Akt1/protein kinase Bα is critical for ischemic and VEGF-mediated angiogenesis

Journal of Clinical Investigation

Volumn 115, Issue 8, 2005, Pages 2119-2127

  Ackah, Eric ^a   Yu, Jun ^a   Zoellner, Stefan ^a   Iwakiri, Yasuko ^a   Skurk, Carsten ^b   Shibata, Rei ^b   Ouchi, Noriyuki ^b   Easton, Rachael M ^c   Galasso, Gennaro ^b   Birnbaum, Morris J ^c   Walsh, Kenneth ^b   Sessa, William C ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN KINASE B; PROTEIN KINASE B ALPHA; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL CELL; ARTICLE; CELL METABOLISM; CELL MIGRATION; CELL SURVIVAL; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ANALYSIS; FIBROBLAST; GENE EXPRESSION; ISCHEMIA; LIMB BLOOD FLOW; LIMB ISCHEMIA; MOUSE; NONHUMAN; PERIPHERAL VASCULAR DISEASE; POSTNATAL CARE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; STEM CELL MOBILIZATION;

ANIMALS; BLOOD FLOW VELOCITY; CELL MOVEMENT; ENDOTHELIUM, VASCULAR; FIBROBLASTS; HINDLIMB; HUMANS; ISCHEMIA; MICE; MICE, KNOCKOUT; NEOVASCULARIZATION, PATHOLOGIC; NITRIC OXIDE; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 23644446866     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI24726     Document Type: Article

References (47)

1. Mazure, N.M., Chen, E.V., Laderoute, K.R., and Giaccia, A.J. 1997. Induction of vascular endochelial growth factor by hypoxia is modulated by a phosphatidylinosicol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcrtptional element. Blood. 90:3322-3331.
2. Gerber, H.P., et al. 1998. Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation. J. Biol. Chem. 273:30336-30343.
3. Fujio, Y., and Watsh, K. 1999. Akt mediates cytoprotection of endothelial cells by vascular endothetial growth factor in an anchorage-dependent manner, J. Biol Chem. 274:16349-16354.
4. Papapetropoulos, A., et al. 2000. Angiopoietin-1 inhibits endothelial cell apoptosis via the Akt/sarvivin pathway. J. Biol. Chem. 275:9102-9105.
5. Lee, M.J., et al. 2001. Akt-mediaced phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial celt chemotaxis. Mol. Cell 8:693-704.
6. Morales-Ruiz, M., et al. 2001. Sphingosine 1-phosphate activates Akt, nitric oxide production, and chemotaxis through a Gi protein/phosphoinositide 3-kinase pathway in endothelial cells. J. Biol. Chem. 276:19672-19677.
7. Kureishi, Y., et al. 2000, The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals, Nat. Med. 6:1004-1010.
8. Cho, H., Thorvaldsen, J.L., Chu, Q., Feng, F., and Birnbaum, M.J. 2001. Akc1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasts in mice. J. Biol. Chem. 276:38349-38352.
9. Cho, H., et al. 2001, Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Science. 292:1728-1731.
10. Chen, W.S., et al. 2001. Growth retardation and increased apoptosis in mice with homozygous disruption of the Akr1 gene. Genes Dev. 15:2203-2208.
11. Yang, Z.Z., et al. 2003. Protein kmase B alpha/Akt1 regulates placental development and fetal growth. J. Biol. Chem. 278:32124-32131.
12. Asahara, T., et al. 1999. VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells. EMBO J. 18:3964-3972.
13. Rehman, J., Li, J., Orschell, C.M., and March, K.L. 2003. Peripheral blood "endothelial progenitor cells" are derived from monocyte/macrophages and secrete angiogenic growth factors. Circulation. 107:1164-1169.
14. Badorff, C., et al. 2003. Transdifferentiation of blood-derived human adult endothelial progenitor cells into functionally active cardiomyocytes. Circulation. 107:1024-1032.
15. Chan, J., Bayliss, P.E., Wood, J.M., and Roberts, T.M. 2002. Dissection of angiogenic signaling in zebrafish using a chemical genetic approach. Cancer Cell, 1:257-267.
16. Jiang, B.H., Zheng, J.Z., Aoki, M., and Vogt, P.K. 2000. Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endotheliai cells. Proc. Natl. Acad. Sci. U. S. A. 97:1749-1753.
17. Morales-Ruiz, M., et al. 2000. Vascular endothelial growth factor-stimulated actin reorganization and migration of endothelial cells is regulated via the serine/threonine kinase Akt. Circ. Res. 86:892-896.
18. Fulton, D., et al. 1999. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt, Nature. 399:597-601.
19. Summers, S.A., Lipfert, L., and Birnbaum, M.J. 1998. Polyoma middle T antigen activates the Ser/Thr kinase Akt in a PI3-kinase-dependent manner. Biochem. Biophys. Res. Commun. 246:76-81.
20. Dimmeler, S., et al. 1999. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature. 399:601-605.
21. Michell, B.J., et al. 1999. The Akt kinase signals directly to endothelial nitric oxide synthase. Curr. Biol. 9:845-848.
22. Papapetropoulos, A., Garcia-Cardena, G., Madri, J.A., and Sessa, W.C 1997. Nitric oxide production contributes to the angiogenic properties of vascular endochelial growth factor in human endothelial cells. J. Clin. Invest. 100:3131-3139.
23. Murohara, T., et al. 1998. Nitric oxide synthase modulates angiogenesis in response to tissue ischemia. J. Clin. Invest, 101:2567-2578.
24. Fukumura, D., et al. 2001. Ptedominant role of endothelial nitric oxide synchase in vascular endothelial growth factor-induced angiogenesis and vascular permeability. Proc. Natl. Acad. Sci. U. S. A. 98:2604-2609.
25. Aicher, A., et al. 2003. Essential role of endothelial nicric oxide synthase for mobilization of stem and progenitor cells. Nat. Med. 9:1370-1376.
26. Gracton, J.P., et al. 2003. Selective inhibition of tumor micro vascular permeability by cavtratin blocks tumor progression in mice. Cancer Cell. 4:31-39.
27. Fong, G.H., Rossant, J., Gertsenstein, M., and Breitman, M.L. 1995. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature. 376:66-70.
28. Shalaby, F., et al, 1995. Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature. 376:62-66.
29. Carmeliet, P., et al. 1996. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature. 380:435-439.
30. Ferrara, N., et al. 1996. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature. 380:439-442.
31. Carmeliet, P., et al. 2001. Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions. Nat. Med. 7:575-583.
32. Heil, M., and Schaper, W. 2004, Influence of mechanical, cellular, and molecular factors on collateral artery growth (arteriogenesis). Circ. Res. 95:449-458.
33. Scholz., D., et al. 2002. Contribution of arteriogenesis and angiogenesis to postocclusive hindlimb perfusion in mice. J. Mol. Cell Cardiol. 34:775-787.
34. Takahashi, T., et al. 1999. Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization. Nat Med. 5:434-438.
35. Yamamoto, K., et al. 2004. Molecular evaluation of endothelial progenitor cells in patients with ischemic limbs: therapeutic effect by stem cell transplantation. Arterloscler. Thromb. Vasc. Biol. 24:e192-e196.
36. Ziegelhoeffer, T., et al. 2004, Bone m arrow-derived cells do not incorporate into the adult growing vasculature. Circ. Res. 94:230-238.
37. Khmelewski, E., Becker, A., Meinertz. T., and Ito, W.D. 2004. Tissue resident cells play a dominant role in arteriogenesis and concomitant macrophage accumulation. Circ. Res. 95:E56-E64.
38. Chung, C.Y., Potikyan, G., and Firtel, R.A. 2001. Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa. Mol. Cell. 7:937-947.
39. Dimmeler, S., Dernbach, E., and Zeiher, A.M. 2000. Phosphorylation of the endothelial nitric oxide synthase at ser-1177 is required for VEGF-induced endothelial cell migration. FEBS Lett. 477:258-262.
40. Six, I., Kureishi, Y., Luo, Z., and Walsh, K. 2002. Akt signaling mediates VEGF/VPF vascular permeability in vivo. FEBS Lett. 532:67-69.
41. Eliceiri, B.P., et al. 1999. Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability. Mol Cell. 4:915-924.
42. Haynes, M.P., et al 2003. Src kinase mediates phosphatidylinositol 3-kinase/Akt-dependent rapid endothelial nitric-oxide synthase activation by estrogen. J. Bio. Chem. 278:2118-2123.
43. Davis, M.E., Cai, H., Drummond, G.R., and Harrison, D.G. 2001. Shear stress regulates endothelial nitric oxide synthase expression through c-Src by divergent signaling pathways. Circ. Res. 89:1073-1080.
44. Davis, M.E., Cai, H., McCann, L., Fukai, T., and Harrison, D.G. 2003. Role of c-Src in regulation of endothelial nitric oxide synthase expression during exercise training. Am. J. Physiol. Heart Circ. Physiol, 284:H1449-H1453.
45. Shibata, R., et al. 2004, Adiponectin stimulates angiogenesis in response to tissue ischemia through stimulation of AMP-activated protein kinase signaling. J. Biol Chem. 279:28670-28674.
46. Calera, M.R., et al. 1998. Insulin increases the association of Akt-2 with Glut4-containmg vesicles, J. Biol. Chem. 273:7201-7204.
47. Easton, R.M., et al. 2005. Role for Akt/protein kinase Bgamma in attainment of normal brain size. Mol. Cell. Biol. 25:1869-1878.