메뉴 건너뛰기




Volumn 2, Issue 10, 2000, Pages 737-744

Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

Author keywords

[No Author keywords available]

Indexed keywords

3 [(4,5 DIMETHYL 1H PYRROL 2 YL)METHYLENE] 1,3 DIHYDRO 2H INDOL 2 ONE; GELATINASE B; UROKINASE; VASCULOTROPIN; VASCULOTROPIN RECEPTOR;

EID: 0000391746     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/35036374     Document Type: Article
Times cited : (2380)

References (43)
  • 1
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan, D. & Weinberg, R. The hallmarks of cancer. Cell 100, 57-70 (2000).
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.2
  • 2
    • 85013312416 scopus 로고
    • Tumour angiogenesis: Therapeutic implications
    • Folkman, J. Tumour angiogenesis: therapeutic implications. N. Engl. J. Med. 285, 1182-1186 (1971).
    • (1971) N. Engl. J. Med. , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 3
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumourigenesis
    • Hanahan, D. & Folkman, J. Patterns and emerging mechanisms of the angiogenic switch during tumourigenesis. Cell 86, 353-364 (1996).
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 5
    • 0021888904 scopus 로고
    • Heritable formation of pancreatic β-cell tumours in transgenic mice harboring recombinant insulin/simian virus 40 oncogenes
    • Hanahan, D. Heritable formation of pancreatic β-cell tumours in transgenic mice harboring recombinant insulin/simian virus 40 oncogenes. Nature 315, 115-122 (1985).
    • (1985) Nature , vol.315 , pp. 115-122
    • Hanahan, D.1
  • 6
    • 0024549349 scopus 로고
    • Induction of angiogenesis during the transition from hyperplasia to neoplasia
    • Folkman, J., Watson, K., Ingber, D. & Hanahan, D. Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature 339, 58-61 (1989).
    • (1989) Nature , vol.339 , pp. 58-61
    • Folkman, J.1    Watson, K.2    Ingber, D.3    Hanahan, D.4
  • 7
    • 0032889698 scopus 로고    scopus 로고
    • Vascular permeability factor/vascular endothelial growth factor and the significance of microvascular hyperpermeability in angiogenesis
    • Dvorak, H. F., Nagy, J. A., Feng, D., Brown, L. F. & Dvorak, A. M. Vascular permeability factor/vascular endothelial growth factor and the significance of microvascular hyperpermeability in angiogenesis. Curr. Top. Microbiol. Immunol. 237, 97-132 (1999).
    • (1999) Curr. Top. Microbiol. Immunol. , vol.237 , pp. 97-132
    • Dvorak, H.F.1    Nagy, J.A.2    Feng, D.3    Brown, L.F.4    Dvorak, A.M.5
  • 8
    • 0031858958 scopus 로고    scopus 로고
    • Establishing a link between oncogenes and tumour angiogenesis
    • Kerbel, R. S., Viloria-Petit, A., Okada, F. & Rak, J. Establishing a link between oncogenes and tumour angiogenesis. Mol. Med. 4, 286-295 (1998).
    • (1998) Mol. Med. , vol.4 , pp. 286-295
    • Kerbel, R.S.1    Viloria-Petit, A.2    Okada, F.3    Rak, J.4
  • 9
    • 0032891180 scopus 로고    scopus 로고
    • Endothelial cell responses to hypoxic stress
    • Faller, D. V. Endothelial cell responses to hypoxic stress. Clin. Exp. Pharmacol. Physiol. 26, 74-84 (1999).
    • (1999) Clin. Exp. Pharmacol. Physiol. , vol.26 , pp. 74-84
    • Faller, D.V.1
  • 10
    • 0030512608 scopus 로고    scopus 로고
    • Transgenic mouse models of tumour angiogenesis: The angiogenic switch, its molecular controls, and prospects for preclinical therapeutic models
    • Hanahan, D., Christofori, G., Naik, P. & Arbeit, J. Transgenic mouse models of tumour angiogenesis: the angiogenic switch, its molecular controls, and prospects for preclinical therapeutic models. Eur. J. Cancer 32A, 2386-2393 (1996).
    • (1996) Eur. J. Cancer , vol.32 A , pp. 2386-2393
    • Hanahan, D.1    Christofori, G.2    Naik, P.3    Arbeit, J.4
  • 11
    • 0028856096 scopus 로고
    • Vascular endothelial growth factor and its receptors, flt-1 and flk-1, are expressed in normal pancreatic islets and throughout islet cell tumourigenesis
    • Christofori, G., Naik, P. & Hanahan, D. Vascular endothelial growth factor and its receptors, flt-1 and flk-1, are expressed in normal pancreatic islets and throughout islet cell tumourigenesis. Mol. Endocrinol. 9, 1760-1770 (1995).
    • (1995) Mol. Endocrinol. , vol.9 , pp. 1760-1770
    • Christofori, G.1    Naik, P.2    Hanahan, D.3
  • 12
    • 0031045279 scopus 로고    scopus 로고
    • Neovasculature induced by vascular endothelial growth factor is fenestrated
    • Roberts W. G. & Palade, G. E . Neovasculature induced by vascular endothelial growth factor is fenestrated. Cancer Res. 57, 765-72 (1997).
    • (1997) Cancer Res. , vol.57 , pp. 765-772
    • Roberts, W.G.1    Palade, G.E.2
  • 13
    • 0033107767 scopus 로고    scopus 로고
    • Inhibition of tumour growth, angiogenesis, and microcirculation by the novel flk-1 inhibitor SU5416 as assessed by intravital multi-fluorescence videomicroscopy
    • Vajkoczy, P. et al. Inhibition of tumour growth, angiogenesis, and microcirculation by the novel flk-1 inhibitor SU5416 as assessed by intravital multi-fluorescence videomicroscopy. Neoplasia 1, 31-41 (1999).
    • (1999) Neoplasia , vol.1 , pp. 31-41
    • Vajkoczy, P.1
  • 14
    • 0032080427 scopus 로고    scopus 로고
    • Vascular endothelial growth factor as a marker of tumour endothelium
    • Brekken, R. A., Huang, X., King, S. W. & Thorpe, P. E. Vascular endothelial growth factor as a marker of tumour endothelium. Cancer Res. 58, 1952-1959 (1998).
    • (1998) Cancer Res. , vol.58 , pp. 1952-1959
    • Brekken, R.A.1    Huang, X.2    King, S.W.3    Thorpe, P.E.4
  • 15
    • 0030665066 scopus 로고    scopus 로고
    • Intracerebral tumour-associated hemorrhage caused by overexpression of the vascular endothelial growth factor isoforms VEGF121 and VEGF165 but not VEGF189
    • Cheng, S. Y., Nagane, M., Huang, H. S. & Cavenee, W. K. Intracerebral tumour-associated hemorrhage caused by overexpression of the vascular endothelial growth factor isoforms VEGF121 and VEGF165 but not VEGF189. Proc. Natl Acad. Sci. USA 94, 12081-12087 (1997).
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 12081-12087
    • Cheng, S.Y.1    Nagane, M.2    Huang, H.S.3    Cavenee, W.K.4
  • 16
    • 0030004485 scopus 로고    scopus 로고
    • Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
    • Ferrara, N. et al. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 380, 439-442 (1996).
    • (1996) Nature , vol.380 , pp. 439-442
    • Ferrara, N.1
  • 17
    • 0343920277 scopus 로고    scopus 로고
    • Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
    • Carmeliet, P. et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 380, 435-439 (1996).
    • (1996) Nature , vol.380 , pp. 435-439
    • Carmeliet, P.1
  • 18
    • 0032832479 scopus 로고    scopus 로고
    • Regulation of angiostatin production by matrix metalloproteinase-2 in a model of concomitant resistance
    • O'Reilly, M. S., Widerschain, D., Stetler-Stevenson, W. G., Folkman, J. & Moses, M. A. Regulation of angiostatin production by matrix metalloproteinase-2 in a model of concomitant resistance. J. Biol. Chem. 274, 29568-29571 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 29568-29571
    • O'Reilly, M.S.1    Widerschain, D.2    Stetler-Stevenson, W.G.3    Folkman, J.4    Moses, M.A.5
  • 19
    • 0030484843 scopus 로고    scopus 로고
    • Experimental and clinical studies on the use of matrix metalloprotease inhibitors for the treatment of cancer
    • Talbot, D. C. & Brown, P. D. Experimental and clinical studies on the use of matrix metalloprotease inhibitors for the treatment of cancer. Eur. J. Cancer 32A, 2528-2533. (1996).
    • (1996) Eur. J. Cancer , vol.32 A , pp. 2528-2533
    • Talbot, D.C.1    Brown, P.D.2
  • 21
    • 0028856897 scopus 로고
    • Synthesis and structure-activity relationships of gelatinase inhibitors derived from matlystatins
    • Tamaki, K. et al. Synthesis and structure-activity relationships of gelatinase inhibitors derived from matlystatins. Chem. Pharmaceut. Bull 43, 1883-1893 (1995).
    • (1995) Chem. Pharmaceut. Bull , vol.43 , pp. 1883-1893
    • Tamaki, K.1
  • 22
    • 0033617532 scopus 로고    scopus 로고
    • Differential effects of angiogenesis inhibitors on distinct stages of carcinogenesis
    • Bergers, G., Javaherian, K., Lo, K-M., Folkman, J. & Hanahan, D. Differential effects of angiogenesis inhibitors on distinct stages of carcinogenesis. Science 284, 808-812 (1999).
    • (1999) Science , vol.284 , pp. 808-812
    • Bergers, G.1    Javaherian, K.2    Lo, K.-M.3    Folkman, J.4    Hanahan, D.5
  • 23
    • 0346963598 scopus 로고    scopus 로고
    • MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes
    • Vu, T.H. et al. MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. Cell 93, 411-422 (1998).
    • (1998) Cell , vol.93 , pp. 411-422
    • Vu, T.H.1
  • 24
    • 0030884231 scopus 로고    scopus 로고
    • Unaltered secretion of beta-amyloid precursor protein in gelatinase A (matrix metalloprotease 2)-deficient mice
    • Itoh, T. et al. Unaltered secretion of beta-amyloid precursor protein in gelatinase A (matrix metalloprotease 2)-deficient mice. J. Biol. Chem. 272, 22389-22392 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 22389-22392
    • Itoh, T.1
  • 25
    • 0032031861 scopus 로고    scopus 로고
    • Reduced angiogenesis and tumour progression in gelatinase A-deficient mice
    • Itoh, T. et al. Reduced angiogenesis and tumour progression in gelatinase A-deficient mice. Cancer Res. 58, 1048-1051 (1998).
    • (1998) Cancer Res. , vol.58 , pp. 1048-1051
    • Itoh, T.1
  • 26
    • 16944363984 scopus 로고    scopus 로고
    • Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation
    • Carmeliet, P. et al. Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation. Nature Gen. 17, 439-444 (1997).
    • (1997) Nature Gen. , vol.17 , pp. 439-444
    • Carmeliet, P.1
  • 27
    • 0025013701 scopus 로고
    • Extracellular matrix-resident growth factors and enzymes: Possible involvement in tumour metastasis and angiogenesis
    • Vlodavsky, I et al. Extracellular matrix-resident growth factors and enzymes: possible involvement in tumour metastasis and angiogenesis. Cancer Metastasis Rev., 9, 203-226 (1990).
    • (1990) Cancer Metastasis Rev. , vol.9 , pp. 203-226
    • Vlodavsky, I.1
  • 28
    • 0033028789 scopus 로고    scopus 로고
    • Cloning of mammalian heparanase, an important enzyme in tumour invasion and metastasis
    • Hulett, M. D. et al. Cloning of mammalian heparanase, an important enzyme in tumour invasion and metastasis. Nature Med. 7, 803-809 (1999).
    • (1999) Nature Med. , vol.7 , pp. 803-809
    • Hulett, M.D.1
  • 29
    • 0033057962 scopus 로고    scopus 로고
    • Mammalian heparanase: Gene cloning, expression and function in tumour progression and metastasis
    • Vlodavsky, I. et al. Mammalian heparanase: gene cloning, expression and function in tumour progression and metastasis. Nature Med. 7, 793-802 (1999).
    • (1999) Nature Med. , vol.7 , pp. 793-802
    • Vlodavsky, I.1
  • 30
    • 0033151608 scopus 로고    scopus 로고
    • Inflammatory mast cells upregulate angiogenesis during squamous epithelial carcinogenesis
    • Coussens, L. M. et al. Inflammatory mast cells upregulate angiogenesis during squamous epithelial carcinogenesis. Genes Dev. 13, 1382-1397 (1999).
    • (1999) Genes Dev. , vol.13 , pp. 1382-1397
    • Coussens, L.M.1
  • 31
    • 0033027858 scopus 로고    scopus 로고
    • VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation
    • Gerber, H-P. et al. VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nature Med. 5, 623-628 (1999).
    • (1999) Nature Med. , vol.5 , pp. 623-628
    • Gerber, H.-P.1
  • 32
    • 85046526104 scopus 로고    scopus 로고
    • MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis
    • in the press
    • Coussens, L. M., Tinkle, C. L., Hanahan, D. & Werb, Z. MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis. Cell (in the press).
    • Cell
    • Coussens, L.M.1    Tinkle, C.L.2    Hanahan, D.3    Werb, Z.4
  • 33
    • 0032836427 scopus 로고    scopus 로고
    • Measurement of matrix metalloprotease and tissue inhibitors of metalloproteinases in blood and tissues. Clinical and experimental applications
    • Zucker, S. et al. Measurement of matrix metalloprotease and tissue inhibitors of metalloproteinases in blood and tissues. Clinical and experimental applications. Ann. NY Acad. Sci. 878, 212-227 (1999).
    • (1999) Ann. NY Acad. Sci. , vol.878 , pp. 212-227
    • Zucker, S.1
  • 34
    • 0034635995 scopus 로고    scopus 로고
    • Matrix metalloproteinase-2 is required for the switch to the angiogenic phenotype in a tumour model
    • Fang, J. et al. Matrix metalloproteinase-2 is required for the switch to the angiogenic phenotype in a tumour model. Proc, Natl Acad. Sci. USA 97, 3884-3889 (2000).
    • (2000) Proc, Natl Acad. Sci. USA , vol.97 , pp. 3884-3889
    • Fang, J.1
  • 35
    • 0034635966 scopus 로고    scopus 로고
    • Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I
    • Zhou, Z. et al. Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I. Proc. Natl Acad. Sci. USA 97, 4052-1057 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 4052-11057
    • Zhou, Z.1
  • 36
    • 0034650486 scopus 로고    scopus 로고
    • Cell surface-localized metalloproteinase-9 proteolyically activates TGF-beta and promotes tumour invasion and angiogenesis
    • Yu, Q. & Stamenkovic, I. Cell surface-localized metalloproteinase-9 proteolyically activates TGF-beta and promotes tumour invasion and angiogenesis. Genes Dev. 14, 163-176 (2000).
    • (2000) Genes Dev. , vol.14 , pp. 163-176
    • Yu, Q.1    Stamenkovic, I.2
  • 37
    • 0032510494 scopus 로고    scopus 로고
    • A causal role for E-cadherin in the transition from adenoma to carcinoma
    • Perl, A. K. et al. A causal role for E-cadherin in the transition from adenoma to carcinoma. Nature 392, 190-193 (1998).
    • (1998) Nature , vol.392 , pp. 190-193
    • Perl, A.K.1
  • 38
    • 0026599715 scopus 로고
    • Metalloproteinases mediate extracellular matrix degradation by cells from mouse blastocyst outgrowths
    • Behrendtsen, O., Alexander, C. M. & Werb, Z. Metalloproteinases mediate extracellular matrix degradation by cells from mouse blastocyst outgrowths. Development 114, 447-456 (1992).
    • (1992) Development , vol.114 , pp. 447-456
    • Behrendtsen, O.1    Alexander, C.M.2    Werb, Z.3
  • 39
    • 0029833679 scopus 로고    scopus 로고
    • The rise and fall of apoptosis during multistage tumourigenesis: Downmodulation contributes to progression from angiogenic progenitors
    • Naik, R, Karrim, J. & Hanahan, D. The rise and fall of apoptosis during multistage tumourigenesis: downmodulation contributes to progression from angiogenic progenitors. Genes Dev. 10, 2105-2116 (1996).
    • (1996) Genes Dev. , vol.10 , pp. 2105-2116
    • Naik, R.1    Karrim, J.2    Hanahan, D.3
  • 40
    • 0023035995 scopus 로고
    • Secretion of metalloproteinases by stimulated capillary endothelial cells. I. Production of procollagenases and prostromelysin exceeds expression of proteolytic activity
    • Herron, G. S., Werb, Z., Dwyer, K. & Banda, M. J. Secretion of metalloproteinases by stimulated capillary endothelial cells. I. Production of procollagenases and prostromelysin exceeds expression of proteolytic activity. J. Biol. Chem. 261, 2810-2813 (1986).
    • (1986) J. Biol. Chem. , vol.261 , pp. 2810-2813
    • Herron, G.S.1    Werb, Z.2    Dwyer, K.3    Banda, M.J.4
  • 41
    • 0022979424 scopus 로고
    • Secretion of metalloproteinases by stimulated capillary endothelial cells. II. Expression of collagenase and stromelysin activities is regulated by endogenous inhibitors
    • Herron, G. S., Banda, M. J., Clark, E. J., Gavrilovic, J. & Werb, Z. Secretion of metalloproteinases by stimulated capillary endothelial cells. II. Expression of collagenase and stromelysin activities is regulated by endogenous inhibitors. J. Biol. Chem. 261, 2814-2818 (1986).
    • (1986) J. Biol. Chem. , vol.261 , pp. 2814-2818
    • Herron, G.S.1    Banda, M.J.2    Clark, E.J.3    Gavrilovic, J.4    Werb, Z.5
  • 42
    • 0025804851 scopus 로고
    • Proteinases of the mammary gland: Developmental regulation in vivo and vectorial secretion in culture
    • Talhouk, R. S., Chin, J. R., Unemori, E. N., Werb, Z. & Bissell, M. J. Proteinases of the mammary gland: developmental regulation in vivo and vectorial secretion in culture. Development 112, 439-449 (1991).
    • (1991) Development , vol.112 , pp. 439-449
    • Talhouk, R.S.1    Chin, J.R.2    Unemori, E.N.3    Werb, Z.4    Bissell, M.J.5
  • 43
    • 0028818712 scopus 로고
    • Tumour suppressor loci on mouse chromosomes 9 and 16 are lost at distinct stages of tumourigenesis in a transgenic model of islet cell carcinoma
    • Parangi, S., Dietrich, W., Christofori, G., Lander, E. S. & Hanahan, D. Tumour suppressor loci on mouse chromosomes 9 and 16 are lost at distinct stages of tumourigenesis in a transgenic model of islet cell carcinoma. Cancer Res. 55, 6071-6076 (1995).
    • (1995) Cancer Res. , vol.55 , pp. 6071-6076
    • Parangi, S.1    Dietrich, W.2    Christofori, G.3    Lander, E.S.4    Hanahan, D.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.