Global expression profiling identifies signatures of tumor virulence in MMTV-PyMT-transgenic mice: Correlation to human disease

Cancer Research

Volumn 64, Issue 17, 2004, Pages 5973-5981

  Qiu, Ting Hu ^a   Chandramouli, Gadisetti V R ^a   Hunter, Kent W ^a   Alkharouf, Nawal W ^a   Green, Jeffrey E ^a   Liu, Edison T ^a,b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b GENOME INSTITUTE OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

CD24 ANTIGEN; GELSOLIN; LIPOCALIN; LIPOCALIN 2; PROCOLLAGEN; STAT3 PROTEIN; UNCLASSIFIED DRUG;

ACTG2 GENE; ANIMAL MODEL; ARTICLE; BREAST CARCINOGENESIS; BREAST TUMOR; CNN1 GENE; COLIA1 GENE; COLIA2 GENE; DHPS GENE; DNA MICROARRAY; EIF4EL3 GENE; GENE; GENE EXPRESSION; GENOMICS; HLA DPB1 GENE; HNRPAB GENE; LMNBI GENE; LUNG METASTASIS; METASTASIS; MOUSE; MOUSE MAMMARY TUMOR ONCOVIRUS; MT3 GENE; MYH11 GENE; MYLK GENE; NONHUMAN; NR4A1 GENE; PNG1 GENE; PRIORITY JOURNAL; RBM5 GENE; RUNX1 GENE; SNRPF GENE; TRANSGENIC MOUSE; TUMOR GROWTH;

ANIMALS; ANTIGENS, POLYOMAVIRUS TRANSFORMING; CELL TRANSFORMATION, NEOPLASTIC; DISEASE MODELS, ANIMAL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MAMMARY NEOPLASMS, EXPERIMENTAL; MAMMARY TUMOR VIRUS, MOUSE; MICE; MICE, TRANSGENIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS;

EID: 4344688268     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-04-0242     Document Type: Article

References (39)

1. Ramaswamy S, Ross KN, Lander ES, Golub TR. A molecular signature of metastasis in primary solid tumors. Nat Genet 2003;33:49-54.
2. Guy CT, Cardiff RD, Muller WJ. Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease. Mol Cell Biol 1992;12:954-61.
3. Andrechek ER, Muller WJ. Tyrosine kinase signalling in breast cancer: tyrosine kinase-mediated signal transduction in transgenic mouse models of human breast cancer. Breast Cancer Res 2000;2:211-6.
4. Cheng SH, Harvey R, Espino PC, et al. Peptide antibodies to the human c-fyn gene product demonstrate pp59c-fyn is capable of complex formation with the middle-T antigen of polyomavirus. EMBO J 1988;7:3845-55.
5. Courtneidge SA, Smith AE. The complex of polyoma virus middle-T antigen and pp60c-Src. EMBO J 1984;3:585-91.
6. Webster MA, Cardiff RD, Muller WJ. Induction of mammary epithelial hyperplasias and mammary tumors in transgenic mice expressing a murine mammary tumor virus/activated c-Src fusion gene. Proc Natl Acad Sci USA 1995;92:7849-53.
7. Courtneidge SA, Heber A. An 81 kd protein complexed with middle T antigen and pp60c-Src: a possible phosphatidylinositol kinase. Cell 1987;50:1031-7.
8. Whitman M, Kaplan DR, Schaffhausen B, et al. Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation. Nature (Lond) 1985;315:239-42.
9. Alessi DR, Deak M, Casamayor A, et al. 3-Phosphoinositide-dependent protein kinase-1 (PDK1); structural and functional homology with the Drosophila DSTPK61 kinase. Curr Biol 1997;7:776-89.
10. Kane LP, Shapiro VS, Stokoe D, Weiss A. Induction of NF-kappaB by the Akt/PKB kinase. Curr Biol 1999;9:601-4.
11. Cardone MH, Roy N, Stennicke HR, et al. Regulation of cell death protease caspase-9 by phosphorylation. Science (Wash D C) 1998;282:1318-21.
12. Datta SR, Dudek H, Tao X, et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997;91:231-41.
13. Blaikie PA, Fournier E, Dilworth SM, et al. The role of the Shc phosphotyrosine interaction/phosphotyrosine binding domain and tyrosine phosphorylation sites in polyoma middle T antigen-mediated cell transformation. J Biol Chem 1997;272:20671-7.
14. Campbell KS, Ogris E, Burke B, et al. Polyoma middle tumor antigen interacts with SHC protein via the NPTY (Asn-Pro-Thr-Tyr) motif in middle tumor antigen. Proc Natl Acad Sci USA 1994;91:6344-8.
15. Dilworth SM, Brewster CE, Jones MD, et al. Transformation by polyoma virus middle T-antigen involves the binding and tyrosine phosphorylation of Shc. Nature (Lond) 1994;367:87-90.
16. Srinivas S, Schonthal A, Eckhart W. Polyomavirus middle-sized tumor antigen modulates c-Jun phosphorylation and transcriptional activity. Proc Natl Acad Sci USA 1994;91:10064-8.
17. Lifsted T, Le Voyer T, Williams M, et al. Identification of inbred mouse strains harboring genetic modifiers of mammary tumor age of onset and metastatic progression. Int J Cancer 1998;77:640-4.
18. Eberwine J, Yeh H, Miyashiro K, et al. Analysis of gene expression in single live neurons. Proc Natl Acad Sci USA 1992;89:3010-4.
19. Chandrasekharan S, Qiu TH, Alkharouf N, et al. Characterization of mice deficient in the Src family nonreceptor tyrosine kinase Frk/rak. Mol Cell Biol 2002;22;5235-47.
20. Tusher VG, Tibshirani R, Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA 2001;98:5116-21.
21. Eisen MB, Spellman PT, Brown PO, Botstein D. Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci USA 1998;95:14863-8.
22. Desai KV, Xiao N, Wang W, et al. Initiating oncogenic event determines gene-expression patterns of human breast cancer models. Proc Natl Acad Sci USA 2002;99:6967-72.
23. Hunter K, Welch DR, Liu ET. Genetic background is an important determinant of metastatic potential. Nat Genet 2003;34:23-4.
24. Andrechek ER, Muller WJ. Tyrosine kinase signalling in breast cancer: tyrosine kinase-mediated signal transduction in transgenic mouse models of human breast cancer. Breast Cancer Res 2000;2:211-6.
25. Soltoff SP, Carpenter CL, Auger KR, et al. Phosphatidylinositol-3 kinase and growth regulation. Cold Spring Harb Symp Quant Biol 1992;57:75-80.
26. Webster MA, Hutchinson JN, Rauh MJ, et al. Requirement for both Shc and phosphatidylinositol 3′ kinase signaling pathways in polyomavirus middle T-mediated mammary tumorigenesis. Mol Cell Biol 1998;18:2344-59.
27. Pines J. Cell cycle: reaching for a role for the Cks proteins. Curr Biol 1996;6:1399-402.
28. Spruck C, Strohmaier H, Watson M, et al. A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1. Mol Cell 2001;7:639-50.
29. Ganoth D, Bornstein G, Ko TK, et al. The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27. Nat Cell Biol 2001;3:321-4.
30. Slingerland J, Pagano M. Regulation of the cdk inhibitor p27 and its deregulation in cancer. J Cell Physiol 2000;183:10-7.
31. Pestell KE, Ducruet AP, Wipf P, Lazo JS. Small molecule inhibitors of dual specificity protein phosphatases. Oncogene 2000;19:6607-12.
32. Jinno S, Suto K, Nagata A, et al. Cdc25A is a novel phosphatase functioning early in the cell cycle. EMBO J 1994;13:1549-56.
33. Le Voyer T, Lu Z, Babb J, Lifsted T, Williams M, Hunter K. An epistatic interaction controls the latency of a transgene-induced mammary tumor. Mamm Genome 2000;11:883-9.
34. Cozma D, Lukes L, Rouse J, et al. A bioinformatics-based strategy identifies c-Myc and Cdc25A as candidates for the Apmt mammary tumor latency modifiers. Genome Res 2002;12:969-75.
35. Sazawa A, Watanabe T, Tanaka M, et al. Adenovirus mediated gelsolin gene therapy for orthotopic human bladder cancer in nude mice. J Urol 2002;168:1182-7.
36. Thor AD, Edgerton SM, Liu S, Moore DH, Kwiatkowski DJ. Gelsolin as a negative prognostic factor and effector of motility in erbB-2-positive epidermal growth factor receptor-positive breast cancers. Clin Cancer Res 2001;7:2415-24.
37. Asch HL, Head K, Dong Y, et al. Widespread loss of gelsolin in breast cancers of humans, mice, and rats. Cancer Res 1996;56:4841-5.
38. Winston JS, Asch HL, Zhang PJ, et al. Downregulation of gelsolin correlates with the progression to breast carcinoma. Breast Cancer Res Treat 2001;65:11-21.
39. Vandekerckhove J, Bauw G, Vancompernolle K, Honore B, Celis J. Comparative two-dimensional gel analysis and microsequencing identifies gelsolin as one of the most prominent downregulated markers of transformed human fibroblast and epithelial cells. J Cell Biol 1990;111:95-102.