Both p16Ink4a and the p19Arf-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 15, 2006, Pages 5947-5952

  Bardeesy, Nabeel ^a   Aguirre, Andrew J ^a   Chu, Gerald C ^a,b   Cheng, Kuang Hung ^a   Lopez, Lyle V ^a   Hezel, Aram F ^a   Feng, Bin ^a   Brennan, Cameron ^d   Weissleder, Ralph ^c   Mahmood, Umar ^c   Hanahan, Douglas ^e   Redston, Mark S ^b   Chin, Lynda ^a   DePinho, Ronald A ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Array comparative genomic hybridization; KRAS; Mouse models; Pancreatic cancer; Tumor suppressor

Indexed keywords

ARF PROTEIN; ASPARTIC ACID; GLYCINE; PROTEIN P16INK4A; PROTEIN P19; PROTEIN P19ARF; PROTEIN P53; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARRAY COMPARATIVE GENOMIC HYBRIDIZATION; ARTICLE; CANCER INHIBITION; CANCER MODEL; COMPARATIVE GENOMIC HYBRIDIZATION; GENE; GENE DELETION; GENE INACTIVATION; GENE MUTATION; GENOME ANALYSIS; GENOTYPE; HETEROZYGOSITY; HISTOPATHOLOGY; HOMOZYGOSITY; HOMOZYGOUS DELETION; LATENT PERIOD; METASTASIS POTENTIAL; MOUSE; MOUSE MUTANT; NONHUMAN; ONCOGENE K RAS; P16INK4A GENE; PANCREAS ADENOCARCINOMA; PANCREAS DUCTAL ADENOCARCINOMA; PRECANCER; PRIORITY JOURNAL; PROTEIN DEPLETION; TUMOR DIFFERENTIATION; TUMOR SUPPRESSOR GENE;

ADENOCARCINOMA; ANIMALS; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; GENE DELETION; GENES, P53; HOMOZYGOTE; MICE; MICE, KNOCKOUT; PANCREATIC NEOPLASMS; TUMOR SUPPRESSOR PROTEIN P14ARF; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA; MURINAE;

EID: 33645824724     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0601273103     Document Type: Article

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