Induction of cytochrome P450 enzymes and over-generation of oxygen radicals in beta-carotene supplemented rats

Carcinogenesis

Volumn 22, Issue 9, 2001, Pages 1483-1495

  Paolini, Moreno ^a   Antelli, Alessandra ^a   Pozzetti, Laura ^a   Spetlova, Denisa ^a   Perocco, Paolo ^a   Valgimigli, Luca ^a   Pedulli, Gian Franco ^a   Cantelli Forti, Giorgio ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

4 NITROPHENOL; 4 NITROPHENOL HYDROXYLASE; 7 ETHOXYCOUMARIN DEETHYLASE; AMINOPYRINE N DEMETHYLASE; BETA CAROTENE; BIOCHEMICAL MARKER; BIS(1 HYDROXY 2,2,6,6 TETRAMETHYL 4 PIPERIDINYL)DECANDIOATE; CARCINOGEN; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2C11; CYTOCHROME P450 2E1; CYTOCHROME P450 3A; CYTOCHROME P450 ISOENZYME; DRUG METABOLIZING ENZYME; ETHOXYRESORUFIN DEETHYLASE; HYDROXYLAMINE; METHOXYRESORUFIN O DEMETHYLASE; MICROSOME ENZYME; NITROXIDE; OXIDIZING AGENT; OXYGEN RADICAL; PENTOXYRESORUFIN DEALKYLASE; REACTIVE OXYGEN METABOLITE; TESTOSTERONE HYDROXYLASE; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CATALYSIS; CELL FRACTIONATION; CONTROLLED STUDY; DENSITOMETRY; DIET SUPPLEMENTATION; DOSE RESPONSE; DRUG MEGADOSE; ELECTRON SPIN RESONANCE; ENZYME INDUCTION; ENZYME SUBSTRATE; FEMALE; INTESTINE; KIDNEY; LIVER; LUNG; MALE; MEASUREMENT; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; STEREOCHEMISTRY; STEROID HYDROXYLATION; WESTERN BLOTTING;

EID: 0034807085     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/22.9.1483     Document Type: Article

References (86)

1. Can dietary beta carotene materially reduce human cancer rate?
2. Effects of carotenoids in cellular and animal systems
3. Nutrition intervention trials in Linxian, China: Supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population
4. Carotenoids, vitamin C and E, and mortality in an elderly population
5. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers
6. Retinoid chemo-prevention studies in upper urodigestive tract and lung carcinogenesis
7. A clinical trial of antioxidant vitamins to prevent colorectal adenoma
8. Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease
9. Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease
10. CARET and ATBC refine conclusions about β-carotene
11. Carotenoids and retinoids: A review of research, clinical, and public health applications
12. Beta-carotene and disease: A suggested pro-oxidant mechanism and speculations concerning its role in cigarette smoking
13. Beta-carotene increased lung cancer in cigarette smokers
14. Beta-carotene and human health: A review of current research
15. Antioxidant vs. carotenoids. Inhibitors or promoters of experimental colorectal cancers
16. Supplementation with vitamin E but not beta-carotene in vivo protects low density lipoprotein from lipid peroxidation in vitro: Effect of cigarette smoking
17. Effect of dietary antioxidant combinations in humans: Protection of LDL by vitamin E but not by beta-carotene
18. Antioxidant and prooxidant role of beta-carotene in murine normal and tumor thymocytes: Effects of oxygen partial pressure
19. Fruit, vegetables, and cancer prevention: A review of the epidemiological evidence
20. Antimutagenic and anticarcinogenic effects of carotenoids and dietary polin oil
21. Antimutagenicity profile of some natural substances
22. In vivo antimutagenic activity of beta-carotene in rat spleen lymphocytes
23. Increased expression of cytochrome P450 IIIA2 in male rat liver after dietary vitamin A supplementation
24. 4-induced liver injury by a single dose of retinol
25. Identification of human cytochrome P450 isoforms that contribute to all-trans-retinoic acid 4-hydroxylation
26. Reduction of thyroid hormone may participate in the modulation of cytochromes P450 2C11 and 3A2 by retinol
27. Beta-Apo-8'-carotenal, but not beta-carotene, is a strong inducer of liver cytochrome P4501A1 and 1A2 in rat
28. Effect of dietary supplementation with carotenoids on xenobiotic metabolizing enzymes in the liver, lung, kidney and small intestine of the rat
29. Effects of provitamin A or non-provitamin A carotenoids on liver xenobiotic-metabolizing enzymes in mice
30. Beta-carotene and aryl hydrocarbon hydroxylase in the rat: An effect of beta-carotene independent of vitamin A activity
31. Further mechanisms of non-genotoxic carcinogenesis
32. Co-carcinogenic effect of beta-carotene
33. Hydroxylamines derived from hindered amines
34. Bile acid structure and selective modulation of murine hepatic cytochrome P450-linked enzymes
35. Experiments illustrating drug metabolism in vitro
36. Colorimetric estimation of formaldehyde by means of Hantzsch reaction
37. p-Nitrophenol hydroxylation. A microsomal oxidation which is higly inducible by ethanol
38. Dealkylation of pentoxyresorufin. A rapid and sensitive assay for measuring induction of cytochrome(s) P450 by phenobarbital and other xenobiotics in rat
39. Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: A series of substrates to distinguish between different induced cytochromes P450
40. A simple and sensitive assay of 7-ethoxycoumarin deethylation
41. Genetically engineered V79 Chinese hamster cell. Expression of purified cytochrome P450 2B1 monooxygenase activity
42. Development of basal and induced testosterone hydroxylase activity in the chicken embryo in ovo
43. Assay of hepatic microsomal testosterone hydroxylases by high-performance liquid chromatography
44. Involvement of CYP3A1, 2B1, and 2E1 in C-8 hydroxylation and CYP 1A2 and flavin-containing monooxygenase in N-demethylation of caffeine: Identified by using inducer treated rat liver microsomes that are metabolic patterns
45. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
46. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
47. Redox cycling of resorufin catalyzed by rat liver microsomal NADPH-cytochrome P450 reductase
48. Protein measurement with Folin phenol reagent
49. Paramagnetic resonance in detecting carcinogenic risk from cytochrome P450 overexpression
50. Distribution of dietary palm carotenes and their metabolites in the rabbit
51. Determination of carotenoids in vegetable foods and plasma
52. Retinol, α-tocopherol, lycopene, and α- and β-carotene simultaneously determined in plasma by isocratic liquid chromatography
53. Testosterone hydroxylase as multibiomarker of effect in evaluating vinclozolin cocarcinogenesis
54. The role of individual susceptibility in cancer burden related to environmental exposure
55. Retinoid signaling and activator protein-1 expression in ferrets given beta-carotene supplements and exposed to tobacco smoke
56. Intestinal absorption and tissue distribution of carotenoids
57. Carotenoids: Biology and treatment
58. Acetone-dependent regulation of cytochromes P4502E1 and P4502B1 in rat nasal mucosa
59. Effect of starvation and chlormethiazole on cytochrome P450s of rat nasal mucosa
60. The oxidation of drugs by liver microsomes: On the role of TPNH and oxygen
61. Is formation of reactive oxygen by cytochrome P450 perilous and predictable?
62. Rat liver microsomal NADPH-supported oxidase activity and lipid peroxidation dependent on ethanol-inducible cytochrome P450 (P450IIE1)
63. Production of reactive oxygen species by microsomes enriched in specific human cytochrome P450 enzymes
64. Beta carotene and its oxidation products have different effects on microsome mediated binding of benzo[a]pyrene to DNA
65. Beta-carotene: An unusual type of lipid antioxidant
66. Beta-carotene and protein oxidation: Effects of ascorbic acid and alpha-tocopherol
67. Antioxidant and prooxidant role of beta-carotene in murine normal and tumor thymocytes: Effects of oxygen partial pressure
68. Effects of beta-carotene and alpha-tocopherol on photogenotoxicity induced by 8-methoxypsoralen: The role of oxygen
69. Modulation of oxidative stress by β-carotene in chicken embryo fibroblasts
70. Effects of supplemental beta-carotene, cigarette smoking, and alcohol consumption on serum carotenoids in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study
71. Metabolism and metabolic effects of ethanol, including interaction with drugs, carcinogens and nutrition
72. Hepatotoxicity of vitamin A and ethanol in the rat
73. Interaction of ethanol with beta-carotene: Delayed blood clearance and enhanced hepatotoxicity
74. Serum carotenoids and oxidative damage in human lymphocytes
75. Chemoprevention of lung cancer: The rise and demise of beta-carotene
76. Can antioxidant vitamins materially reduce oxidative damage in humans?
77. Antioxidant vitamins in the prevention of cancer
78. Chemoprevention of lung cancer
79. Chemoprevention of cancer: Lessons to be learned from beta-carotene trials
80. Lung cancer chemoprevention
81. Prevention of lung cancer
82. Early detection and prevention of lung cancer