고    scopus 로고
    • Constitutive activation of protein kinase B alpha by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells
    • Hajduch E, Alessi DR, Hemmings BA, and Hundal HS. Constitutive activation of protein kinase B alpha by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells. Diabetes 47: 1006-1013, 1998.
    • (1998) Diabetes , vol.47 , pp. 1006-1013
    • Hajduch, E.1    Alessi, D.R.2    Hemmings, B.A.3    Hundal, H.S.4
  • 15
    • 0035896366 scopus 로고    scopus 로고
    • Protein kinase B (PKB/Akt) - A key regulator of glucose transport?
    • Hajduch E, Litherland GJ, and Hundal HS. Protein kinase B (PKB/ Akt)-a key regulator of glucose transport? FEBS Lett 492: 199-203, 2001.
    • (2001) FEBS Lett , vol.492 , pp. 199-203
    • Hajduch, E.1    Litherland, G.J.2    Hundal, H.S.3
  • 17
    • 0037821794 scopus 로고    scopus 로고
    • Phosphoinositide-dependent kinase- 2 is a distinct protein kinase enriched in a novel cytoskeletal fraction associated with adipocyte plasma membranes
    • Hresko RC, Murata H, and Mueckler M. Phosphoinositide-dependent kinase-2 is a distinct protein kinase enriched in a novel cytoskeletal fraction associated with adipocyte plasma membranes. J Biol Chem 278: 21615-21622, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 21615-21622
    • Hresko, R.C.1    Murata, H.2    Mueckler, M.3
  • 18
    • 0036871965 scopus 로고    scopus 로고
    • Epinephrine inhibits insulin-stimulated muscle glucose transport
    • Hunt DG and Ivy JL. Epinephrine inhibits insulin-stimulated muscle glucose transport. J Appl Physiol 93: 1638-1643, 2002.
    • (2002) J Appl Physiol , vol.93 , pp. 1638-1643
    • Hunt, D.G.1    Ivy, J.L.2
  • 19
    • 0026489335 scopus 로고
    • Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: Differential reversibility to glycemic control by islet cell transplantation
    • Inoguchi T, Battan R, Handler E, Sportsman JR, Heath W, and King GL. Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation. Proc Natl Acad Sci USA 89: 11059-11063, 1992.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 11059-11063
    • Inoguchi, T.1    Battan, R.2    Handler, E.3    Sportsman, J.R.4    Heath, W.5    King, G.L.6
  • 20
    • 0036300538 scopus 로고    scopus 로고
    • Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and 1kappaB-alpha
    • Itani SI, Ruderman NB, Schmieder F, and Boden G. Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and 1kappaB-alpha. Diabetes 51: 2005-2011, 2002.
    • (2002) Diabetes , vol.51 , pp. 2005-2011
    • Itani, S.I.1    Ruderman, N.B.2    Schmieder, F.3    Boden, G.4
  • 21
    • 0037934650 scopus 로고    scopus 로고
    • Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing
    • Jiang ZY, Zhou QL, Coleman KA, Chouinard M, Boese Q, and Czech MP. Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing. Proc Natl Acad Sci USA 100: 7569-7574, 2003.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 7569-7574
    • Jiang, Z.Y.1    Zhou, Q.L.2    Coleman, K.A.3    Chouinard, M.4    Boese, Q.5    Czech, M.P.6
  • 22
    • 0035044213 scopus 로고    scopus 로고
    • Clinical review 125: The insulin receptor and its cellular targets
    • Kido Y, Nakae J, and Accili D. Clinical review 125: the insulin receptor and its cellular targets. J Clin Endocrinol Metab 86: 972-979, 2001.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 972-979
    • Kido, Y.1    Nakae, J.2    Accili, D.3
  • 24
    • 0036068327 scopus 로고    scopus 로고
    • Troglitazone but not metformin restores insulin-stimulated phosphoinositide 3-kinase activity and increases p 110beta protein levels in skeletal muscle of type 2 diabetic subjects
    • Kim YB, Ciaraldi TP, Kong A, Kim D, Chu N, Mohideen P, Mudaliar S, Henry RR, and Kahn BB. Troglitazone but not metformin restores insulin-stimulated phosphoinositide 3-kinase activity and increases p110beta protein levels in skeletal muscle of type 2 diabetic subjects. Diabetes 51: 443-448, 2002.
    • (2002) Diabetes , vol.51 , pp. 443-448
    • Kim, Y.B.1    Ciaraldi, T.P.2    Kong, A.3    Kim, D.4    Chu, N.5    Mohideen, P.6    Mudaliar, S.7    Henry, R.R.8    Kahn, B.B.9
  • 25
    • 0032698470 scopus 로고    scopus 로고
    • Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes
    • Kim YB, Nikoulina SE, Ciaraldi TP, Henry RR, and Kahn BB. Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes. J Clin Invest 104: 733-741, 1999.
    • (1999) J Clin Invest , vol.104 , pp. 733-741
    • Kim, Y.B.1    Nikoulina, S.E.2    Ciaraldi, T.P.3    Henry, R.R.4    Kahn, B.B.5
  • 26
    • 0033046582 scopus 로고    scopus 로고
    • Glucosamine infusion in rats rapidly impairs insulin stimulation of phosphoinositide 3-kinase but does not alter activation of Akt/protein kinase B in skeletal muscle
    • Kim YB, Zhu JS, Zierath JR, Shen HQ, Baron AD, and Kahn BB. Glucosamine infusion in rats rapidly impairs insulin stimulation of phosphoinositide 3-kinase but does not alter activation of Akt/protein kinase B in skeletal muscle. Diabetes 48: 310-320, 1999.
    • (1999) Diabetes , vol.48 , pp. 310-320
    • Kim, Y.B.1    Zhu, J.S.2    Zierath, J.R.3    Shen, H.Q.4    Baron, A.D.5    Kahn, B.B.6
  • 28
    • 0030827388 scopus 로고    scopus 로고
    • Improved glucose tolerance restores insulin-stimulated Akt kinase activity and glucose transport in skeletal muscle from diabetic Goto-Kakizaki rats
    • Krook A, Kawano Y, Song XM, Efendic S, Roth RA, Wallberg-Henrickson H, and Zierath JR. Improved glucose tolerance restores insulin-stimulated Akt kinase activity and glucose transport in skeletal muscle from diabetic Goto-Kakizaki rats. Diabetes 46: 2110-2114, 1997.
    • (1997) Diabetes , vol.46 , pp. 2110-2114
    • Krook, A.1    Kawano, Y.2    Song, X.M.3    Efendic, S.4    Roth, R.A.5    Wallberg-Henrickson, H.6    Zierath, J.R.7
  • 29
    • 0033009465 scopus 로고    scopus 로고
    • Hyperglycemia inhibits insulin activation of Akt/protein kinase B but not phosphatidylinositol 3-kinase in rat skeletal muscle
    • Kurowski TG, Lin Y, Luo Z, Tsichlis PN, Buse MG, Heydrick SJ, and Ruderman NB. Hyperglycemia inhibits insulin activation of Akt/protein kinase B but not phosphatidylinositol 3-kinase in rat skeletal muscle. Diabetes 48: 658-663, 1999.
    • (1999) Diabetes , vol.48 , pp. 658-663
    • Kurowski, T.G.1    Lin, Y.2    Luo, Z.3    Tsichlis, P.N.4    Buse, M.G.5    Heydrick, S.J.6    Ruderman, N.B.7
  • 30
    • 0034845958 scopus 로고    scopus 로고
    • PKB/Akt: A key mediator of cell proliferation, survival and insulin responses?
    • Lawlor MA and Alessi DR. PKB/Akt: a key mediator of cell proliferation, survival and insulin responses? J Cell Sci 114: 2903-2910, 2001.
    • (2001) J Cell Sci , vol.114 , pp. 2903-2910
    • Lawlor, M.A.1    Alessi, D.R.2
  • 32
    • 0042668528 scopus 로고    scopus 로고
    • Economic impact of diabetic ketoacidosis in a multiethnic indigent population: Analysis of costs based on the precipitating cause
    • Maldonado MR, Chong ER, Oehl MA, and Balasubramanyam A. Economic impact of diabetic ketoacidosis in a multiethnic indigent population: analysis of costs based on the precipitating cause. Diabetes Care 26: 1265-1269, 2003.
    • (2003) Diabetes Care , vol.26 , pp. 1265-1269
    • Maldonado, M.R.1    Chong, E.R.2    Oehl, M.A.3    Balasubramanyam, A.4
  • 33
    • 0036723741 scopus 로고    scopus 로고
    • Troglitazone treatment increases protein kinase B phosphorylation in skeletal muscle of normoglycemic subjects at risk for the development of type 2 diabetes
    • Meyer MM, Levin K, Grimmsmann T, Perwitz N, Eirich A, Beck-Nielsen H, and Klein HH. Troglitazone treatment increases protein kinase B phosphorylation in skeletal muscle of normoglycemic subjects at risk for the development of type 2 diabetes. Diabetes 51: 2691-2697, 2002.
    • (2002) Diabetes , vol.51 , pp. 2691-2697
    • Meyer, M.M.1    Levin, K.2    Grimmsmann, T.3    Perwitz, N.4    Eirich, A.5    Beck-Nielsen, H.6    Klein, H.H.7
  • 35
    • 0344298921 scopus 로고    scopus 로고
    • Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle
    • Patti ME, Virkamaki A, Landaker EJ, Kahn CR, and Yki-Jarvinen H. Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle. Diabetes 48: 1562-1571, 1999.
    • (1999) Diabetes , vol.48 , pp. 1562-1571
    • Patti, M.E.1    Virkamaki, A.2    Landaker, E.J.3    Kahn, C.R.4    Yki-Jarvinen, H.5
  • 36
    • 0035950408 scopus 로고    scopus 로고
    • Regulation of IRS-2 tyrosine phosphorylation in fasting and diabetes
    • Rojas FA, Hirata AE, and Saad MJ. Regulation of IRS-2 tyrosine phosphorylation in fasting and diabetes. Mol Cell Endocrinol 183: 63-69, 2001.
    • (2001) Mol Cell Endocrinol , vol.183 , pp. 63-69
    • Rojas, F.A.1    Hirata, A.E.2    Saad, M.J.3
  • 37
    • 0023275573 scopus 로고
    • Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats
    • Rossetti L, Smith D, Shulman GI, Papachristou D, and DeFronzo RA. Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats. J Clin Invest 79: 1510-1515, 1987.
    • (1987) J Clin Invest , vol.79 , pp. 1510-1515
    • Rossetti, L.1    Smith, D.2    Shulman, G.I.3    Papachristou, D.4    DeFronzo, R.A.5
  • 38
    • 0034810894 scopus 로고    scopus 로고
    • Defects of the insulin receptor substrate (IRS) system in human metabolic disorders
    • Sesti G, Federici M, Hribal ML, Lauro D, Sbraccia P, and Lauro R. Defects of the insulin receptor substrate (IRS) system in human metabolic disorders. FASEB J 15: 2099-2111, 2001.
    • (2001) FASEB J , vol.15 , pp. 2099-2111
    • Sesti, G.1    Federici, M.2    Hribal, M.L.3    Lauro, D.4    Sbraccia, P.5    Lauro, R.6
  • 41
    • 0037666792 scopus 로고    scopus 로고
    • Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation
    • Troussard AA, Mawji NM, Ong C, Mui A, St-Arnaud R, and Dedhar S. Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation. J Biol Chem 278: 22374-22378, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 22374-22378
    • Troussard, A.A.1    Mawji, N.M.2    Ong, C.3    Mui, A.4    St-Arnaud, R.5    Dedhar, S.6
  • 42
    • 0032891637 scopus 로고    scopus 로고
    • Akt kinases and 2-deoxyglucose uptake in rat skeletal muscles in vivo: Study with insulin and exercise
    • Turinsky J and Damrau-Abney A. Akt kinases and 2-deoxyglucose uptake in rat skeletal muscles in vivo: study with insulin and exercise. Am J Physiol Regul Integr Comp Physiol 276: R277-R282, 1999.
    • (1999) Am J Physiol Regul Integr Comp Physiol , vol.276
    • Turinsky, J.1    Damrau-Abney, A.2
  • 44
    • 0042570843 scopus 로고    scopus 로고
    • Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance
    • Virkamaki A, Ueki K, and Kahn CR. Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance. J Clin Invest 103: 931-943, 1999.
    • (1999) J Clin Invest , vol.103 , pp. 931-943
    • Virkamaki, A.1    Ueki, K.2    Kahn, C.R.3
  • 45
    • 0032055131 scopus 로고    scopus 로고
    • Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: Comparison with protein kinase B alpha
    • Walker KS, Deak M, Paterson A, Hudson K, Cohen P, and Alessi DR. Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha. Biochem J 331: 299-308, 1998.
    • (1998) Biochem J , vol.331 , pp. 299-308
    • Walker, K.S.1    Deak, M.2    Paterson, A.3    Hudson, K.4    Cohen, P.5    Alessi, D.R.6
  • 46
    • 0033049422 scopus 로고    scopus 로고
    • Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts
    • Wang Q, Somwar R, Bilan PJ, Liu Z, Jin J, Woodgett JR, and Klip A. Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts. Mol Cell Biol 19: 4008-4018, 1999.
    • (1999) Mol Cell Biol , vol.19 , pp. 4008-4018
    • Wang, Q.1    Somwar, R.2    Bilan, P.J.3    Liu, Z.4    Jin, J.5    Woodgett, J.R.6    Klip, A.7
  • 47
    • 0036710280 scopus 로고    scopus 로고
    • IRS proteins and the common path to diabetes
    • White MF. IRS proteins and the common path to diabetes. Am J Physiol Endocrinol Metab 283: E413-E422, 2002.
    • (2002) Am J Physiol Endocrinol Metab , vol.283
    • White, M.F.1
  • 48
    • 0023198901 scopus 로고
    • Hyperglycemia decreases glucose uptake in type I diabetes
    • Yki-Jarvinen H, Helve E, and Koivisto VA. Hyperglycemia decreases glucose uptake in type I diabetes. Diabetes 36: 892-896, 1987.
    • (1987) Diabetes , vol.36 , pp. 892-896
    • Yki-Jarvinen, H.1    Helve, E.2    Koivisto, V.A.3
  • 49
    • 0028204464 scopus 로고
    • Effects of glycaemia on glucose transport in isolated skeletal muscle from patients with NIDDM: In vitro reversal of muscular insulin resistance
    • Zierath JR, Galuska D, Nolte LA, Thorne A, Kristensen JS, and Wallberg-Henriksson H. Effects of glycaemia on glucose transport in isolated skeletal muscle from patients with NIDDM: in vitro reversal of muscular insulin resistance. Diabetologia 37: 270-277, 1994.
    • (1994) Diabetologia , vol.37 , pp. 270-277
    • Zierath, J.R.1    Galuska, D.2    Nolte, L.A.3    Thorne, A.4    Kristensen, J.S.5    Wallberg-Henriksson, H.6
  • 50
    • 0033942001 scopus 로고    scopus 로고
    • Insulin action and insulin resistance in human skeletal muscle
    • Zierath JR, Krook A, and Wallberg-Henriksson H. Insulin action and insulin resistance in human skeletal muscle. Diabetologia 43: 821-835, 2000.
    • (2000) Diabetologia , vol.43 , pp. 821-835
    • Zierath, J.R.1    Krook, A.2    Wallberg-Henriksson, H.3


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