Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 29, 2007, Pages 12111-12116

  Liu, Xiaoling ^a   Holstege, Henne ^a   Van Der Gulden, Hanneke ^a   Treur Mulder, Marcelle ^a   Zevenhoven, John ^a   Velds, Arno ^a   Kerkhoven, Ron M ^a   Van Vliet, Martin H ^a,b   Wessels, Lodewyk F A ^a,b   Petersen, Johannes L ^a   Berns, Anton ^a   Jonkers, Jos ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b Delft University of Technology ^*  (Netherlands)

Author keywords

Conditional knockout; Mouse models

Indexed keywords

BRCA1 PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; PROTEIN P53;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; CELL DIFFERENTIATION; CELL PROLIFERATION; FEMALE; GENE MUTATION; GENOMIC INSTABILITY; HETEROZYGOSITY LOSS; HISTOPATHOLOGY; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; SOMATIC MUTATION;

ALLELES; ANIMALS; BRCA1 PROTEIN; BREAST NEOPLASMS; CLUSTER ANALYSIS; EPITHELIAL CELLS; FEMALE; GENOMIC INSTABILITY; HUMANS; LOSS OF HETEROZYGOSITY; MAMMARY NEOPLASMS, ANIMAL; MICE; MUTATION; SPECIES SPECIFICITY; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53;

MUS;

EID: 34547496282     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0702969104     Document Type: Article

References (45)

1. Thompson D, Easton DF (2002) J Natl Cancer Inst 94:1358-1365.
2. Wooster R, Weber BL (2003) N Engl J Med 348:2339-2347.
3. Scully R, Livingston DM (2000) Nature 408:429-432.
4. Narod SA, Foulkes WD (2004) Nat Rev Cancer 4:665-676.
5. Venkitaraman AR (2002) Cell 108:171-182.
6. Lakhani SR, Jacquemier J, Sloane JP, Gusterson BA, Anderson TJ, van de Vijver MJ, Farid LM, Venter D, Antoniou A, Storfer-Isser A, et al. (1998) J Natl Cancer Inst 90:1138-1145.
7. Lakhani SR, Reis-Filho JS, Fulford L, Penault-Llorca F, van de Vijver MJ, Parry S, Bishop T, Benitez J, Rivas C, Bignon YJ, et al. (2005) Clin Cancer Res 11:5175-5180.
8. Perou CM, Sorlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, et al. (2000) Nature 406:747-752.
9. Sorlie T, Tibshirani R, Parker J, Hastie T, Marron JS, Nobel A, Deng S, Johnsen H, Pesich R, Geisler S, et al. (2003) Proc Natl Acad Sci USA 100:8418-8423.
10. Turner N, Tutt A, Ashworth A (2004) Nat Rev Cancer 4:814-819.
11. Evers B, Jonkers J (2006) Oncogene 25:5885-5897.
12. Ludwig T, Chapman DL, Papaioannou VE, Efstratiadis A (1997) Genes Dev 11:1226-1241.
13. Hakem R, de la Pompa JL, Sirard C, Mo R, Woo M, Hakem A, Wakeham A, Potter J, Reitmair A, Billia F, et al. (1996) Cell 85:1009-1023.
14. Gowen LC, Johnson BL, Latour AM, Sulik KK, Koller BH (1996) Nat Genet 12:191-194.
15. Ludwig T, Fisher P, Ganesan S, Efstratiadis A (2001) Genes Dev 15:1188-1193.
16. Xu X, Qiao W, Linke SP, Cao L, Li WM, Furth PA, Harris CC, Deng CX (2001) Nat Genet 28:266-271.
17. Brodie SG, Xu X, Qiao W, Li WM, Cao L, Deng CX (2001) Oncogene 20:7514-7523.
18. Xu X, Wagner KU, Larson D, Weaver Z, Li C, Ried T, Hennighausen L, Wynshaw-Boris A, Deng CX (1999) Nat Genet 22:37-43.
19. Mixon M, Kittrell F, Medina D (2000) Oncogene 19:5237-5243.
20. Crook T, Crossland S, Crompton MR, Osin P, Gusterson BA (1997) Lancet 350:638-639.
21. Donehower LA, Harvey M, Slagle BL, McArthur MJ, Montgomery CA, Butel JS, Bradley A (1992) Nature 356:215-221.
22. Jacks T, Remington L, Williams BO, Schmitt EM, Halachmi S, Bronson RT, Weinberg RA (1994) Curr Biol 4:1-7.
23. Purdie CA, Harrison DJ, Peter A, Dobbie L, White S, Howie SE, Salter DM, Bird CC, Wyllie AH, Hooper ML, et al. (1994) Oncogene 9:603-609.
24. Jonkers J, Berns A (2002) Nat Rev Cancer 2:251-265.
25. Jonkers J, Meuwissen R, van der Gulden H, Peterse H, van der Valk M, Berns A (2001) Nat Genet 29:418-425.
26. Pihan G, Doxsey SJ (2003) Cancer Cell 4:89-94.
27. Fukasawa K, Choi T, Kuriyama R, Rulong S, Vande Woude GF (1996) Science 271:1744-1747.
28. Xu X, Weaver Z, Linke SP, Li C, Gotay J, Wang XW, Harris CC, Ried T, Deng CX (1999) Mol Cell 3:389-395.
29. Weng L, Dai H, Zhan Y, He Y, Stepaniants SB, Bassett DE (2006) Bioinformatics 22:1111-1121.
30. Turner NC, Reis-Filho JS, Russell AM, Springall RJ, Ryder K, Steele D, Savage K, Gillett CE, Schmitt FC, Ashworth A, et al. (2007) Oncogene 26:2126-2132.
31. Ribeiro-Silva A, Ramalho LN, Garcia SB, Brandao DF, Chahud F, Zucoloto S (2005) Histopathology 47:458-466.
32. Foulkes WD, Stefansson IM, Chappuis PO, Begin LR, Goffin JR, Wong N, Trudel M, Akslen LA (2003) J Natl Cancer Inst 95:1482-1485.
33. Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, et al. (2005) Proc Natl Acad Sci USA 102:15545-15550.
34. Shackleton M, Vaillant F, Simpson KJ, Stingl J, Smyth GK, Asselin-Labat ML, Wu L, Lindeman GJ, Visvader JE (2006) Nature 439:84-88.
35. Stingl J, Eirew P, Ricketson I, Shackleton M, Vaillant F, Choi D, Li HI, Eaves CJ (2006) Nature 439:993-997.
36. Furuta S, Jiang X, Gu B, Cheng E, Chen PL, Lee WH (2005) Proc Natl Acad Sci USA 102:9176-9181.
37. McPherson JP, Hande MP, Poonepalli A, Lemmers B, Zablocki E, Migon E, Shehabeldin A, Porras A, Karaskova J, Vukovic B, et al. (2006) Hum Mol Genet 15:831-838.
38. Ganesan S, Silver DP, Greenberg RA, Avni D, Drapkin R, Miron A, Mok SC, Randrianarison V, Brodie S, Salstrom J, et al. (2002) Cell 111:393-405.
39. Welcsh PL, Lee MK, Gonzalez-Hernandez RM, Black DJ, Mahadevappa M, Swisher EM, Warrington JA, King MC (2002) Proc Natl Acad Sci USA 99:7560-7565.
40. Rottenberg S, Nygren AOH, Pajic M, van Leeuwen FWB, van der Heijden I, van de Wetering K, Liu X, de Visser KE, Gilhuijs KG, van Tellingen O, et al. (2007) Proc Natl Acad Sci USA 104:12117-12122.
41. Farmer H, McCabe N, Lord CJ, Tutt AN, Johnson DA, Richardson TB, Santarosa M, Dillon KJ, Hickson I, Knights C, et al. (2005) Nature 434:917-921.
42. Bryant HE, Schultz N, Thomas HD, Parker KM, Flower D, Lopez E, Kyle S, Meuth M, Curtin NJ, Helleday T (2005) Nature 434:913-917.
43. Derksen PW, Liu X, Saridin F, van der Gulden H, Zevenhoven J, Evers B, van Beijnum JR, Griffioen AW, Vink J, Krimpenfort P, et al. (2006) Cancer Cell 10:437-449.
44. Chung YJ, Jonkers J, Kitson H, Fiegler H, Humphray S, Scott C, Hunt S, Yu Y, Nishijima I, Velds A, et al. (2004) Genome Res 14:188-196.
45. Tusher VG, Tibshirani R, Chu G (2001) Proc Natl Acad Sci USA 98:5116-5121.