Recent advances in the protocols of transgenic mouse mutation assays

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 455, Issue 1-2, 2000, Pages 191-215

  Nohmi, Takehiko ^a   Suzuki, Takayoshi ^a   Masumura, Ken Ichi ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

6 Thioguanine selection; cII selection; DNA sequencing analysis; Mutation assays; Spi selection; Transgenic mouse

Indexed keywords

CARCINOGEN; MUTAGENIC AGENT; TIOGUANINE;

BACTERIOPHAGE LAMBDA; CARCINOGENESIS; DNA SEQUENCE; GENE MUTATION; GERM CELL; MOUSE; MUTATION RATE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ASSAY; REVIEW; SPONTANEOUS MUTATION; TRANSGENE; TRANSGENIC MOUSE;

EID: 0034693862     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(00)00077-4     Document Type: Article

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14. Mutagenesis of a single AT basepair in mice transgenic for PhiX174 am3, cs70
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41. UVB-induced cyclobutane pyrimidine dimer frequency correlates with skin cancer mutational hotspots in p53
42. Spectrum of mutations in kidney, stomach and liver from lacI transgenic mice recovered after treatment with tris(2,3-dibromopropyl)phosphate
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44. Misincorporation rate and type on the leading and lagging strands of UV- damaged DNA
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54. No direct correlation between mutant frequencies and cancer incidence induced by MeIQ in various organs of Big Blue mice
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56. Comparison of mutant frequencies and types of mutations induced by thiotepa in the endogenous Hprt gene and transgenic lacI gene of Big Blue rats
57. Comparison of in vivo mutagenesis in the endogenous Hprt gene and the lacI transgene of Big Blue(R) rats treated with 7, 12- dimethylbenz(a)anthracene
58. On the origin of spontaneous somatic mutations and sectored plaques detected in transgenic mice
59. Comparison of the X-gal- and P-gal-based systems for screening of mutant lambda lacZ phages originating from the transgenic mouse strain 40.6
60. Sources of variability in data from a lacI transgenic mouse mutation assay
61. Statistical analysis of lacZ mutant frequency data from MutaMouse mutagenicity assays
62. Study design and sample sizes for a lacI transgenic mouse mutation assay
63. Initial consideration for use of transgenic mutation assays in a regulatory submission
64. A preliminary evaluation of the performance of the Muta Mouse (lacZ) and Big Blue (lacI) transgenic mouse mutation assays
65. A strategy for the application of transgenic rodent mutagenesis assays
66. Induction of mutations in transgenic animal models: BigBlue and Muta Mouse
67. Tk+/- mouse model for detecting in vivo mutation in an endogenous, autosomal gene
68. APRT: A versatile in vivo resident reporter of local mutation and loss of heterozygosity
69. Comparison of the molecular characteristics of lacZ transgenic mouse mutations detected by visual and positive selection
70. Genotypic selection methods for the direct analysis of point mutations
71. High efficiency restriction-deficient in vitro packaging extracts for bacteriophage lambda DNA using a new E. coli lysogen
72. Intestinal mutagenicity of two carcinogenic food mutagens in transgenic mice: 2-Amino-1-methyl-6-phenylimidazo [4,5-b]pyridine and amino(alpha)carboline
73. In vivo mutagenicity and DNA adduct levels of heterocyclic amines in Muta mice and c-myc/lacZ double transgenic mice
74. Induction of mutations by 2-acetylaminofluorene in lacI transgenic B6C3F1 mouse liver
75. The detection of gene mutation in transgenic mice (Muta Mouse) following a single oral dose of 2-acetylaminofluorene
76. Mutations in liver DNA of lacI transgenic mice (Big Blue) following subchronic exposure to 2-acetylaminofluorene
77. Relative activities of methyl methanesulphonate (MMS) as a genotoxin, clastogen and gene mutagen to the liver and bone marrow of MutaMouse mice
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79. Detection of chemical mutagens using Muta Mouse: A transgenic mouse model
80. Somatic and germ cell mutagenesis in lambda lacZ transgenic mice treated with acrylamide or ethylnitrosourea
81. In vivo mutagenesis induced by CC-1065 and adozelesin DNA alkylation in a transgenic mouse model
82. Aflatoxin B1 induced lacI mutation in liver and kidney of transgenic mice C57BL/6N: Effect of phorone
83. Tamoxifen induces G:C→T:A mutations in the cII gene in the liver of lambda/lacI transgenic rats but not at 5'-CpG-3' dinucleotide sequences as found in the lacI transgene
84. Genotoxicity of agaritine in the lacI transgenic mouse mutation assay: Evaluation of the health risk of mushroom consumption
85. Mutagenicity of the human bladder carcinogen 4-aminobiphenyl to the bladder of MutaMouse transgenic mice
86. Mutagenicity of o-anisidine to the bladder of
87. Analysis of gene mutations and clastogenicity following short-term treatment with azathioprine in MutaMouse
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89. Inhalation of benzene leads to an increase in the mutant frequencies of a lacI transgene in lung and spleen tissues of mice
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96. Effect of eugenol on the mutagenicity of benzo(a)pyrene and the formation of benzo(a)pyrene-DNA adducts in the lambda-lacZ-transgenic mouse
97. Benzo(a)pyrene site of contact mutagenicity in skin of Muta Mouse
98. Assessment of 1,3-butadiene mutagenicity in the bone marrow of B6C3F1 lacI transgenic mice (Big Blue): A review of mutational spectrum and lacI mutant frequency after a 5-day 625 ppm 1,3-butadiene exposure
99. The in vivo mutagenicity and mutational spectrum at the lacI transgene recovered from the spleens of B6C3F1 lacI transgenic mice following a 4- week inhalation exposure to 1,3-butadiene
100. Use of transgenic mice for assessing the mutagenicity of 1,3-butadiene in vivo
101. A preliminary assessment of the toxic and mutagenic potential of steroidal alkaloids in transgenic mice
102. Effect of mitogenic or regenerative cell proliferation on lacz mutant frequency in the liver of MutaTMMice treated with 5 9-dimethyldibenzoc, gcarbazole
103. Detection of gene mutation in skin, stomach and liver of MutaMouse following oral or topical treatment with N-methyl-N'-nitro-N-nitrosoguanidine or 1-chloromethylpyrene: Some preliminary observations
104. Evaluation of the in vivo genotoxic potential of three carcinogenic aromatic amines using the Big Blue transgenic mouse mutation assay
105. Tissue-specific mutant frequencies and mutational spectra in cyclophosphamide-treated lacI transgenic mice
106. Detection of cyclophosphamide-induced mutations at the Hprt but not the lacI locus in splenic lymphocytes of exposed mice
107. Mutation studies in lacI transgenic mice after exposure to radiation or cyclophosphamide
108. The DNA damaging drug cyproterone acetate causes gene mutations and induces glutathione-S-transferase P in the liver of female Big Blue transgenic F344 rats
109. Differential in vivo mutagenicity of the carcinogen/non-carcinogen pair 2,4- and 2,6-diaminotoluene
110. Mutagenic activity of carcinogens detected in transgenic rodent mutagenicity assays at dose levels used in chronic rodent cancer bioassays
111. Assessment of the mutagenicity of dichloroacetic acid in lacI transgenic B6C3F1 mouse liver
112. Mutagenicity of the potent rat hepatocarcinogen 6BT to the liver of transgenic (lacI) rats: Consideration of a reduced mutation assay protocol
113. Hepatic gene mutations induced in Big Blue rats by both the potent rat liver azo-carcinogen 6BT and its reported noncarcinogenic analogue 5BT
114. Mutational spectra in the lacI gene in skin from 7,12-dimethylbenz[a]anthracene-treated and untreated transgenic mice
115. Induction of lacZ mutation by 7,12-dimethylbenz[a]anthracene in various tissues of transgenic mice
116. Mutagenesis induced by oral carcinogens in lacZ mouse (MutaMouse) tongue and other oral tissues
117. The second collaborative study on the transgenic mouse mutation assay by the JEMS/MMS: A comparability of the cII gene with the lacZ gene in the MutaMouse
118. Correlation of carcinogenic potency with mouse-skin 32p-postlabeling and muta(®) mouse lacZ-mutation data for DMBA and its K-region sulphur isostere: Comparison with activities observed in standard geno-toxicity assays
119. Assessment of the in vivo mutagenicity of ethylene oxide in the tissues of B6C3F1 lacI transgenic mice following inhalation exposure
120. Can nongenotoxic carcinogens be detected with the lacI transgenic mouse mutation assay?
121. Relative sensitivity of the endogenous hprt gene and lacI transgene in ENU-treated Big Blue B6C3F1 mice
122. Frequency and spectrum of ethylnitrosourea-induced mutation at the hprt and lacI loci in splenic lymphocytes of exposed lacI transgenic mice
123. Comparison of mutant frequencies at the transgenic lambda LacI and cII/cI loci in control and ENU-treated Big Blue mice
124. Characterization of mutations induced by ethylnitrosourea in seminiferous tubule germ cells of transgenic B6C3F1 mice
125. Organ variation in the mutagenicity of ethylnitrosourea in Muta mouse: Results of the collaborative study on the transgenic mutation assay by JEMS/MMS, The Collaborative Study Group for the Transgenic Mouse Mutation Assay Mammalian Mutagenesis Study Group of the Environmental Mutagen Society of Japan
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127. A test for neutrality of mutations of the lacZ transgene
128. Temporal and molecular characteristics of mutations induced by ethylnitrosourea in germ cells isolated from seminiferous tubules and in spermatozoa of lacZ transgenic mice
129. Somatic mutation in the mammary gland: Influence of time and estrus
130. The cII locus in the MutaMouse system
131. Enhanced liver cell mutations in trematode-infected Big Blue transgenic mice
132. Antimutagenic structural modification of quinoline assessed by an in vivo mutagenesis assay using lacZ-transgenic mice
133. Effect of maternal folate levels on somatic mutation frequency in the developing colon
134. Radiation-induced point mutations, deletions and micronuclei in lacI transgenic mice
135. Mutant frequencies in lacZ transgenic mice following the internal irradiation from 89Sr or the external gamma-ray irradiation
136. Mutagenicity of high fat diets in the colon and small intestine of transgenic mice
137. Bone marrow and liver mutagenesis in lacZ transgenic mice treated with hexavalent chromium
138. Evidence for in vivo non-mutagenicity of the carcinogen hydrazine sulfate in target tissues of lacZ transgenic mice
139. Hyperglycemia-induced embryonic dysmorphogenesis correlates with genomic DNA mutation frequency in vitro and in vivo
140. Mutational analysis of the liver, colon and kidney of Big Blue® rats treated with 2-amino-3-methylimidazo(4, 5-f)quinoline
141. Studies on mutations in male germ cells of transgenic mice following exposure to isopropyl methanesulfonate, ethylnitrosourea or X-ray
142. Lack of mutagenicity of levofloxacin in lacZ transgenic mice
143. Organ variation in the mutagenicity of MeIQ in Big Blue lacI transgenic mice
144. Tissue-specific mutational spectra of 2-amino-3,4-dimethylimidazo(4,5-f)quinoline in the liver and bone marrow of lacI transgenic mice
145. In vivo mutagenicity and hepatocarcinogenicity of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in bitransgenic c-myc/lambda lacZ mice
146. Evaluation of the genetic toxicity of the peroxisome proliferator and carcinogen methyl clofenapate, including assays using Muta Mouse and Big Blue transgenic mice
147. Induction of hepatic mutations in lacI transgenic mice
148. Mutagenicity of methyl methanesulfonate (MMS) in vivo at the Dlb-1 native locus and a lacI transgene
149. Germ cell mutagenesis in lacZ transgenic mice treated with methyl methanesulfonate
150. Tissue-specific induction of mutations by acute oral administration of N-methyl-N'-nitro-N-nitrosoguanidine and beta-propiolactone to the Muta Mouse: Preliminary data on stomach, liver and bone marrow
151. Transgenic systems for in vivo mutation analysis
152. The lacI transgenic mouse mutagenicity assay: Quantitative evaluation in comparison to tests for carcinogenicity and cytogenetic damage in vivo
153. - selection
154. Nickel subsulfide is genotoxic in vitro but shows no mutagenic potential in respiratory tract tissues of BigBlue rats and Muta Mouse mice in vivo after inhalation
155. Mutagenicity of 4-nitroquinoline 1-oxide in the MutaMouse
156. Initial experiences and future directions for transgenic mouse mutation assays
157. Sodium phenobarbital-enhanced mutation frequency in the liver DNA of lacZ transgenic mice treated with diethylnitrosamine
158. Mutation studies with dimethyl nitrosamine in young and old lacI transgenic mice
159. Organ variation in the mutagenicity of dimethylnitrosamine in Big Blue mice
160. Specific mutational spectrum of dimethylnitrosamine in the lacI transgene of Big Blue C57BL/6 mice
161. Hepatic lacI and cII mutation in transgenic (lambdaLIZ) rats treated with dimethylnitrosamine
162. Comparison of lacI and lacZ transgenic mouse mutation assays: An EU- sponsored interlaboratory study
163. DNA adducts, mutant frequencies and mutation spectra in lambda lacZ transgenic mice treated with N-nitrosodimethylamine
164. N-Nitrosodi-n-propylamine induces organ specific mutagenesis with specific expression times in lacZ transgenic mice
165. Oxazepam is mutagenic in vivo in Big Blue transgenic mice
166. Organ distinctive mutagenicity in MutaMouse after short-term exposure to PhIP
167. Mutagenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the new gpt delta transgenic mouse
168. 6-methylguanine
169. Procarbazine genotoxicity in the MutaMouse; strong clastogenicity and organ-specific induction of lacZ mutations
170. Mutation induction by N-propyl-N-nitrosourea in eight MutaMouse organs
171. Tissue-specific induction of mutations by streptozotocin in vivo
172. Tamoxifen causes gene mutations in the livers of lambda/lacI transgenic rats
173. Evidence for the lack of base-change and small-deletion mutation induction by trichloroethylene in lacZ transgenic mice
174. The genetic analysis of lacI mutations in sectored plaques from Big Blue transgenic mice
175. X-ray-and ultraviolet-radiation-induced mutations in Muta mouse
176. Mutagenicity of ethyl carbamate to
177. Spontaneous mutation frequency and pattern in Big Blue mice fed a vitamin E-supplemented diet