Comparative Oncogenomics Identifies NEDD9 as a Melanoma Metastasis Gene

Cell

Volumn 125, Issue 7, 2006, Pages 1269-1281

  Kim, Minjung ^a   Gans, Joseph D ^a   Nogueira, Cristina ^a,b   Wang, Audrey ^a   Paik, Ji Hye ^a   Feng, Bin ^a   Brennan, Cameron ^c   Hahn, William C ^a,d   Cordon Cardo, Carlos ^c   Wagner, Stephan N ^e   Flotte, Thomas J ^f   Duncan, Lyn M ^f   Granter, Scott R ^g   Chin, Lynda ^a,h  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b University of Porto   (Portugal)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^e Universitatsklinik fur Dermatologie   (Austria)

^f MASSACHUSETTS GENERAL HOSPITAL   (United States)

^g BRIGHAM AND WOMEN S HOSPITAL   (United States)

^h HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; FOCAL ADHESION KINASE; NEDD9 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CANCER GENETICS; CANCER INVASION; CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; COMPARATIVE STUDY; GENE AMPLIFICATION; GENE IDENTIFICATION; GENE OVEREXPRESSION; GENOME; GENOMICS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALIGNANT TRANSFORMATION; MELANOCYTE; MELANOMA; MELANOMA CELL; METASTASIS; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; VALIDATION STUDY;

EID: 33745288277     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cell.2006.06.008     Document Type: Article

References (44)

1. Aguirre A.J., Brennan C., Bailey G., Sinha R., Feng B., Leo C., Zhang Y., Zhang J., Gans J.D., Bardeesy N., et al. High-resolution characterization of the pancreatic adenocarcinoma genome. Proc. Natl. Acad. Sci. USA 101 (2004) 9067-9072
2. Bastian B.C., LeBoit P.E., Hamm H., Brocker E.B., and Pinkel D. Chromosomal gains and losses in primary cutaneous melanomas detected by comparative genomic hybridization. Cancer Res. 58 (1998) 2170-2175
3. Bastian B.C., Olshen A.B., LeBoit P.E., and Pinkel D. Classifying melanocytic tumors based on DNA copy number changes. Am. J. Pathol. 163 (2003) 1765-1770
4. Bernards R., and Weinberg R.A. A progression puzzle. Nature 418 (2002) 823
5. Boukerche H., Su Z.Z., Emdad L., Baril P., Balme B., Thomas L., Randolph A., Valerie K., Sarkar D., and Fisher P.B. mda-9/Syntenin: a positive regulator of melanoma metastasis. Cancer Res. 65 (2005) 10901-10911
6. Brennan C., Zhang Y., Leo C., Feng B., Cauwels C., Aguirre A.J., Kim M., Protopopov A., and Chin L. High-resolution global profiling of genomic alterations with long oligonucleotide microarray. Cancer Res. 64 (2004) 4744-4748
7. Carrasco D.R., Tonon G., Huang Y., Zhang Y., Sinha R., Feng B., Stewart J.P., Zhan F., Khatry D., Protopopova M., et al. High-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients. Cancer Cell 9 (2006) 313-325
8. Chin L. The genetics of malignant melanoma: lessons from mouse and man. Nat. Rev. Cancer 3 (2003) 559-570
9. Chin L., Tam A., Pomerantz J., Wong M., Holash J., Bardeesy N., Shen Q., O'Hagan R., Pantginis J., Zhou H., et al. Essential role for oncogenic Ras in tumour maintenance. Nature 400 (1999) 468-472
10. Chudnovsky Y., Khavari P.A., and Adams A.E. Melanoma genetics and the development of rational therapeutics. J. Clin. Invest. 115 (2005) 813-824
11. Davies H., Bignell G.R., Cox C., Stephens P., Edkins S., Clegg S., Teague J., Woffendin H., Garnett M.J., Bottomley W., et al. Mutations of the BRAF gene in human cancer. Nature 417 (2002) 949-954
12. Disatnik M.H., and Rando T.A. Integrin-mediated muscle cell spreading. The role of protein kinase c in outside-in and inside-out signaling and evidence of integrin cross-talk. J. Biol. Chem. 274 (1999) 32486-32492
13. Fidler I.J. The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Nat. Rev. Cancer 3 (2003) 453-458
14. Garraway L.A., Widlund H.R., Rubin M.A., Getz G., Berger A.J., Ramaswamy S., Beroukhim R., Milner D.A., Granter S.R., Du J., et al. Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. Nature 436 (2005) 117-122
15. Gupta P.B., Kuperwasser C., Brunet J.P., Ramaswamy S., Kuo W.L., Gray J.W., Naber S.P., and Weinberg R.A. The melanocyte differentiation program predisposes to metastasis after neoplastic transformation. Nat. Genet. 37 (2005) 1047-1054
16. Hanahan D., and Weinberg R.A. The hallmarks of cancer. Cell 100 (2000) 57-70
17. Hess A.R., and Hendrix M.J. Focal adhesion kinase signaling and the aggressive melanoma phenotype. Cell Cycle 5 (2006) 478-480
18. Hess A.R., Postovit L.M., Margaryan N.V., Seftor E.A., Schneider G.B., Seftor R.E., Nickoloff B.J., and Hendrix M.J. Focal adhesion kinase promotes the aggressive melanoma phenotype. Cancer Res. 65 (2005) 9851-9860
19. Hoek K., Rimm D.L., Williams K.R., Zhao H., Ariyan S., Lin A., Kluger H.M., Berger A.J., Cheng E., Trombetta E.S., et al. Expression profiling reveals novel pathways in the transformation of melanocytes to melanomas. Cancer Res. 64 (2004) 5270-5282
20. Kinsella T.M., and Nolan G.P. Episomal vectors rapidly and stably produce high-titer recombinant retrovirus. Hum. Gene Ther. 7 (1996) 1405-1413
21. Kumar S., Tomooka Y., and Noda M. Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochem. Biophys. Res. Commun. 185 (1992) 1155-1161
22. Law S.F., Estojak J., Wang B., Mysliwiec T., Kruh G., and Golemis E.A. Human enhancer of filamentation 1, a novel p130cas-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae. Mol. Cell. Biol. 16 (1996) 3327-3337
23. Lillington D.M., Kingston J.E., Coen P.G., Price E., Hungerford J., Domizio P., Young B.D., and Onadim Z. Comparative genomic hybridization of 49 primary retinoblastoma tumors identifies chromosomal regions associated with histopathology, progression, and patient outcome. Genes Chromosomes Cancer 36 (2003) 121-128
24. Lucito R., Healy J., Alexander J., Reiner A., Esposito D., Chi M., Rodgers L., Brady A., Sebat J., Troge J., et al. Representational oligonucleotide microarray analysis: a high-resolution method to detect genome copy number variation. Genome Res. 13 (2003) 2291-2305
25. McLean G.W., Carragher N.O., Avizienyte E., Evans J., Brunton V.G., and Frame M.C. The role of focal-adhesion kinase in cancer - a new therapeutic opportunity. Nat. Rev. Cancer 5 (2005) 505-515
26. Meierjohann S., Wende E., Kraiss A., Wellbrock C., and Schartl M. The oncogenic epidermal growth factor receptor variant Xiphophorus melanoma receptor kinase induces motility in melanocytes by modulation of focal adhesions. Cancer Res. 66 (2006) 3145-3152
27. Minn A.J., Gupta G.P., Siegel P.M., Bos P.D., Shu W., Giri D.D., Viale A., Olshen A.B., Gerald W.L., and Massague J. Genes that mediate breast cancer metastasis to lung. Nature 436 (2005) 518-524
28. Namiki T., Yanagawa S., Izumo T., Ishikawa M., Tachibana M., Kawakami Y., Yokozeki H., Nishioka K., and Kaneko Y. Genomic alterations in primary cutaneous melanomas detected by metaphase comparative genomic hybridization with laser capture or manual microdissection: 6p gains may predict poor outcome. Cancer Genet. Cytogenet. 157 (2005) 1-11
29. O'Hagan R.C., Chang S., Maser R.S., Mohan R., Artandi S.E., Chin L., and DePinho R.A. Telomere dysfunction provokes regional amplification and deletion in cancer genomes. Cancer Cell 2 (2002) 149-155
30. O'Neill G.M., Fashena S.J., and Golemis E.A. Integrin signalling: a new Cas(t) of characters enters the stage. Trends Cell Biol. 10 (2000) 111-119
31. O'Neill G.M., and Golemis E.A. Proteolysis of the docking protein HEF1 and implications for focal adhesion dynamics. Mol. Cell. Biol. 21 (2001) 5094-5108
32. Pugacheva E.N., and Golemis E.A. The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome. Nat. Cell Biol. 7 (2005) 937-946
33. Singh-Gasson S., Green R.D., Yue Y., Nelson C., Blattner F., Sussman M.R., and Cerrina F. Maskless fabrication of light-directed oligonucleotide microarrays using a digital micromirror array. Nat. Biotechnol. 17 (1999) 974-978
34. Stokke T., DeAngelis P., Smedshammer L., Galteland E., Steen H.B., Smeland E.B., Delabie J., and Holte H. Loss of chromosome 11q21-23.1 and 17p and gain of chromosome 6p are independent prognostic indicators in B-cell non-Hodgkin's lymphoma. Br. J. Cancer 85 (2001) 1900-1913
35. Storchova Z., and Pellman D. From polyploidy to aneuploidy, genome instability and cancer. Nat. Rev. Mol. Cell Biol. 5 (2004) 45-54
36. Thompson F., Emerson J., Dalton W., Yang J.M., McGee D., Villar H., Knox S., Massey K., Weinstein R., Bhattacharyya A., et al. Clonal chromosome abnormalities in human breast carcinomas. I. Twenty-eight cases with primary disease. Genes Chromosomes Cancer 7 (1993) 185-193
37. Tonon G., Wong K.K., Maulik G., Brennan C., Feng B., Zhang Y., Khatry D.B., Protopopov A., You M.J., Aguirre A.J., et al. High-resolution genomic profiles of human lung cancer. Proc. Natl. Acad. Sci. USA 102 (2005) 9625-9630
38. Tsao H., Goel V., Wu H., Yang G., and Haluska F.G. Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma. J. Invest. Dermatol. 122 (2004) 337-341
39. van Nimwegen M.J., Verkoeijen S., van Buren L., Burg D., and van de Water B. Requirement for focal adhesion kinase in the early phase of mammary adenocarcinoma lung metastasis formation. Cancer Res. 65 (2005) 4698-4706
40. van Seventer G.A., Salmen H.J., Law S.F., O'Neill G.M., Mullen M.M., Franz A.M., Kanner S.B., Golemis E.A., and van Seventer J.M. Focal adhesion kinase regulates beta1 integrin-dependent T cell migration through an HEF1 effector pathway. Eur. J. Immunol. 31 (2001) 1417-1427
41. Yang J., Mani S.A., Donaher J.L., Ramaswamy S., Itzykson R.A., Come C., Savagner P., Gitelman I., Richardson A., and Weinberg R.A. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 117 (2004) 927-939
42. Zhang X.A., He B., Zhou B., and Liu L. Requirement of the p130CAS-Crk coupling for metastasis suppressor KAI1/CD82-mediated inhibition of cell migration. J. Biol. Chem. 278 (2003) 27319-27328
43. Zhao X., Weir B.A., LaFramboise T., Lin M., Beroukhim R., Garraway L., Beheshti J., Lee J.C., Naoki K., Richards W.G., et al. Homozygous deletions and chromosome amplifications in human lung carcinomas revealed by single nucleotide polymorphism array analysis. Cancer Res. 65 (2005) 5561-5570
44. Zielke H.R., and Littlefield J.W. Repetitive synchronization of human lymphoblast cultures with excess thymidine. Methods Cell Biol. 8 (1974) 107-121