Carotenoids in chemoprevention: Lycopene;Carotenoides en quimioprevención: Licopeno

Acta Bioquimica Clinica Latinoamericana

Volumn 44, Issue 2, 2010, Pages 195-238

  Vitale, Arturo Alberto ^a   Bernatene, Eduardo Alberto ^a   Pomilio, Alicia Beatriz ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Antioxidants; Carotenoids; Chemoprevention; Lycopene; Tomato

Indexed keywords

LYCOPERSICON ESCULENTUM;

EID: 77956528478     PISSN: 03252957     EISSN: 03252957     Source Type: Journal    
DOI: None     Document Type: Article

References (279)

1. Gros EG, Pomilio AB, Seldes AM, Burton G. Introducción al estudio de los Productos Naturales. Serie Química, Monografía No 30, Secretaría General de la Organización de Estados Americanos (OEA), Programa Regional de Desarrollo Científico y Tecnológico, 1985.
2. Stahl W, Sies H. Bioactivity and protective effects of natural carotenoids. Biochim Biophys Acta 2005; 1740 (2): 101-107
3. O'Sullivan L, Ryan L, O'Brien N. Comparison of the uptake and secretion of carotene and xanthophyll carotenoids by Caco-2 intestinal cells. Br J Nutr 2007; 98 (1): 38-44.
4. Tadmor Y, King S, Levi A, Davis A, Meir A, Wasserman B, et al. Comparative fruit colouration in watermelon and tomato. Food Res Int 2005; 38 (8-9): 837-841
5. Levy J, Sharoni Y. The functions of tomato lycopene and its role in human health. Herbal Gram 2004; (62): 49-56.
6. Clinton SK, Emenhiser C, Schwartz SJ, Bostwick DG, Williams AW, Moore BJ, et al. cis-trans Lycopene isomers, carotenoids, and retinol in the human prostate. Cancer Epidemiol Biomarkers Prev 1996; 5 (10): 823-833
7. Boileau AC, Merchen NR, Wasson K, Atkinson CA, Erdman Jr JW. cis-Lycopene is more bioavailable than translycopene in vitro and in vivo in lymph-cannulated ferrets. J Nutr 1999; 129 (6): 1176-1181
8. Stahl W, Sies H. Lycopene: a biologically important carotenoid for humans? Arch Biochem Biophys 1996; 336 (1): 1-9.
9. van Breemen RB, Pajkovic N. Multitargeted therapy of cancer by lycopene. Cancer Lett 2008; 269 (2): 339-351
10. Hoppe PP, Kramer K, van den Berg H, Steenge G, van Vliet T. Synthetic and tomato-based lycopene have identical bioavailability in humans. Eur J Nutr 2003; 42 (5): 272-278
11. Goñi I, Serrano J, Saura-Calixto F. Bioaccessibility of β-carotene, lutein, and lycopene from fruits and vegetables. J Agric Food Chem 2006; 54 (15): 5382-5387
12. Khachik F, Carvalho L, Bernstein PS, Muir GJ, Zhao DY, Katz NB. Chemistry, distribution, and metabolism of tomato carotenoids and their impact on human health. Exp Biol Med 2002; 227 (10): 845-851
13. Campbell JK, Engelmann NJ, Lila MA, Erdman JW. Phytoene, phytobuene, and lycopene from tomato powder differentially accumulate in tissues of male Fisher 344 Rats. Nutr Res 2007; 27 (12): 794-801.
14. Hurst JS, Contreras JE, Siems WG, Van Kuijk FJ. Oxidation of carotenoids by heat and tobacco smoke. Biofactors 2004; 20 (1): 23-35.
15. Nara E, Hayashi H, Kotake M, Miyashita K, Nagao A. Acyclic carotenoids and their oxidation mixtures inhibit the growth of HL-60 human promyelocytic leukemia cells. Nutr Cancer 2001; 39 (2): 273-283
16. Rao AV, Agarwal S. Bioavailability and in vivo antioxidant properties of lycopene from tomato products and their possible role in the prevention of cancer. Nutr Cancer 1998; 31 (3): 199-203.
17. Sies H, Stahl W. Lycopene: Antioxidant and biological effects and its bioavailability in the human. Proc Soc Exp Biol Med 1998; 218 (2): 121-124
18. Toor RK, Savage GP. Changes in major antioxidant components of tomatoes during post-harvest storage. Food Chemistry 2006; 99 (4): 724-727
19. Fraser PD, Enfissi EMA, Bramley PM. Genetic engineering of carotenoid formation in tomato fruit and the potential application of systems and synthetic biology approaches. Arch Biochem Biophys 2009; 483 (2): 196-204.
20. Markovic K, Hruškar M, Vahcic N. Lycopene content of tomato products and their contribution to the lycopene intake of Croatians. Nutr Res 2006; 26 (11): 556-560
21. Periago MJ, Rincón F, Agüera MD, Ros G. Mixture approach for optimizing lycopene extraction from tomato and tomato products. J Agric Food Chem 2004; 52 (19): 5796-5802
22. Campbell JK, Canene-Adams K, Lindshield BL, Boileau TW-M, Clinton SK, Erdman Jr JW. Tomato phytochemicals and prostate cancer risk. J Nutr 2004; 134 (12 Suppl): 3486S-92S.
23. Abushita AA, Daood HG, Biacs PA. Change in carotenoids and antioxidant vitamins in tomato as a function of varietal and technological factors. J Agric Food Chem 2000; 48 (6): 2075-2081
24. Sahlin E, Savage GP, Lister CE. Investigation of the antioxidant properties of tomatoes after processing. J Food Compos Anal 2004; 17 (5): 635-647
25. Capanoglu E, Beekwilder J, Boyacioglu D, Hall R, de Vos R. Changes in antioxidant and metabolite profiles during production of tomato paste. J Agric Food Chem 2008; 56 (3): 964-973
26. Minoggio M, Bramati L, Simonetti P, Gardana C, Iemoli L, Santangelo E, et al. Polyphenol pattern and antioxidant activity of different tomato lines and cultivars. Ann Nutr Metab 2003; 47 (2): 64-69
27. Toor RK, Lister CE, Savage GP. Antioxidant activities of New Zealand-grown tomatoes. Int J Food Sci Nutr 2005; 56 (8): 597-605.
28. Spencer JPE, Kuhnle GGC, Hajirezaei M, Mock HP, Sonnewald U, Rice-Evans C. The genotypic variation of the antioxidant potential of different tomato varieties. Free Radic Res 2005; 39 (9): 1005-1016
29. Frusciante L, Carli P, Ercolano MR, Pernice R, Di Matteo A, Fogliano V, et al. Antioxidant nutritional quality of tomato. Mol Nutr Food Res 2007; 51 (5): 609-617
30. Dewanto V, Wu x, Adom KK, Liu RH. Thermal processing enhances the nutritional value of tomatoes by increasing total antioxidant capacity. J Agric Food Chem 2002; 50 (10): 3010-3014
31. Chang C-H, Liu Y-C. Study on lycopene and antioxidant contents variations in tomatoes under air-drying process. J Food Sci 2007; 72 (9): E532-40.
32. Hwang E-S. Tomato-based products and lycopene in the prevention of cancer: Bioavailability and antioxidant properties. Cancer Prev Res 2005; 10 (2): 81-88
33. Chen L, Stacewicz-Sapuntzakis M, Duncan C, Sharifi R, Ghosh L, van Breemen R, et al. Oxidative DNA damage in prostate cancer patients consuming tomato saucebased entrees as a whole-food intervention. J Natl Cancer Inst 2001; 93 (24): 1872-1879
34. Richelle M, Bortlik K, Liardet S, Hager C, Lambelet P, Baur M, et al. A food-based formulation provides lycopene with the same bioavailability to humans as that from tomato paste. J Nutr 2002; 132 (3): 404-408
35. Tang FY, Cho HJ, Pai MH, Chen YH. Concomitant supplementation of lycopene and eicosapentaenoic acid inhibits the proliferation of human colon cancer cells. J Nutr Biochem 2009; 20 (6): 426-434
36. Sharoni Y, Danilenko M, Dubi N, Ben-Dor A, Levy J. Carotenoids and transcription. Arch Biochem Biophys 2004; 430 (1): 89-96.
37. Wertz K, Siler U, Goralczyk R. Lycopene: modes of action to promote prostate health. Arch Biochem Biophys 2004; 430 (1): 127-134
38. Mossine VV, Chopra P, Mawhinney TP. Interaction of tomato lycopene and ketosamine against rat prostate tumorigenesis. Cancer Res 2008; 68 (11): 4384-4391
39. Birt DF. Phytochemicals and cancer prevention: From epidemiology to mechanism of action. J Am Diet Assoc 2006; 106 (1): 20-21
40. Venkateswaran V, Klotz LH, Ramani M, Sugar LM, Jacob LE, Nam RK, et al. A combination of micronutrients is beneficial in reducing the incidence of prostate cancer and increasing survival in the lady transgenic model. Cancer Prev Res 2009; 2 (5): 473-483
41. Lean ME, Noroozi M, Kelly I, Burns J, Talwar D, Sattar N, et al. Dietary bavonols protect diabetic human lymphocytes against oxidative damage to DNA. Diabetes 1999; 48 (1): 176-181
42. De S, Ganguly C, Das S. Natural dietary agents can protect against DMBA genotoxicity in lymphocytes as revealed by single cell gel electrophoresis assay. Teratog Carcinog Mutagen 2003; (Suppl 1): 71-78
43. Di Mascio P, Kaiser S, Sies H. Lycopene as the most efficient biological carotenoid singlet oxygen quencher. Arch Biochem Biophys 1989; 274 (2): 532-538
44. Hadley CW, Clinton SK, Schwartz SJ. The consumption of processed tomato products enhances plasma lycopene concentrations in association with a reduced lipoprotein sensitivity to oxidative damage. J Nutr 2003; 133 (3): 727-732
45. Porrini M, Riso P. Lymphocyte lycopene concentration and DNA protection from oxidative damage is increased in women after a short period of tomato consumption. J Nutr 2000; 130 (2): 189-192
46. Breinholt V, Lauridsen ST, Daneshvar B, Jakobsen J. Dose-response effects of lycopene on selected drug-metabolizing and antioxidant enzymes in the rat. Cancer Lett 2000; 154 (2): 201-210
47. Bhuvaneswari V, Velmurugan B, Nagini S. Induction of glutathione- dependent hepatic biotransformation enzymes by lycopene in the hamster cheek pouch carcinogenesis model. J Biochem Mol Biol Biophys 2002; 6 (4): 257-260
48. Velmurugan B, Bhuvaneswari V, Burra UK, Nagini S. Prevention of N-methyl-N'-nitro-N-nitroso-guanidine and saturated sodium chloride-induced gastric carcinogenesis in Wistar rats by lycopene. Eur J Cancer Prev 2002; 11 (1): 19-26.
49. Voskuil DW, Vrieling A, van't Veer LJ, Kampman E, Rookus MA. The insulin-like growth factor system in cancer prevention: potential of dietary intervention strategies. Cancer Epidemiol Biomarkers Prev 2005; 14 (1): 195-203.
50. Kaaks R, Lukanova A. Energy balance and cancer: the role of insulin and IGF-I. Proc Nutr Soc 2001; 60 (1): 91-106.
51. Jones JI, Clemmons DR. Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev 1995; 16 (1): 3-34.
52. Mucci LA, Tamimi R, Lagiou P, Trichopoulou A, Benetou V, Spanos E, et al. Are dietary inbuences on the risk of prostate cancer mediated through the insulin-like growth factor system? BJU Int 2001; 87 (9): 814-820 (Pubitemid 34204321)
53. Siler U, Barella L, Spitzer V, Schnorr J, Lein M, Goralczyk R, et al. Lycopene and vitamin E interfere with autocrine/paracrine loops in the Dunning prostate cancer model. FASEB J 2004; 18 (9): 1019-1021
54. Gunnell D, Oliver SE, Peters TJ, Donovan JL, Persad R, Maynard M, et al. Are diet-prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-I and IGFBP-3 in healthy middle-aged men. Br J Cancer 2003; 88 (11): 1682-1686
55. Liu C, Lian F, Smith DE, Russell RM, Wang XD. Lycopene supplementation inhibits lung squamous metaplasia and induces apoptosis via up-regulating insulin-like growth factor-binding protein 3 in cigarette smoke-exposed ferrets. Cancer Res 2003; 63 (12): 3138-3144
56. Kanagaraj P, Vijayababu MR, Ravisankar B, Anbalagan J, Aruldhas MM, Arunakaran J. Effect of lycopene on insulin-like growth factor-I, IGF binding protein-3 and IGF type-I receptor in prostate cancer cells. J Cancer Res Clin Oncol 2007; 133 (6): 351-359
57. Karas M, Amir H, Fishman D, Danilenko M, Segal S, Nahum A, et al. Lycopene interferes with cell cycle progression and insulin-like growth factor I signaling in mammary cancer cells. Nutr Cancer 2000; 36 (1): 101-111
58. Wang S, DeGroff VL, Clinton SK. Tomato and soy polyphenols reduce insulin-like growth factor-Istimulated rat prostate cancer cell proliferation and apoptotic resistance in vitro via inhibition of intracellular signaling pathways involving tyrosine kinase. J Nutr 2003; 133 (7): 2367-2376
59. Herzog A, Siler U, Spitzer V, Seifert N, Denelavas A, Hunziker PB, et al. Lycopene reduced gene expression of steroid targets and inbammatory markers in normal rat prostate. FASEB J 2005; 19 (2): 272-274
60. Ivanov NI, Cowell SP, Brown P, Rennie PS, Guns ES, Cox ME. Lycopene differentially induces quiescence and apoptosis in androgen-responsive and -independent prostate cancer cell lines. Clin Nutr 2007; 26 (2): 252-263
61. Renehan AG, Zwahlen M, Minder C, O'Dwyer ST, Shalet SM, Egger M. Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis. Lancet 2004; 363 (9418): 1346-1353
62. Signorello LB, Kuper H, Lagiou P, Wuu J, Mucci LA, Trichopoulos D, et al. Lifestyle factors and insulin-like growth factor 1 levels among elderly men. Eur J Cancer Prev 2000; 9 (3): 173-178 (Pubitemid 30395354)
63. Holmes MD, Pollak MN, Willett WC, Hankinson SE. Dietary correlates of plasma insulin-like growth factor I and insulin-like growth factor binding protein 3 concentrations. Cancer Epidemiol Biomarkers Prev 2002; 11 (9): 852-861
64. Vrieling A, Voskuil DW, Bueno de Mesquita HB, Kaaks R, van Noord PA, Keinan-Boker L, et al. Dietary determinants of circulating insulin-like growth factor (IGF)- I and IGF binding proteins 1, -2 and -3 in women in the Netherlands. Cancer Causes Control 2004; 15 (8): 787-796
65. Tran CD, Diorio C, Berube S, Pollak M, Brisson J. Relation of insulin-like growth factor (IGF) I and IGF-binding protein 3 concentrations with intakes of fruit, vegetables, and antioxidants. Am J Clin Nutr 2006; 84 (6): 1518-1526
66. Vrieling A, Voskuil DW, Bonfrer JM, Korse CM, van Doorn J, Cats A, et al. Lycopene supplementation elevates circulating insulin-like growth factor binding protein-1 and -2 concentrations in persons at greater risk of colorectal cancer. Am J Clin Nutr 2007; 86 (5): 1456-1462
67. Obermüller-Jevic UC, Olano-Martin E, Corbacho AM, Eiserich JP, van der Vliet A, Valacchi G, et al. Lycopene inhibits the growth of normal human prostate epithelial cells in vitro. J Nutr 2003; 133 (11): 3356-3360
68. Kip1 in the cyclin E-cdk2 complexes. Oncogene 2001; 20 (26): 3428-3436
69. Stahl W, von Laar J, Martin HD, Emmerich T, Sies H. Stimulation of gap junctional communication: comparison of acyclo-retinoic acid and lycopene. Arch Biochem Biophys 2000; 373 (1): 271-274
70. Aust O, Ale-Agha N, Zhang L, Wollersen H, Sies H, Stahl W. Lycopene oxidation product enhances gap junctional communication. Food Chem Toxicol 2003; 41 (10): 1399-1407
71. Forbes K, Gillette K, Sehgal I. Lycopene increases urokinase receptor and fails to inhibit growth or connexin expression in a metastatically passaged prostate cancer cell line: a brief communication. Exp Biol Med 2003; 228 (8): 967-971
72. Livny O, Kaplan I, Reifen R, Polak-Charcon S, Madar Z, Schwartz B. Lycopene inhibits proliferation and enhances gap-junction communication of KB-1 human oral tumor cells. J Nutr 2002; 132 (12): 3754-3759
73. Durak I, Biri H, Avci A, Sözen S, Devrim E. Tomato juice inhibits adenosine deaminase activity in human prostate tissue from patient with prostate cancer. Nutr Res 2003; 23 (9): 1183-1188
74. van Breemen RB, Xu X, Viana MA, Chen L, Stacewicz-Sapuntzakis M, Duncan C, et al. Liquid chromatographymass spectrometry of cis- and all-trans-lycopene in human serum and prostate tissue after dietary supplementation with tomato sauce. J Agric Food Chem 2002; 50 (8): 2214-2219
75. Cohn W, Thürmann P, Tenter U, Aebischer C, Schierle J, Schalch W. Comparative multiple dose plasma kinetics of lycopene administered in tomato juice, tomato soup or lycopene tablets. Eur J Nutr 2004; 43 (5): 304-312
76. Burgess LC, Rice E, Fischer T, Seekins JR, Burgess TP, Sticka SJ, et al. Lycopene has limited effect on cell proliferation in only two of seven human cell lines (both cancerous and noncancerous) in an in vitro system with doses across the physiological range. Toxicol In Vitro 2008; 22 (5): 1297-1300
77. Gitenay D, Lyan B, Talvas J, Mazur A, Georgé S, Caris-Veyrat C, et al. Serum from rats fed red or yellow tomatoes induces Connexin43 expression independently from lycopene in a prostate cancer cell line. Biochem Biophys Res Commun 2007; 364 (3): 578-582
78. Salman H, Bergman M, Djaldetti M, Bessler H. Lycopene affects proliferation and apoptosis of four malignant cell lines. Biomed Pharmacother 2007; 61 (6): 366-369
79. Clinton SK. Tomatoes or lycopene: a role in prostate carcinogenesis? J Nutr 2005; 135 (Suppl): 2057S-9S.
80. Boveris DL, Boveris A. Oxygen delivery to the tissues and mitochondrial respiration. Front Biosci 2007; 12 (3): 1014-1023
81. Valdez LB, Lores Arnaiz S, Bustamante J, Alvarez S, Costa LE, Boveris A. Free radical chemistry in biological systems. Biol Res 2000; 33 (2): 65-70.
82. Valdez LB, Boveris A. Mitochondrial nitric oxide synthase, a voltage-dependent enzyme, is responsible for nitric oxide diffusion to cytosol. Front Biosci 2007; 12 (3): 1210-1219
83. Khan N, Afaq F, Mukhtar H. Cancer chemoprevention through dietary antioxidants: progress and promise. Antiox Redox Signal 2008; 10 (3): 475-510.
84. Giovannucci E. Tomatoes, tomato-based products, lycopene, and cancer: Review of the epidemiologic literature. J Natl Cancer Inst 1999; 91 (4): 317-331
85. Upritchard J, Sutherland W, Mann J. Effect of supplementation with tomato juice, vitamin E, and vitamin C on LDL oxidation and products of inflammatory activity in type 2 diabetes. Diabetes Care 2000; 23 (6): 733-738
86. Krinsky NI, Johnson EJ. Carotenoid actions and their relation to health and disease. Mol Aspects Med 2005; 26 (6): 459-516.
87. Böhm V, Bitsch R. Intestinal absortion of lycopene from different matrices and interactions to other carotenoids, the lipid status, and the antioxidant capacity of human plasma. Eur J Nutr 1999; 38 (3): 118-125
88. Fridovich I. Superoxide radical and superoxide dismutases. Annu Rev Biochem 1995; 64: 97-112.
89. Muradiana KK, Utko NA, Fraifeld V, Mozzhukhina TG, Pishel IN, Litoshenko AY. Superoxide dismutase, catalase and glutathione peroxidase activities in the liver of young and old mice: linear regression and correlation. Arch Gerontol Geriatr 2002; 35 (3): 205-211
90. Navarro A, Gómez C, Sánchez-Pino MJ, González H, Bández MJ, Boveris AD, et al. Vitamin E at high doses improves survival, neurological performance, and brain mitochondrial function in aging male mice. Am J Physiol-Regul Integr Comp Physiol 2005; 289 (5): R1392-9.
91. Nishino H, Tokuda H, Satomi Y, Masuda M, Osaka Y, Yogosawa S, et al. Cancer prevention by antioxidants. Biofactors 2004; 22 (1-4): 57-61.
92. Eichler O, Sies H, Stahl W. Divergent optimum levels of lycopene, β-carotene and lutein protecting against UVB irradiation in human fibroblasts. Photochem Photobiol 2002; 75 (5): 503-506
93. Olmedilla B, Granado F, Southon S, Wright AJ, Blanco I, Gil-Martinez E, et al. A European multicentre, placebo-controlled supplementation study with α-tocopherol, carotene-rich palm oil, lutein or lycopene: analysis of serum responses. Clin Sci (Lond) 2002; 102 (4): 447-456
94. Rao AV, Balachadran B. Role of oxidative stress and antioxidants in neurodegenerative diseases. Review. Nutr Neurosci 2002; 5 (5): 291-309.
95. Lam PY, Yin F, Hamilton RT, Boveris A, Cadenas E. Elevated neuronal nitric oxide synthase expression during ageing and mitochondrial energy production. Free Radic Res 2009; 43 (5): 431-439
96. Valdez LB, Zaobornyj T, Boveris A. Functional activity of mitochondrial nitric oxide synthase. Methods Enzymol 2005; 396: 444-455
97. Navarro A, Boveris A. Mitochondrial nitric oxide synthase, mitochondrial brain dysfunction in aging, and mitochondria-targeted antioxidants. Review. Adv Drug Deliv Rev 2008; 60 (13-14): 1534-1544
98. Navarro A, Boveris A, Bández MJ, Sánchez-Pino MJ, Gómez C, Muntané G, et al. Human brain cortex: mitochondrial oxidative damage and adaptive response in Parkinson disease and in dementia with Lewy bodies. Free Radic Biol Med 2009; 46 (12): 1574-1580
99. Serra JA, Domínguez RO, Marschoff ER, Guareschi EM, Famulari AL, Boveris A. Systemic oxidative stress associated with the neurological diseases of aging. Neurochem Res 2009 Jun 2 [Epub ahead of print]. PMID: 19488852.
100. McNulty H, Jacob RF, Mason RP. Biologic activity of carotenoids related to distinct membrane physicochemical interactions. Am J Cardiol 2008; 101 (10A): 20D-9D.
101. Devaraj S, Mathur S, Basu A, Aung HH, Vasu VT, Meyers S, et al. A dose-response study on the effects of purified lycopene supplementation on biomarkers of oxidative stress. J Am Coll Nutr 2008; 27 (2): 267-273
102. Rao CV, Indranie C, Simi B, Manning PT, Connor JR, Reddy BS. Chemopreventive properties of a selective inducible nitric oxide synthase inhibitor in colon carcinogenesis, administered alone or in combination with celecoxib, a selective cyclooxygenase-2 inhibitor. Cancer Res 2002; 62 (1): 165-170
103. Farinati F, Cardin R, Degan P, De Maria N, Floyd RA, Van Thiel DH, et al. Oxidative DNA damage in circulating leukocytes occurs as an early event in chronic HCV infection. Free Radic Biol Med 1999; 27 (11-12): 1284-1291
104. Bowen P, Chen L, Stacewicz-Sapuntzakis M, Sharifi R, Ghosh L, van Breemen R, et al. Tomato sauce supplementation and prostate cancer: lycopene accumulation and modulation of biomarkers of carcinogenesis. Exp Biol Med 2002; 227 (10): 886-893
105. Erdman JW Jr, Ford NA, Lindshield BL. Are the health attributes of lycopene related to its antioxidant function? Arch Biochem Biophys 2009; 483 (2): 229-235
106. Hu K-Q, Liu C, Ernst H, Krinsky NI, Russell RM, Wang X-D. The biochemical characterization of ferret carotene-9', 10'-monooxygenase catalyzing cleavage of carotenoids in vitro and in vivo. J Biol Chem 2006; 281 (28): 19327-19338
107. Lindshield BL, Canene-Adams K, Erdman Jr JW. Lycopenoids: are lycopene metabolites bioactive? Arch Biochem Bioph 2007; 458 (2): 136-140
108. Steinberg FM, Chait A. Antioxidant vitamin supplementation and lipid peroxidation in smokers. Am J Clin Nutr 1998; 68 (2): 319-327
109. Visioli F, Riso P, Grande S, Galli C, Porrini M. Protective activity of tomato products on in vivo markers of lipid oxidation. Eur J Nutr 2003; 42 (4): 201-206
110. Porrini M, Riso P, Brusamolino A, Berti C, Guarnieri S, Visioli F. Daily intake of a formulated tomato drink affects carotenoid plasma and lymphocyte concentrations and improves cellular antioxidant protection. Br J Nutr 2005; 93 (1): 93-99
111. Hininger IA, Meyer-Wenger A, Moser U, Wright A, Southon S, Thurnham D, et al. No significant effects of lutein, lycopene or β-carotene supplementation on biological markers of oxidative stress and LDL oxidizability in healthy adult subjects. J Am Coll Nutr 2001; 20 (3): 232-238
112. Briviba K, Schnäbele K, Rechkemmer G, Bub A. Supplementation of a diet low in carotenoids with tomato or carrot juice does not affect lipid peroxidation in plasma and feces of healthy men. J Nutr 2004; 134 (5): 1081-1083
113. Riso P, Visioli F, Erba D, Testolin G, Porrini M. Lycopene and vitamin C concentrations increased in plasma and lymphocytes after tomato intake. Effects on cellular antioxidant protection. Eur J Clin Nutr. 2004; 58 (10): 1350-1358
114. Porrini M, Riso P, Oriani G. Spinach and tomato consumption increases lymphocyte DNA resistance to oxidative stress but this is not related to cell carotenoid concentrations. Eur J Nutr 2002; 41 (3): 95-100.
115. Canene-Adams K, Campbell JK, Zaripheh S, Jeffery EH, Erdman JW. The tomato as a functional food. J Nutr 2005; 135 (5): 1226-1230
116. Fuhrman B, Volkova N, Rosenblat M, Aviram M. Lycopene synergistically inhibits LDL oxidation in combination with vitamin E, glabridin, rosmarinic acid, carnosic acid, or garlic. Antiox Redox Signal 2000; 2 (3): 491-506.
117. Shi J, Kakuda Y, Yeung D. Antioxidative properties of lycopene and other carotenoids from tomatoes: synergistic effects. Biofactors 2004; 21 (1-4): 203-210 (Pubitemid 40921855)
118. Stewart AJ, Bozonnet S, Mullen W, Jenkins GI, Lean MEJ, Crozier A. Occurrence of flavonols in tomatoes and tomato-based products. J Agric Food Chem 2000; 48 (7): 2663-2669
119. Bovy A, Schijlen E, Hall RD. Metabolic engineering of flavonoids in tomato (Solanum lycopersicum): the potential for metabolomics. Metabolomics 2007; 3 (3): 399-412.
120. Torres CA, Davies NM, Yañez JA, Andrewa K. Disposition of selected bavonoids in fruit tissues of various tomato (Lycopersicon esculentum Mill.) genotypes. J Agric Food Chem 2005; 53 (24): 9536-9543
121. Re R, Mishra GD, Thane CW, Bates CJ. Tomato consumption and plasma lycopene concentration in people aged 65 and over in a British National Survey. Eur J Clin Nutr 2003; 57 (12): 1545-1554
122. Watanabe S, Zhuo XG, Kimira M. Food safety and epidemiology: new database of functional food factors. Biofactors 2004; 22 (1-4): 213-219
123. Madrid A E, Vásquez Z D, Leyton A F, Mandiola C, Escobar F JA. El consumo de Lycopersicum esculentum podría aumentar lipoproteínas de alta densidad (HDL) y disminuir el estrés oxidativo a corto plazo. Rev Méd Chile 2006; 134 (7): 855-862
124. Periago MJ, Garcia-Alonso J, Jacob K, Olivares AB, Bernal MJ, Iniesta MD, et al. Bioactive compounds, folates and antioxidant properties of tomatoes (Lycopersicum esculentum) during vine ripening. Int J Food Sci Nutr 2008 Mar 12: 1-15. [Epub ahead of print]. PMID: 18608536
125. Gitenay D, Lyan B, Rambeau M, Mazur A, Rock E. Comparison of lycopene and tomato effects on biomarkers of oxidative stress in vitamin E deficient rats. Eur J Nutr 2007; 46 (8): 468-475
126. Shen YC, Chen SL, Zhuang SR, Wang CK. Contribution of tomato phenolics to suppression of COx-2 expression in KB cells. Food Sci 2008; 73 (1): C1-10.
127. Jacob K, Periago MJ, Böhm V, Berruezo GR. Influence of lycopene and vitamin C from tomato juice on biomarkers of oxidative stress and inflammation. Br J Nutr 2008; 99 (1): 137-146
128. Morisco F, Vitaglione P, Carbone A, Stingo S, Scarpati S, Ascione A, et al. Tomato-based functional food as interferon adjuvant in HCV eradication therapy. J Clin Gastroenterol 2004; 38 (6 Suppl): S118-20.
129. Vitaglione P, Fogliano V, Stingo S, Scalfi L, Caporaso N, Morisco F. Development of a tomato-based food for special medical purposes as therapy adjuvant for patients with HCV infection. Eur J Clin Nutr 2007; 61 (7): 906-915
130. Hoelzl C, Knasmüller S, Misík M, Collins A, Dusinská M, Nersesyan A. Use of single cell gel electrophoresis assays for the detection of DNA-protective effects of dietary factors in humans: recent results and trends. Mutat Res 2009; 681 (1): 68-79.
131. Conn PF, Schalch W, Truscott TG. The singlet oxygen and carotenoid interactions. J Photochem Photobiol B Biol 1991; 11 (1): 41-47
132. Miller NJ, Sampson J, Candeias LP, Bramley PM, Rice-Evans CA. Antioxidant activities of carotenes and xanthophylls. FEBS Lett 1996; 384 (3): 240-242
133. Hirayama O, Nakamura K, Hamada S, Kobayasi Y. Singlet oxygen quenching ability of naturally occurring carotenoids. Lipids 1994; 29 (2): 149-150
134. Rao AV, Agarwal S. Role of lycopene as antioxidant carotenoid in the prevention of chronic diseases: a review. Nutr Res 1999; 19 (2): 305-323
135. Krutovskikh V, Asamoto M, Takasuka N, Murakoshi M, Nishino H, Tsuda H. Differential dose-dependent effects of α-, β-carotenes and lycopene on gap-junctional intercellular communication in rat liver in vivo. Jpn J Cancer Res 1997; 88 (12): 1121-1124
136. Abraham CM. Moléculas de adhesión. Importancia en la respuesta inmune e inbamatoria. Rev Cubana Hematol Inmunol Hemoter 2006; 22 (2): 1-15.
137. Blum A, Monir M, Khazim K, Peleg A, Blum N. Tomato-rich (Mediterranean) diet does not modify inbammatory markers. Clin Invest Med 2007; 30 (2): E70-4.
138. Hung CF, Huang TF, Chen BH, Shieh JM, Wu PH, Wu WB. Lycopene inhibits TNF-α-induced endothelial ICAM-1 expression and monocyte-endothelial adhesion. Eur J Pharmacol 2008; 586 (1-3): 275-282
139. Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 1997; 275 (5308): 1943-1947
140. Sarker D, Reid AH, Yap TA, de Bono JS. Targeting the PI3K/AKT pathway for the treatment of prostate cancer. Clin Cancer Res 2009; 15 (15): 4799-4805
141. Tokunaga E, Oki E, Egashira A, Sadanaga N, Morita M, Kakeji Y, et al. Deregulation of the Akt pathway in human cancer. Curr Cancer Drug Targets 2008; 8 (1): 27-36.
142. Tang FY, Shih CJ, Cheng LH, Ho HJ, Chen HJ. Lycopene inhibits growth of human colon cancer cells via suppression of the Akt signaling pathway. Mol Nutr Food Res 2008; 52 (6): 646-654
143. Müller K, Carpenter KL, Challis IR, Skepper JN, Arends MJ. Carotenoids induce apoptosis in the T-lymphoblast cell line Jurkat E6.1. Free Radic Res 2002; 36 (7): 791-802.
144. Kobayashi T, Iijima K, Mitamura T, Toriizuka K, Cyong JC, Nagasawa H. Effects of lycopene, a carotenoid, on intrathymic T cell differentiation and peripheral CD4/CD8 ratio in a high mammary tumor strain of SHN retired mice. Anticancer Drugs 1996; 7 (2): 195-198
145. Bessler H, Salman H, Bergman M, Alcalay Y, Djaldetti M. In vitro effect of lycopene on cytokine production by human peripheral blood mononuclear cells. Immunol Invest 2008; 37 (3): 183-190
146. Espondaburu OR, Fara Hunt VA, Ocampo LI. El proceso aterogénico y su desarrollo en las enfermedades autoinmunes. Acta Bioquím Clín Latinoam 2004; 38 (2): 181-192
147. Willcox JK, Catignani GL, Lazarus S. Tomatoes and cardiovascular health. Review. Crit Rev Food Sci Nutr 2003; 43 (1): 1-18.
148. Blum A, Monir M, Wirsansky I, Ben-Arzi S. The beneficial effects of tomatoes. Eur J Int Medicine 2005; 16 (6): 402-404
149. Blum A, Merei M, Karem A, Blum N, Ben-Arzi S, Wirsansky I, et al. Effects of tomatoes on the lipid profile. Clin Invest Med 2006; 29 (5): 298-300.
150. Bose KS, Agrawal BK. Effect of long term supplementation of tomatoes (cooked) on levels of antioxidant enzymes, lipid peroxidation rate, lipid profile and glycated haemoglobin in Type 2 diabetes mellitus. West Indian Med J 2006; 55 (4): 274-278
151. Bose KS, Agrawal BK. Effect of lycopene from tomatoes (cooked) on plasma antioxidant enzymes, lipid peroxidation rate and lipid profile in grade-I hypertension. Ann Nutr Metab 2007; 51 (5): 477-481
152. Silaste ML, Alfthan G, Aro A, Kesäniemi YA, Hörkkö S. Tomato juice decreases LDL cholesterol levels and increases LDL resistance to oxidation. Br J Nutr 2007; 98 (6): 1251-1258
153. Shen YC, Chen SL, Wang CK. Contribution of tomato phenolics to antioxidation and down-regulation of blood lipids. J Agric Food Chem 2007; 55 (16): 6475-6481
154. Hsu YM, Lai CH, Chang CY, Fan CT, Chen CT, Wu CH. Characterizing the lipid-lowering effects and antioxidant mechanisms of tomato paste. Biosci Biotechnol Biochem 2008; 72 (3): 677-685
155. Lo HM, Hung CF, Tseng YL, Chen BH, Jian JS, Wu WB. Lycopene binds PDGF-BB and inhibits PDGF-BB-induced intracellular signaling transduction pathway in rat smooth muscle cells. Biochem Pharmacol 2007; 74 (1): 54-63.
156. Bose KS, Agrawal BK. Effect of lycopene from cooked tomatoes on serum antioxidant enzymes, lipid peroxidation rate and lipid profile in coronary heart disease. Singapore Med J 2007; 48 (5): 415-420
157. Wood LG, Garg ML, Powell H, Gibson PG. Lycopene-rich treatments modify noneosinophilic airway inbammation in asthma: proof of concept. Free Radic Res 2008; 42 (1): 94-102.
158. Sung WS, Lee IS, Lee DG. Damage to the cytoplasmic membrane and cell death caused by lycopene in Candida albicans. J Microbiol Biotechnol 2007; 17 (11): 1797-1804
159. Giovannucci E, Ascherio A, Rim EB, Stampfer MJ, Colditz GA, Willet WC. Intake of carotenoids and retinol in relation to risk of prostate cancer. J Natl Cancer Inst 1995; 87 (23): 1767-1776
160. Schmitz-Dräger BJ, Eichholzer M, Beiche B, Ebert T. Nutrition and prostate cancer. (Review). Urol Int 2001; 67 (1): 1-11.
161. Stacewicz-Sapuntzakis M, Bowen PE. Role of lycopene and tomato products in prostate health. Biochim Biophys Acta 2005; 1740 (2): 202-205
162. Kamangar F, Dores GM, Anderson WF. Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol 2006; 24 (14): 2137-2150
163. Mosher CE, Sloane R, Morey MC, Snyder DC, Cohen HJ, Miller PE, et al. Associations between lifestyle factors and quality of life among older long-term breast, prostate, and colorectal cancer survivors. Cancer 2009 Jul 27. [Epub ahead of print]. PMID: 19637244.
164. Moore SC, Peters TM, Ahn J, Park Y, Schatzkin A, Albanes D, et al. Age-specific physical activity and prostate cancer risk among white men and black men. Cancer 2009 Jul 30. [Epub ahead of print]. PMID: 19645029.
165. Freedland SJ, Isaacs WB, Explaining racial differences in prostate cancer in the United States: sociology or biology? Prostate 2005; 62 (3): 243-252
166. Pathak SK, Sharma RA, Mellon JK. Chemoprevention of prostate cancer by
167. Goetzl MA, Holzbeierlein JM, Finasteride as a chemopreventive agent in prostate cancer: Impact of the prostate cancer prevention trial on urologic practice. Nat Clin Pract Urol 2006; 3 (8): 422-429
168. van Weerden WM, Bangma C, de Wit R, Human xenograft models as useful tools to assess the potential of novel therapeutics in prostate cancer. Br J Cancer 2009; 100 (1): 13-18
169. Damber J-E, Aus G. Prostate cancer. Lancet 2008; 371 (9625): 1710-1721
170. Chan JM, Gann PH, Giovannucci EL. Role of diet in prostate cancer development and progression. J Clin Oncol 2005; 23 (32): 8152-8160
171. Theobald S. Ernährung und Prostatakrebs. Was ist wissenschaftlich gesichert? [Nutrition and prostate cancer-what is the scientific evidence?]. Med Monatsschr Pharm 2006; 29 (10): 371-377
172. Cohen LA. Nutrition and prostate cancer: a review. Ann N Y Acad Sci 2002; 963: 148-155
173. Cohen LA. A review of animal model studies of tomato carotenoids, lycopene, and cancer chemoprevention. Exp Biol Med (Maywood) 2002; 227 (10): 864-868
174. Fleshner N, Zlotta AR. Prostate cancer prevention: past, present, and future. Review. Cancer 2007; 110 (9): 1889-1899
175. Giovannucci E, Clinton SK. Tomatoes, lycopene, and prostate cancer. Proc Soc Exp Biol Med 1998; 218 (2): 129-139
176. Giovannucci E. A review of epidemiologic studies of tomatoes, lycopene, and prostate cancer. Exp Biol Med 2002; 227 (10): 852-859
177. Imaida K, Tamano S, Kato K, Ikeda Y, Asamoto M, Takahashi S, et al. Lack of chemopreventive effects of lycopene and curcumin on experimental rat prostate carcinogenesis. Carcinogenesis 2001; 22 (3): 467-472
178. Nikoli MC, Anese M, Parpinel MT, Francesci S, Lerici CR. Loss and/or formation of antioxidants during food processing and storage. Cancer Lett 1997; 114 (1-2): 71-74
179. Gahler S, Otto K, Böhm V. Alterations of vitamin C, total phenolics, and antioxidant capacity as affected by processing tomatoes to different products. J Agric Food Chem 2003; 51 (27): 7962-7968
180. Boileau TW-M, Liao Z, Kim S, Lemeshow S, Erdman JW, Clinton SK. Prostate carcinogenesis in N-methyl-N-nitrosourea (NMU)-testosterone-treated rats fed tomato powder, lycopene, or energy-restricted diets. J Natl Cancer Inst 2003; 95 (21): 1578-1586
181. Basu A, Imrhan V. Tomatoes versus lycopene in oxidative stress and carcinogenesis: conclusions from clinical trials. Eur J Clin Nutr 2007; 61 (3): 295-303.
182. Finot P-A. Historical perspective of the Maillard reaction in food science. Ann N Y Acad Sci 2005; 1043: 1-8.
183. Glinsky GV, Price JE, Glinsky VV, Mossine VV, Kiriakova G, Metcalf JB. Inhibition of human breast cancer metastasis in nude mice by synthetic glycoamines. Cancer Res 1996; 56 (23): 5319-5324
184. Glinsky VV, Glinsky GV, Glinskii OV, Huxley VH, Turk JR, Mossine VV, et al. Intravascular metastatic cancer cell homotypic aggregation at the sites of primary attachment to the endothelium. Cancer Res 2003; 63 (13): 3805-3811
185. Glinsky GV, Mossine VV, Price JE, Bielenberg D, Glinsky VV, Ananthaswamy HN, et al. Inhibition of colony formation in agarose of metastatic human breast carcinoma and melanoma cells by synthetic glycoamine analogs. Clin Exp Metastasis 1996; 14 (3): 253-267
186. Canene-Adams K, Lindshield BL, Wang S, Jeffery EH, Clinton SK, Erdman JW Jr. Combinations of tomato and broccoli enhance antitumor activity in dunning r3327-h prostate adenocarcinomas. Cancer Res 2007; 67 (2): 836-843
187. Venkateswaran V, Fleshner NE, Sugar LM, Klotz LH. Antioxidants block prostate cancer in lady transgenic mice. Cancer Res 2004; 64 (16): 5891-5896
188. Sengupta A, Ghosh S, Das S. Modulatory inbuence of garlic and tomato on cyclooxygenase-2 activity, cell proliferation and apoptosis during azoxymethane induced colon carcinogenesis in rat. Cancer Lett 2004; 208 (2): 127-136
189. Bhuvaneswari V, Abraham SK, Nagini S. Combinatorial antigenotoxic and anticarcinogenic effects of tomato and garlic through modulation of xenobiotic-metabolizing enzymes during hamster buccal pouch carcinogenesis. Nutrition 2005; 21 (6): 726-731
190. Mossine VV, Mawhinney TP. N-(1-Deoxy-D-fructos-1-yl)-L-histidine ("D-fructose-L-histidine"): a potent copper chelator from tomato powder. J Agric Food Chem 2007; 55 (25): 10373-10381
191. Bosland MC, McCormick DL. Antioxidant supplementation and cancer prevention. J Amer Med Assoc 2009; 301 (18): 1877-1878
192. DeWeese TL, Hruszkewycz AM, Marnett LJ. Oxidative stress in chemoprevention trials. Urology 2001; 57 (4A): 137-140
193. Nelson WG, DeWeese TL, DeMarzo AM. The diet, prostate inbammation, and the development of prostate cancer. Cancer Metastasis Rev 2002; 21 (1): 3-16.
194. Siddiqui IA, Adhami VM, Saleem M, Mukhtar H. Beneficial effects of tea and its polyphenols against prostate cancer. Mol Nutr Food Res 2006; 50 (2): 130-143 (Pubitemid 43325654)
195. Vinson JA, Hao Y, Su X, Zubik L. Phenol antioxidant quantity and quality in foods: vegetables. J Agric Food Chem 1998; 46 (9): 3630-3634
196. Liu A, Pajkovic N, Pang Y, Zhu D, Calamini B, Mesecar AL, et al. Absorption and subcellular localization of lycopene in human prostate cancer cells. Mol Cancer Ther 2006; 5 (11): 2879-2885
197. Sengupta A, Ghosh S, Das RK, Bhattacharjee S, Bhattacharya S. Chemopreventive potential of diallylsulfide, lycopene and theaflavin during chemically induced colon carcinogenesis in rat colon through modulation of cyclooxygenase-2 and inducible nitric oxide synthase pathways. Eur J Cancer Prev 2006; 15 (4): 301-305
198. Kim JM, Araki S, Kim DJ, Park CB, Takasuka N, Baba-Toriyama H, et al. Chemopreventive effects of carotenoids and curcumins on mouse colon carcinogenesis after 1,2-dimethylhydrazine initiation. Carcinogenesis 1998; 19 (1): 81-85
199. Narisawa T, Fukaura Y, Hasebe M, Ito M, Aizawa R, Murakoshi M, et al. Inhibitory effects of natural carotenoids, α-carotene, β-carotene, lycopene and lutein, on colonic aberrant crypt foci formation in rats. Cancer Lett 1996; 107 (1): 137-142
200. Narisawa T, Fukaura Y, Hasebe M, Nomura S, Oshima S, Sakamoto H, et al. Prevention of N-methylnitrosourea-induced colon carcinogenesis in F344 rats by lycopene and tomato juice rich in lycopene. Jpn J Cancer Res 1998; 89 (10): 1003-1008
201. Raju J, Swamy MV, Cooma I, Patlolla JM, Pittman B, Reddy BS, et al. Low doses of β-carotene and lutein inhibit AOM-induced rat colonic FCA formation but high doses augment FCA incidence. Int J Cancer 2005; 113 (5): 798-802.
202. Choi SY, Park JH, Kim JS, Kim MK, Aruoma OI, Sung MK. Effects of quercetin and β-carotene supplementation on azoxymethane-induced colon carcinogenesis and inbammatory responses in rats fed with high-fat diet rich in omega-6 fatty acids. Biofactors 2006; 27 (1-4): 137-146
203. Walfisch S, Walfisch Y, Kirilov E, Linde N, Mnitentag H, Agbaria R, et al. Tomato lycopene extract supplementation decreases insulin-like growth factor-I levels in colon cancer patients. Eur J Cancer Prev 2007; 16 (4): 298-303.
204. Palozza P, Serini S, Boninsegna A, Bellovino D, Lucarini M, Monastra G, et al. The growth-inhibitory effects of tomatoes digested in vitro in colon adenocarcinoma cells occur through down regulation of cyclin D1, Bcl-2 and Bcl-xL. Br J Nutr 2007; 98 (4): 789-795
205. Palozza P, Bellovino D, Simone R, Boninsegna A, Cellini F, Monastra G, et al. Effect of β-carotene-rich tomato lycopene β-cyclase (tlcy-b) on cell growth inhibition in HT-29 colon adenocarcinoma cells. Br J Nutr 2009; 102 (2): 207-214
206. Kim DJ, Takasuka N, Kim JM, Sekine K, Ota T, Asamoto M, Murakoshi M, Nishino H, Nir Z, Tsuda H. Chemoprevention by lycopene of mouse lung neoplasia after combined initiation treatment with DEN, MNU and DMH. Cancer Lett 1997; 120 (1): 15-22
207. Kim DJ, Takasuka N, Nishino H, Tsuda H. Chemoprevention of lung cancer by lycopene. Biofactors 2000; 13 (1-4): 95-102.
208. Männistö S, Smith-Warner SA, Spiegelman D, Albanes D, Anderson K, van den Brandt PA, et al. Dietary carotenoids and risk of lung cancer in a pooled analysis of seven cohort studies. Cancer Epidemiol Biomarkers Prev 2004; 13 (1): 40-48 (Pubitemid 38116619)
209. Gallicchio L, Boyd K, Matanoski G, Tao XG, Chen L, Lam TK, et al. Carotenoids and the risk of developing lung cancer: a systematic review. Am J Clin Nutr 2008; 88 (2): 372-383
210. Huang JP, Zhang M, Holman CD, Xie X. Dietary carotenoids and risk of breast cancer in Chinese women. Asia J Clin Nutr 2007; 16 (Suppl 1): 437-442
211. Voskuil DW, Vrieling A, Korse CM, Beijnen JH, Bonfrer JM, van Doorn J, et al. Effects of lycopene on the insulin-like growth factor (IGF) system in premenopausal breast cancer survivors and women at high familial breast cancer risk. Nutr Cancer 2008; 60 (3): 342-353
212. King-Batoon A, Leszczynska JM, Klein CB, Modulation of gene methylation by genistein or lycopene in breast cancer cells. Environ Mol Mutagen 2008; 49 (1): 36-45.
213. Zhang M, Holman CD, Binns CW. Intake of specific carotenoids and the risk of epithelial ovarian cancer. Br J Nutr 2007; 98 (1): 187-193
214. Okajima E, Ozono S, Endo T, Majima T, Tsutsumi M, Fukuda T, et al. Chemopreventive efficacy of piroxicam administered alone or in combination with lycopene and β-carotene on the development of rat urinary bladder carcinoma after N-butyl-N-(4-hydroxybutyl)nitrosamine treatment. Jpn J Cancer Res 1997; 88 (6): 543-552
215. Okajima E, Tsutsumi M, Ozono S, Akai H, Denda A, Nishino H, et al. Inhibitory effect of tomato juice on rat urinary bladder carcinogenesis after N-butyl-N-(4-hydroxybutyl)nitrosamine initiation. Jpn J Cancer Res 1998; 89 (1): 22-26
216. Kozuki Y, Miura Y, Yagasaki K. Inhibitory effects of carotenoids on the invasion of rat ascites hepatoma cells in culture. Cancer Lett 2000; 151 (1): 111-115
217. Watanabe S, Kitade Y, Masaki T, Nishioka M, Satoh K, Nishino H. Effects of lycopene and Sho-saiko-to on hepatocarcinogenesis in a rat model of spontaneous liver cancer. Nutr Cancer 2001; 39 (1): 96-101.
218. Scolastici C, Lopes GA, Barbisan LF, Salvadori DM. Tomato oleoresin inhibits DNA damage but not diethylnitrosamine-induced rat hepatocarcinogenesis. Exp Toxicol Pathol 2008; 60 (1): 59-68.
219. Pelucchi C, Dal Maso L, Montella M, Parpinel M, Negri E, Talamini R, et al. Dietary intake of carotenoids and retinol and endometrial cancer risk in an Italian case-control study. Cancer Causes Control 2008; 19 (10): 1209-1215
220. Ziegler RG. A review of epidemiologic evidence that carotenoids reduce the risk of cancer. J Nutr 1989; 119 (1): 116-122
221. Steinmetz KA, Potter JD. Vegetables, fruit, and cancer prevention: A review. J Am Diet Assoc 1996; 96 (10): 1027-1039
222. Flagg EW, Coates RJ, Greenberg RS. Epidemiologic studies of antioxidants and cancer in humans. J Am Coll Nutr 1995; 14 (5): 419-427
223. Vena JE, Graham S, Freudenheim J, Marshall J, Zielezny M, Swanson M, et al. Diet in the epidemiology of bladder cancer in western New York. Nutr Cancer 1992; 18 (3): 255-264 (Pubitemid 23015570)
224. Rock CL, Saxe GA, Ruffin MT 4th, August DA, Schottenfeld D. Carotenoids, vitamin A, and estrogen receptor status in breast cancer. Nutr Cancer 1996; 25 (3): 281-296
225. Wang C, Baumgartner RN, Yang D, Slattery ML, Murtagh MA, Byers T, et al. No evidence of association between breast cancer risk and dietary carotenoids, retinols, vitamin C and tocopherols in Southwestern Hispanic and non-Hispanic White women. Breast Cancer Res Treat 2009; 114 (1): 137-145
226. Zheng W, Sellers TA, Doyle TJ, Kushi LH, Potter JD, Folsom AR. Retinol, antioxidant vitamins, and cancer of the upper digestive tract in a prospective cohort study of postmenopausal women. Am J Epidemiol 1995; 142 (9): 955-960
227. Larsson SC, Bergkvist L, Naslund I, Rutegard J, Wolk A. Vitamin A, retinol, and carotenoids and the risk of gastric cancer: A prospective cohort study. Am J Clinical Nutr 2007; 85 (2): 497-503. (Pubitemid 46220954)
228. The α-Tocopherol, β-Carotene (ATBC) Cancer Prevention Study Group. The α-tocopherol, β-carotene lung cancer prevention study: design, methods, participant characteristics, and compliance. Ann Epidemiol 1994; 4 (1): 1-10.
229. The α-Tocopherol, β-Carotene (ATBC) Cancer Prevention Study Group. The effect of vitamin E and β-carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 1994; 330 (15): 1029-1035
230. Albanes D, Heinonen OP, Huttunen JK, Taylor PR, Virtamo J, Edwards BK, et al. Effects of α-tocopherol and β-carotene supplements on cancer incidence in the α-Tocopherol β-Carotene Cancer Prevention Study. Am J Clin Nutr 1995; 62 (6 suppl): 1427S-30S.
231. Albanes D, Heinonen OP, Taylor PR, Virtamo J, Edwards BK, Rautalahti M, et al. α-Tocopherol and β-carotene supplements and lung cancer incidence in the α-Tocopherol, β-Carotene Cancer Prevention Study: Effects of base-line characteristics and study compliance. J Natl Cancer Inst 1996; 88 (21): 1560-1570
232. Heinonen OP, Albanes D, Virtamo J, Taylor PR, Huttunen JK, Hartman AM, et al. Prostate cancer and supplementation with α-tocopherol and β-carotene: Incidence and mortality in a controlled trial. J Natl Cancer Inst 1998; 90 (6): 440-446
233. Leppälä JM, Virtamo J, Fogelholm R, Huttunen JK, Albanes D, Taylor PR, et al. Controlled trial of α-tocopherol and β-carotene supplements on stroke incidence and mortality in male smokers. Arteroscler Thromb Vasc Biol 2000; 20 (1): 230-235
234. Omenn GS, Goodman GE, Thornquist MD, Balmes J, Cullen MR, Glass A, et al. Risk factors for lung cancer and for intervention effects in CARET, the β-Carotene and Retinol Efficacy Trial. J Natl Cancer Inst 1996; 88 (21): 1550-1559
235. Omenn GS, Goodman GE, Thornquist MD, Balmes J, Cullen MR, Glass A, Keogh JP, Meyskens FL, Valanis B, Williams JH Jr, Barnhart S, Hammar S. Effects of a combination of β-carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med 1996; 334 (18): 1150-1155
236. The ATBC Study Group. Incidence of Cancer and Mortality Following α-Tocopherol and β-Carotene Supplementation: A postintervention follow-up. JAMA 2003; 290 (4): 476-485
237. Goodman GE, Thornquist MD, Balmes J, Cukken MR, Meyskens FL Jr, Omenn GS, et al. The β-Carotene and Retinol Efficacy Trial (CARET): Incidence of lung cancer and cardiovascular disease mortality during 6-year follow-up after stopping β-carotene and retinol supplements. J. Natl Cancer Inst 2004; 96 (23): 1743-1750
238. Omenn GS. Chemoprevention of lung cancers: lessons from CARET, The β-Carotene and Retinol Efficacy Trial, and prospects for the future. Eur J Cancer Prev 2007; 16 (3): 184-191
239. Albanes D. β-Carotene and lung cancer: a case study. Am J Clin Nutr 1999; 69 (6): 1345S-50S.
240. Hennekens CH, Buring JE. Methodologic considerations in the design and conduct of randomized trials: The U.S. Physicians' Health Study. Controlled Clin Trials 1989; 10 (4 Suppl): 142S-50S.
241. Satterfield S, Greco PJ, Goldhaber SZ, Stampfer MJ, Swartz SL, Stein EA, et al. Biochemical markers of compliance in the Physicians' Health Study. Am J Prev Med 1990; 6 (5): 290-294
242. Hennekens CH, Buring JE, Manson JE, Stampfer M, Roser B, Cook NR, et al. Lack of effect of long-term supplementation with β-carotene on the incidence of malignant neoplasms and cardiovascular disease. N Engl Med 1996; 334 (18): 1145-1149
243. Frieling UM, Schaumberg DA, Kupper TS, Muntwyler J, Hennekens CH. A randomized, 12-year primary-prevention trial of β-carotene supplementation for non-melanoma skin cancer in the Physicians' Health Study. Arch Dermatol 2000; 136 (2): 179-184
244. Lee I-M, Cook NR, Manson JE, Buring JE, Hennekens CH. β-Carotene supplementation and incidence of cancer and cardiovascular disease: The Women's Health Study. J Natl Cancer Inst 1999; 91 (24): 2102-2106
245. Vitale S, West S, Hallfrisch J, Alston C, Wang F, Moorman C, et al. Plasma antioxidants and risk of cortical and nuclear cataract. Epidemiology 1993; 4 (3): 195-203.
246. Christen WG, Gaziano JM, Hennekens CH. Design of Physicians' Health Study II: A randomized trial of β-carotene, vitamins E and C, and multivitamins, in prevention of cancer, cardiovascular disease, and eye disease, and review of results of completed trials. Ann Epidemiol 2000; 10 (2): 125-134
247. Grodstein F, Kang JH, Glynn RJ, Cook NR, Gaziano JM. A randomized trial of β-carotene supplementation and cognitive function in men: The Physicians' Health Study II. Arch Intern Med 2007; 167 (20): 2184-2190
248. Keefe KA, Schell MJ, Brewer C, McHale M, Brewster W, Chapman JA, et al. A randomized, double blind, Phase III trial using oral β-carotene supplementation for women with high-grade cervical intraepithelial neoplasia. Cancer Epidemiol Biomarkers Prev 2001; 10 (10): 1029-1035
249. Tornwall ME, Virtamo J, Haukka JK, Albanes D, Huttunen JK. α-Tocopherol (vitamin E) and β-carotene supplementation does not affect the risk for large abdominal aortic aneurysm in a controlled trial. Atherosclerosis 2001; 157 (1): 167-173
250. Schaumberg DA, Frieling UM, Rifai N, Cook N. No effect of β-carotene supplementation on risk of non-melanoma skin cancer among men with low baseline plasma β-carotene. Cancer Epidemiol Biomarkers Prev 2004; 13 (6): 1079-1080
251. Druesne-Pecollo N, Latino-Martel P, Norat T, Barrandon E, Bertrais S, Galan P, Hercberg S. β-Carotene supplementation and cancer risk: a systematic review and meta-analysis of randomized controlled trials. Int J Cancer. 2009 Oct 28. [Epub ahead of print] PMID: 19876916
252. Rodrigues MJ, Bouyon A, Alexandre J. Place en oncologie des compléments et suppléments en antioxydants en sus d'un régime équilibre; revue générale de la littérature. Bull Cancer 2009; 96 (6): 677-684
253. Myung S-K, Kim Y, Ju W, Choi HJ, Bae WK. Effects of antioxidant supplements on cancer prevention: meta-analysis of randomized controlled trials. Ann Oncol 2010; 21 (1): 166-179
254. Neuhouser ML, Patterson RE, Thornquist MD, Omenn GS, King IB, Goodman GE. Fruits and vegetables are associated with lower lung cancer risk only in the placebo arm of the β-carotene and retinol efficacy trial (CARET). Cancer Epidemiol Biomarkers Prev 2003; 12 (4): 350-358
255. Lam TK, Gallicchio L, Lindsley K, Shiels M, Hammond E, Tao X, et al. Cruciferous vegetable consumption and lung cancer risk: A systematic review. Cancer Epidemiol. Biomarkers Prev 2009; 18 (1): 184-195
256. Goralczyk R. β-Carotene and lung cancer in smokers: review of hypotheses and status of research. Nutr Cancer 2009; 61 (6): 767-774
257. White WS, Stacewicz-Sapuntzakis M, Erdman JW Jr, Bowen PE. Pharmacokinetics of β-carotene and canthaxanthin after ingestion of individual and combined doses by human subjects. J Am Coll Nutr 1994; 13 (6): 665-671
258. Wang XD, Russell RM. Procarcinogenic and anticarcinogenic effects of β-carotene. Nutr Rev 1999; 57 (9 Pt 1): 263-272
259. Brambilla D, Mancuso C, Scuderi MR, Bosco P, Cantarella G, Lempereur L, et al. The role of antioxidant supplement in immune system, neoplastic, and neurodegenerative disorders: a point of view for an assessment of the risk/benefit profile. Nutr J 2008; 7: 29-37.
260. Palozza P, Simone R, Mele MC. Interplay of carotenoids with cigarette smoking: implications in lung cancer. Curr Med Chem 2008; 15 (9): 844-854
261. Wang X-D, Liu C, Bronson RT, Smith DE, Krinsky NI, Russell RM. Retinoid signaling and activator protein-1 expression in ferrets given β-carotene supplements and exposed to tobacco smoke. J Natl Cancer Inst 1999; 91 (1): 60-66
262. Liu C, Wang X-D, Bronson RT, Smith DE, Krinsky NI, Russell RM. Effects of physiological versus pharmacological β-carotene supplementation on cell proliferation and histopathological changes in the lungs of cigarette smoke-exposed ferrets. Carcinogenesis 2000; 21 (12): 2245-2253
263. Witschi H, Espiritu I, Suffia M, Pinkerton KE. Expression of cyclin D1/2 in the lungs of strain A/J mice fed chemopreventive agents. Carcinogenesis 2002; 23 (2): 289-294
264. Yang K, Lamprecht SA, Liu Y, Shinozaki H, Fan K, Leung D, et al. Chemoprevention studies of the flavonoids quercetin and rutin in normal and azoxymethane-treated mouse colon. Carcinogenesis 2000; 21 (9): 1655-1660
265. Choi JA, Kim JY, Lee JY, Kang CM, Kwon HJ, Yoo YD, et al. Induction of cell cycle arrest and apopotosis in human breast cancer cells by quercetin. Int J Oncol 2001; 19 (4): 837-844
266. Morrow DM, Fitzsimmons PEE, Chopra M, McGlynn H. Dietary supplementation with the anti-tumour promoter quercetin: Its effects on matrix matalloproteinase gene regulation. Mutat Res 2001; 480-481: 269-276
267. Salgo MG, Cueto R, Winston GW, Pryor WA. β-Carotene and its oxidation products have different effects on microsome mediated binding of benzo[a]pyrene to DNA. Free Radic Biol Med 1999; 26 (1-2): 162-173
268. Paolini M, Antelli A, Pozzetti L, Spetlova D, Perocco P, Valgimigli L, et al. Induction of cytochrome P450 enzymes and over-generation of oxygen radicals in β-carotene supplemented rats. Carcinogenesis 2001; 22 (9): 1483-1495
269. Obermeier MT, White RE, Yang CS. Effects of bioflavonoids on hepatic P450 activities. Xenobiotica 1995; 25 (6): 575-584
270. Rahden-Staron I, Czeczot H, Szumilo M. Induction of rat liver cytochrome P450 isoenzymes CYP 1A and CYP 2B by different fungicides, nitrofurans, and quercetin. Mutat Res 2001; 498 (1-2): 57-66
271. Valerio LG Jr, Kepa JK, Pickwell GV, Quattrochi LC. Induction of human NAD(P)H: quinone oxidoreductase (NQO1) gene expression by the flavonol quercetin. Toxicol Lett 2001; 119 (1): 49-57.
272. Poulain S, Evenou F, Carré MC, Corbel S, Vignaud JM, Martinet N. Vitamin A/retinoids signalling in the human lung. Lung Cancer 2009; 66 (1): 1-7.
273. Bogos K, Renyi-Vamos F, Kovacs G, Tovari J, Dome B. Role of retinoic receptors in lung carcinogenesis. J Exp Clin Cancer Res 2008; 27 (1): 18-25.
274. Leo MA, Lieber CS. Alcohol, vitamin A, and β-carotene: adverse interactions, including hepatotoxicity and carcinogenicity. Am J Clin Nutr 1999; 69 (6): 1071-1085
275. Ni R, Leo MA, Zhao J, Lieber CS. Toxicity of β-carotene and its exacerbation by acetaldehyde in HepG2 cells. Alcohol Alcohol 2001; 36 (4): 281-285
276. Albanes D, Virtamo J, Taylor PR, Rautalahti M, Pierinen P, Heinonen OP. Effects of supplemental β-carotene, cigarette smoking, and alcohol consumption on serum carotenoids in the α-Tocopherol, β-Carotene Cancer Prevention Study. Am J Clin Nutr 1997; 66 (2): 366-372
277. Bandera EV, Freudenheim JL, Marshall JR, Zielezny M, Priore RL, Brasure J, et al. Diet and alcohol consumption and lung cancer risk in the New York State Cohort (United States). Cancer Causes Control 1997; 8 (6): 828-840
278. Feskanich D, Ziegler RG, Michaud DS, Giovannucci EL, Speizer FE, Willett WC, et al. Prospective study of fruit and vegetable consumption and risk of lung cancer among men and women. J Natl Cancer Inst 2000; 92 (22): 1812-1823
279. Michaud DS, Feskanich D, Rimm EB, Colditz GA, Speizer FE, Willett WC, et al. Intake of specific carotenoids and risk of lung cancer in 2 prospective US cohorts. Am J Clin Nutr 2000; 72 (4): 990-997