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Volumn 9, Issue 6, 2009, Pages 389-399

High-throughput insertional mutagenesis screens in mice to identify oncogenic networks

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[No Author keywords available]

Indexed keywords

DNA;

EID: 67649450275     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc2647     Document Type: Review
Times cited : (104)

References (78)
  • 1
    • 27944496521 scopus 로고    scopus 로고
    • Retroviral insertional mutagenesis: Past, present and future
    • Uren,A. G., Kool, J., Berns, A. &van Lohuizen, M. Retroviral insertional mutagenesis: past, present and future. Oncogene 24, 7656-7672 (2005).
    • (2005) Oncogene , vol.24 , pp. 7656-7672
    • Uren, A.G.1    Kool, J.2    Berns, A.3    van Lohuizen, M.4
  • 2
    • 0029892554 scopus 로고    scopus 로고
    • Retroviral insertional mutagenesis as a strategy to identify cancer genes
    • Jonkers, J. & Berns, A. Retroviral insertional mutagenesis as a strategy to identify cancer genes. Biochim. Biophys.Acta 1287, 29-57 (1996).
    • (1996) Biochim. Biophys.Acta , vol.1287 , pp. 29-57
    • Jonkers, J.1    Berns, A.2
  • 3
    • 43149084575 scopus 로고    scopus 로고
    • ARF-and p53-deficient mice identifies cancer genes and their collaborative networks
    • ARF-and p53-deficient mice identifies cancer genes and their collaborative networks. Cell 133, 727-741 (2008).
    • (2008) Cell , vol.133 , pp. 727-741
    • Uren, A.G.1
  • 4
    • 0031024689 scopus 로고    scopus 로고
    • Activation of a novel proto-oncogene, Frat 1, contributes to progression of mouse T-cell lymphomas
    • Jonkers, J., Korswagen, H. C., Acton, D., Breuer, M. & Berns, A. Activation of a novel proto-oncogene, Frat 1, contributes to progression of mouse T-cell lymphomas. EMBO J. 16, 441-450 (1997).
    • (1997) EMBO J , vol.16 , pp. 441-450
    • Jonkers, J.1    Korswagen, H.C.2    Acton, D.3    Breuer, M.4    Berns, A.5
  • 5
    • 0030067703 scopus 로고    scopus 로고
    • Murine leukemia virus envelope protein in transgenicmouse serum blocks infection in vitro
    • Nihrane, A., Fujita, K., Willey, R., Lyu, M. S. & Silver, J. Murine leukemia virus envelope protein in transgenicmouse serum blocks infection in vitro. J. Virol. 70, 1882-1889 (1996).
    • (1996) J. Virol , vol.70 , pp. 1882-1889
    • Nihrane, A.1    Fujita, K.2    Willey, R.3    Lyu, M.S.4    Silver, J.5
  • 6
    • 0024459452 scopus 로고
    • Fv-4 resistance gene: A truncated endogenous murine leukemia virus with ecotropic interference properties
    • Ikeda, H. & Sugimura, H. Fv-4 resistance gene: a truncated endogenous murine leukemia virus with ecotropic interference properties. J. Virol. 63, 5405-5412 (1989).
    • (1989) J. Virol , vol.63 , pp. 5405-5412
    • Ikeda, H.1    Sugimura, H.2
  • 7
    • 0026627849 scopus 로고
    • Basis for receptor specificity of nonecotropic murine leukemia virus surface glycoprotein gp70SU
    • Ott, D. & Rein, A. Basis for receptor specificity of nonecotropic murine leukemia virus surface glycoprotein gp70SU. J. Virol. 66, 4632-4638 (1992).
    • (1992) J. Virol , vol.66 , pp. 4632-4638
    • Ott, D.1    Rein, A.2
  • 8
    • 0024121507 scopus 로고
    • An indicator gene to demonstrate intracellular transposition of defective retroviruses
    • Heidmann,T., Heidmann,O. & Nicolas, J. F. An indicator gene to demonstrate intracellular transposition of defective retroviruses. Proc. Natl Acad. Sci. USA 85, 2219-2223 (1988).
    • (1988) Proc. Natl Acad. Sci. USA , vol.85 , pp. 2219-2223
    • Heidmann, T.1    Heidmann, O.2    Nicolas, J.F.3
  • 9
    • 0025977210 scopus 로고
    • Defective retroviruses can disperse in the human genome by intracellular transposition
    • Tchenio, T. & Heidmann, T. Defective retroviruses can disperse in the human genome by intracellular transposition. J. Virol. 65, 2113-2118 (1991).
    • (1991) J. Virol , vol.65 , pp. 2113-2118
    • Tchenio, T.1    Heidmann, T.2
  • 10
    • 0033604291 scopus 로고    scopus 로고
    • Expression of mouse mammary tumour virus envelope protein does not prevent superinfection in vivo or in vitro
    • Dzuris, J. L., Zhu, W., Kapkov, D., Golovkina, T. V. & Ross, S. R. Expression of mouse mammary tumour virus envelope protein does not prevent superinfection in vivo or in vitro. Virology 263, 418-426 (1999).
    • (1999) Virology , vol.263 , pp. 418-426
    • Dzuris, J.L.1    Zhu, W.2    Kapkov, D.3    Golovkina, T.V.4    Ross, S.R.5
  • 11
    • 33746569501 scopus 로고    scopus 로고
    • Tumour suppressor gene identification using retroviral insertional mutagenesis in Blm-deficient mice
    • Suzuki, T., Minehata, K., Akagi, K., Jenkins, N. A. & Copeland, N. G. Tumour suppressor gene identification using retroviral insertional mutagenesis in Blm-deficient mice. EMBOJ. 25, 3422-3431 (2006).
    • (2006) EMBOJ , vol.25 , pp. 3422-3431
    • Suzuki, T.1    Minehata, K.2    Akagi, K.3    Jenkins, N.A.4    Copeland, N.G.5
  • 12
    • 0036725051 scopus 로고    scopus 로고
    • New genes involved in cancer identified by retroviral tagging
    • Suzuki, T. et al. New genes involved in cancer identified by retroviral tagging. Nature Genet. 32, 166-174 (2002).
    • (2002) Nature Genet , vol.32 , pp. 166-174
    • Suzuki, T.1
  • 13
    • 34347213450 scopus 로고    scopus 로고
    • Insertional mutagenesis reveals progression genes and checkpoints in MYC/Runx2 lymphomas
    • Stewart, M. et al. Insertional mutagenesis reveals progression genes and checkpoints in MYC/Runx2 lymphomas. Cancer Res. 67, 5126-5133 (2007).
    • (2007) Cancer Res , vol.67 , pp. 5126-5133
    • Stewart, M.1
  • 14
    • 0036729878 scopus 로고    scopus 로고
    • High-throughput retroviral tagging to identify components of specific signaling pathways in cancer
    • Mikkers, H. et al. High-throughput retroviral tagging to identify components of specific signaling pathways in cancer. Nature Genet. 32, 153-159 (2002).
    • (2002) Nature Genet , vol.32 , pp. 153-159
    • Mikkers, H.1
  • 15
    • 0842347703 scopus 로고    scopus 로고
    • Large-scale identification of disease genes involved in acute myeloid leukemia
    • Erkeland, S. J. et al. Large-scale identification of disease genes involved in acute myeloid leukemia. J. Virol. 78, 1971-1980 (2004).
    • (2004) J. Virol , vol.78 , pp. 1971-1980
    • Erkeland, S.J.1
  • 16
    • 0036725322 scopus 로고    scopus 로고
    • Genome-wide retroviral insertional tagging of genes involved in cancer in Cdkn2a-deficient mice
    • Lund, A. H. et al. Genome-wide retroviral insertional tagging of genes involved in cancer in Cdkn2a-deficient mice. Nature Genet. 32, 160-165 (2002).
    • (2002) Nature Genet , vol.32 , pp. 160-165
    • Lund, A.H.1
  • 17
    • 34249812953 scopus 로고    scopus 로고
    • MMTV insertional mutagenesis identifies genes, gene families and pathways involved in mammary cancer
    • Theodorou, V. et al. MMTV insertional mutagenesis identifies genes, gene families and pathways involved in mammary cancer. Nature Genet. 39, 759-769 (2007).
    • (2007) Nature Genet , vol.39 , pp. 759-769
    • Theodorou, V.1
  • 18
    • 0037301370 scopus 로고    scopus 로고
    • Genome-based identification of cancer genes by proviral tagging in mouse retrovirus-induced T-cell lymphomas
    • Kim, R. et al. Genome-based identification of cancer genes by proviral tagging in mouse retrovirus-induced T-cell lymphomas. J. Virol. 77, 2056-2062 (2003).
    • (2003) J. Virol , vol.77 , pp. 2056-2062
    • Kim, R.1
  • 19
    • 43249084218 scopus 로고    scopus 로고
    • Mutation of C/EBPα predisposes to the development of myeloid leukemia in a retroviral insertional mutagenesis screen
    • Hasemann, M. S. et al. Mutation of C/EBPα predisposes to the development of myeloid leukemia in a retroviral insertional mutagenesis screen. Blood 111, 4309-4321 (2008).
    • (2008) Blood , vol.111 , pp. 4309-4321
    • Hasemann, M.S.1
  • 20
    • 53649106195 scopus 로고    scopus 로고
    • Next-generation DNA sequencing
    • Shendure, J. & Ji, H. Next-generation DNA sequencing. Nature Biotechnol. 26, 1135-1145 (2008).
    • (2008) Nature Biotechnol , vol.26 , pp. 1135-1145
    • Shendure, J.1    Ji, H.2
  • 21
    • 22444431606 scopus 로고    scopus 로고
    • Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system
    • Dupuy, A. J., Akagi, K., Largaespada, D. A., Copeland, N. G. & Jenkins, N. A. Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system. Nature 436, 221-226 (2005).
    • (2005) Nature , vol.436 , pp. 221-226
    • Dupuy, A.J.1    Akagi, K.2    Largaespada, D.A.3    Copeland, N.G.4    Jenkins, N.A.5
  • 22
    • 22444444402 scopus 로고    scopus 로고
    • Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse
    • Collier, L. S., Carlson, C. M., Ravimohan, S., Dupuy, A. J. & Largaespada, D. A. Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse. Nature 436, 272-276 (2005).
    • (2005) Nature , vol.436 , pp. 272-276
    • Collier, L.S.1    Carlson, C.M.2    Ravimohan, S.3    Dupuy, A.J.4    Largaespada, D.A.5
  • 23
    • 21344463833 scopus 로고    scopus 로고
    • Insertional mutagenesis in mice: New perspectives and tools
    • Carlson, C. M. & Largaespada, D. A. Insertional mutagenesis in mice: new perspectives and tools. Nature Rev. Genet. 6, 568-580 (2005).
    • (2005) Nature Rev. Genet , vol.6 , pp. 568-580
    • Carlson, C.M.1    Largaespada, D.A.2
  • 24
    • 62149116794 scopus 로고    scopus 로고
    • A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma
    • Keng, V. W. et al. A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma. Nature Biotechnol. 27, 264-274 (2009).
    • (2009) Nature Biotechnol , vol.27 , pp. 264-274
    • Keng, V.W.1
  • 25
    • 63049105067 scopus 로고    scopus 로고
    • A transposon-based genetic screen in mice identifies genes altered in colorectal cancer
    • Starr, T. K. et al. A transposon-based genetic screen in mice identifies genes altered in colorectal cancer. Science 323, 1747-1750 (2009).
    • (2009) Science , vol.323 , pp. 1747-1750
    • Starr, T.K.1
  • 26
    • 23844446044 scopus 로고    scopus 로고
    • Suppression of p53 by Notch in lymphomagenesis: Implications for initiation and regression
    • Beverly, L. J., Felsher, D. W. & Capobianco, A. J. Suppression of p53 by Notch in lymphomagenesis: implications for initiation and regression. Cancer Res. 65, 7159-7168 (2005).
    • (2005) Cancer Res , vol.65 , pp. 7159-7168
    • Beverly, L.J.1    Felsher, D.W.2    Capobianco, A.J.3
  • 28
    • 19944427423 scopus 로고    scopus 로고
    • Identification of cooperative genes for NUP98-HOXA9 in myeloid leukemogenesis using a mouse model
    • Iwasaki, M. et al. Identification of cooperative genes for NUP98-HOXA9 in myeloid leukemogenesis using a mouse model. Blood 105, 784-793 (2005).
    • (2005) Blood , vol.105 , pp. 784-793
    • Iwasaki, M.1
  • 29
    • 11144353866 scopus 로고    scopus 로고
    • Identification of genes that synergize with Cbfb-MYH 11 in the pathogenesis of acute myeloid leukemia
    • Castilla, L. H. et al. Identification of genes that synergize with Cbfb-MYH 11 in the pathogenesis of acute myeloid leukemia. Proc. NatlAcad. Sci. USA 101, 4924-4929 (2004).
    • (2004) Proc. NatlAcad. Sci. USA , vol.101 , pp. 4924-4929
    • Castilla, L.H.1
  • 30
    • 0030700399 scopus 로고    scopus 로고
    • Pim1 cooperates with E2a-Pbx1 to facilitate the progression of thymic lymphomas in transgenic mice
    • Feldman, B. J., Reid, T. R. &Cleary, M. L. Pim1 cooperates with E2a-Pbx1 to facilitate the progression of thymic lymphomas in transgenic mice. Oncogene 15, 2735-2742 (1997).
    • (1997) Oncogene , vol.15 , pp. 2735-2742
    • Feldman, B.J.1    Reid, T.R.2    Cleary, M.L.3
  • 31
    • 34347213447 scopus 로고    scopus 로고
    • Retroviral insertional mutagenesis identifies genes that collaborate with NUP98-HOXD13 during leukemic transformation
    • Slape, C. et al. Retroviral insertional mutagenesis identifies genes that collaborate with NUP98-HOXD13 during leukemic transformation. Cancer Res. 67, 5148-5155 (2007).
    • (2007) Cancer Res , vol.67 , pp. 5148-5155
    • Slape, C.1
  • 32
    • 0032726951 scopus 로고    scopus 로고
    • Leukaemia disease genes: Large-scale cloning and pathway predictions
    • Li, J. et al. Leukaemia disease genes: large-scale cloning and pathway predictions. Nature Genet. 23, 348-353 (1999).
    • (1999) Nature Genet , vol.23 , pp. 348-353
    • Li, J.1
  • 33
    • 31544447174 scopus 로고    scopus 로고
    • Significance of murine retroviral mutagenesis for identification of disease genes in human acute myeloid leukemia
    • Erkeland, S. J. et al. Significance of murine retroviral mutagenesis for identification of disease genes in human acute myeloid leukemia. Cancer Res. 66, 622-626 (2006).
    • (2006) Cancer Res , vol.66 , pp. 622-626
    • Erkeland, S.J.1
  • 34
    • 0022380768 scopus 로고
    • The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
    • Adams, J. M. et al. The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature 318, 533-538 (1985).
    • (1985) Nature , vol.318 , pp. 533-538
    • Adams, J.M.1
  • 35
    • 0141569009 scopus 로고    scopus 로고
    • Myc-driven murine prostate cancer shares molecular features with human prostate tumours
    • Ellwood-Yen, K. et al. Myc-driven murine prostate cancer shares molecular features with human prostate tumours. Cancer Cell 4, 223-238 (2003).
    • (2003) Cancer Cell , vol.4 , pp. 223-238
    • Ellwood-Yen, K.1
  • 36
    • 0033569429 scopus 로고    scopus 로고
    • Bmi-1 collaborates with c-Myc in tumourigenesis by inhibiting c-Myc- induced apoptosis via INK4a/ARF
    • Jacobs, J. J. et al. Bmi-1 collaborates with c-Myc in tumourigenesis by inhibiting c-Myc- induced apoptosis via INK4a/ARF. Genes Dev. 13, 2678-2690 (1999).
    • (1999) Genes Dev , vol.13 , pp. 2678-2690
    • Jacobs, J.J.1
  • 37
    • 0028988929 scopus 로고
    • Proviral tagging in E mu-myc transgenic mice lacking the Pim-1 proto-oncogene leads to compensatory activation of Pim-2
    • van der Lugt, N. M. et al. Proviral tagging in E mu-myc transgenic mice lacking the Pim-1 proto-oncogene leads to compensatory activation of Pim-2. EMBOJ. 14, 2536-2544 (1995).
    • (1995) EMBOJ , vol.14 , pp. 2536-2544
    • van der Lugt, N.M.1
  • 38
    • 53349103292 scopus 로고    scopus 로고
    • Modelling Myc inhibition as a cancer therapy
    • Soucek, L. et al. Modelling Myc inhibition as a cancer therapy. Nature 455, 679-683 (2008).
    • (2008) Nature , vol.455 , pp. 679-683
    • Soucek, L.1
  • 39
    • 0025021488 scopus 로고
    • Long-distance activation of the Myc protooncogene by provirus insertion in Mlvi-1 or Mlvi-4 in ratT-cell lymphomas
    • Lazo, P. A., Lee, J. S. &Tsichlis, P. N. Long-distance activation of the Myc protooncogene by provirus insertion in Mlvi-1 or Mlvi-4 in ratT-cell lymphomas. Proc. NatlAcad. Sci. USA 87, 170-173 (1990).
    • (1990) Proc. NatlAcad. Sci. USA , vol.87 , pp. 170-173
    • Lazo, P.A.1    Lee, J.S.2    Tsichlis, P.N.3
  • 40
    • 0037364415 scopus 로고    scopus 로고
    • RecQ helicases: Caretakers of the genome
    • Hickson, I. D. RecQ helicases: caretakers of the genome. Nature Rev. Cancer 3, 169-178 (2003).
    • (2003) Nature Rev. Cancer , vol.3 , pp. 169-178
    • Hickson, I.D.1
  • 41
    • 0033667704 scopus 로고    scopus 로고
    • Cancer predisposition caused by elevated mitotic recombination in Bloom mice
    • Luo, G. et al. Cancer predisposition caused by elevated mitotic recombination in Bloom mice. Nature Genet. 26, 424-429 (2000).
    • (2000) Nature Genet , vol.26 , pp. 424-429
    • Luo, G.1
  • 42
    • 37749003752 scopus 로고    scopus 로고
    • A mechanism misregulating p27 in tumours discovered in a functional genomic screen
    • Garrett-Engele, C. M. et al. A mechanism misregulating p27 in tumours discovered in a functional genomic screen. PLoS Genet. 3, e219 (2007).
    • (2007) PLoS Genet , vol.3
    • Garrett-Engele, C.M.1
  • 43
    • 0032980308 scopus 로고    scopus 로고
    • The prognostic significance of altered cyclin-dependent kinase inhibitors in human cancer
    • Tsihlias, J., Kapusta, L. & Slingerland, J. The prognostic significance of altered cyclin-dependent kinase inhibitors in human cancer. Annu. Rev. Med. 50, 401-423 (1999).
    • (1999) Annu. Rev. Med , vol.50 , pp. 401-423
    • Tsihlias, J.1    Kapusta, L.2    Slingerland, J.3
  • 44
    • 0032992316 scopus 로고    scopus 로고
    • p27 and Rb are on overlapping pathways suppressing tumourigenesis in mice
    • Park, M. S. et al. p27 and Rb are on overlapping pathways suppressing tumourigenesis in mice. Proc. NatlAcad. Sci. USA 96, 6382-6387 (1999).
    • (1999) Proc. NatlAcad. Sci. USA , vol.96 , pp. 6382-6387
    • Park, M.S.1
  • 45
    • 20044375763 scopus 로고    scopus 로고
    • Array comparative genomic hybridization and its applications in cancer
    • Pinkel, D. & Albertson, D. G. Array comparative genomic hybridization and its applications in cancer. Nature Genet. 37, S11 -S17 (2005).
    • (2005) Nature Genet , vol.37
    • Pinkel, D.1    Albertson, D.G.2
  • 46
    • 33645769276 scopus 로고    scopus 로고
    • High-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients
    • Carrasco, D. R. et al. High-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients. Cancer Cell 9, 313-325 (2006).
    • (2006) Cancer Cell , vol.9 , pp. 313-325
    • Carrasco, D.R.1
  • 47
    • 36248962105 scopus 로고    scopus 로고
    • The genomic landscapes of human breast and colorectal cancers
    • Wood, L. D. et al. The genomic landscapes of human breast and colorectal cancers. Science 318, 1108-1113 (2007).
    • (2007) Science , vol.318 , pp. 1108-1113
    • Wood, L.D.1
  • 48
    • 33749993417 scopus 로고    scopus 로고
    • The consensus coding sequences of human breast and colorectal cancers
    • Sjoblom,T. et al. The consensus coding sequences of human breast and colorectal cancers. Science 314, 268-274 (2006).
    • (2006) Science , vol.314 , pp. 268-274
    • Sjoblom, T.1
  • 49
    • 52949127312 scopus 로고    scopus 로고
    • An integrated genomic analysis of human glioblastoma multiforme
    • Parsons, D. W. et al. An integrated genomic analysis of human glioblastoma multiforme. Science 321, 1807-1812 (2008).
    • (2008) Science , vol.321 , pp. 1807-1812
    • Parsons, D.W.1
  • 50
    • 52149123619 scopus 로고    scopus 로고
    • Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
    • Jones, S. et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 321, 1801 -1806 (2008).
    • (2008) Science , vol.321 , pp. 1801-1806
    • Jones, S.1
  • 51
    • 43049162845 scopus 로고    scopus 로고
    • Molecular pathogenesis of feline leukemia virus-induced malignancies: Insertional mutagenesis
    • Fujino, Y., Ohno, K. &Tsujimoto, H. Molecular pathogenesis of feline leukemia virus-induced malignancies: insertional mutagenesis. Vet. Immunol. Immunopathol. 123, 138-143 (2008).
    • (2008) Vet. Immunol. Immunopathol , vol.123 , pp. 138-143
    • Fujino, Y.1    Ohno, K.2    Tsujimoto, H.3
  • 52
    • 0023864608 scopus 로고
    • Rapid induction of B-cell lymphomas: Insertional activation of c-myb by avian leukosis virus
    • Kanter, M. R., Smith, R. E. & Hayward, W. S. Rapid induction of B-cell lymphomas: insertional activation of c-myb by avian leukosis virus. J. Virol. 62, 1423-1432 (1988).
    • (1988) J. Virol , vol.62 , pp. 1423-1432
    • Kanter, M.R.1    Smith, R.E.2    Hayward, W.S.3
  • 53
    • 58849122389 scopus 로고    scopus 로고
    • Functional identification of genes causing estrogen independence of human breast cancer cells
    • van Agthoven, T. et al. Functional identification of genes causing estrogen independence of human breast cancer cells. Breast Cancer Res. Treat. 114, 23-30 (2009).
    • (2009) Breast Cancer Res. Treat , vol.114 , pp. 23-30
    • van Agthoven, T.1
  • 54
    • 0027185314 scopus 로고
    • Induction of antiestrogen resistance in human breast cancer cells by random insertional mutagenesis using defective retroviruses: Identification of bcar-1, a common integration site
    • Dorssers, L. C., van, A. T., Dekker, A., van Agthoven, T. L. & Kok, E. M. Induction of antiestrogen resistance in human breast cancer cells by random insertional mutagenesis using defective retroviruses: identification of bcar-1, a common integration site. Mol. Endocrinol. 7, 870-878 (1993).
    • (1993) Mol. Endocrinol , vol.7 , pp. 870-878
    • Dorssers, L.C.1    van, A.T.2    Dekker, A.3    van Agthoven, T.L.4    Kok, E.M.5
  • 55
    • 0034684987 scopus 로고    scopus 로고
    • Bcar1/p1 30Cas protein and primary breast cancer: Prognosis and response to tamoxifen treatment
    • van der, F. S. et al. Bcar1/p1 30Cas protein and primary breast cancer: prognosis and response to tamoxifen treatment. J. Natl Cancer Inst. 92, 120-127 (2000).
    • (2000) J. Natl Cancer Inst , vol.92 , pp. 120-127
    • van der, F.S.1
  • 56
    • 34248328788 scopus 로고    scopus 로고
    • Retroviral insertional mutagenesis identifies RUNX genes involved in chronic myeloid leukemia disease persistence under imatinib treatment
    • Miething, C. et al. Retroviral insertional mutagenesis identifies RUNX genes involved in chronic myeloid leukemia disease persistence under imatinib treatment. Proc. NatlAcad. Sci. USA 104, 4594-4599 (2007).
    • (2007) Proc. NatlAcad. Sci. USA , vol.104 , pp. 4594-4599
    • Miething, C.1
  • 57
    • 20544449915 scopus 로고    scopus 로고
    • Expression analysis of genes involved in brain tumour progression driven by retroviral insertional mutagenesis in mice
    • Johansson, F. K., Goransson, H. & Westermark, B. Expression analysis of genes involved in brain tumour progression driven by retroviral insertional mutagenesis in mice. Oncogene 24, 3896-3905 (2005).
    • (2005) Oncogene , vol.24 , pp. 3896-3905
    • Johansson, F.K.1    Goransson, H.2    Westermark, B.3
  • 58
    • 11144356176 scopus 로고    scopus 로고
    • Integration of human T-cell leukemia virus type 1 in genes of leukemia cells of patients with adult T-cell leukemia
    • Hanai, S. et al. Integration of human T-cell leukemia virus type 1 in genes of leukemia cells of patients with adult T-cell leukemia. Cancer Sci. 95, 306-310 (2004).
    • (2004) Cancer Sci , vol.95 , pp. 306-310
    • Hanai, S.1
  • 59
    • 3042753389 scopus 로고    scopus 로고
    • Pathogenesis of HIV-associated non-Hodgkin lymphoma
    • Killebrew, D. & Shiramizu, B. Pathogenesis of HIV-associated non-Hodgkin lymphoma. Curr. HIV Res. 2, 215-221 (2004).
    • (2004) Curr. HIV Res , vol.2 , pp. 215-221
    • Killebrew, D.1    Shiramizu, B.2
  • 60
    • 33748939587 scopus 로고    scopus 로고
    • Gene therapy: X-SCID transgene leukaemogenicity
    • discussion E6-E7
    • Thrasher, A. J. et al. Gene therapy: X-SCID transgene leukaemogenicity. Nature 443, E5-E6; discussion E6-E7 (2006).
    • (2006) Nature , vol.443
    • Thrasher, A.J.1
  • 61
    • 33846025793 scopus 로고    scopus 로고
    • Detecting statistically significant common insertion sites in retroviral insertional mutagenesis screens
    • de Ridder, J., Uren, A., Kool, J., Reinders, M. & Wessels, L. Detecting statistically significant common insertion sites in retroviral insertional mutagenesis screens. PLoS Comput. Biol. 2, e1 66 (2006).
    • (2006) PLoS Comput. Biol , vol.2
    • de Ridder, J.1    Uren, A.2    Kool, J.3    Reinders, M.4    Wessels, L.5
  • 62
    • 0037841763 scopus 로고    scopus 로고
    • Transcription start regions in the human genome are favored targets for MLV integration
    • Wu, X., Li, Y., Crise, B. & Burgess, S. M. Transcription start regions in the human genome are favored targets for MLV integration. Science 300, 1749-1751 (2003).
    • (2003) Science , vol.300 , pp. 1749-1751
    • Wu, X.1    Li, Y.2    Crise, B.3    Burgess, S.M.4
  • 63
    • 33751418954 scopus 로고    scopus 로고
    • Selection of target sites for mobile DNA integration in the human genome
    • Berry, C., Hannenhalli, S., Leipzig, J. & Bushman, F. D. Selection of target sites for mobile DNA integration in the human genome. PLoS Comput. Biol. 2, e1 57 (2006).
    • (2006) PLoS Comput. Biol , vol.2
    • Berry, C.1    Hannenhalli, S.2    Leipzig, J.3    Bushman, F.D.4
  • 64
    • 33745684269 scopus 로고    scopus 로고
    • Retroviral DNA integration: Viral and cellular determinants of target-site selection
    • Lewinski, M. K. et al. Retroviral DNA integration: viral and cellular determinants of target-site selection. PLoS Pathog. 2, e60 (2006).
    • (2006) PLoS Pathog , vol.2
    • Lewinski, M.K.1
  • 65
    • 19344375031 scopus 로고    scopus 로고
    • Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences
    • Mitchell, R. S. et al. Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences. PLoS Biol. 2, e234 (2004).
    • (2004) PLoS Biol , vol.2
    • Mitchell, R.S.1
  • 66
    • 77950961510 scopus 로고    scopus 로고
    • Transcription factor binding sites are genetic determinants of retroviral integration in the human genome
    • Felice, B. et al. Transcription factor binding sites are genetic determinants of retroviral integration in the human genome. PLoS ONE 4, e4571 (2009).
    • (2009) PLoS ONE , vol.4
    • Felice, B.1
  • 67
    • 38349107912 scopus 로고    scopus 로고
    • Quantitative expression profiling guided by common retroviral insertion sites reveals novel and cell type specific cancer genes in leukemia
    • Sauvageau, M. et al. Quantitative expression profiling guided by common retroviral insertion sites reveals novel and cell type specific cancer genes in leukemia. Blood 111, 790-799 (2008).
    • (2008) Blood , vol.111 , pp. 790-799
    • Sauvageau, M.1
  • 68
    • 58149401193 scopus 로고    scopus 로고
    • A DNA transposon-based approach to validate oncogenic mutations in the mouse
    • Su, Q. et al. A DNA transposon-based approach to validate oncogenic mutations in the mouse. Proc. Natl Acad. Sci. USA 105, 19904-19909 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 19904-19909
    • Su, Q.1
  • 69
    • 33845981514 scopus 로고    scopus 로고
    • PiggyBac transposon-mediated gene transfer in human cells
    • Wilson, M. H., Coates, C. J. & George, A. L. Jr. PiggyBac transposon-mediated gene transfer in human cells. Mol. Ther. 15, 139-145 (2007).
    • (2007) Mol. Ther , vol.15 , pp. 139-145
    • Wilson, M.H.1    Coates, C.J.2    George Jr., A.L.3
  • 70
    • 0141566659 scopus 로고    scopus 로고
    • Transposon mutagenesis of the mouse germline
    • Carlson, C.M.et al. Transposon mutagenesis of the mouse germline. Genetics 165, 243-256 (2003).
    • (2003) Genetics , vol.165 , pp. 243-256
    • Carlson, C.M.1
  • 71
    • 0024432837 scopus 로고
    • N-myc is frequently activated by proviral insertion in MuLV-inducedTcell lymphomas
    • van Lohuizen, M., Breuer, M. & Berns, A. N-myc is frequently activated by proviral insertion in MuLV-inducedTcell lymphomas. EMBOJ. 8, 133-136 (1989).
    • (1989) EMBOJ , vol.8 , pp. 133-136
    • van Lohuizen, M.1    Breuer, M.2    Berns, A.3
  • 72
    • 0032576841 scopus 로고    scopus 로고
    • A full-length Notch1 allele is dispensable for transformation associated with a provirally activated truncated Notch 1 allele in Moloney MuLV-infected MMTVD/myc transgenic mice
    • Girard, L. &Jolicoeur, P. A full-length Notch1 allele is dispensable for transformation associated with a provirally activated truncated Notch 1 allele in Moloney MuLV-infected MMTVD/myc transgenic mice. Oncogene 16, 517-522 (1998).
    • (1998) Oncogene , vol.16 , pp. 517-522
    • Girard, L.1    Jolicoeur, P.2
  • 73
    • 5044225888 scopus 로고    scopus 로고
    • Activating mutations of NOTCH 1 in human T cell acute lymphoblastic leukemia
    • Weng, A. P. et al. Activating mutations of NOTCH 1 in human T cell acute lymphoblastic leukemia. Science 306, 269-271 (2004).
    • (2004) Science , vol.306 , pp. 269-271
    • Weng, A.P.1
  • 74
    • 12944255642 scopus 로고    scopus 로고
    • Fringe glycosyltransferases differentially modulate Notch 1 proteolysis induced by Delta 1 and Jagged 1
    • Yang, L. T. et al. Fringe glycosyltransferases differentially modulate Notch 1 proteolysis induced by Delta 1 and Jagged 1. Mol. Biol. Cell 16, 927-942 (2005).
    • (2005) Mol. Biol. Cell , vol.16 , pp. 927-942
    • Yang, L.T.1
  • 75
    • 0141995063 scopus 로고    scopus 로고
    • Glycosylation regulates Notch signalling
    • Haines, N. & Irvine, K. D. Glycosylation regulates Notch signalling. Nature Rev. Mol. Cell Biol. 4, 786-797 (2003).
    • (2003) Nature Rev. Mol. Cell Biol , vol.4 , pp. 786-797
    • Haines, N.1    Irvine, K.D.2
  • 76
    • 0001395691 scopus 로고    scopus 로고
    • Fringe is a glycosyltransferase that modifies Notch
    • Moloney, D. J. et al. Fringe is a glycosyltransferase that modifies Notch. Nature 406, 369-375 (2000).
    • (2000) Nature , vol.406 , pp. 369-375
    • Moloney, D.J.1
  • 77
    • 0029074056 scopus 로고
    • Retroviral integration at the Evi-2 locus in BXH-2 myeloid leukemia cell lines disrupts Nf1 expression without changes in steady-state Ras-GTP levels
    • Largaespada, D. A.,Shaughnessy, J. D. Jr, Jenkins, N. A. & Copeland, N. G. Retroviral integration at the Evi-2 locus in BXH-2 myeloid leukemia cell lines disrupts Nf1 expression without changes in steady-state Ras-GTP levels. J. Virol. 69, 5095-5102 (1995).
    • (1995) J. Virol , vol.69 , pp. 5095-5102
    • Largaespada, D.A.1    Shaughnessy Jr, J.D.2    Jenkins, N.A.3    Copeland, N.G.4
  • 78
    • 0028865482 scopus 로고
    • Frequent disruption of the Nf1 gene by a novel murine AIDS virus-related provirus in BXH-2 murine myeloid lymphomas
    • Cho, B. C. et al. Frequent disruption of the Nf1 gene by a novel murine AIDS virus-related provirus in BXH-2 murine myeloid lymphomas. J. Virol. 69, 7138-7146 (1995).
    • (1995) J. Virol , vol.69 , pp. 7138-7146
    • Cho, B.C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.