Molecular biology of breast cancer metastasis. Clinical implications of experimental studies on metastatic inefficiency

Breast Cancer Research

Volumn 2, Issue 6, 2000, Pages 400-407

  Chambers, Ann F ^a   Naumov, George N ^a   Vantyghem, Sharon A ^a   Tuck, Alan B ^b  

^a LONDON REGIONAL CANCER PROGRAM   (Canada)

^b LONDON HEALTH SCIENCES CENTRE   (Canada)

Author keywords

In vivo videomicroscopy; Isolated tumour cells; Metastatic inefficiency; Micrometastases; Tumour dormancy

Indexed keywords

ANIMAL CELL; ANIMAL TISSUE; BLOOD; BONE MARROW; BREAST CANCER; CELL ISOLATION; CELL SURVIVAL; CHICK EMBRYO; CLINICAL STUDY; EMBRYO; HUMAN; IN VIVO STUDY; LYMPH NODE; METASTASIS; METASTASIS INHIBITION; MICROSCOPY; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; OUTCOMES RESEARCH; REVIEW; TUMOR CELL;

3T3 CELLS; ANIMALS; BREAST NEOPLASMS; CELL LINE, TRANSFORMED; CELL MOVEMENT; CELL SURVIVAL; CHICK EMBRYO; COMPUTER SYSTEMS; FEMALE; FIBROBLASTS; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; HUMANS; LIVER; LUMINESCENT PROTEINS; LYMPHATIC METASTASIS; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICROSCOPY, VIDEO; MICROSPHERES; NEOPLASM CIRCULATING CELLS; NEOPLASM METASTASIS; NEOPLASM PROTEINS; RATS; TRANSFECTION; TUMOR MARKERS, BIOLOGICAL;

EID: 0034468235     PISSN: 14655411     EISSN: None     Source Type: Journal    
DOI: 10.1186/bcr86     Document Type: Review

References (44)

1. Estimates of the worldwide mortality from 25 cancers in 1990
2. Erratum: Estimates of the worldwide mortality from 25 cancers in 1990
3. Meta-analyses of studies on bone marrow micrometastases: An independent prognostic impact remains to be substantiated
4. Minimal solid tumor involvement of regional and distant sites: When is a metastasis not a metastasis?
5. Metastatic inefficiency
6. Absence of metastatic sequelae during long-term treatment of malignant ascites by peritoneo-venous shunting. A clinico-pathological report
7. Mechanisms of human tumor metastasis studied in patients with peritoneovenous shunts
8. 125 I-5-iodo-2′-deoxyuridine
9. Quantitation of cell shedding into efferent blood of mammary adenocarcinoma
10. Quantitative relationships of intravascular tumor cells, tumor vessels, and pulmonary metastases following tumor implantation
11. Steps in tumor metastasis: New concepts from intravital videomicroscopy
12. In vivo videomicroscopy of experimental hematogenous metastasis: Cancer cell arrest, extravasation and migration
13. Preclinical assessment of anti-cancer therapeutic strategies using in vivo videomicroscopy
14. The metastatic process: Basic research and clinical implications
15. Clinical targets for anti-metastasis therapy
16. Fate of melanoma cells entering the microcirculation: Over 80% survive and extravasate
17. Multistep nature of metastatic inefficiency: Dormancy of solitary cells after successful extravasation, and limited survival of early micrometastases
18. Early interactions of cancer cells with the microvasculature in mouse liver and muscle during hematogenous metastasis: Videomicroscopic analysis
19. Mammary carcinoma cell lines of high and low metastatic potential differ not in extravasation but in subsequent migration and growth
20. Cellular expression of green fluorescent protein, coupled with high-resolution in vivo videomicroscopy, to monitor steps in tumor metastasis
21. Cell motility of tumor cells visualized in living intact primary tumors using green fluorescent protein
22. Primary tumor size-dependent inhibition of angiogenesis at a secondary site: An intravital microscopic study in mice
23. Intravital videomicroscopic evidence for regulation of metastasis by the hepatic microvasculature: Effects of interleukin-1α on metastasis and the location of B16F1 melanoma cell arrest
24. Evidence for the clonal origin of spontaneous metastases
25. R B16F1 murine melanoma cells to assess clonality of experimental metastases in the immune-deficient chick embryo
26. Independence of metastatic ability and extravasation: Metastatic ras-transformed and control fibroblasts extravasate equally well
27. Technical considerations for studying cancer metastasis in vivo
28. Temporal progression of metastasis in lung: Cell survival, dormancy, and location dependence of metastatic inefficiency
29. Molecular biology of breast cancer metastasis: Genetic regulation of human breast carcinoma metastasis
30. Chromosome 17-mediated dormancy of AT6.1 prostate cancer micrometastases
31. Metastasis-suppressed C8161 melanoma cells arrest in lung but fail to proliferate
32. A critical step in metastasis: In vivo analysis of intravasation at the primary tumor
33. Cells shed from tumours show reduced clonogenicity, resistance to apoptosis, and in vivo tumorigenicity
34. Occult metastases in the sentinel lymph nodes of patients with early stage breast carcinoma: A preliminary study
35. Caution concerning micrometastatic breast carcinoma in sentinel lymph nodes
36. Classification of isolated tumor cells and micrometastasis
37. Detection and characterization of carcinoma cells in the blood
38. Detection of intraoperative tumor cell dissemination in patients with breast cancer by use of reverse transcription and polymerase chain reaction
39. Induction of tumour cell shedding into effluent venous blood breast cancer surgery
40. Molecular detection of circulating solid carcinoma cells in the peripheral blood: The concept of early systemic disease
41. Clinical significance of molecular detection of carcinoma cells in lymph nodes and peripheral blood by reverse transcription-polymerase chain reaction in patients with gastro-intestinal or breast carcinomas
42. Tumor cells in venous blood draining mammary carcinomas
43. Lymph node metastases. Indicators, but not governors of survival
44. Breast cancer: A systemic or local disease?