-
1
-
-
49249091689
-
Is tumor growth sustained by rare cancer stem cells or dominant clones?
-
Adams, J.M., Strasser, A., Is tumor growth sustained by rare cancer stem cells or dominant clones?. Cancer Res. 68 (2008), 4018–4021.
-
(2008)
Cancer Res.
, vol.68
, pp. 4018-4021
-
-
Adams, J.M.1
Strasser, A.2
-
2
-
-
3543035792
-
Mutagenic insertion and chromosome engineering resource (MICER)
-
Adams, D.J., et al. Mutagenic insertion and chromosome engineering resource (MICER). Nat. Genet. 36 (2004), 867–871.
-
(2004)
Nat. Genet.
, vol.36
, pp. 867-871
-
-
Adams, D.J.1
-
3
-
-
0345863840
-
RTCGD: Retroviral tagged cancer gene database
-
Akagi, K., et al. RTCGD: Retroviral tagged cancer gene database. Nucleic Acids Res. 32 (2004), D523–D527.
-
(2004)
Nucleic Acids Res.
, vol.32
, pp. D523-D527
-
-
Akagi, K.1
-
4
-
-
3142512612
-
Molecular characterization of the tumor microenvironment in breast cancer
-
Allinen, M., et al. Molecular characterization of the tumor microenvironment in breast cancer. Cancer Cell 6 (2004), 17–32.
-
(2004)
Cancer Cell
, vol.6
, pp. 17-32
-
-
Allinen, M.1
-
5
-
-
0028233614
-
Progressive squamous epithelial neoplasia in K14-human papillomavirus type 16 transgenic mice
-
Arbeit, J.M., et al. Progressive squamous epithelial neoplasia in K14-human papillomavirus type 16 transgenic mice. J. Virol. 68 (1994), 4358–4368.
-
(1994)
J. Virol.
, vol.68
, pp. 4358-4368
-
-
Arbeit, J.M.1
-
6
-
-
0034632717
-
Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
-
Artandi, S.E., et al. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature 406 (2000), 641–645.
-
(2000)
Nature
, vol.406
, pp. 641-645
-
-
Artandi, S.E.1
-
7
-
-
22144449265
-
Probing p53 biological functions through the use of genetically engineered mouse models
-
Attardi, L.D., Donehower, L.A., Probing p53 biological functions through the use of genetically engineered mouse models. Mutat. Res. 576 (2005), 4–21.
-
(2005)
Mutat. Res.
, vol.576
, pp. 4-21
-
-
Attardi, L.D.1
Donehower, L.A.2
-
8
-
-
4644335311
-
Cancer: An inflammatory link
-
Balkwill, F., Coussens, L.M., Cancer: An inflammatory link. Nature 431 (2004), 405–406.
-
(2004)
Nature
, vol.431
, pp. 405-406
-
-
Balkwill, F.1
Coussens, L.M.2
-
9
-
-
33645824724
-
Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse
-
Bardeesy, N., et al. Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. Proc. Natl. Acad. Sci. USA 103 (2006), 5947–5952.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 5947-5952
-
-
Bardeesy, N.1
-
10
-
-
15844426692
-
Atm-deficient mice: A paradigm of ataxia telangiectasia
-
Barlow, C., et al. Atm-deficient mice: A paradigm of ataxia telangiectasia. Cell 86 (1996), 159–171.
-
(1996)
Cell
, vol.86
, pp. 159-171
-
-
Barlow, C.1
-
11
-
-
0030797223
-
Tetracycline-controlled transcription in eukaryotes: Novel transactivators with graded transactivation potential
-
Baron, U., et al. Tetracycline-controlled transcription in eukaryotes: Novel transactivators with graded transactivation potential. Nucleic Acids Res. 25 (1997), 2723–2729.
-
(1997)
Nucleic Acids Res.
, vol.25
, pp. 2723-2729
-
-
Baron, U.1
-
12
-
-
33645736793
-
Genetically engineered models have advantages over xenografts for preclinical studies
-
discussion 3358–3359
-
Becher, O.J., Holland, E.C., Genetically engineered models have advantages over xenografts for preclinical studies. Cancer Res. 66 (2006), 3355–3358 discussion 3358–3359.
-
(2006)
Cancer Res.
, vol.66
, pp. 3355-3358
-
-
Becher, O.J.1
Holland, E.C.2
-
13
-
-
0023813658
-
Inactivation of the p53 oncogene by internal deletion or retroviral integration in erythroleukemic cell lines induced by Friend leukemia virus
-
Ben David, Y., et al. Inactivation of the p53 oncogene by internal deletion or retroviral integration in erythroleukemic cell lines induced by Friend leukemia virus. Oncogene 3 (1988), 179–185.
-
(1988)
Oncogene
, vol.3
, pp. 179-185
-
-
Ben David, Y.1
-
14
-
-
0025332921
-
Selective inhibition of activated but not basal transcription by the acidic activation domain of VP16: Evidence for transcriptional adaptors
-
Berger, S.L., et al. Selective inhibition of activated but not basal transcription by the acidic activation domain of VP16: Evidence for transcriptional adaptors. Cell 61 (1990), 1199–1208.
-
(1990)
Cell
, vol.61
, pp. 1199-1208
-
-
Berger, S.L.1
-
15
-
-
0037967272
-
Tumorigenesis and the angiogenic switch
-
Bergers, G., Benjamin, L.E., Tumorigenesis and the angiogenic switch. Nat. Rev. Cancer 3 (2003), 401–410.
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 401-410
-
-
Bergers, G.1
Benjamin, L.E.2
-
16
-
-
0000391746
-
Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis
-
Bergers, G., et al. Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nat. Cell Biol. 2 (2000), 737–744.
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 737-744
-
-
Bergers, G.1
-
17
-
-
1942454409
-
Orthotopic models of cancer for preclinical drug evaluation: Advantages and disadvantages
-
Bibby, M.C., Orthotopic models of cancer for preclinical drug evaluation: Advantages and disadvantages. Eur. J. Cancer 40 (2004), 852–857.
-
(2004)
Eur. J. Cancer
, vol.40
, pp. 852-857
-
-
Bibby, M.C.1
-
18
-
-
33748274499
-
Human embryonic stem cells have a unique epigenetic signature
-
Bibikova, M., et al. Human embryonic stem cells have a unique epigenetic signature. Genome Res. 16 (2006), 1075–1083.
-
(2006)
Genome Res.
, vol.16
, pp. 1075-1083
-
-
Bibikova, M.1
-
19
-
-
42249099328
-
Conditional transgenic mouse models: From the basics to genome-wide sets of knockouts and current studies of tissue regeneration
-
Bockamp, E., et al. Conditional transgenic mouse models: From the basics to genome-wide sets of knockouts and current studies of tissue regeneration. Regen. Med. 3 (2008), 217–235.
-
(2008)
Regen. Med.
, vol.3
, pp. 217-235
-
-
Bockamp, E.1
-
20
-
-
0346503889
-
Talking about a revolution: The impact of site-specific recombinases on genetic analyses in mice
-
Branda, C.S., Dymecki, S.M., Talking about a revolution: The impact of site-specific recombinases on genetic analyses in mice. Dev. Cell 6 (2004), 7–28.
-
(2004)
Dev. Cell
, vol.6
, pp. 7-28
-
-
Branda, C.S.1
Dymecki, S.M.2
-
21
-
-
15544364093
-
The genomes of recombinant inbred lines
-
Broman, K.W., The genomes of recombinant inbred lines. Genetics 169 (2005), 1133–1146.
-
(2005)
Genetics
, vol.169
, pp. 1133-1146
-
-
Broman, K.W.1
-
22
-
-
40849106619
-
Quiet as a mouse: Dissecting the molecular and genetic basis of hearing
-
Brown, S.D., et al. Quiet as a mouse: Dissecting the molecular and genetic basis of hearing. Nat. Rev. Genet. 9 (2008), 277–290.
-
(2008)
Nat. Rev. Genet.
, vol.9
, pp. 277-290
-
-
Brown, S.D.1
-
23
-
-
0034252564
-
Inducible chromosomal translocation of AML1 and ETO genes through Cre/loxP-mediated recombination in the mouse
-
Buchholz, F., et al. Inducible chromosomal translocation of AML1 and ETO genes through Cre/loxP-mediated recombination in the mouse. EMBO Rep. 1 (2000), 133–139.
-
(2000)
EMBO Rep.
, vol.1
, pp. 133-139
-
-
Buchholz, F.1
-
24
-
-
19544371373
-
Gene targeting in mice: Functional analysis of the mammalian genome for the twenty-first century
-
Capecchi, M.R., Gene targeting in mice: Functional analysis of the mammalian genome for the twenty-first century. Nat. Rev. Genet. 6 (2005), 507–512.
-
(2005)
Nat. Rev. Genet.
, vol.6
, pp. 507-512
-
-
Capecchi, M.R.1
-
25
-
-
33749363890
-
Mouse modeling in oncologic preclinical and translational research
-
Carver, B.S., Pandolfi, P.P., Mouse modeling in oncologic preclinical and translational research. Clin. Cancer Res. 12 (2006), 5305–5311.
-
(2006)
Clin. Cancer Res.
, vol.12
, pp. 5305-5311
-
-
Carver, B.S.1
Pandolfi, P.P.2
-
26
-
-
0034057170
-
Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis
-
Chai, Y., et al. Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis. Development 127 (2000), 1671–1679.
-
(2000)
Development
, vol.127
, pp. 1671-1679
-
-
Chai, Y.1
-
27
-
-
0034468235
-
Molecular biology of breast cancer metastasis. Clinical implications of experimental studies on metastatic inefficiency
-
Chambers, A.F., et al. Molecular biology of breast cancer metastasis. Clinical implications of experimental studies on metastatic inefficiency. Breast Cancer Res. 2 (2000), 400–407.
-
(2000)
Breast Cancer Res.
, vol.2
, pp. 400-407
-
-
Chambers, A.F.1
-
28
-
-
70349696230
-
Expression of human BRCA1 variants in mouse ES cells allows functional analysis of BRCA1 mutations
-
Chang, S., et al. Expression of human BRCA1 variants in mouse ES cells allows functional analysis of BRCA1 mutations. J. Clin. Invest. 119 (2009), 3160–3171.
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 3160-3171
-
-
Chang, S.1
-
29
-
-
52549103273
-
The Collaborative Cross at Oak Ridge National Laboratory: Developing a powerful resource for systems genetics
-
Chesler, E.J., et al. The Collaborative Cross at Oak Ridge National Laboratory: Developing a powerful resource for systems genetics. Mamm. Genome 19 (2008), 382–389.
-
(2008)
Mamm. Genome
, vol.19
, pp. 382-389
-
-
Chesler, E.J.1
-
30
-
-
0033553516
-
p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis
-
Chin, L., et al. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell 97 (1999), 527–538.
-
(1999)
Cell
, vol.97
, pp. 527-538
-
-
Chin, L.1
-
31
-
-
0028865482
-
Frequent disruption of the Nf1 gene by a novel murine AIDS virus-related provirus in BXH-2 murine myeloid lymphomas
-
Cho, B.C., et al. Frequent disruption of the Nf1 gene by a novel murine AIDS virus-related provirus in BXH-2 murine myeloid lymphomas. J. Virol. 69 (1995), 7138–7146.
-
(1995)
J. Virol.
, vol.69
, pp. 7138-7146
-
-
Cho, B.C.1
-
32
-
-
14644441018
-
The Collaborative Cross, a community resource for the genetic analysis of complex traits
-
Churchill, G.A., et al. The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat. Genet. 36 (2004), 1133–1137.
-
(2004)
Nat. Genet.
, vol.36
, pp. 1133-1137
-
-
Churchill, G.A.1
-
33
-
-
0032763861
-
Mouse models of tumor development in neurofibromatosis type 1
-
Cichowski, K., et al. Mouse models of tumor development in neurofibromatosis type 1. Science 286 (1999), 2172–2176.
-
(1999)
Science
, vol.286
, pp. 2172-2176
-
-
Cichowski, K.1
-
34
-
-
22444444402
-
Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse
-
Collier, L.S., et al. Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse. Nature 436 (2005), 272–276.
-
(2005)
Nature
, vol.436
, pp. 272-276
-
-
Collier, L.S.1
-
35
-
-
70350537021
-
Whole-body sleeping beauty mutagenesis can cause penetrant leukemia/lymphoma and rare high-grade glioma without associated embryonic lethality
-
Collier, L.S., et al. Whole-body sleeping beauty mutagenesis can cause penetrant leukemia/lymphoma and rare high-grade glioma without associated embryonic lethality. Cancer Res. 69 (2009), 8429–8437.
-
(2009)
Cancer Res.
, vol.69
, pp. 8429-8437
-
-
Collier, L.S.1
-
36
-
-
0034252206
-
Inter-chromosomal recombination of Mll and Af9 genes mediated by cre-loxP in mouse development
-
Collins, E.C., et al. Inter-chromosomal recombination of Mll and Af9 genes mediated by cre-loxP in mouse development. EMBO Rep. 1 (2000), 127–132.
-
(2000)
EMBO Rep.
, vol.1
, pp. 127-132
-
-
Collins, E.C.1
-
37
-
-
0030797904
-
Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis
-
Cormier, R.T., et al. Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis. Nat. Genet. 17 (1997), 88–91.
-
(1997)
Nat. Genet.
, vol.17
, pp. 88-91
-
-
Cormier, R.T.1
-
38
-
-
0029844435
-
Genetic predisposition and parameters of malignant progression in K14-HPV16 transgenic mice
-
Coussens, L.M., et al. Genetic predisposition and parameters of malignant progression in K14-HPV16 transgenic mice. Am. J. Pathol. 149 (1996), 1899–1917.
-
(1996)
Am. J. Pathol.
, vol.149
, pp. 1899-1917
-
-
Coussens, L.M.1
-
39
-
-
0033151608
-
Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis
-
Coussens, L.M., et al. Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis. Genes Dev. 13 (1999), 1382–1397.
-
(1999)
Genes Dev.
, vol.13
, pp. 1382-1397
-
-
Coussens, L.M.1
-
40
-
-
0035970092
-
A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors
-
Crabtree, J.S., et al. A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors. Proc. Natl. Acad. Sci. USA 98 (2001), 1118–1123.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 1118-1123
-
-
Crabtree, J.S.1
-
41
-
-
33746506286
-
Germline polymorphisms in SIPA1 are associated with metastasis and other indicators of poor prognosis in breast cancer
-
Crawford, N.P., et al. Germline polymorphisms in SIPA1 are associated with metastasis and other indicators of poor prognosis in breast cancer. Breast Cancer Res., 8, 2006, R16.
-
(2006)
Breast Cancer Res.
, vol.8
, pp. R16
-
-
Crawford, N.P.1
-
42
-
-
57749173152
-
VEGF inhibition: Insights from preclinical and clinical studies
-
Crawford, Y., Ferrara, N., VEGF inhibition: Insights from preclinical and clinical studies. Cell Tissue Res. 335 (2009), 261–269.
-
(2009)
Cell Tissue Res.
, vol.335
, pp. 261-269
-
-
Crawford, Y.1
Ferrara, N.2
-
43
-
-
0035876445
-
The lac operator–repressor system is functional in the mouse
-
Cronin, C.A., et al. The lac operator–repressor system is functional in the mouse. Genes Dev. 15 (2001), 1506–1517.
-
(2001)
Genes Dev.
, vol.15
, pp. 1506-1517
-
-
Cronin, C.A.1
-
44
-
-
10944254152
-
Transcription and processing of human microRNA precursors
-
Cullen, B.R., Transcription and processing of human microRNA precursors. Mol. Cell. 16 (2004), 861–865.
-
(2004)
Mol. Cell.
, vol.16
, pp. 861-865
-
-
Cullen, B.R.1
-
45
-
-
0034470397
-
Angiogenesis in transgenic models of multistep carcinogenesis
-
D'Angelo, M., et al. Angiogenesis in transgenic models of multistep carcinogenesis. J. Neurooncol. 50 (2000), 89–98.
-
(2000)
J. Neurooncol.
, vol.50
, pp. 89-98
-
-
D'Angelo, M.1
-
46
-
-
0042881036
-
Cancer susceptibility in the mouse: Genetics, biology and implications for human cancer
-
Demant, P., Cancer susceptibility in the mouse: Genetics, biology and implications for human cancer. Nat. Rev. Genet. 4 (2003), 721–734.
-
(2003)
Nat. Rev. Genet.
, vol.4
, pp. 721-734
-
-
Demant, P.1
-
47
-
-
0041766597
-
In vivo targeting of tumor endothelial cells by systemic delivery of lentiviral vectors
-
De Palma, M., et al. In vivo targeting of tumor endothelial cells by systemic delivery of lentiviral vectors. Hum. Gene Ther. 14 (2003), 1193–1206.
-
(2003)
Hum. Gene Ther.
, vol.14
, pp. 1193-1206
-
-
De Palma, M.1
-
48
-
-
33746040164
-
The inflammatory tumor microenvironment and its impact on cancer development
-
de Visser, K.E., Coussens, L.M., The inflammatory tumor microenvironment and its impact on cancer development. Contrib. Microbiol. 13 (2006), 118–137.
-
(2006)
Contrib. Microbiol.
, vol.13
, pp. 118-137
-
-
de Visser, K.E.1
Coussens, L.M.2
-
49
-
-
19344365408
-
De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent
-
de Visser, K.E., et al. De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent. Cancer Cell 7 (2005), 411–423.
-
(2005)
Cancer Cell
, vol.7
, pp. 411-423
-
-
de Visser, K.E.1
-
50
-
-
30144443269
-
Paradoxical roles of the immune system during cancer development
-
de Visser, K.E., et al. Paradoxical roles of the immune system during cancer development. Nat. Rev. Cancer 6 (2006), 24–37.
-
(2006)
Nat. Rev. Cancer
, vol.6
, pp. 24-37
-
-
de Visser, K.E.1
-
51
-
-
34347344980
-
Tissue-specific and reversible RNA interference in transgenic mice
-
Dickins, R.A., et al. Tissue-specific and reversible RNA interference in transgenic mice. Nat. Genet. 39 (2007), 914–921.
-
(2007)
Nat. Genet.
, vol.39
, pp. 914-921
-
-
Dickins, R.A.1
-
52
-
-
0027363063
-
Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse
-
Dietrich, W.F., et al. Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse. Cell 75 (1993), 631–639.
-
(1993)
Cell
, vol.75
, pp. 631-639
-
-
Dietrich, W.F.1
-
53
-
-
23744479962
-
Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice
-
Ding, S., et al. Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice. Cell 122 (2005), 473–483.
-
(2005)
Cell
, vol.122
, pp. 473-483
-
-
Ding, S.1
-
54
-
-
0037732512
-
10 years of mouse cancer modifier loci: Human relevance
-
Dragani, T.A., 10 years of mouse cancer modifier loci: Human relevance. Cancer Res. 63 (2003), 3011–3018.
-
(2003)
Cancer Res.
, vol.63
, pp. 3011-3018
-
-
Dragani, T.A.1
-
55
-
-
0035258737
-
A method for the generation of conditional gene repair mutations in mice
-
Dragatsis, I., Zeitlin, S., A method for the generation of conditional gene repair mutations in mice. Nucleic Acids Res., 29, 2001, E10.
-
(2001)
Nucleic Acids Res.
, vol.29
, pp. E10
-
-
Dragatsis, I.1
Zeitlin, S.2
-
56
-
-
68149157175
-
Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase
-
DuPage, M., et al. Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase. Nat. Protoc. 4 (2009), 1064–1072.
-
(2009)
Nat. Protoc.
, vol.4
, pp. 1064-1072
-
-
DuPage, M.1
-
57
-
-
22444431606
-
Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system
-
Dupuy, A.J., et al. Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system. Nature 436 (2005), 221–226.
-
(2005)
Nature
, vol.436
, pp. 221-226
-
-
Dupuy, A.J.1
-
58
-
-
70350227239
-
A modified sleeping beauty transposon system that can be used to model a wide variety of human cancers in mice
-
Dupuy, A.J., et al. A modified sleeping beauty transposon system that can be used to model a wide variety of human cancers in mice. Cancer Res. 69 (2009), 8150–8156.
-
(2009)
Cancer Res.
, vol.69
, pp. 8150-8156
-
-
Dupuy, A.J.1
-
59
-
-
0242584454
-
Chromosomal instability and tumors promoted by DNA hypomethylation
-
Eden, A., et al. Chromosomal instability and tumors promoted by DNA hypomethylation. Science, 300, 2003, 455.
-
(2003)
Science
, vol.300
, pp. 455
-
-
Eden, A.1
-
60
-
-
0037112436
-
Elimination of colon cancer in germ-free transforming growth factor beta 1-deficient mice
-
Engle, S.J., et al. Elimination of colon cancer in germ-free transforming growth factor beta 1-deficient mice. Cancer Res. 62 (2002), 6362–6366.
-
(2002)
Cancer Res.
, vol.62
, pp. 6362-6366
-
-
Engle, S.J.1
-
61
-
-
33749007676
-
Mouse models of BRCA1 and BRCA2 deficiency: Past lessons, current understanding and future prospects
-
Evers, B., Jonkers, J., Mouse models of BRCA1 and BRCA2 deficiency: Past lessons, current understanding and future prospects. Oncogene 25 (2006), 5885–5897.
-
(2006)
Oncogene
, vol.25
, pp. 5885-5897
-
-
Evers, B.1
Jonkers, J.2
-
62
-
-
0025312728
-
A genetic model for colorectal tumorigenesis
-
Fearon, E., Vogelstein, B., A genetic model for colorectal tumorigenesis. Cell 61 (1990), 759–767.
-
(1990)
Cell
, vol.61
, pp. 759-767
-
-
Fearon, E.1
Vogelstein, B.2
-
63
-
-
0017704436
-
Metastasis results from preexisting variant cells within a malignant tumor
-
Fidler, I.J., Kripke, M.L., Metastasis results from preexisting variant cells within a malignant tumor. Science 197 (1977), 893–895.
-
(1977)
Science
, vol.197
, pp. 893-895
-
-
Fidler, I.J.1
Kripke, M.L.2
-
64
-
-
15944376562
-
Strategies for mapping and cloning quantitative trait genes in rodents
-
Flint, J., et al. Strategies for mapping and cloning quantitative trait genes in rodents. Nat. Rev. Genet. 6 (2005), 271–286.
-
(2005)
Nat. Rev. Genet.
, vol.6
, pp. 271-286
-
-
Flint, J.1
-
65
-
-
0015311426
-
Anti-angiogenesis: New concept for therapy of solid tumors
-
Folkman, J., Anti-angiogenesis: New concept for therapy of solid tumors. Ann. Surg. 175 (1972), 409–416.
-
(1972)
Ann. Surg.
, vol.175
, pp. 409-416
-
-
Folkman, J.1
-
66
-
-
0345582392
-
Engineering de novo reciprocal chromosomal translocations associated with Mll to replicate primary events of human cancer
-
Forster, A., et al. Engineering de novo reciprocal chromosomal translocations associated with Mll to replicate primary events of human cancer. Cancer Cell 3 (2003), 449–458.
-
(2003)
Cancer Cell
, vol.3
, pp. 449-458
-
-
Forster, A.1
-
67
-
-
33746463949
-
Chromosomal translocation engineering to recapitulate primary events of human cancer
-
Forster, A., et al. Chromosomal translocation engineering to recapitulate primary events of human cancer. Cold Spring Harb. Symp. Quant. Biol. 70 (2005), 275–282.
-
(2005)
Cold Spring Harb. Symp. Quant. Biol.
, vol.70
, pp. 275-282
-
-
Forster, A.1
-
68
-
-
18744412961
-
The invertor knock-in conditional chromosomal translocation mimic
-
Forster, A., et al. The invertor knock-in conditional chromosomal translocation mimic. Nat. Methods 2 (2005), 27–30.
-
(2005)
Nat. Methods
, vol.2
, pp. 27-30
-
-
Forster, A.1
-
69
-
-
34548217651
-
Maximizing mouse cancer models
-
Frese, K.K., Tuveson, D.A., Maximizing mouse cancer models. Nat. Rev. Cancer 7 (2007), 645–658.
-
(2007)
Nat. Rev. Cancer
, vol.7
, pp. 645-658
-
-
Frese, K.K.1
Tuveson, D.A.2
-
70
-
-
41449105438
-
EUCOMM—The European conditional mouse mutagenesis program
-
Friedel, R.H., et al. EUCOMM—The European conditional mouse mutagenesis program. Brief Funct. Genomic Proteomic 6 (2007), 180–185.
-
(2007)
Brief Funct. Genomic Proteomic
, vol.6
, pp. 180-185
-
-
Friedel, R.H.1
-
71
-
-
0025992469
-
Promoter traps in embryonic stem cells: A genetic screen to identify and mutate developmental genes in mice
-
Friedrich, G., Soriano, P., Promoter traps in embryonic stem cells: A genetic screen to identify and mutate developmental genes in mice. Genes Dev. 5 (1991), 1513–1523.
-
(1991)
Genes Dev.
, vol.5
, pp. 1513-1523
-
-
Friedrich, G.1
Soriano, P.2
-
72
-
-
42749091529
-
Exploiting dendritic cells and natural killer T cells in immunotherapy against malignancies
-
Fujii, S., Exploiting dendritic cells and natural killer T cells in immunotherapy against malignancies. Trends Immunol. 29 (2008), 242–249.
-
(2008)
Trends Immunol.
, vol.29
, pp. 242-249
-
-
Fujii, S.1
-
73
-
-
0242584449
-
Induction of tumors in mice by genomic hypomethylation
-
Gaudet, F., et al. Induction of tumors in mice by genomic hypomethylation. Science 300 (2003), 489–492.
-
(2003)
Science
, vol.300
, pp. 489-492
-
-
Gaudet, F.1
-
74
-
-
33847615623
-
Mice expressing a humanized form of VEGF-A may provide insights into the safety and efficacy of anti-VEGF antibodies
-
Gerber, H.P., et al. Mice expressing a humanized form of VEGF-A may provide insights into the safety and efficacy of anti-VEGF antibodies. Proc. Natl. Acad. Sci. USA 104 (2007), 3478–3483.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 3478-3483
-
-
Gerber, H.P.1
-
75
-
-
0027331383
-
Bloom syndrome: A mendelian prototype of somatic mutational disease
-
German, J., Bloom syndrome: A mendelian prototype of somatic mutational disease. Medicine (Baltimore) 72 (1993), 393–406.
-
(1993)
Medicine (Baltimore)
, vol.72
, pp. 393-406
-
-
German, J.1
-
76
-
-
4944239035
-
An amino-bisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis
-
Giraudo, E., et al. An amino-bisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis. J. Clin. Invest. 114 (2004), 623–633.
-
(2004)
J. Clin. Invest.
, vol.114
, pp. 623-633
-
-
Giraudo, E.1
-
77
-
-
54049097547
-
Unaltered repopulation properties of mouse hematopoietic stem cells transduced with lentiviral vectors
-
Gonzalez-Murillo, A., et al. Unaltered repopulation properties of mouse hematopoietic stem cells transduced with lentiviral vectors. Blood 112 (2008), 3138–3147.
-
(2008)
Blood
, vol.112
, pp. 3138-3147
-
-
Gonzalez-Murillo, A.1
-
78
-
-
33749549907
-
Inhibiting vascular endothelial growth factor receptor-2 signaling reduces tumor burden in the ApcMin/+ mouse model of early intestinal cancer
-
Goodlad, R.A., et al. Inhibiting vascular endothelial growth factor receptor-2 signaling reduces tumor burden in the ApcMin/+ mouse model of early intestinal cancer. Carcinogenesis 27 (2006), 2133–2139.
-
(2006)
Carcinogenesis
, vol.27
, pp. 2133-2139
-
-
Goodlad, R.A.1
-
79
-
-
0037144601
-
Enhanced tumor formation in mice heterozygous for Blm mutation
-
Goss, K.H., et al. Enhanced tumor formation in mice heterozygous for Blm mutation. Science 297 (2002), 2051–2053.
-
(2002)
Science
, vol.297
, pp. 2051-2053
-
-
Goss, K.H.1
-
80
-
-
0026720075
-
Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
-
Gossen, M., Bujard, H., Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. USA 89 (1992), 5547–5551.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 5547-5551
-
-
Gossen, M.1
Bujard, H.2
-
81
-
-
0024374202
-
Efficient rescue of integrated shuttle vectors from transgenic mice: A model for studying mutations in vivo
-
Gossen, J.A., et al. Efficient rescue of integrated shuttle vectors from transgenic mice: A model for studying mutations in vivo. Proc. Natl. Acad. Sci. USA 86 (1989), 7971–7975.
-
(1989)
Proc. Natl. Acad. Sci. USA
, vol.86
, pp. 7971-7975
-
-
Gossen, J.A.1
-
82
-
-
0030482695
-
Mom1 is a semi-dominant modifier of intestinal adenoma size and multiplicity in Min/+ mice
-
Gould, K.A., et al. Mom1 is a semi-dominant modifier of intestinal adenoma size and multiplicity in Min/+ mice. Genetics 144 (1996), 1769–1776.
-
(1996)
Genetics
, vol.144
, pp. 1769-1776
-
-
Gould, K.A.1
-
83
-
-
4043088499
-
IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer
-
Greten, F.R., et al. IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 118 (2004), 285–296.
-
(2004)
Cell
, vol.118
, pp. 285-296
-
-
Greten, F.R.1
-
84
-
-
0029849597
-
Re-entry into the cell cycle is required for bFGF-induced oligodendroglial dedifferentiation and survival
-
Grinspan, J.B., et al. Re-entry into the cell cycle is required for bFGF-induced oligodendroglial dedifferentiation and survival. J. Neurosci. Res. 46 (1996), 456–464.
-
(1996)
J. Neurosci. Res.
, vol.46
, pp. 456-464
-
-
Grinspan, J.B.1
-
85
-
-
0018096661
-
Viral etiology of cancer and leukemia: A look into the past, present and future—G.H.A. Clowes Memorial Lecture
-
Gross, L., Viral etiology of cancer and leukemia: A look into the past, present and future—G.H.A. Clowes Memorial Lecture. Cancer Res. 38 (1978), 485–493.
-
(1978)
Cancer Res.
, vol.38
, pp. 485-493
-
-
Gross, L.1
-
86
-
-
69949129056
-
Cancer stem cells: Mirage or reality?
-
Gupta, P.B., et al. Cancer stem cells: Mirage or reality?. Nat. Med. 15 (2009), 1010–1012.
-
(2009)
Nat. Med.
, vol.15
, pp. 1010-1012
-
-
Gupta, P.B.1
-
87
-
-
33645524364
-
Harnessing preclinical mouse models to inform human clinical cancer trials
-
Gutmann, D.H., et al. Harnessing preclinical mouse models to inform human clinical cancer trials. J. Clin. Invest. 116 (2006), 847–852.
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 847-852
-
-
Gutmann, D.H.1
-
88
-
-
21444450373
-
Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib
-
Haas-Kogan, D.A., et al. Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib. J. Natl. Cancer Inst. 97 (2005), 880–887.
-
(2005)
J. Natl. Cancer Inst.
, vol.97
, pp. 880-887
-
-
Haas-Kogan, D.A.1
-
89
-
-
0033401823
-
Tumor cells utilize multiple pathways to down-modulate apoptosis. Lessons from a mouse model of islet cell carcinogenesis
-
Hager, J.H., Hanahan, D., Tumor cells utilize multiple pathways to down-modulate apoptosis. Lessons from a mouse model of islet cell carcinogenesis. Ann. NY Acad. Sci. 887 (1999), 150–163.
-
(1999)
Ann. NY Acad. Sci.
, vol.887
, pp. 150-163
-
-
Hager, J.H.1
Hanahan, D.2
-
90
-
-
58149190329
-
Glioma formation, cancer stem cells, and akt signaling
-
Hambardzumyan, D., et al. Glioma formation, cancer stem cells, and akt signaling. Stem Cell Rev. 4 (2008), 203–210.
-
(2008)
Stem Cell Rev.
, vol.4
, pp. 203-210
-
-
Hambardzumyan, D.1
-
91
-
-
2642513907
-
DNA repair factors and telomere-chromosome integrity in mammalian cells
-
Hande, M.P., DNA repair factors and telomere-chromosome integrity in mammalian cells. Cytogenet. Genome Res. 104 (2004), 116–122.
-
(2004)
Cytogenet. Genome Res.
, vol.104
, pp. 116-122
-
-
Hande, M.P.1
-
92
-
-
53549114498
-
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells
-
Hansen, G.M., et al. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Genome Res. 18 (2008), 1670–1679.
-
(2008)
Genome Res.
, vol.18
, pp. 1670-1679
-
-
Hansen, G.M.1
-
93
-
-
28944432805
-
Selective evolution of stromal mesenchyme with p53 loss in response to epithelial tumorigenesis
-
Hill, R., et al. Selective evolution of stromal mesenchyme with p53 loss in response to epithelial tumorigenesis. Cell 123 (2005), 1001–1011.
-
(2005)
Cell
, vol.123
, pp. 1001-1011
-
-
Hill, R.1
-
94
-
-
12944313465
-
Oncogenic mechanisms of Evi-1 protein
-
Hirai, H., et al. Oncogenic mechanisms of Evi-1 protein. Cancer Chemother. Pharmacol. 48:Suppl 1 (2001), S35–S40.
-
(2001)
Cancer Chemother. Pharmacol.
, vol.48
, pp. S35-S40
-
-
Hirai, H.1
-
95
-
-
45349108598
-
Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development
-
Hirasawa, R., et al. Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development. Genes Dev. 22 (2008), 1607–1616.
-
(2008)
Genes Dev.
, vol.22
, pp. 1607-1616
-
-
Hirasawa, R.1
-
96
-
-
62449135386
-
Imaging cancer dynamics in vivo at the tumor and cellular level with fluorescent proteins
-
Hoffman, R.M., Imaging cancer dynamics in vivo at the tumor and cellular level with fluorescent proteins. Clin. Exp. Metastasis 26 (2009), 345–355.
-
(2009)
Clin. Exp. Metastasis
, vol.26
, pp. 345-355
-
-
Hoffman, R.M.1
-
97
-
-
70350132605
-
Clonality of mouse and human cardiomyogenesis in vivo
-
Hosoda, T., et al. Clonality of mouse and human cardiomyogenesis in vivo. Proc. Natl. Acad. Sci. USA 106 (2009), 17169–17174.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 17169-17174
-
-
Hosoda, T.1
-
98
-
-
57449115476
-
The future of mouse QTL mapping to diagnose disease in mice in the age of whole-genome association studies
-
Hunter, K.W., Crawford, N.P., The future of mouse QTL mapping to diagnose disease in mice in the age of whole-genome association studies. Annu. Rev. Genet. 42 (2008), 131–141.
-
(2008)
Annu. Rev. Genet.
, vol.42
, pp. 131-141
-
-
Hunter, K.W.1
Crawford, N.P.2
-
99
-
-
0035893391
-
Predisposition to efficient mammary tumor metastatic progression is linked to the breast cancer metastasis suppressor gene Brms1
-
Hunter, K.W., et al. Predisposition to efficient mammary tumor metastatic progression is linked to the breast cancer metastasis suppressor gene Brms1. Cancer Res. 61 (2001), 8866–8872.
-
(2001)
Cancer Res.
, vol.61
, pp. 8866-8872
-
-
Hunter, K.W.1
-
100
-
-
57449096198
-
Genetically engineered mouse models of brain cancer and the promise of preclinical testing
-
Huse, J.T., Holland, E.C., Genetically engineered mouse models of brain cancer and the promise of preclinical testing. Brain Pathol. 19 (2009), 132–143.
-
(2009)
Brain Pathol.
, vol.19
, pp. 132-143
-
-
Huse, J.T.1
Holland, E.C.2
-
101
-
-
58349086939
-
The analysis of metastasis in transgenic mouse models
-
Husemann, Y., Klein, C.A., The analysis of metastasis in transgenic mouse models. Transgenic Res. 18 (2009), 1–5.
-
(2009)
Transgenic Res.
, vol.18
, pp. 1-5
-
-
Husemann, Y.1
Klein, C.A.2
-
102
-
-
37349079197
-
Systemic spread is an early step in breast cancer
-
Husemann, Y., et al. Systemic spread is an early step in breast cancer. Cancer Cell 13 (2008), 58–68.
-
(2008)
Cancer Cell
, vol.13
, pp. 58-68
-
-
Husemann, Y.1
-
103
-
-
52549130734
-
The Collaborative Cross, developing a resource for mammalian systems genetics: A status report of the Wellcome Trust cohort
-
Iraqi, F.A., et al. The Collaborative Cross, developing a resource for mammalian systems genetics: A status report of the Wellcome Trust cohort. Mamm. Genome 19 (2008), 379–381.
-
(2008)
Mamm. Genome
, vol.19
, pp. 379-381
-
-
Iraqi, F.A.1
-
104
-
-
0030662074
-
Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cells
-
Ivics, Z., et al. Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cells. Cell 91 (1997), 501–510.
-
(1997)
Cell
, vol.91
, pp. 501-510
-
-
Ivics, Z.1
-
105
-
-
0035893252
-
Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras
-
Jackson, E.L., et al. Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev. 15 (2001), 3243–3248.
-
(2001)
Genes Dev.
, vol.15
, pp. 3243-3248
-
-
Jackson, E.L.1
-
106
-
-
4744372577
-
Severe global DNA hypomethylation blocks differentiation and induces histone hyperacetylation in embryonic stem cells
-
Jackson, M., et al. Severe global DNA hypomethylation blocks differentiation and induces histone hyperacetylation in embryonic stem cells. Mol. Cell. Biol. 24 (2004), 8862–8871.
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 8862-8871
-
-
Jackson, M.1
-
107
-
-
57349182464
-
Annual report to the nation on the status of cancer, 1975–2005, featuring trends in lung cancer, tobacco use, and tobacco control
-
Jemal, A., et al. Annual report to the nation on the status of cancer, 1975–2005, featuring trends in lung cancer, tobacco use, and tobacco control. J. Natl. Cancer Inst. 100 (2008), 1672–1694.
-
(2008)
J. Natl. Cancer Inst.
, vol.100
, pp. 1672-1694
-
-
Jemal, A.1
-
108
-
-
0034010326
-
Fate of the mammalian cardiac neural crest
-
Jiang, X., et al. Fate of the mammalian cardiac neural crest. Development 127 (2000), 1607–1616.
-
(2000)
Development
, vol.127
, pp. 1607-1616
-
-
Jiang, X.1
-
109
-
-
0035953550
-
Somatic activation of the K-ras oncogene causes early onset lung cancer in mice
-
Johnson, L., et al. Somatic activation of the K-ras oncogene causes early onset lung cancer in mice. Nature 410 (2001), 1111–1116.
-
(2001)
Nature
, vol.410
, pp. 1111-1116
-
-
Johnson, L.1
-
110
-
-
33847065486
-
The epigenomics of cancer
-
Jones, P.A., Baylin, S.B., The epigenomics of cancer. Cell 128 (2007), 683–692.
-
(2007)
Cell
, vol.128
, pp. 683-692
-
-
Jones, P.A.1
Baylin, S.B.2
-
111
-
-
0029892554
-
Retroviral insertional mutagenesis as a strategy to identify cancer genes
-
Jonkers, J., Berns, A., Retroviral insertional mutagenesis as a strategy to identify cancer genes. Biochim. Biophys. Acta 1287 (1996), 29–57.
-
(1996)
Biochim. Biophys. Acta
, vol.1287
, pp. 29-57
-
-
Jonkers, J.1
Berns, A.2
-
112
-
-
0035866802
-
Intestinal microflora are necessary for development of spontaneous adenocarcinoma of the large intestine in T-cell receptor beta chain and p53 double-knockout mice
-
Kado, S., et al. Intestinal microflora are necessary for development of spontaneous adenocarcinoma of the large intestine in T-cell receptor beta chain and p53 double-knockout mice. Cancer Res. 61 (2001), 2395–2398.
-
(2001)
Cancer Res.
, vol.61
, pp. 2395-2398
-
-
Kado, S.1
-
113
-
-
0033135110
-
Tumor spectrum in ARF-deficient mice
-
Kamijo, T., et al. Tumor spectrum in ARF-deficient mice. Cancer Res. 59 (1999), 2217–2222.
-
(1999)
Cancer Res.
, vol.59
, pp. 2217-2222
-
-
Kamijo, T.1
-
114
-
-
49749094793
-
Alterations of DNA methylation and clinicopathological diversity of human cancers
-
Kanai, Y., Alterations of DNA methylation and clinicopathological diversity of human cancers. Pathol. Int. 58 (2008), 544–558.
-
(2008)
Pathol. Int.
, vol.58
, pp. 544-558
-
-
Kanai, Y.1
-
115
-
-
46749140321
-
Molecular-genetic imaging based on reporter gene expression
-
Kang, J.H., Chung, J.K., Molecular-genetic imaging based on reporter gene expression. J. Nucl. Med. 49:Suppl 2 (2008), 164S–179S.
-
(2008)
J. Nucl. Med.
, vol.49
, pp. 164S-179S
-
-
Kang, J.H.1
Chung, J.K.2
-
116
-
-
0033605145
-
p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2
-
Karlseder, J., et al. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science 283 (1999), 1321–1325.
-
(1999)
Science
, vol.283
, pp. 1321-1325
-
-
Karlseder, J.1
-
117
-
-
62149116794
-
A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma
-
Keng, V.W., et al. A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma. Nat. Biotechnol. 27 (2009), 264–274.
-
(2009)
Nat. Biotechnol.
, vol.27
, pp. 264-274
-
-
Keng, V.W.1
-
118
-
-
16244367163
-
Modeling metastasis in vivo
-
Khanna, C., Hunter, K., Modeling metastasis in vivo. Carcinogenesis 26 (2005), 513–523.
-
(2005)
Carcinogenesis
, vol.26
, pp. 513-523
-
-
Khanna, C.1
Hunter, K.2
-
119
-
-
11144357298
-
The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis
-
Khanna, C., et al. The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis. Nat. Med. 10 (2004), 182–186.
-
(2004)
Nat. Med.
, vol.10
, pp. 182-186
-
-
Khanna, C.1
-
120
-
-
33746394560
-
Mouse models of human non-small-cell lung cancer: Raising the bar
-
Kim, C.F., et al. Mouse models of human non-small-cell lung cancer: Raising the bar. Cold Spring Harb. Symp. Quant. Biol. 70 (2005), 241–250.
-
(2005)
Cold Spring Harb. Symp. Quant. Biol.
, vol.70
, pp. 241-250
-
-
Kim, C.F.1
-
121
-
-
33745288277
-
Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene
-
Kim, M., et al. Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene. Cell 125 (2006), 1269–1281.
-
(2006)
Cell
, vol.125
, pp. 1269-1281
-
-
Kim, M.1
-
122
-
-
0025838289
-
Analysis of spontaneous and induced mutations in transgenic mice using a lambda ZAP/lacI shuttle vector
-
Kohler, S.W., et al. Analysis of spontaneous and induced mutations in transgenic mice using a lambda ZAP/lacI shuttle vector. Environ. Mol. Mutagen. 18 (1991), 316–321.
-
(1991)
Environ. Mol. Mutagen.
, vol.18
, pp. 316-321
-
-
Kohler, S.W.1
-
123
-
-
67649450275
-
High-throughput insertional mutagenesis screens in mice to identify oncogenic networks
-
Kool, J., Berns, A., High-throughput insertional mutagenesis screens in mice to identify oncogenic networks. Nat. Rev. Cancer 9 (2009), 389–399.
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 389-399
-
-
Kool, J.1
Berns, A.2
-
124
-
-
34547519439
-
Inhibition of VEGF-A prevents the angiogenic switch and results in increased survival of Apc+/min mice
-
Korsisaari, N., et al. Inhibition of VEGF-A prevents the angiogenic switch and results in increased survival of Apc+/min mice. Proc. Natl. Acad. Sci. USA 104 (2007), 10625–10630.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 10625-10630
-
-
Korsisaari, N.1
-
125
-
-
40749138225
-
Blocking vascular endothelial growth factor-A inhibits the growth of pituitary adenomas and lowers serum prolactin level in a mouse model of multiple endocrine neoplasia type 1
-
Korsisaari, N., et al. Blocking vascular endothelial growth factor-A inhibits the growth of pituitary adenomas and lowers serum prolactin level in a mouse model of multiple endocrine neoplasia type 1. Clin. Cancer Res. 14 (2008), 249–258.
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 249-258
-
-
Korsisaari, N.1
-
126
-
-
33845984919
-
Modeling non-random deletions in cancer
-
Kost-Alimova, M., Imreh, S., Modeling non-random deletions in cancer. Semin. Cancer Biol. 17 (2007), 19–30.
-
(2007)
Semin. Cancer Biol.
, vol.17
, pp. 19-30
-
-
Kost-Alimova, M.1
Imreh, S.2
-
127
-
-
47849098044
-
Inflammation: Gearing the journey to cancer
-
Kundu, J.K., Surh, Y.J., Inflammation: Gearing the journey to cancer. Mutat. Res. 659 (2008), 15–30.
-
(2008)
Mutat. Res.
, vol.659
, pp. 15-30
-
-
Kundu, J.K.1
Surh, Y.J.2
-
128
-
-
0026638820
-
Targeted oncogene activation by site-specific recombination in transgenic mice
-
Lakso, M., et al. Targeted oncogene activation by site-specific recombination in transgenic mice. Proc. Natl. Acad. Sci. USA 89 (1992), 6232–6236.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 6232-6236
-
-
Lakso, M.1
-
129
-
-
85097870728
-
Diversity Outbred and Collaborative Cross mice to offer maximum allelic variation
-
The Jackson Laboratory Bar Harbor, ME
-
Lambert, R., Diversity Outbred and Collaborative Cross mice to offer maximum allelic variation. Jax Notes, Vol. 514., 2009, The Jackson Laboratory, Bar Harbor, ME, 2.
-
(2009)
Jax Notes, Vol. 514.
, pp. 2
-
-
Lambert, R.1
-
130
-
-
13644260907
-
Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome
-
Lang, G.A., et al. Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome. Cell 119 (2004), 861–872.
-
(2004)
Cell
, vol.119
, pp. 861-872
-
-
Lang, G.A.1
-
131
-
-
0029074056
-
Retroviral insertion at the Evi-2 locus in BXH-2 myeloid leukemia cell lines disrupts Nf1 expression without changes in steady state ras-GTP levels
-
Largaespada, D.A., et al. Retroviral insertion at the Evi-2 locus in BXH-2 myeloid leukemia cell lines disrupts Nf1 expression without changes in steady state ras-GTP levels. J. Virol. 69 (1995), 5095–5102.
-
(1995)
J. Virol.
, vol.69
, pp. 5095-5102
-
-
Largaespada, D.A.1
-
132
-
-
33646422463
-
Reversible kinetic analysis of Myc targets in vivo provides novel insights into Myc-mediated tumorigenesis
-
Lawlor, E.R., et al. Reversible kinetic analysis of Myc targets in vivo provides novel insights into Myc-mediated tumorigenesis. Cancer Res. 66 (2006), 4591–4601.
-
(2006)
Cancer Res.
, vol.66
, pp. 4591-4601
-
-
Lawlor, E.R.1
-
133
-
-
0032499210
-
Essential role of mouse telomerase in highly proliferative organs
-
Lee, H.W., et al. Essential role of mouse telomerase in highly proliferative organs. Nature 392 (1998), 569–574.
-
(1998)
Nature
, vol.392
, pp. 569-574
-
-
Lee, H.W.1
-
134
-
-
34247183694
-
Xenograft models for the preclinical evaluation of new therapies in acute leukemia
-
Lee, E.M., et al. Xenograft models for the preclinical evaluation of new therapies in acute leukemia. Leuk. Lymphoma 48 (2007), 659–668.
-
(2007)
Leuk. Lymphoma
, vol.48
, pp. 659-668
-
-
Lee, E.M.1
-
135
-
-
37349067098
-
Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells
-
Lee, J., et al. Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells. Cancer Cell 13 (2008), 69–80.
-
(2008)
Cancer Cell
, vol.13
, pp. 69-80
-
-
Lee, J.1
-
136
-
-
67651102866
-
Humanized mice for modeling human infectious disease: Challenges, progress, and outlook
-
Legrand, N., et al. Humanized mice for modeling human infectious disease: Challenges, progress, and outlook. Cell Host Microbe 6 (2009), 5–9.
-
(2009)
Cell Host Microbe
, vol.6
, pp. 5-9
-
-
Legrand, N.1
-
137
-
-
0029803192
-
De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells
-
Lei, H., et al. De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells. Development 122 (1996), 3195–3205.
-
(1996)
Development
, vol.122
, pp. 3195-3205
-
-
Lei, H.1
-
138
-
-
36148931645
-
Animal models for disease: Knockout, knock-in, and conditional mutant mice
-
LePage, D.F., Conlon, R.A., Animal models for disease: Knockout, knock-in, and conditional mutant mice. Methods Mol. Med. 129 (2006), 41–67.
-
(2006)
Methods Mol. Med.
, vol.129
, pp. 41-67
-
-
LePage, D.F.1
Conlon, R.A.2
-
139
-
-
0037673984
-
Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells
-
Lessard, J., Sauvageau, G., Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature 423 (2003), 255–260.
-
(2003)
Nature
, vol.423
, pp. 255-260
-
-
Lessard, J.1
Sauvageau, G.2
-
140
-
-
0031823908
-
Identification of inbred mouse strains harboring genetic modifiers of mammary tumor age of onset and metastatic progression
-
Lifsted, T., et al. Identification of inbred mouse strains harboring genetic modifiers of mammary tumor age of onset and metastatic progression. Int. J. Cancer 77 (1998), 640–644.
-
(1998)
Int. J. Cancer
, vol.77
, pp. 640-644
-
-
Lifsted, T.1
-
141
-
-
0035911221
-
Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy
-
Lin, E.Y., et al. Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy. J. Exp. Med. 193 (2001), 727–740.
-
(2001)
J. Exp. Med.
, vol.193
, pp. 727-740
-
-
Lin, E.Y.1
-
142
-
-
0033551379
-
Transformation by v-Myb
-
Lipsick, J.S., Wang, D.M., Transformation by v-Myb. Oncogene 18 (1999), 3047–3055.
-
(1999)
Oncogene
, vol.18
, pp. 3047-3055
-
-
Lipsick, J.S.1
Wang, D.M.2
-
143
-
-
34547496282
-
Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer
-
Liu, X., et al. Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer. Proc. Natl. Acad. Sci. USA 104 (2007), 12111–12116.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 12111-12116
-
-
Liu, X.1
-
144
-
-
52149120102
-
Modeling chromosomal translocations using conditional alleles to recapitulate initiating events in human leukemias
-
Lobato, M.N., et al. Modeling chromosomal translocations using conditional alleles to recapitulate initiating events in human leukemias. J. Natl. Cancer Inst. Monogr. 39 (2008), 58–63.
-
(2008)
J. Natl. Cancer Inst. Monogr.
, vol.39
, pp. 58-63
-
-
Lobato, M.N.1
-
145
-
-
34248375693
-
New mouse models of cancer: Single-cell knockouts
-
Lozano, G., Behringer, R.R., New mouse models of cancer: Single-cell knockouts. Proc. Natl. Acad. Sci. USA 104 (2007), 4245–4246.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 4245-4246
-
-
Lozano, G.1
Behringer, R.R.2
-
146
-
-
0033667704
-
Cancer predisposition caused by elevated mitotic recombination in Bloom mice
-
Luo, G., et al. Cancer predisposition caused by elevated mitotic recombination in Bloom mice. Nat. Genet. 26 (2000), 424–429.
-
(2000)
Nat. Genet.
, vol.26
, pp. 424-429
-
-
Luo, G.1
-
147
-
-
13644251904
-
Advances in imaging mouse tumour models in vivo
-
Lyons, S.K., Advances in imaging mouse tumour models in vivo. J. Pathol. 205 (2005), 194–205.
-
(2005)
J. Pathol.
, vol.205
, pp. 194-205
-
-
Lyons, S.K.1
-
148
-
-
0032954092
-
Insights into cancer from transgenic mouse models
-
Macleod, K.F., Jacks, T., Insights into cancer from transgenic mouse models. J. Pathol. 187 (1999), 43–60.
-
(1999)
J. Pathol.
, vol.187
, pp. 43-60
-
-
Macleod, K.F.1
Jacks, T.2
-
149
-
-
0028998255
-
The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia
-
MacPhee, M., et al. The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia. Cell 81 (1995), 957–966.
-
(1995)
Cell
, vol.81
, pp. 957-966
-
-
MacPhee, M.1
-
150
-
-
13644266446
-
New approaches for modelling cancer mechanisms in the mouse
-
Maddison, K., Clarke, A.R., New approaches for modelling cancer mechanisms in the mouse. J. Pathol. 205 (2005), 181–193.
-
(2005)
J. Pathol.
, vol.205
, pp. 181-193
-
-
Maddison, K.1
Clarke, A.R.2
-
151
-
-
0036738398
-
Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets
-
Maedler, K., et al. Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets. J. Clin. Invest. 110 (2002), 851–860.
-
(2002)
J. Clin. Invest.
, vol.110
, pp. 851-860
-
-
Maedler, K.1
-
152
-
-
2542447230
-
Techniques: Reporter mice—A new way to look at drug action
-
Maggi, A., et al. Techniques: Reporter mice—A new way to look at drug action. Trends Pharmacol. Sci. 25 (2004), 337–342.
-
(2004)
Trends Pharmacol. Sci.
, vol.25
, pp. 337-342
-
-
Maggi, A.1
-
153
-
-
69949087520
-
A microarray-based DNA methylation study of glioblastoma multiforme
-
Martinez, R., et al. A microarray-based DNA methylation study of glioblastoma multiforme. Epigenetics 4 (2009), 255–264.
-
(2009)
Epigenetics
, vol.4
, pp. 255-264
-
-
Martinez, R.1
-
154
-
-
58149330085
-
Development of a novel mouse glioma model using lentiviral vectors
-
Marumoto, T., et al. Development of a novel mouse glioma model using lentiviral vectors. Nat. Med. 15 (2009), 110–116.
-
(2009)
Nat. Med.
, vol.15
, pp. 110-116
-
-
Marumoto, T.1
-
155
-
-
34250863886
-
Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers
-
Maser, R.S., et al. Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers. Nature 447 (2007), 966–971.
-
(2007)
Nature
, vol.447
, pp. 966-971
-
-
Maser, R.S.1
-
156
-
-
4644223259
-
Mechanisms of gene silencing by double-stranded RNA
-
Meister, G., Tuschl, T., Mechanisms of gene silencing by double-stranded RNA. Nature 431 (2004), 343–349.
-
(2004)
Nature
, vol.431
, pp. 343-349
-
-
Meister, G.1
Tuschl, T.2
-
157
-
-
27744606737
-
Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors
-
Mellinghoff, I.K., et al. Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors. N. Engl. J. Med. 353 (2005), 2012–2024.
-
(2005)
N. Engl. J. Med.
, vol.353
, pp. 2012-2024
-
-
Mellinghoff, I.K.1
-
158
-
-
0034842640
-
Site- and time-specific gene targeting in the mouse
-
Metzger, D., Chambon, P., Site- and time-specific gene targeting in the mouse. Methods 24 (2001), 71–80.
-
(2001)
Methods
, vol.24
, pp. 71-80
-
-
Metzger, D.1
Chambon, P.2
-
159
-
-
16644382855
-
Gene targeting and transgenic strategies for the analysis of hematopoietic development in the mouse
-
Mikkola, H.K., Orkin, S.H., Gene targeting and transgenic strategies for the analysis of hematopoietic development in the mouse. Methods Mol. Med. 105 (2005), 3–22.
-
(2005)
Methods Mol. Med.
, vol.105
, pp. 3-22
-
-
Mikkola, H.K.1
Orkin, S.H.2
-
160
-
-
27844529586
-
Bioluminescence technology for imaging cell proliferation
-
Momota, H., Holland, E.C., Bioluminescence technology for imaging cell proliferation. Curr. Opin. Biotechnol. 16 (2005), 681–686.
-
(2005)
Curr. Opin. Biotechnol.
, vol.16
, pp. 681-686
-
-
Momota, H.1
Holland, E.C.2
-
161
-
-
65249101260
-
The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy
-
Montini, E., et al. The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy. J. Clin. Invest. 119 (2009), 964–975.
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 964-975
-
-
Montini, E.1
-
162
-
-
43149107660
-
Induction of neural stem cell-like cells (NSCLCs) from mouse astrocytes by Bmi1
-
Moon, J.H., et al. Induction of neural stem cell-like cells (NSCLCs) from mouse astrocytes by Bmi1. Biochem. Biophys. Res. Commun. 371 (2008), 267–272.
-
(2008)
Biochem. Biophys. Res. Commun.
, vol.371
, pp. 267-272
-
-
Moon, J.H.1
-
163
-
-
52549101134
-
Establishment of “The Gene Mine”: A resource for rapid identification of complex trait genes
-
Morahan, G., et al. Establishment of “The Gene Mine”: A resource for rapid identification of complex trait genes. Mamm. Genome 19 (2008), 390–393.
-
(2008)
Mamm. Genome
, vol.19
, pp. 390-393
-
-
Morahan, G.1
-
164
-
-
0023678897
-
Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell lines
-
Morishita, K., et al. Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell lines. Cell 54 (1988), 831–840.
-
(1988)
Cell
, vol.54
, pp. 831-840
-
-
Morishita, K.1
-
165
-
-
0026568524
-
The Min (multiple intestinal neoplasia) mutation: Its effect on gut epithelial cell differentiation and interaction with a modifier system
-
Moser, A.R., et al. The Min (multiple intestinal neoplasia) mutation: Its effect on gut epithelial cell differentiation and interaction with a modifier system. J. Cell Biol. 116 (1992), 1517–1526.
-
(1992)
J. Cell Biol.
, vol.116
, pp. 1517-1526
-
-
Moser, A.R.1
-
166
-
-
0021835959
-
Rearrangements of the cellular p53 gene in erythroleukaemic cells transformed by Friend virus
-
Mowat, M., et al. Rearrangements of the cellular p53 gene in erythroleukaemic cells transformed by Friend virus. Nature 314 (1985), 633–636.
-
(1985)
Nature
, vol.314
, pp. 633-636
-
-
Mowat, M.1
-
167
-
-
34248396031
-
Modeling sporadic loss of heterozygosity in mice by using mosaic analysis with double markers (MADM)
-
Muzumdar, M.D., et al. Modeling sporadic loss of heterozygosity in mice by using mosaic analysis with double markers (MADM). Proc. Natl. Acad. Sci. USA 104 (2007), 4495–4500.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 4495-4500
-
-
Muzumdar, M.D.1
-
168
-
-
0034054962
-
Analysing complex genetic traits with chromosome substitution strains
-
Nadeau, J.H., et al. Analysing complex genetic traits with chromosome substitution strains. Nat. Genet. 24 (2000), 221–225.
-
(2000)
Nat. Genet.
, vol.24
, pp. 221-225
-
-
Nadeau, J.H.1
-
169
-
-
0036426628
-
The mifepristone-inducible gene regulatory system in mouse models of disease and gene therapy
-
Ngan, E.S., et al. The mifepristone-inducible gene regulatory system in mouse models of disease and gene therapy. Semin. Cell Dev. Biol. 13 (2002), 143–149.
-
(2002)
Semin. Cell Dev. Biol.
, vol.13
, pp. 143-149
-
-
Ngan, E.S.1
-
170
-
-
33947308285
-
How is pluripotency determined and maintained?
-
Niwa, H., How is pluripotency determined and maintained?. Development 134 (2007), 635–646.
-
(2007)
Development
, vol.134
, pp. 635-646
-
-
Niwa, H.1
-
171
-
-
0029865151
-
Ecdysone-inducible gene expression in mammalian cells and transgenic mice
-
No, D., et al. Ecdysone-inducible gene expression in mammalian cells and transgenic mice. Proc. Natl. Acad. Sci. USA 93 (1996), 3346–3351.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 3346-3351
-
-
No, D.1
-
172
-
-
0034693862
-
Recent advances in the protocols of transgenic mouse mutation assays
-
Nohmi, T., et al. Recent advances in the protocols of transgenic mouse mutation assays. Mutat. Res. 455 (2000), 191–215.
-
(2000)
Mutat. Res.
, vol.455
, pp. 191-215
-
-
Nohmi, T.1
-
173
-
-
72749111836
-
Target-based therapies in breast cancer: Current status and future perspectives
-
Normanno, N., et al. Target-based therapies in breast cancer: Current status and future perspectives. Endocr. Relat. Cancer 16 (2009), 675–702.
-
(2009)
Endocr. Relat. Cancer
, vol.16
, pp. 675-702
-
-
Normanno, N.1
-
174
-
-
0036417287
-
Inducing cellular dedifferentiation: A potential method for enhancing endogenous regeneration in mammals
-
Odelberg, S.J., Inducing cellular dedifferentiation: A potential method for enhancing endogenous regeneration in mammals. Semin. Cell Dev. Biol. 13 (2002), 335–343.
-
(2002)
Semin. Cell Dev. Biol.
, vol.13
, pp. 335-343
-
-
Odelberg, S.J.1
-
175
-
-
0000839280
-
Telomere dysfunction provokes regional amplification and deletion in cancer genomes
-
O'Hagan, R.C., et al. Telomere dysfunction provokes regional amplification and deletion in cancer genomes. Cancer Cell 2 (2002), 149–155.
-
(2002)
Cancer Cell
, vol.2
, pp. 149-155
-
-
O'Hagan, R.C.1
-
176
-
-
0033615717
-
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
-
Okano, M., et al. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99 (1999), 247–257.
-
(1999)
Cell
, vol.99
, pp. 247-257
-
-
Okano, M.1
-
177
-
-
67149143399
-
Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
-
Olive, K.P., et al. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 324 (2009), 1457–1461.
-
(2009)
Science
, vol.324
, pp. 1457-1461
-
-
Olive, K.P.1
-
178
-
-
0030005902
-
Antiangiogenic therapy of transgenic mice impairs de novo tumor growth
-
Parangi, S., et al. Antiangiogenic therapy of transgenic mice impairs de novo tumor growth. Proc. Natl. Acad. Sci. USA 93 (1996), 2002–2007.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 2002-2007
-
-
Parangi, S.1
-
179
-
-
0038349957
-
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
-
Park, I.K., et al. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature 423 (2003), 302–305.
-
(2003)
Nature
, vol.423
, pp. 302-305
-
-
Park, I.K.1
-
180
-
-
0037267495
-
Multiple cross and inbred strain haplotype mapping of complex-trait candidate genes
-
Park, Y.G., et al. Multiple cross and inbred strain haplotype mapping of complex-trait candidate genes. Genome Res. 13 (2003), 118–121.
-
(2003)
Genome Res.
, vol.13
, pp. 118-121
-
-
Park, Y.G.1
-
181
-
-
25844511053
-
Sipa1 is a candidate for underlying the metastasis efficiency modifier locus Mtes1
-
Park, Y.G., et al. Sipa1 is a candidate for underlying the metastasis efficiency modifier locus Mtes1. Nat. Genet. 37 (2005), 1055–1062.
-
(2005)
Nat. Genet.
, vol.37
, pp. 1055-1062
-
-
Park, Y.G.1
-
182
-
-
33745240353
-
Cross-species oncogenomics in cancer gene identification
-
Peeper, D., Berns, A., Cross-species oncogenomics in cancer gene identification. Cell 125 (2006), 1230–1233.
-
(2006)
Cell
, vol.125
, pp. 1230-1233
-
-
Peeper, D.1
Berns, A.2
-
183
-
-
33747348485
-
Application and potential limitations of animal models utilized in the development of trastuzumab (Herceptin): A case study
-
Pegram, M., Ngo, D., Application and potential limitations of animal models utilized in the development of trastuzumab (Herceptin): A case study. Adv. Drug Deliv. Rev. 58 (2006), 723–734.
-
(2006)
Adv. Drug Deliv. Rev.
, vol.58
, pp. 723-734
-
-
Pegram, M.1
Ngo, D.2
-
184
-
-
0037013147
-
Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression
-
Pelengaris, S., et al. Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression. Cell 109 (2002), 321–334.
-
(2002)
Cell
, vol.109
, pp. 321-334
-
-
Pelengaris, S.1
-
185
-
-
33845732301
-
The mouse as a model for human biology: A resource guide for complex trait analysis
-
Peters, L.L., et al. The mouse as a model for human biology: A resource guide for complex trait analysis. Nat. Rev. Genet. 8 (2007), 58–69.
-
(2007)
Nat. Rev. Genet.
, vol.8
, pp. 58-69
-
-
Peters, L.L.1
-
186
-
-
4644324186
-
NF-kappaB functions as a tumour promoter in inflammation-associated cancer
-
Pikarsky, E., et al. NF-kappaB functions as a tumour promoter in inflammation-associated cancer. Nature 431 (2004), 461–466.
-
(2004)
Nature
, vol.431
, pp. 461-466
-
-
Pikarsky, E.1
-
187
-
-
33747341699
-
Tissue-specific transgenic and knockout mice
-
Porret, A., et al. Tissue-specific transgenic and knockout mice. Methods Mol. Biol. 337 (2006), 185–205.
-
(2006)
Methods Mol. Biol.
, vol.337
, pp. 185-205
-
-
Porret, A.1
-
188
-
-
0038408736
-
The role of transgenic mouse models in carcinogen identification
-
Pritchard, J.B., et al. The role of transgenic mouse models in carcinogen identification. Environ. Health Perspect. 111 (2003), 444–454.
-
(2003)
Environ. Health Perspect.
, vol.111
, pp. 444-454
-
-
Pritchard, J.B.1
-
189
-
-
1542464838
-
Transgenics at breaking-point
-
Prosser, H., Bradley, A., Transgenics at breaking-point. Cancer Cell 3 (2003), 411–413.
-
(2003)
Cancer Cell
, vol.3
, pp. 411-413
-
-
Prosser, H.1
Bradley, A.2
-
190
-
-
4344688268
-
Global expression profiling identifies signatures of tumor virulence in MMTV-PyMT-transgenic mice: Correlation to human disease
-
Qiu, T.H., et al. Global expression profiling identifies signatures of tumor virulence in MMTV-PyMT-transgenic mice: Correlation to human disease. Cancer Res. 64 (2004), 5973–5981.
-
(2004)
Cancer Res.
, vol.64
, pp. 5973-5981
-
-
Qiu, T.H.1
-
191
-
-
42549152045
-
No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas
-
Qiu, W., et al. No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas. Nat. Genet. 40 (2008), 650–655.
-
(2008)
Nat. Genet.
, vol.40
, pp. 650-655
-
-
Qiu, W.1
-
192
-
-
57349143739
-
Efficient tumour formation by single human melanoma cells
-
Quintana, E., et al. Efficient tumour formation by single human melanoma cells. Nature 456 (2008), 593–598.
-
(2008)
Nature
, vol.456
, pp. 593-598
-
-
Quintana, E.1
-
193
-
-
0037226593
-
A molecular signature of metastasis in primary solid tumors
-
Ramaswamy, S., et al. A molecular signature of metastasis in primary solid tumors. Nat. Genet. 33 (2003), 49–54.
-
(2003)
Nat. Genet.
, vol.33
, pp. 49-54
-
-
Ramaswamy, S.1
-
194
-
-
0033812187
-
Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects
-
Reilly, K.M., et al. Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects. Nat. Genet. 26 (2000), 109–113.
-
(2000)
Nat. Genet.
, vol.26
, pp. 109-113
-
-
Reilly, K.M.1
-
195
-
-
31544475397
-
An imprinted locus epistatically influences Nstr1 and Nstr2 to control resistance to nerve sheath tumors in a neurofibromatosis type 1 mouse model
-
Reilly, K.M., et al. An imprinted locus epistatically influences Nstr1 and Nstr2 to control resistance to nerve sheath tumors in a neurofibromatosis type 1 mouse model. Cancer Res. 66 (2006), 62–68.
-
(2006)
Cancer Res.
, vol.66
, pp. 62-68
-
-
Reilly, K.M.1
-
196
-
-
64249106832
-
Mouse xenograft models vs GEM models for human cancer therapeutics
-
Richmond, A., Su, Y., Mouse xenograft models vs GEM models for human cancer therapeutics. Dis. Model Mech. 1 (2008), 78–82.
-
(2008)
Dis. Model Mech.
, vol.1
, pp. 78-82
-
-
Richmond, A.1
Su, Y.2
-
197
-
-
0028828611
-
Absence of secretory phospholipase A2 gene alterations in human colorectal cancer
-
Riggins, G.J., et al. Absence of secretory phospholipase A2 gene alterations in human colorectal cancer. Cancer Res. 55 (1995), 5184–5186.
-
(1995)
Cancer Res.
, vol.55
, pp. 5184-5186
-
-
Riggins, G.J.1
-
198
-
-
25644448153
-
Mammalian RNAi: A practical guide
-
Sandy, P., et al. Mammalian RNAi: A practical guide. Biotechniques. 39 (2005), 215–224.
-
(2005)
Biotechniques.
, vol.39
, pp. 215-224
-
-
Sandy, P.1
-
199
-
-
33645734205
-
Contributions of human tumor xenografts to anticancer drug development
-
discussion 3354
-
Sausville, E.A., Burger, A.M., Contributions of human tumor xenografts to anticancer drug development. Cancer Res. 66 (2006), 3351–3354 discussion 3354.
-
(2006)
Cancer Res.
, vol.66
, pp. 3351-3354
-
-
Sausville, E.A.1
Burger, A.M.2
-
200
-
-
21044436267
-
Genomewide production of multipurpose alleles for the functional analysis of the mouse genome
-
Schnutgen, F., et al. Genomewide production of multipurpose alleles for the functional analysis of the mouse genome. Proc. Natl. Acad. Sci. USA 102 (2005), 7221–7226.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 7221-7226
-
-
Schnutgen, F.1
-
201
-
-
59849119654
-
Recombineering: A homologous recombination-based method of genetic engineering
-
Sharan, S.K., et al. Recombineering: A homologous recombination-based method of genetic engineering. Nat. Protoc. 4 (2009), 206–223.
-
(2009)
Nat. Protoc.
, vol.4
, pp. 206-223
-
-
Sharan, S.K.1
-
202
-
-
33748331308
-
The mighty mouse: Genetically engineered mouse models in cancer drug development
-
Sharpless, N.E., Depinho, R.A., The mighty mouse: Genetically engineered mouse models in cancer drug development. Nat. Rev. Drug Discov. 5 (2006), 741–754.
-
(2006)
Nat. Rev. Drug Discov.
, vol.5
, pp. 741-754
-
-
Sharpless, N.E.1
Depinho, R.A.2
-
203
-
-
34547630698
-
Tumor angiogenesis: Cause or consequence of cancer?
-
Shchors, K., Evan, G., Tumor angiogenesis: Cause or consequence of cancer?. Cancer Res. 67 (2007), 7059–7061.
-
(2007)
Cancer Res.
, vol.67
, pp. 7059-7061
-
-
Shchors, K.1
Evan, G.2
-
204
-
-
33748680731
-
The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1beta
-
Shchors, K., et al. The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1beta. Genes Dev. 20 (2006), 2527–2538.
-
(2006)
Genes Dev.
, vol.20
, pp. 2527-2538
-
-
Shchors, K.1
-
205
-
-
0026703169
-
Cloning and stable maintenance of 300-kilobase-pair fragments of human DNA in Escherichia coli using an F-factor-based vector
-
Shizuya, H., et al. Cloning and stable maintenance of 300-kilobase-pair fragments of human DNA in Escherichia coli using an F-factor-based vector. Proc. Natl. Acad. Sci. USA 89 (1992), 8794–8797.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 8794-8797
-
-
Shizuya, H.1
-
206
-
-
0037049767
-
Transforming pathways activated by the v-Abl tyrosine kinase
-
Shore, S.K., et al. Transforming pathways activated by the v-Abl tyrosine kinase. Oncogene 21 (2002), 8568–8576.
-
(2002)
Oncogene
, vol.21
, pp. 8568-8576
-
-
Shore, S.K.1
-
207
-
-
27644436787
-
Second-generation shRNA libraries covering the mouse and human genomes
-
Silva, J.M., et al. Second-generation shRNA libraries covering the mouse and human genomes. Nat. Genet. 37 (2005), 1281–1288.
-
(2005)
Nat. Genet.
, vol.37
, pp. 1281-1288
-
-
Silva, J.M.1
-
208
-
-
60649100077
-
Applications of lentiviral vectors for shRNA delivery and transgenesis
-
Singer, O., Verma, I.M., Applications of lentiviral vectors for shRNA delivery and transgenesis. Curr. Gene Ther. 8 (2008), 483–488.
-
(2008)
Curr. Gene Ther.
, vol.8
, pp. 483-488
-
-
Singer, O.1
Verma, I.M.2
-
209
-
-
2642588005
-
A public gene trap resource for mouse functional genomics
-
Skarnes, W.C., et al. A public gene trap resource for mouse functional genomics. Nat. Genet. 36 (2004), 543–544.
-
(2004)
Nat. Genet.
, vol.36
, pp. 543-544
-
-
Skarnes, W.C.1
-
210
-
-
0032923739
-
Generalized lacZ expression with the ROSA26 Cre reporter strain
-
Soriano, P., Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat. Genet. 21 (1999), 70–71.
-
(1999)
Nat. Genet.
, vol.21
, pp. 70-71
-
-
Soriano, P.1
-
211
-
-
47249123315
-
Imatinib mesylate for the treatment of chronic myeloid leukemia
-
Soverini, S., et al. Imatinib mesylate for the treatment of chronic myeloid leukemia. Expert Rev. Anticancer Ther. 8 (2008), 853–864.
-
(2008)
Expert Rev. Anticancer Ther.
, vol.8
, pp. 853-864
-
-
Soverini, S.1
-
212
-
-
63049105067
-
A transposon-based genetic screen in mice identifies genes altered in colorectal cancer
-
Starr, T.K., et al. A transposon-based genetic screen in mice identifies genes altered in colorectal cancer. Science 323 (2009), 1747–1750.
-
(2009)
Science
, vol.323
, pp. 1747-1750
-
-
Starr, T.K.1
-
213
-
-
24944560377
-
A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells
-
Stegmeier, F., et al. A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells. Proc. Natl. Acad. Sci. USA 102 (2005), 13212–13217.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 13212-13217
-
-
Stegmeier, F.1
-
214
-
-
0038643444
-
Astrocytes as stem cells: Nomenclature, phenotype, and translation
-
Steindler, D.A., Laywell, E.D., Astrocytes as stem cells: Nomenclature, phenotype, and translation. Glia 43 (2003), 62–69.
-
(2003)
Glia
, vol.43
, pp. 62-69
-
-
Steindler, D.A.1
Laywell, E.D.2
-
215
-
-
52949113428
-
A system for Cre-regulated RNA interference in vivo
-
Stern, P., et al. A system for Cre-regulated RNA interference in vivo. Proc. Natl. Acad. Sci. USA 105 (2008), 13895–13900.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 13895-13900
-
-
Stern, P.1
-
216
-
-
33746569501
-
Tumor suppressor gene identification using retroviral insertional mutagenesis in Blm-deficient mice
-
Suzuki, T., et al. Tumor suppressor gene identification using retroviral insertional mutagenesis in Blm-deficient mice. EMBO J. 25 (2006), 3422–3431.
-
(2006)
EMBO J.
, vol.25
, pp. 3422-3431
-
-
Suzuki, T.1
-
217
-
-
2342536999
-
BAC rescue: A tool for functional analysis of the mouse genome
-
Swing, D.A., Sharan, S.K., BAC rescue: A tool for functional analysis of the mouse genome. Methods Mol. Biol. 256 (2004), 183–198.
-
(2004)
Methods Mol. Biol.
, vol.256
, pp. 183-198
-
-
Swing, D.A.1
Sharan, S.K.2
-
218
-
-
33747195353
-
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
-
Takahashi, K., Yamanaka, S., Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126 (2006), 663–676.
-
(2006)
Cell
, vol.126
, pp. 663-676
-
-
Takahashi, K.1
Yamanaka, S.2
-
219
-
-
33751210076
-
The cancer stem cell hypothesis: A work in progress
-
Tan, B.T., et al. The cancer stem cell hypothesis: A work in progress. Lab. Invest. 86 (2006), 1203–1207.
-
(2006)
Lab. Invest.
, vol.86
, pp. 1203-1207
-
-
Tan, B.T.1
-
220
-
-
58149356248
-
Pharmacogenetics in breast cancer therapy
-
Tan, S.H., et al. Pharmacogenetics in breast cancer therapy. Clin. Cancer Res. 14 (2008), 8027–8041.
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 8027-8041
-
-
Tan, S.H.1
-
221
-
-
62749107149
-
In vivo/ex vivo and in situ assays used in cancer research: A brief review
-
Teicher, B.A., In vivo/ex vivo and in situ assays used in cancer research: A brief review. Toxicol. Pathol. 37 (2009), 114–122.
-
(2009)
Toxicol. Pathol.
, vol.37
, pp. 114-122
-
-
Teicher, B.A.1
-
222
-
-
36048995442
-
NKT cells in immunoregulation of tumor immunity: A new immunoregulatory axis
-
Terabe, M., Berzofsky, J.A., NKT cells in immunoregulation of tumor immunity: A new immunoregulatory axis. Trends Immunol. 28 (2007), 491–496.
-
(2007)
Trends Immunol.
, vol.28
, pp. 491-496
-
-
Terabe, M.1
Berzofsky, J.A.2
-
223
-
-
56849090964
-
The role of NKT cells in tumor immunity
-
Terabe, M., Berzofsky, J.A., The role of NKT cells in tumor immunity. Adv. Cancer Res. 101 (2008), 277–348.
-
(2008)
Adv. Cancer Res.
, vol.101
, pp. 277-348
-
-
Terabe, M.1
Berzofsky, J.A.2
-
224
-
-
0032915956
-
Early induction of angiogenetic signals in gliomas of GFAP-v-src transgenic mice
-
Theurillat, J.P., et al. Early induction of angiogenetic signals in gliomas of GFAP-v-src transgenic mice. Am. J. Pathol. 154 (1999), 581–590.
-
(1999)
Am. J. Pathol.
, vol.154
, pp. 581-590
-
-
Theurillat, J.P.1
-
225
-
-
2442584612
-
CRE recombinase-inducible RNA interference mediated by lentiviral vectors
-
Tiscornia, G., et al. CRE recombinase-inducible RNA interference mediated by lentiviral vectors. Proc. Natl. Acad. Sci. USA 101 (2004), 7347–7351.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 7347-7351
-
-
Tiscornia, G.1
-
226
-
-
33645739790
-
Tumor stroma and regulation of cancer development
-
Tlsty, T.D., Coussens, L.M., Tumor stroma and regulation of cancer development. Annu. Rev. Pathol. 1 (2006), 119–150.
-
(2006)
Annu. Rev. Pathol.
, vol.1
, pp. 119-150
-
-
Tlsty, T.D.1
Coussens, L.M.2
-
227
-
-
9144257882
-
The Centre for Modeling Human Disease Gene Trap resource
-
To, C., et al. The Centre for Modeling Human Disease Gene Trap resource. Nucleic Acids Res. 32 (2004), D557–D559.
-
(2004)
Nucleic Acids Res.
, vol.32
, pp. D557-D559
-
-
To, C.1
-
228
-
-
0029827781
-
Variants at the secretory phospholipase A2 (PLA2G2A) locus: Analysis of associations with familial adenomatous polyposis and sporadic colorectal tumours
-
Tomlinson, I.P., et al. Variants at the secretory phospholipase A2 (PLA2G2A) locus: Analysis of associations with familial adenomatous polyposis and sporadic colorectal tumours. Ann. Hum. Genet. 60 (1996), 369–376.
-
(1996)
Ann. Hum. Genet.
, vol.60
, pp. 369-376
-
-
Tomlinson, I.P.1
-
229
-
-
38649132916
-
The use of xenograft models for the selection of cancer treatments with the EGFR as an example
-
Troiani, T., et al. The use of xenograft models for the selection of cancer treatments with the EGFR as an example. Crit. Rev. Oncol. Hematol. 65 (2008), 200–211.
-
(2008)
Crit. Rev. Oncol. Hematol.
, vol.65
, pp. 200-211
-
-
Troiani, T.1
-
230
-
-
27944496521
-
Retroviral insertional mutagenesis: Past, present and future
-
Uren, A.G., et al. Retroviral insertional mutagenesis: Past, present and future. Oncogene 24 (2005), 7656–7672.
-
(2005)
Oncogene
, vol.24
, pp. 7656-7672
-
-
Uren, A.G.1
-
231
-
-
43149084575
-
Large-scale mutagenesis in p19(ARF)- and p53-deficient mice identifies cancer genes and their collaborative networks
-
Uren, A.G., et al. Large-scale mutagenesis in p19(ARF)- and p53-deficient mice identifies cancer genes and their collaborative networks. Cell 133 (2008), 727–741.
-
(2008)
Cell
, vol.133
, pp. 727-741
-
-
Uren, A.G.1
-
232
-
-
33645217146
-
Simulating the collaborative cross: Power of quantitative trait loci detection and mapping resolution in large sets of recombinant inbred strains of mice
-
Valdar, W., et al. Simulating the collaborative cross: Power of quantitative trait loci detection and mapping resolution in large sets of recombinant inbred strains of mice. Genetics 172 (2006), 1783–1797.
-
(2006)
Genetics
, vol.172
, pp. 1783-1797
-
-
Valdar, W.1
-
233
-
-
65549088559
-
Chromosome engineering in ES cells
-
van der Weyden, L., et al. Chromosome engineering in ES cells. Methods Mol. Biol. 530 (2009), 49–77.
-
(2009)
Methods Mol. Biol.
, vol.530
, pp. 49-77
-
-
van der Weyden, L.1
-
234
-
-
0037169361
-
Cancer modeling in the modern era: Progress and challenges
-
Van Dyke, T., Jacks, T., Cancer modeling in the modern era: Progress and challenges. Cell 108 (2002), 135–144.
-
(2002)
Cell
, vol.108
, pp. 135-144
-
-
Van Dyke, T.1
Jacks, T.2
-
235
-
-
0025609571
-
Tumorigenesis by slow-transforming retroviruses—An update
-
van Lohuizen, M., Berns, A., Tumorigenesis by slow-transforming retroviruses—An update. Biochim. Biophys. Acta 1032 (1990), 213–235.
-
(1990)
Biochim. Biophys. Acta
, vol.1032
, pp. 213-235
-
-
van Lohuizen, M.1
Berns, A.2
-
236
-
-
0024432837
-
N-myc is frequently activated by proviral insertion in MuLV-induced T cell lymphomas
-
van Lohuizen, M., et al. N-myc is frequently activated by proviral insertion in MuLV-induced T cell lymphomas. EMBO J. 8 (1989), 133–136.
-
(1989)
EMBO J.
, vol.8
, pp. 133-136
-
-
van Lohuizen, M.1
-
237
-
-
0025863346
-
Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging
-
van Lohuizen, M., et al. Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging. Cell 65 (1991), 737–752.
-
(1991)
Cell
, vol.65
, pp. 737-752
-
-
van Lohuizen, M.1
-
238
-
-
18244409687
-
Gene expression profiling predicts clinical outcome of breast cancer
-
van 't Veer, L.J., et al. Gene expression profiling predicts clinical outcome of breast cancer. Nature 415 (2002), 530–536.
-
(2002)
Nature
, vol.415
, pp. 530-536
-
-
van 't Veer, L.J.1
-
239
-
-
3142708570
-
Cre-lox-regulated conditional RNA interference from transgenes
-
Ventura, A., et al. Cre-lox-regulated conditional RNA interference from transgenes. Proc. Natl. Acad. Sci. USA 101 (2004), 10380–10385.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 10380-10385
-
-
Ventura, A.1
-
240
-
-
64949119219
-
Chr 19(A/J) modifies tumor resistance in a sex- and parent-of-origin-specific manner
-
Walrath, J.C., et al. Chr 19(A/J) modifies tumor resistance in a sex- and parent-of-origin-specific manner. Mamm. Genome 20 (2009), 214–223.
-
(2009)
Mamm. Genome
, vol.20
, pp. 214-223
-
-
Walrath, J.C.1
-
241
-
-
11844280278
-
Genetics of variation in HDL cholesterol in humans and mice
-
Wang, X., Paigen, B., Genetics of variation in HDL cholesterol in humans and mice. Circ. Res. 96 (2005), 27–42.
-
(2005)
Circ. Res.
, vol.96
, pp. 27-42
-
-
Wang, X.1
Paigen, B.2
-
242
-
-
0033587687
-
Development of gene-switch transgenic mice that inducibly express transforming growth factor beta1 in the epidermis
-
Wang, X.J., et al. Development of gene-switch transgenic mice that inducibly express transforming growth factor beta1 in the epidermis. Proc. Natl. Acad. Sci. USA 96 (1999), 8483–8488.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 8483-8488
-
-
Wang, X.J.1
-
243
-
-
20544467972
-
Identifying novel genes for atherosclerosis through mouse-human comparative genetics
-
Wang, X., et al. Identifying novel genes for atherosclerosis through mouse-human comparative genetics. Am. J. Hum. Genet. 77 (2005), 1–15.
-
(2005)
Am. J. Hum. Genet.
, vol.77
, pp. 1-15
-
-
Wang, X.1
-
244
-
-
34248395599
-
Induced mitotic recombination of p53 in vivo
-
Wang, W., et al. Induced mitotic recombination of p53 in vivo. Proc. Natl. Acad. Sci. USA 104 (2007), 4501–4505.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 4501-4505
-
-
Wang, W.1
-
245
-
-
0036303398
-
Mouse models for human DNA mismatch-repair gene defects
-
Wei, K., et al. Mouse models for human DNA mismatch-repair gene defects. Trends Mol. Med. 8 (2002), 346–353.
-
(2002)
Trends Mol. Med.
, vol.8
, pp. 346-353
-
-
Wei, K.1
-
246
-
-
36549064137
-
Is metastasis predetermined?
-
author reply 265–266
-
Weinberg, R.A., Is metastasis predetermined?. Mol. Oncol. 1 (2007), 263–264 author reply 265–266.
-
(2007)
Mol. Oncol.
, vol.1
, pp. 263-264
-
-
Weinberg, R.A.1
-
247
-
-
42649097906
-
Coevolution in the tumor microenvironment
-
Weinberg, R.A., Coevolution in the tumor microenvironment. Nat. Genet. 40 (2008), 494–495.
-
(2008)
Nat. Genet.
, vol.40
, pp. 494-495
-
-
Weinberg, R.A.1
-
248
-
-
33746419566
-
Dissecting cancer pathways and vulnerabilities with RNAi
-
Westbrook, T.F., et al. Dissecting cancer pathways and vulnerabilities with RNAi. Cold Spring Harb. Symp. Quant. Biol. 70 (2005), 435–444.
-
(2005)
Cold Spring Harb. Symp. Quant. Biol.
, vol.70
, pp. 435-444
-
-
Westbrook, T.F.1
-
249
-
-
0030879563
-
atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity
-
Westphal, C.H., et al. atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity. Nat. Genet. 16 (1997), 397–401.
-
(1997)
Nat. Genet.
, vol.16
, pp. 397-401
-
-
Westphal, C.H.1
-
250
-
-
33845981514
-
PiggyBac transposon-mediated gene transfer in human cells
-
Wilson, M.H., et al. PiggyBac transposon-mediated gene transfer in human cells. Mol. Ther. 15 (2007), 139–145.
-
(2007)
Mol. Ther.
, vol.15
, pp. 139-145
-
-
Wilson, M.H.1
-
251
-
-
65449158038
-
A multifunctional reporter mouse line for Cre- and FLP-dependent lineage analysis
-
Yamamoto, M., et al. A multifunctional reporter mouse line for Cre- and FLP-dependent lineage analysis. Genesis 47 (2009), 107–114.
-
(2009)
Genesis
, vol.47
, pp. 107-114
-
-
Yamamoto, M.1
-
252
-
-
32544456277
-
Metastasis predictive signature profiles pre-exist in normal tissues
-
Yang, H., et al. Metastasis predictive signature profiles pre-exist in normal tissues. Clin. Exp. Metastasis 22 (2005), 593–603.
-
(2005)
Clin. Exp. Metastasis
, vol.22
, pp. 593-603
-
-
Yang, H.1
-
253
-
-
54549095884
-
Nf1-dependent tumors require a microenvironment containing Nf1+/– and c-kit-dependent bone marrow
-
Yang, F.C., et al. Nf1-dependent tumors require a microenvironment containing Nf1+/– and c-kit-dependent bone marrow. Cell 135 (2008), 437–448.
-
(2008)
Cell
, vol.135
, pp. 437-448
-
-
Yang, F.C.1
-
254
-
-
40649128599
-
Interaction between bevacizumab and murine VEGF-A: A reassessment
-
Yu, L., et al. Interaction between bevacizumab and murine VEGF-A: A reassessment. Invest. Ophthalmol. Vis. Sci. 49 (2008), 522–527.
-
(2008)
Invest. Ophthalmol. Vis. Sci.
, vol.49
, pp. 522-527
-
-
Yu, L.1
-
255
-
-
49449100095
-
Epigenetic plasticity of chromatin in embryonic and hematopoietic stem/progenitor cells: Therapeutic potential of cell reprogramming
-
Zardo, G., et al. Epigenetic plasticity of chromatin in embryonic and hematopoietic stem/progenitor cells: Therapeutic potential of cell reprogramming. Leukemia 22 (2008), 1503–1518.
-
(2008)
Leukemia
, vol.22
, pp. 1503-1518
-
-
Zardo, G.1
-
256
-
-
33745253109
-
Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach
-
Zender, L., et al. Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell 125 (2006), 1253–1267.
-
(2006)
Cell
, vol.125
, pp. 1253-1267
-
-
Zender, L.1
-
257
-
-
0036294527
-
Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells
-
Zeng, Y., et al. Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells. Mol. Cell 9 (2002), 1327–1333.
-
(2002)
Mol. Cell
, vol.9
, pp. 1327-1333
-
-
Zeng, Y.1
-
258
-
-
0036386059
-
Retinoblastoma tumor suppressor and genome stability
-
Zheng, L., Lee, W.H., Retinoblastoma tumor suppressor and genome stability. Adv. Cancer Res. 85 (2002), 13–50.
-
(2002)
Adv. Cancer Res.
, vol.85
, pp. 13-50
-
-
Zheng, L.1
Lee, W.H.2
-
259
-
-
38549108547
-
Induction of abnormal proliferation by nonmyelinating Schwann cells triggers neurofibroma formation
-
Zheng, H., et al. Induction of abnormal proliferation by nonmyelinating Schwann cells triggers neurofibroma formation. Cancer Cell 13 (2008), 117–128.
-
(2008)
Cancer Cell
, vol.13
, pp. 117-128
-
-
Zheng, H.1
-
260
-
-
0037012848
-
Neurofibromas in NF1: Schwann cell origin and role of tumor environment
-
Zhu, Y., et al. Neurofibromas in NF1: Schwann cell origin and role of tumor environment. Science 296 (2002), 920–922.
-
(2002)
Science
, vol.296
, pp. 920-922
-
-
Zhu, Y.1
-
261
-
-
23644443053
-
Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma
-
Zhu, Y., et al. Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma. Cancer Cell 8 (2005), 119–130.
-
(2005)
Cancer Cell
, vol.8
, pp. 119-130
-
-
Zhu, Y.1
|