Whole-body sleeping beauty mutagenesis can cause penetrant leukemia/lymphoma and rare high-grade glioma without associated embryonic lethality

Cancer Research

Volumn 69, Issue 21, 2009, Pages 8429-8437

  Collier, Lara S ^a,h   Adams, David J ^b   Hackett, Christopher S ^c   Bendzick, Laura E ^a   Akagi, Keiko ^d,i   Davies, Michael N ^a   Diers, Miechaleen D ^a   Rodriguez, Fausto J ^e   Bender, Aaron M ^e   Tieu, Christina ^e   Matise, Ilze ^a   Dupuy, Adam J ^f   Copeland, Neal G ^g   Jenkins, Nancy A ^g   Hodgson, J Graeme ^c   Weiss, William A ^c   Jenkins, Robert B ^e   Largaespada, David A ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

^e MAYO CLINIC   (United States)

^f UNIVERSITY OF IOWA   (United States)

^g INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^h UNIVERSITY OF WISCONSIN MADISON   (United States)

ⁱ OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSPOSASE;

ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CHROMOSOME DELETION; GENE MUTATION; GENOMIC INSTABILITY; GLIOMA; LEUKEMIA; LYMPHOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SLEEPING BEAUTY GENE; SOMATIC CELL; TRANSPOSON; TUMOR GENE;

ANIMALS; COMPARATIVE GENOMIC HYBRIDIZATION; DNA TRANSPOSABLE ELEMENTS; EMBRYO, MAMMALIAN; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; GENES, LETHAL; GENOMIC INSTABILITY; GLIOMA; IMMUNOENZYME TECHNIQUES; LEUKEMIA; LYMPHOMA; MICE; MICE, TRANSGENIC; MUTAGENESIS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; SURVIVAL RATE; TRANSPOSASES; TUMOR MARKERS, BIOLOGICAL;

EID: 70350537021     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-09-1760     Document Type: Article

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