Isoform-specific defects of insulin stimulation of Akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients

Diabetologia

Volumn 51, Issue 3, 2008, Pages 512-521

  Cozzone, D ^a,b,c,d,e   Frojdo S ^a,b,c,d,e   Disse, E ^e   Debard, C ^a,b,c,d,e   Laville, M ^a,b,c,d,e   Pirola, L ^a,b,c,d,e   Vidal, H ^a,b,c,d,e  

^a INSERM   (France)

^b CEMAGREF   (France)

^c UNIVERSITÉ DE LYON   (France)

^d UNIVERSITÉ LYON 1   (France)

^e HOSPICES CIVILS DE LYON   (France)

Author keywords

Akt isoforms; Insulin resistance; Insulin signalling; Myotubes; PDK1; PHLPP1 2; PI 3 kinase; Skeletal muscle

Indexed keywords

PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PHOSPHOPROTEIN PHOSPHATASE 1; PROTEIN KINASE B; SERINE; THREONINE;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FEMALE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MALE; MUSCLE CELL; MYOTUBE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SKELETAL MUSCLE;

ADULT; DIABETES MELLITUS, TYPE 2; ENZYME ACTIVATION; FEMALE; HUMANS; INSULIN; ISOENZYMES; MALE; MIDDLE AGED; MUSCLE, SKELETAL; NUCLEAR PROTEINS; PHOSPHORYLATION; PHOSPHOSERINE; PHOSPHOTHREONINE; PROTO-ONCOGENE PROTEINS C-AKT; REFERENCE VALUES; RNA, MESSENGER;

EID: 39049172652     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-007-0913-8     Document Type: Article

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