The mighty mouse: Genetically engineered mouse models in cancer drug development

Nature Reviews Drug Discovery

Volumn 5, Issue 9, 2006, Pages 741-754

  Sharpless, Norman E ^a   DePinho, Ronald A ^b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b Belfer Institute for Innovative Cancer Science   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ANGIOGENESIS INHIBITOR; ANGIOSTATIN; ANTINEOPLASTIC AGENT; AVASTATIN; AZACITIDINE; BEVACIZUMAB; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR; DNA METHYLTRANSFERASE INHIBITOR; ENDOSTATIN; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; FLAVOPIRIDOL; GEFITINIB; IMATINIB; MATRIX METALLOPROTEINASE INHIBITOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PLATELET DERIVED GROWTH FACTOR RECEPTOR INHIBITOR; PROSTAGLANDIN INHIBITOR; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR; RAPAMYCIN; RAPAMYCIN DERIVATIVE; RECEPTOR BLOCKING AGENT; RETINOBLASTOMA PROTEIN; TAMOXIFEN; TROGLITAZONE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN INHIBITOR;

ANIMAL MODEL; CANCER GENETICS; CANCER MODEL; CANCER RESEARCH; COLON CANCER; DIABETES MELLITUS; DRUG MECHANISM; DRUG RESEARCH; DRUG RESPONSE; GASTROINTESTINAL TOXICITY; GENE ACTIVATION; GENETIC CODE; GENETIC ENGINEERING; HUMAN; LUNG CANCER; LYMPHOMA; MOUSE; NONHUMAN; NUDE MOUSE; PANCREAS CANCER; PHARMACODYNAMICS; PRIORITY JOURNAL; REVIEW; SCID MOUSE; SKIN TOXICITY; TRANSGENIC ANIMAL; TUMOR SUPPRESSOR GENE; TUMOR XENOGRAFT; VALIDATION PROCESS; XENOTRANSPLANTATION;

ANIMALS; ANTINEOPLASTIC AGENTS; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MICE; MICE, TRANSGENIC; NEOPLASMS, EXPERIMENTAL; REPRODUCIBILITY OF RESULTS;

EID: 33748331308     PISSN: 14741776     EISSN: 14741784     Source Type: Journal    
DOI: 10.1038/nrd2110     Document Type: Review

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