-
1
-
-
34547663507
-
Cell motility and cytoskeletal regulation in invasion and metastasis
-
DOI 10.1007/s10911-007-9046-4
-
Kedrin D, van Rheenen J, Hernandez L, Condeelis J, Segall JE. Cell motility and cytoskeletal regulation in invasion and metastasis. J Mammary Gland Biol Neoplasia. 2007;12:143-152 (Pubitemid 47215432)
-
(2007)
Journal of Mammary Gland Biology and Neoplasia
, vol.12
, Issue.2-3
, pp. 143-152
-
-
Kedrin, D.1
Van Rheenen, J.2
Hernandez, L.3
Condeelis, J.4
Segall, J.E.5
-
3
-
-
56049111865
-
Drug development against metastasisrelated genes and their pathways: A rationale for cancer therapy
-
Iiizumi M, Liu W, Pai SK, Furuta E, Watabe K. Drug development against metastasisrelated genes and their pathways: a rationale for cancer therapy. Biochim Biophys Acta. 2008;1786:87-104.
-
(2008)
Biochim Biophys Acta
, vol.1786
, pp. 87-104
-
-
Iiizumi, M.1
Liu, W.2
Pai, S.K.3
Furuta, E.4
Watabe, K.5
-
4
-
-
0033952145
-
The biology of cell locomotion within three-dimensional extracellular matrix
-
Friedl P, Brocker EB. The biology of cell locomotion within three-dimensional extracellular matrix. Cell Mol Life Sci. 2000;57:41-64.
-
(2000)
Cell Mol Life Sci
, vol.57
, pp. 41-64
-
-
Friedl, P.1
Brocker, E.B.2
-
5
-
-
0030045346
-
Cell migration: A physically integrated molecular process
-
Lauffenburger DA, Horwitz AF. Cell migration: a physically integrated molecular process. Cell. 1996;84:359-369
-
(1996)
Cell
, vol.84
, pp. 359-369
-
-
Lauffenburger, D.A.1
Horwitz, A.F.2
-
6
-
-
0344305784
-
Cell migration: Integrating signals from front to back
-
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR. Cell migration: integrating signals from front to back. Science. 2003; 302:1704-1709
-
(2003)
Science
, vol.302
, pp. 1704-1709
-
-
Ridley, A.J.1
Schwartz, M.A.2
Burridge, K.3
Firtel, R.A.4
Ginsberg, M.H.5
Borisy, G.6
Parsons, J.T.7
Horwitz, A.R.8
-
7
-
-
0030049170
-
Actin-based cell motility and cell locomotion
-
Mitchison TJ, Cramer LP. Actin-based cell motility and cell locomotion. Cell. 1996; 84:371-379
-
(1996)
Cell
, vol.84
, pp. 371-379
-
-
Mitchison, T.J.1
Cramer, L.P.2
-
8
-
-
0038049137
-
Tumour-cell invasion and migration: Diversity and escape mechanisms
-
Friedl P, Wolf K. Tumour-cell invasion and migration: diversity and escape mechanisms. Nat Rev Cancer. 2003;3:362-374
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 362-374
-
-
Friedl, P.1
Wolf, K.2
-
10
-
-
0037459075
-
Cellular motility driven by assembly and disassembly of actin fi laments
-
Pollard TD, Borisy GG. Cellular motility driven by assembly and disassembly of actin fi laments. Cell. 2003;112:453-465
-
(2003)
Cell
, vol.112
, pp. 453-465
-
-
Pollard, T.D.1
Borisy, G.G.2
-
11
-
-
2442459672
-
Role of the p70(S6K) pathway in regulating the actin cytoskeleton and cell migration
-
Berven LA, Willard FS, Crouch MF. Role of the p70(S6K) pathway in regulating the actin cytoskeleton and cell migration. Exp Cell Res. 2004;296:183-195
-
(2004)
Exp Cell Res
, vol.296
, pp. 183-195
-
-
Berven, L.A.1
Willard, F.S.2
Crouch, M.F.3
-
12
-
-
0016713286
-
Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization
-
Sehgal SN, Baker H, Vezina C. Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization. J Antibiot (Tokyo). 1975;28:727-732
-
(1975)
J Antibiot (Tokyo)
, vol.28
, pp. 727-732
-
-
Sehgal, S.N.1
Baker, H.2
Vezina, C.3
-
13
-
-
0016724057
-
Rapamycin (AY-22, 989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle
-
Vezina C, Kudelski A, Sehgal SN. Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle. J Antibiot (Tokyo). 1975;28:721-726
-
(1975)
J Antibiot (Tokyo)
, vol.28
, pp. 721-726
-
-
Vezina, C.1
Kudelski, A.2
Sehgal, S.N.3
-
14
-
-
0019870366
-
New antitumor substances of natural origin
-
Douros J, Suffness M. New antitumor substances of natural origin. Cancer Treat Rev. 1981;8:63-87.
-
(1981)
Cancer Treat Rev
, vol.8
, pp. 63-87
-
-
Douros, J.1
Suffness, M.2
-
15
-
-
0021164348
-
Activity of rapamycin (AY-22, 989) against transplanted tumors
-
Eng CP, Sehgal SN, Vezina C. Activity of rapamycin (AY-22,989) against transplanted tumors. J Antibiot (Tokyo). 1984;37:1231-1237
-
(1984)
J Antibiot (Tokyo)
, vol.37
, pp. 1231-1237
-
-
Eng, C.P.1
Sehgal, S.N.2
Vezina, C.3
-
16
-
-
10744227656
-
Simultaneous pancreas-kidney transplantation initial experience
-
Linhares MM, Gonzalez AM, Trivino T, Melaragno C, Moura RM, Garcez MH, Sa JR, Aguiar WF, Succi T, Barbosa CS, Pestana JO. Simultaneous pancreas-kidney transplantation initial experience. Transplant Proc. 2003;35:1109.
-
(2003)
Transplant Proc
, vol.35
, pp. 1109
-
-
Linhares, M.M.1
Gonzalez, A.M.2
Trivino, T.3
Melaragno, C.4
Moura, R.M.5
Garcez, M.H.6
Sa, J.R.7
Aguiar, W.F.8
Succi, T.9
Barbosa, C.S.10
Pestana, J.O.11
-
17
-
-
0035694808
-
Resistance to rapamycin: A novel anticancer drug
-
Huang S, Houghton PJ. Resistance to rapamycin: a novel anticancer drug. Cancer Metastasis Rev. 2001;20:69-78.
-
(2001)
Cancer Metastasis Rev
, vol.20
, pp. 69-78
-
-
Huang, S.1
Houghton, P.J.2
-
18
-
-
0028328655
-
Rapamycin selectively inhibits the growth of childhood rhabdomyosarcoma cells through inhibition of signaling via the type i insulin-like growth factor receptor
-
Dilling MB, Dias P, Shapiro DN, Germain GS, Johnson RK, Houghton PJ. Rapamycin selectively inhibits the growth of childhood rhabdomyosarcoma cells through inhibition of signaling via the type I insulin-like growth factor receptor. Cancer Res. 1994;54:903-907
-
(1994)
Cancer Res
, vol.54
, pp. 903-907
-
-
Dilling, M.B.1
Dias, P.2
Shapiro, D.N.3
Germain, G.S.4
Johnson, R.K.5
Houghton, P.J.6
-
19
-
-
0033557578
-
Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells
-
Hosoi H, Dilling MB, Shikata T, Liu LN, Shu L, Ashmun RA, Germain GS, Abraham RT, Houghton PJ. Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells. Cancer Res. 1999;59: 886-894
-
(1999)
Cancer Res
, vol.59
, pp. 886-894
-
-
Hosoi, H.1
Dilling, M.B.2
Shikata, T.3
Liu, L.N.4
Shu, L.5
Ashmun, R.A.6
Germain, G.S.7
Abraham, R.T.8
Houghton, P.J.9
-
20
-
-
0035866358
-
Antitumor activity of the rapamycin analog CCI-779 in human primitive neuroectodermal tumor/medulloblastoma models as single agent and in combination chemotherapy
-
Geoerger B, Kerr K, Tang CB, Fung KM, Powell B, Sutton LN, Phillips PC, Janss AJ. Antitumor activity of the rapamycin analog CCI-779 in human primitive neuroectodermal tumor/medulloblastoma models as single agent and in combination chemotherapy. Cancer Res. 2001;61:1527-1532
-
(2001)
Cancer Res
, vol.61
, pp. 1527-1532
-
-
Geoerger, B.1
Kerr, K.2
Tang, C.B.3
Fung, K.M.4
Powell, B.5
Sutton, L.N.6
Phillips, P.C.7
Janss, A.J.8
-
21
-
-
0029794614
-
Rapamycin inhibits constitutive p70s6k phosphorylation, cell proliferation, and colony formation in small cell lung cancer cells
-
Seufferlein T, Rozengurt E. Rapamycin inhibits constitutive p70s6k phosphorylation, cell proliferation, and colony formation in small cell lung cancer cells. Cancer Res. 1996;56:3895-3897
-
(1996)
Cancer Res
, vol.56
, pp. 3895-3897
-
-
Seufferlein, T.1
Rozengurt, E.2
-
22
-
-
0032504527
-
Osteoblastic differentiation is enhanced by rapamycin in rat osteoblast-like osteosarcoma (ROS 17/2.8) cells
-
Ogawa T, Tokuda M, Tomizawa K, Matsui H, Itano T, Konishi R, Nagahata S, Hatase O. Osteoblastic differentiation is enhanced by rapamycin in rat osteoblast-like osteosarcoma (ROS 17/2.8) cells. Biochem Biophys Res Commun. 1998;249:226-230
-
(1998)
Biochem Biophys Res Commun
, vol.249
, pp. 226-230
-
-
Ogawa, T.1
Tokuda, M.2
Tomizawa, K.3
Matsui, H.4
Itano, T.5
Konishi, R.6
Nagahata, S.7
Hatase, O.8
-
23
-
-
0033178702
-
Regulation of cell growth and cyclin D1 expression by the constitutively active FRAP-p70s6K pathway in human pancreatic cancer cells
-
Grewe M, Gansauge F, Schmid RM, Adler G, Seufferlein T. Regulation of cell growth and cyclin D1 expression by the constitutively active FRAP-p70s6K pathway in human pancreatic cancer cells. Cancer Res. 1999;59:3581-3587
-
(1999)
Cancer Res
, vol.59
, pp. 3581-3587
-
-
Grewe, M.1
Gansauge, F.2
Schmid, R.M.3
Adler, G.4
Seufferlein, T.5
-
24
-
-
0035193323
-
Estrogen and rapamycin effects on cell cycle progression in T47D breast cancer cells
-
Pang H, Faber LE. Estrogen and rapamycin effects on cell cycle progression in T47D breast cancer cells. Breast Cancer Res Treat. 2001;70:21-26
-
(2001)
Breast Cancer Res Treat
, vol.70
, pp. 21-26
-
-
Pang, H.1
Faber, L.E.2
-
26
-
-
0029086748
-
Rapamycin, a potent immunosuppressive drug, causes programmed cell death in B lymphoma cells
-
Muthukkumar S, Ramesh TM, Bondada S. Rapamycin, a potent immunosuppressive drug, causes programmed cell death in B lymphoma cells. Transplantation. 1995; 60:264-270
-
(1995)
Transplantation
, vol.60
, pp. 264-270
-
-
Muthukkumar, S.1
Ramesh, T.M.2
Bondada, S.3
-
27
-
-
0029775645
-
Inhibition of the phosphatidylinositol 3-kinase/p70(S6)-kinase pathway induces B16 melanoma cell differentiation
-
Busca R, Bertolotto C, Ortonne JP, Ballotti R. Inhibition of the phosphatidylinositol 3-kinase/p70(S6)-kinase pathway induces B16 melanoma cell differentiation. J Biol Chem. 1996;271:31824-31830
-
(1996)
J Biol Chem
, vol.271
, pp. 31824-31830
-
-
Busca, R.1
Bertolotto, C.2
Ortonne, J.P.3
Ballotti, R.4
-
28
-
-
51449096670
-
A phase 2 clinical trial of deforolimus (AP23573, MK-8669), a novel mammalian target of rapamycin inhibitor, in patients with relapsed or refractory hematologic malignancies
-
Rizzieri DA, Feldman E, Dipersio JF, Gabrail N, Stock W, Strair R, Rivera VM, Albitar M, Bedrosian CL, Giles FJ. A phase 2 clinical trial of deforolimus (AP23573, MK-8669), a novel mammalian target of rapamycin inhibitor, in patients with relapsed or refractory hematologic malignancies. Clin Cancer Res. 2008;14:2756-2762
-
(2008)
Clin Cancer Res
, vol.14
, pp. 2756-2762
-
-
Rizzieri, D.A.1
Feldman, E.2
Dipersio, J.F.3
Gabrail, N.4
Stock, W.5
Strair, R.6
Rivera, V.M.7
Albitar, M.8
Bedrosian, C.L.9
Giles, F.J.10
-
29
-
-
0038803927
-
Effects of cyclosporine A and a rapamycin derivative (SAR943) on chronic allergic infl ammation in sensitized rats
-
Eynott PR, Salmon M, Huang TJ, Oates T, Nicklin PL, Chung KF. Effects of cyclosporine A and a rapamycin derivative (SAR943) on chronic allergic infl ammation in sensitized rats. Immunology. 2003;109:461-467
-
(2003)
Immunology
, vol.109
, pp. 461-467
-
-
Eynott, P.R.1
Salmon, M.2
Huang, T.J.3
Oates, T.4
Nicklin, P.L.5
Chung, K.F.6
-
30
-
-
34247620312
-
Percutaneous coronary revascularization using a trilayer metal phosphorylcholinecoated zotarolimus-eluting stent
-
Abizaid A, Lansky AJ, Fitzgerald PJ, Tanajura LF, Feres F, Staico R, Mattos L, Abizaid A, Chaves A, Centemero M, Sousa AG, Sousa JE, Zaugg MJ, Schwartz LB. Percutaneous coronary revascularization using a trilayer metal phosphorylcholinecoated zotarolimus-eluting stent. Am J Cardiol. 2007;99:1403-1408
-
(2007)
Am J Cardiol
, vol.99
, pp. 1403-1408
-
-
Abizaid, A.1
Lansky, A.J.2
Fitzgerald, P.J.3
Tanajura, L.F.4
Feres, F.5
Staico, R.6
Mattos, L.7
Abizaid, A.8
Chaves, A.9
Centemero, M.10
Sousa, A.G.11
Sousa, J.E.12
Zaugg, M.J.13
Schwartz, L.B.14
-
31
-
-
0026092585
-
Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerase related to human FK506-binding protein
-
Koltin Y, Faucette L, Bergsma DJ, Levy MA, Cafferkey R, Koser PL, Johnson RK, Livi GP. Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerase related to human FK506-binding protein. Mol Cell Biol. 1991;11:1718-1723
-
(1991)
Mol Cell Biol
, vol.11
, pp. 1718-1723
-
-
Koltin, Y.1
Faucette, L.2
Bergsma, D.J.3
Levy, M.A.4
Cafferkey, R.5
Koser, P.L.6
Johnson, R.K.7
Livi, G.P.8
-
32
-
-
0025776523
-
Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast
-
Heitman J, Movva NR, Hall MN. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science. 1991;253: 905-909
-
(1991)
Science
, vol.253
, pp. 905-909
-
-
Heitman, J.1
Movva, N.R.2
Hall, M.N.3
-
33
-
-
0027382875
-
Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity
-
Cafferkey R, Young PR, McLaughlin MM, Bergsma DJ, Koltin Y, Sathe GM, Faucette L, Eng WK, Johnson RK, Livi GP. Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity. Mol Cell Biol. 1993;13:6012-6023
-
(1993)
Mol Cell Biol
, vol.13
, pp. 6012-6023
-
-
Cafferkey, R.1
Young, P.R.2
McLaughlin, M.M.3
Bergsma, D.J.4
Koltin, Y.5
Sathe, G.M.6
Faucette, L.7
Eng, W.K.8
Johnson, R.K.9
Livi, G.P.10
-
34
-
-
0027274978
-
FK506 and rapamycin: More than just immunosuppression
-
Kunz J, Hall MN. Cyclosporin A, FK506 and rapamycin: more than just immunosuppression. Trends Biochem Sci. 1993;18:334-338
-
(1993)
Trends Biochem Sci
, vol.18
, pp. 334-338
-
-
Kunz, J.1
Hall, M.N.2
Cyclosporin, A.3
-
35
-
-
0028137771
-
TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast
-
Helliwell SB, Wagner P, Kunz J, Deuter-Reinhard M, Henriquez R, Hall MN. TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast. Mol Biol Cell. 1994;5:105-118
-
(1994)
Mol Biol Cell
, vol.5
, pp. 105-118
-
-
Helliwell, S.B.1
Wagner, P.2
Kunz, J.3
Deuter-Reinhard, M.4
Henriquez, R.5
Hall, M.N.6
-
36
-
-
0029055145
-
Identification of an 11-kDa FKBP12- rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue
-
Chen J, Zheng XF, Brown EJ, Schreiber SL. Identification of an 11-kDa FKBP12- rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue. Proc Natl Acad Sci U S A. 1995;92:4947-4951
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 4947-4951
-
-
Chen, J.1
Zheng, X.F.2
Brown, E.J.3
Schreiber, S.L.4
-
37
-
-
0029842109
-
Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP
-
Choi J, Chen J, Schreiber SL, Clardy J. Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP. Science. 1996;273:239-242
-
(1996)
Science
, vol.273
, pp. 239-242
-
-
Choi, J.1
Chen, J.2
Schreiber, S.L.3
Clardy, J.4
-
38
-
-
0027311858
-
Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression
-
Kunz J, Henriquez R, Schneider U, Deuter- Reinhard M, Movva NR, Hall MN. Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression. Cell. 1993;73:585-596
-
(1993)
Cell
, vol.73
, pp. 585-596
-
-
Kunz, J.1
Henriquez, R.2
Schneider, U.3
Deuter- Reinhard, M.4
Movva, N.R.5
Hall, M.N.6
-
39
-
-
0030045693
-
The TOR signalling pathway and growth control in yeast
-
Hall MN. The TOR signalling pathway and growth control in yeast. Biochem Soc Trans. 1996;24:234-239
-
(1996)
Biochem Soc Trans
, vol.24
, pp. 234-239
-
-
Hall, M.N.1
-
40
-
-
0029071264
-
TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin
-
Zheng XF, Florentino D, Chen J, Crabtree GR, Schreiber SL. TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin. Cell. 1995;82:121-130
-
(1995)
Cell
, vol.82
, pp. 121-130
-
-
Zheng, X.F.1
Florentino, D.2
Chen, J.3
Crabtree, G.R.4
Schreiber, S.L.5
-
41
-
-
0030479340
-
TOR2 is required for organization of the actin cytoskeleton in yeast
-
Schmidt A, Kunz J, Hall MN. TOR2 is required for organization of the actin cytoskeleton in yeast. Proc Natl Acad Sci U S A. 1996;93:13780-13785
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 13780-13785
-
-
Schmidt, A.1
Kunz, J.2
Hall, M.N.3
-
42
-
-
0028360374
-
A mammalian protein targeted by G1-arresting rapamycin-receptor complex
-
Brown EJ, Albers MW, Shin TB, Ichikawa K, Keith CT, Lane WS, Schreiber SL. A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature. 1994; 369:756-758
-
(1994)
Nature
, vol.369
, pp. 756-758
-
-
Brown, E.J.1
Albers, M.W.2
Shin, T.B.3
Ichikawa, K.4
Keith, C.T.5
Lane, W.S.6
Schreiber, S.L.7
-
43
-
-
0028598672
-
RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex
-
Chiu MI, Katz H, Berlin V. RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex. Proc Natl Acad Sci U S A. 1994;91:12574-12578
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 12574-12578
-
-
Chiu, M.I.1
Katz, H.2
Berlin, V.3
-
44
-
-
0028239893
-
RAFT1, a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs
-
Sabatini DM, Erdjument-Bromage H, Lui M, Tempst P, Snyder SH. RAFT1, a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell. 1994;78:35-43.
-
(1994)
Cell
, vol.78
, pp. 35-43
-
-
Sabatini, D.M.1
Erdjument-Bromage, H.2
Lui, M.3
Tempst, P.4
Snyder, S.H.5
-
45
-
-
0028950217
-
Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells
-
Sabers CJ, Martin MM, Brunn GJ, Williams JM, Dumont FJ, Wiederrecht G, Abraham RT. Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells. J Biol Chem. 1995;270:815-822
-
(1995)
J Biol Chem
, vol.270
, pp. 815-822
-
-
Sabers, C.J.1
Martin, M.M.2
Brunn, G.J.3
Williams, J.M.4
Dumont, F.J.5
Wiederrecht, G.6
Abraham, R.T.7
-
46
-
-
0028069835
-
A putative sirolimus (rapamycin) effector protein
-
Chen Y, Chen H, Rhoad AE, Warner L, Caggiano TJ, Failli A, Zhang H, Hsiao CL, Nakanishi K, Molnar-Kimber KL. A putative sirolimus (rapamycin) effector protein. Biochem Biophys Res Commun. 1994;203: 1-7.
-
(1994)
Biochem Biophys Res Commun
, vol.203
, pp. 1-7
-
-
Chen, Y.1
Chen, H.2
Rhoad, A.E.3
Warner, L.4
Caggiano, T.J.5
Failli, A.6
Zhang, H.7
Hsiao, C.L.8
Nakanishi, K.9
Molnar-Kimber, K.L.10
-
47
-
-
0031833563
-
Mammalian target of rapamycin: Immunosuppressive drugs uncover a novel pathway of cytokine receptor signaling
-
Abraham RT. Mammalian target of rapamycin: immunosuppressive drugs uncover a novel pathway of cytokine receptor signaling. Curr Opin Immunol. 1998;10:330-336
-
(1998)
Curr Opin Immunol
, vol.10
, pp. 330-336
-
-
Abraham, R.T.1
-
48
-
-
0028800996
-
PIK-related kinases: DNA repair, recombination, and cell cycle checkpoints
-
Keith CT, Schreiber SL. PIK-related kinases: DNA repair, recombination, and cell cycle checkpoints. Science. 1995;270:50-51
-
(1995)
Science
, vol.270
, pp. 50-51
-
-
Keith, C.T.1
Schreiber, S.L.2
-
49
-
-
0034644525
-
TOR, a central controller of cell growth
-
Schmelzle T, Hall MN. TOR, a central controller of cell growth. Cell. 2000;103:253-262
-
(2000)
Cell
, vol.103
, pp. 253-262
-
-
Schmelzle, T.1
Hall, M.N.2
-
50
-
-
0030598885
-
A signaling pathway to translational control
-
Brown EJ, Schreiber SL. A signaling pathway to translational control. Cell. 1996;86: 517-520
-
(1996)
Cell
, vol.86
, pp. 517-520
-
-
Brown, E.J.1
Schreiber, S.L.2
-
51
-
-
0030707562
-
TOR signalling and control of cell growth
-
Thomas G, Hall MN. TOR signalling and control of cell growth. Curr Opin Cell Biol. 1997;9:782-787
-
(1997)
Curr Opin Cell Biol
, vol.9
, pp. 782-787
-
-
Thomas, G.1
Hall, M.N.2
-
52
-
-
0032508608
-
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
-
Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, Appella E, Kastan MB, Siliciano JD. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science. 1998;281:1677-1679
-
(1998)
Science
, vol.281
, pp. 1677-1679
-
-
Canman, C.E.1
Lim, D.S.2
Cimprich, K.A.3
Taya, Y.4
Tamai, K.5
Sakaguchi, K.6
Appella, E.7
Kastan, M.B.8
Siliciano, J.D.9
-
53
-
-
4043171462
-
Upstream and downstream of mTOR
-
Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes Dev. 2004;18: 1926-1945
-
(2004)
Genes Dev
, vol.18
, pp. 1926-1945
-
-
Hay, N.1
Sonenberg, N.2
-
54
-
-
27644447574
-
The mammalian target of the rapamycin (mTOR) kinase pathway: Its role in tumourigenesis and targeted antitumour therapy
-
Janus A, Robak T, Smolewski P. The mammalian target of the rapamycin (mTOR) kinase pathway: its role in tumourigenesis and targeted antitumour therapy. Cell Mol Biol Lett. 2005;10:479-498
-
(2005)
Cell Mol Biol Lett
, vol.10
, pp. 479-498
-
-
Janus, A.1
Robak, T.2
Smolewski, P.3
-
55
-
-
0035312747
-
Regulation of translation initiation by FRAP/ mTOR
-
Gingras AC, Raught B, Sonenberg N. Regulation of translation initiation by FRAP/ mTOR. Genes Dev. 2001;15:807-826
-
(2001)
Genes Dev
, vol.15
, pp. 807-826
-
-
Gingras, A.C.1
Raught, B.2
Sonenberg, N.3
-
56
-
-
0037462453
-
The ATRs ATMs and TORs are giant HEAT repeat proteins
-
Perry J, Kleckner N. The ATRs, ATMs, and TORs are giant HEAT repeat proteins. Cell. 2003;112:151-155
-
(2003)
Cell
, vol.112
, pp. 151-155
-
-
Perry, J.1
Kleckner, N.2
-
57
-
-
0034974302
-
IGF-I receptor signaling in transformation and differentiation
-
Valentinis B, Baserga R. IGF-I receptor signaling in transformation and differentiation. Mol Pathol. 2001;54:133-137
-
(2001)
Mol Pathol
, vol.54
, pp. 133-137
-
-
Valentinis, B.1
Baserga, R.2
-
58
-
-
0041802820
-
Targeting mTOR signaling for cancer therapy
-
DOI 10.1016/S1471-4892(03)00071-7, PII S1471489203000717
-
Huang S, Houghton PJ. Targeting mTOR signaling for cancer therapy. Curr Opin Pharmacol. 2003;3:371-377 (Pubitemid 36908940)
-
(2003)
Current Opinion in Pharmacology
, vol.3
, Issue.4
, pp. 371-377
-
-
Huang, S.1
Houghton, P.J.2
-
59
-
-
0036712905
-
Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling
-
Gao X, Zhang Y, Arrazola P, Hino O, Kobayashi T, Yeung RS, Ru B, Pan D. Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling. Nat Cell Biol. 2002;4:699-704.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 699-704
-
-
Gao, X.1
Zhang, Y.2
Arrazola, P.3
Hino, O.4
Kobayashi, T.5
Yeung, R.S.6
Ru, B.7
Pan, D.8
-
60
-
-
0036713778
-
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
-
Inoki K, Li Y, Zhu T, Wu J, Guan KL. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol. 2002;4:648-657
-
(2002)
Nat Cell Biol
, vol.4
, pp. 648-657
-
-
Inoki, K.1
Li, Y.2
Zhu, T.3
Wu, J.4
Guan, K.L.5
-
61
-
-
0037108750
-
Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling
-
Tee AR, Fingar DC, Manning BD, Kwiatkowski DJ, Cantley LC, Blenis J. Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proc Natl Acad Sci U S A. 2002;99:13571-13576
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 13571-13576
-
-
Tee, A.R.1
Fingar, D.C.2
Manning, B.D.3
Kwiatkowski, D.J.4
Cantley, L.C.5
Blenis, J.6
-
62
-
-
0038433304
-
Insulin activation of Rheb, a mediator of mTOR/ S6K/4E-BP signaling, is inhibited by TSC1 and 2
-
Garami A, Zwartkruis FJ, Nobukuni T, Joaquin M, Roccio M, Stocker H, Kozma SC, Hafen E, Bos JL, Thomas G. Insulin activation of Rheb, a mediator of mTOR/ S6K/4E-BP signaling, is inhibited by TSC1 and 2. Mol Cell. 2003;11:1457-1466
-
(2003)
Mol Cell
, vol.11
, pp. 1457-1466
-
-
Garami, A.1
Zwartkruis, F.J.2
Nobukuni, T.3
Joaquin, M.4
Roccio, M.5
Stocker, H.6
Kozma, S.C.7
Hafen, E.8
Bos, J.L.9
Thomas, G.10
-
64
-
-
0038304516
-
Rheb is an essential regulator of S6K in controlling cell growth in Drosophila
-
Stocker H, Radimerski T, Schindelholz B, Wittwer F, Belawat P, Daram P, Breuer S, Thomas G, Hafen E. Rheb is an essential regulator of S6K in controlling cell growth in Drosophila. Nat Cell Biol. 2003;5:559-565
-
(2003)
Nat Cell Biol
, vol.5
, pp. 559-565
-
-
Stocker, H.1
Radimerski, T.2
Schindelholz, B.3
Wittwer, F.4
Belawat, P.5
Daram, P.6
Breuer, S.7
Thomas, G.8
Hafen, E.9
-
65
-
-
0038141979
-
Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins
-
Zhang Y, Gao X, Saucedo LJ, Ru B, Edgar BA, Pan D. Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins. Nat Cell Biol. 2003;5:578 81.
-
(2003)
Nat Cell Biol
, vol.5
, Issue.578
, pp. 81
-
-
Zhang, Y.1
Gao, X.2
Saucedo, L.J.3
Ru, B.4
Edgar, B.A.5
Pan, D.6
-
66
-
-
36049043184
-
Rheb activates mTOR by antagonizing its endogenous inhibitor FKBP38
-
Bai X, Ma D, Liu A, Shen X, Wang QJ, Liu Y, Jiang Y. Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38. Science. 2007;318:977-980
-
(2007)
Science
, vol.318
, pp. 977-980
-
-
Bai, X.1
Ma, D.2
Liu, A.3
Shen, X.4
Wang, Q.J.5
Liu, Y.6
Jiang, Y.7
-
67
-
-
55649092252
-
Rheb activates protein synthesis and growth in adult rat ventricular cardiomyocytes
-
Wang Y, Huang BP, Luciani DS, Wang X, Johnson JD, Proud CG. Rheb activates protein synthesis and growth in adult rat ventricular cardiomyocytes. J Mol Cell Cardiol. 2008;45:812-820
-
(2008)
J Mol Cell Cardiol
, vol.45
, pp. 812-820
-
-
Wang, Y.1
Huang, B.P.2
Luciani, D.S.3
Wang, X.4
Johnson, J.D.5
Proud, C.G.6
-
68
-
-
34347220473
-
Defi ning the role of mTOR in cancer
-
Guertin DA, Sabatini DM. Defi ning the role of mTOR in cancer. Cancer Cell. 2007;12:9-22.
-
(2007)
Cancer Cell
, vol.12
, pp. 9-22
-
-
Guertin, D.A.1
Sabatini, D.M.2
-
69
-
-
63749105226
-
Hall MN. mTOR and the control of whole body metabolism
-
Polak P, Hall MN. mTOR and the control of whole body metabolism. Curr Opin Cell Biol. 2009;21:209-218
-
(2009)
Curr Opin Cell Biol
, vol.21
, pp. 209-218
-
-
Polak, P.1
-
70
-
-
0037178781
-
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
-
Hara K, Maruki Y, Long X, Yoshino K, Oshiro N, Hidayat S, Tokunaga C, Avruch J, Yonezawa K. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell. 2002;110:177-189
-
(2002)
Cell
, vol.110
, pp. 177-189
-
-
Hara, K.1
Maruki, Y.2
Long, X.3
Yoshino, K.4
Oshiro, N.5
Hidayat, S.6
Tokunaga, C.7
Avruch, J.8
Yonezawa, K.9
-
71
-
-
0037178786
-
Sabatini DM. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
-
Kim DH, Sarbassov DD, Ali SM, King JE, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell. 2002; 110:163-175
-
(2002)
Cell
, vol.110
, pp. 163-175
-
-
Kim, D.H.1
Sarbassov, D.D.2
Ali, S.M.3
King, J.E.4
Latek, R.R.5
Erdjument-Bromage, H.6
Tempst, P.7
-
72
-
-
57449120941
-
Autophagy: A new phase in the maturation of growth plate chondrocytes is regulated by HIF, mTOR and AMP kinase
-
Srinivas V, Bohensky J, Shapiro IM. Autophagy: a new phase in the maturation of growth plate chondrocytes is regulated by HIF, mTOR and AMP kinase. Cells Tissues Organs. 2009;189:88-92.
-
(2009)
Cells Tissues Organs
, vol.189
, pp. 88-92
-
-
Srinivas, V.1
Bohensky, J.2
Shapiro, I.M.3
-
73
-
-
0037623417
-
GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR
-
Kim DH, Sarbassov DD, Ali SM, Latek RR, Guntur KV, Erdjument-Bromage H, Tempst P, Sabatini DM. GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol Cell. 2003;11:895-904.
-
(2003)
Mol Cell
, vol.11
, pp. 895-904
-
-
Kim, D.H.1
Sarbassov, D.D.2
Ali, S.M.3
Latek, R.R.4
Guntur, K.V.5
Erdjument-Bromage, H.6
Tempst, P.7
Sabatini, D.M.8
-
74
-
-
7944235758
-
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
-
Jacinto E, Loewith R, Schmidt A, Lin S, Ruegg MA, Hall A, Hall MN. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol. 2004;6:1122-1128
-
(2004)
Nat Cell Biol
, vol.6
, pp. 1122-1128
-
-
Jacinto, E.1
Loewith, R.2
Schmidt, A.3
Lin, S.4
Ruegg, M.A.5
Hall, A.6
Hall, M.N.7
-
75
-
-
3342895823
-
Rictor, a novel binding partner of mTOR, defi nes a rapamycininsensitive and raptor-independent pathway that regulates the cytoskeleton
-
Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM. Rictor, a novel binding partner of mTOR, defi nes a rapamycininsensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol. 2004;14:1296-1302
-
(2004)
Curr Biol
, vol.14
, pp. 1296-1302
-
-
Sarbassov, D.D.1
Ali, S.M.2
Kim, D.H.3
Guertin, D.A.4
Latek, R.R.5
Erdjument-Bromage, H.6
Tempst, P.7
Sabatini, D.M.8
-
76
-
-
13844312400
-
Phosphorylation and regulation of Akt/ PKB by the rictor-mTOR complex
-
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/ PKB by the rictor-mTOR complex. Science. 2005;307:1098-1101
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
77
-
-
45449114764
-
Hsp70 associates with Rictor and is required for mTORC2 formation and activity
-
Martin J, Masri J, Bernath A, Nishimura RN, Gera J. Hsp70 associates with Rictor and is required for mTORC2 formation and activity. Biochem Biophys Res Commun. 2008;372:578-583
-
(2008)
Biochem Biophys Res Commun
, vol.372
, pp. 578-583
-
-
Martin, J.1
Masri, J.2
Bernath, A.3
Nishimura, R.N.4
Gera, J.5
-
78
-
-
0028126506
-
PHAS-I as a link between mitogen-activated protein kinase and translation initiation
-
Lin TA, Kong X, Haystead TA, Pause A, Belsham G, Sonenberg N, Lawrence JC Jr. PHAS-I as a link between mitogen-activated protein kinase and translation initiation. Science. 1994;266:653-656
-
(1994)
Science
, vol.266
, pp. 653-656
-
-
Lin, T.A.1
Kong, X.2
Haystead, T.A.3
Pause, A.4
Belsham, G.5
Sonenberg, N.6
Lawrence Jr., J.C.7
-
79
-
-
0028034233
-
Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5-cap function
-
Pause A, Belsham GJ, Gingras AC, Donze O, Lin TA, Lawrence JC Jr, Sonenberg N. Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5-cap function. Nature. 1994;371:762-767
-
(1994)
Nature
, vol.371
, pp. 762-767
-
-
Pause, A.1
Belsham, G.J.2
Gingras, A.C.3
Donze, O.4
Lin, T.A.5
Lawrence Jr., J.C.6
Sonenberg, N.7
-
80
-
-
0032577691
-
4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family
-
Poulin F, Gingras AC, Olsen H, Chevalier S, Sonenberg N. 4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family. J Biol Chem. 1998;273:14002-14007
-
(1998)
J Biol Chem
, vol.273
, pp. 14002-14007
-
-
Poulin, F.1
Gingras, A.C.2
Olsen, H.3
Chevalier, S.4
Sonenberg, N.5
-
81
-
-
0030881836
-
Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin
-
Brunn GJ, Hudson CC, Sekulic A, Williams JM, Hosoi H, Houghton PJ, Lawrence JC Jr, Abraham RT. Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin. Science. 1997; 277:99-101.
-
(1997)
Science
, vol.277
, pp. 99-101
-
-
Brunn, G.J.1
Hudson, C.C.2
Sekulic, A.3
Williams, J.M.4
Hosoi, H.5
Houghton, P.J.6
Lawrence Jr., J.C.7
Abraham, R.T.8
-
82
-
-
0030716488
-
Regulation of eIF-4E BP1 phosphorylation by mTOR
-
Hara K, Yonezawa K, Kozlowski MT, Sugimoto T, Andrabi K, Weng QP, Kasuga M, Nishimoto I, Avruch J. Regulation of eIF-4E BP1 phosphorylation by mTOR. J Biol Chem. 1997;272:26457-26463
-
(1997)
J Biol Chem
, vol.272
, pp. 26457-26463
-
-
Hara, K.1
Yonezawa, K.2
Kozlowski, M.T.3
Sugimoto, T.4
Andrabi, K.5
Weng, Q.P.6
Kasuga, M.7
Nishimoto, I.8
Avruch, J.9
-
83
-
-
0033153166
-
Regulation of 4E-BP1 phosphorylation: A novel two-step mechanism
-
Gingras AC, Gygi SP, Raught B, Polakiewicz RD, Abraham RT, Hoekstra MF, Aebersold R, Sonenberg N. Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism. Genes Dev. 1999;13:1422-1437
-
(1999)
Genes Dev
, vol.13
, pp. 1422-1437
-
-
Gingras, A.C.1
Gygi, S.P.2
Raught, B.3
Polakiewicz, R.D.4
Abraham, R.T.5
Hoekstra, M.F.6
Aebersold, R.7
Sonenberg, N.8
-
84
-
-
0033662156
-
Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1
-
Yang DQ, Kastan MB. Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1. Nat Cell Biol. 2000;2:893-898
-
(2000)
Nat Cell Biol
, vol.2
, pp. 893-898
-
-
Yang, D.Q.1
Kastan, M.B.2
-
86
-
-
0033152072
-
Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G
-
Marcotrigiano J, Gingras AC, Sonenberg N, Burley SK. Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G. Mol Cell. 1999;3:707-716
-
(1999)
Mol Cell
, vol.3
, pp. 707-716
-
-
Marcotrigiano, J.1
Gingras, A.C.2
Sonenberg, N.3
Burley, S.K.4
-
87
-
-
0032834055
-
eIF4 initiation factors: Effectors of mRNA recruit-ment to ribosomes and regulators of translation
-
Gingras AC, Raught B, Sonenberg N. eIF4 initiation factors: effectors of mRNA recruit-ment to ribosomes and regulators of translation. Annu Rev Biochem. 1999;68:913-963
-
(1999)
Annu Rev Biochem
, vol.68
, pp. 913-963
-
-
Gingras, A.C.1
Raught, B.2
Sonenberg, N.3
-
88
-
-
0030806524
-
The insulin-induced signalling pathway leading to S6 and initiation factor 4E binding protein 1 phosphorylation bifurcates at a rapamycinsensitive point immediately upstream of p70s6k
-
von Manteuffel SR, Dennis PB, Pullen N, Gingras AC, Sonenberg N, Thomas G. The insulin-induced signalling pathway leading to S6 and initiation factor 4E binding protein 1 phosphorylation bifurcates at a rapamycinsensitive point immediately upstream of p70s6k. Mol Cell Biol. 1997;17:5426-5436
-
(1997)
Mol Cell Biol
, vol.17
, pp. 5426-5436
-
-
Von Manteuffel, S.R.1
Dennis, P.B.2
Pullen, N.3
Gingras, A.C.4
Sonenberg, N.5
Thomas, G.6
-
89
-
-
0026504296
-
A single gene encodes two isoforms of the p70 S6 kinase: Activation upon mitogenic stimulation
-
Reinhard C, Thomas G, Kozma SC. A single gene encodes two isoforms of the p70 S6 kinase: activation upon mitogenic stimulation. Proc Natl Acad Sci U S A. 1992;89:4052-4056
-
(1992)
Proc Natl Acad Sci U S A
, vol.89
, pp. 4052-4056
-
-
Reinhard, C.1
Thomas, G.2
Kozma, S.C.3
-
90
-
-
0036385637
-
Coordinate regulation of translation by the PI 3-kinase and mTOR pathways
-
Martin KA, Blenis J. Coordinate regulation of translation by the PI 3-kinase and mTOR pathways. Adv Cancer Res. 2002;86:1-39.
-
(2002)
Adv Cancer Res
, vol.86
, pp. 1-39
-
-
Martin, K.A.1
Blenis, J.2
-
91
-
-
0032538890
-
Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase
-
Shima H, Pende M, Chen Y, Fumagalli S, Thomas G, Kozma SC. Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase. EMBO J. 1998;17:6649-6659
-
(1998)
EMBO J
, Issue.17
, pp. 6649-6659
-
-
Shima, H.1
Pende, M.2
Chen, Y.3
Fumagalli, S.4
Thomas, G.5
Kozma, S.C.6
-
92
-
-
0032518467
-
3-Phosphoinositide dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro
-
Alessi DR, Kozlowski MT, Weng QP, Morrice N, Avruch J. 3-Phosphoinositide dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro. Curr Biol. 1998;8:69-81.
-
(1998)
Curr Biol
, vol.8
, pp. 69-81
-
-
Alessi, D.R.1
Kozlowski, M.T.2
Weng, Q.P.3
Morrice, N.4
Avruch, J.5
-
93
-
-
0032578998
-
Phosphorylation and activation of p70s6k by PDK1
-
Pullen N, Dennis PB, Andjelkovic M, Dufner A, Kozma SC, Hemmings BA, Thomas G. Phosphorylation and activation of p70s6k by PDK1. Science. 1998;279:707-710
-
(1998)
Science
, vol.279
, pp. 707-710
-
-
Pullen, N.1
Dennis, P.B.2
Andjelkovic, M.3
Dufner, A.4
Kozma, S.C.5
Hemmings, B.A.6
Thomas, G.7
-
94
-
-
0033607531
-
Immunopurifi ed mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro
-
Isotani S, Hara K, Tokunaga C, Inoue H, Avruch J, Yonezawa K. Immunopurifi ed mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro. J Biol Chem. 1999;274:34493-34498
-
(1999)
J Biol Chem
, vol.274
, pp. 34493-34498
-
-
Isotani, S.1
Hara, K.2
Tokunaga, C.3
Inoue, H.4
Avruch, J.5
Yonezawa, K.6
-
95
-
-
0037205409
-
Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site
-
Saitoh M, Pullen N, Brennan P, Cantrell D, Dennis PB, Thomas G. Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site. J Biol Chem. 2002;277: 20104-20112
-
(2002)
J Biol Chem
, vol.277
, pp. 20104-20112
-
-
Saitoh, M.1
Pullen, N.2
Brennan, P.3
Cantrell, D.4
Dennis, P.B.5
Thomas, G.6
-
98
-
-
0033604521
-
Ribosomal S6 kinase signaling and the control of translation
-
Dufner A, Thomas G. Ribosomal S6 kinase signaling and the control of translation. Exp Cell Res. 1999;253:100-109
-
(1999)
Exp Cell Res
, vol.253
, pp. 100-109
-
-
Dufner, A.1
Thomas, G.2
-
99
-
-
0032843917
-
Drosophila S6 kinase: A regulator of cell size
-
Montagne J, Stewart MJ, Stocker H, Hafen E, Kozma SC, Thomas G. Drosophila S6 kinase: a regulator of cell size. Science. 1999; 285:2126-2129
-
(1999)
Science
, vol.285
, pp. 2126-2129
-
-
Montagne, J.1
Stewart, M.J.2
Stocker, H.3
Hafen, E.4
Kozma, S.C.5
Thomas, G.6
-
100
-
-
0035225023
-
The p70 S6 kinase integrates nutrient and growth signals to control translational capacity
-
Avruch J, Belham C, Weng Q, Hara K, Yonezawa K. The p70 S6 kinase integrates nutrient and growth signals to control translational capacity. Prog Mol Subcell Biol. 2001;26:115-154
-
(2001)
Prog Mol Subcell Biol
, vol.26
, pp. 115-154
-
-
Avruch, J.1
Belham, C.2
Weng, Q.3
Hara, K.4
Yonezawa, K.5
-
101
-
-
0036119219
-
dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1
-
Radimerski T, Montagne J, Rintelen F, Stocker H, van der Kaay J, Downes CP, Hafen E, Thomas G. dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1. Nat Cell Biol. 2002;4:251-255
-
(2002)
Nat Cell Biol
, vol.4
, pp. 251-255
-
-
Radimerski, T.1
Montagne, J.2
Rintelen, F.3
Stocker, H.4
Van Der Kaay, J.5
Downes, C.P.6
Hafen, E.7
Thomas, G.8
-
102
-
-
0028207001
-
Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family
-
Jefferies HB, Reinhard C, Kozma SC, Thomas G. Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family. Proc Natl Acad Sci U S A. 1994;91:4441-4445
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 4441-4445
-
-
Jefferies, H.B.1
Reinhard, C.2
Kozma, S.C.3
-
103
-
-
0028032355
-
Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins
-
Terada N, Patel HR, Takase K, Kohno K, Nairn AC, Gelfand EW. Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins. Proc Natl Acad Sci U S A. 1994;91: 11477-11481
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 11477-11481
-
-
Terada, N.1
Patel, H.R.2
Takase, K.3
Kohno, K.4
Nairn, A.C.5
Gelfand, E.W.6
-
104
-
-
0035200856
-
Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation
-
Tang H, Hornstein E, Stolovich M, Levy G, Livingstone M, Templeton D, Avruch J, Meyuhas O. Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation. Mol Cell Biol. 2001;21:8671-8683
-
(2001)
Mol Cell Biol
, vol.21
, pp. 8671-8683
-
-
Tang, H.1
Hornstein, E.2
Stolovich, M.3
Levy, G.4
Livingstone, M.5
Templeton, D.6
Avruch, J.7
Meyuhas, O.8
-
105
-
-
0036889291
-
Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase mediated pathway but requires neither S6K1 nor rpS6 phosphorylation
-
Stolovich M, Tang H, Hornstein E, Levy G, Cohen R, Bae SS, Birnbaum MJ, Meyuhas O. Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase mediated pathway but requires neither S6K1 nor rpS6 phosphorylation. Mol Cell Biol. 2002;22:8101-8113
-
(2002)
Mol Cell Biol
, vol.22
, pp. 8101-8113
-
-
Stolovich, M.1
Tang, H.2
Hornstein, E.3
Levy, G.4
Cohen, R.5
Bae, S.S.6
Birnbaum, M.J.7
Meyuhas, O.8
-
106
-
-
11144356304
-
S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycinsensitive 5-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway
-
Pende M, Um SH, Mieulet V, Sticker M, Goss VL, Mestan J, Mueller M, Fumagalli S, Kozma SC, Thomas G. S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycinsensitive 5-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway. Mol Cell Biol. 2004;24:3112-3124
-
(2004)
Mol Cell Biol
, vol.24
, pp. 3112-3124
-
-
Pende, M.1
Um, S.H.2
Mieulet, V.3
Sticker, M.4
Goss, V.L.5
Mestan, J.6
Mueller, M.7
Fumagalli, S.8
Kozma, S.C.9
Thomas, G.10
-
107
-
-
27744569843
-
mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events
-
Holz MK, Ballif BA, Gygi SP, Blenis J. mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. Cell. 2005;123:569-580
-
(2005)
Cell
, vol.123
, pp. 569-580
-
-
Holz, M.K.1
Ballif, B.A.2
Gygi, S.P.3
Blenis, J.4
-
108
-
-
0036753494
-
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
-
Loewith R, Jacinto E, Wullschleger S, Lorberg A, Crespo JL, Bonenfant D, Oppliger W, Jenoe P, Hall MN. Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol Cell. 2002;10:457-468
-
(2002)
Mol Cell
, vol.10
, pp. 457-468
-
-
Loewith, R.1
Jacinto, E.2
Wullschleger, S.3
Lorberg, A.4
Crespo, J.L.5
Bonenfant, D.6
Oppliger, W.7
Jenoe, P.8
Hall, M.N.9
-
109
-
-
0037345059
-
Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae
-
Wedaman KP, Reinke A, Anderson S, Yates J III, McCaffery JM, Powers T. Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae. Mol Biol Cell. 2003;14:1204-1220
-
(2003)
Mol Biol Cell
, vol.14
, pp. 1204-1220
-
-
Wedaman, K.P.1
Reinke, A.2
Anderson, S.3
Yates Iii, J.4
McCaffery, J.M.5
Powers, T.6
-
110
-
-
0033540030
-
The TOR signaling pathway controls nuclear localization of nutrient-regulated transcription factors
-
Beck T, Hall MN. The TOR signaling pathway controls nuclear localization of nutrient-regulated transcription factors. Nature. 1999;402:689-692
-
(1999)
Nature
, vol.402
, pp. 689-692
-
-
Beck, T.1
Hall, M.N.2
-
111
-
-
0037312507
-
Tor signalling in bugs, brain and brawn
-
Jacinto E, Hall MN. Tor signalling in bugs, brain and brawn. Nat Rev Mol Cell Biol. 2003;4:117-126
-
(2003)
Nat Rev Mol Cell Biol
, vol.4
, pp. 117-126
-
-
Jacinto, E.1
Hall, M.N.2
-
112
-
-
0030906569
-
The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2
-
Schmidt A, Bickle M, Beck T, Hall MN. The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2. Cell. 1997;88:531-542
-
(1997)
Cell
, vol.88
, pp. 531-542
-
-
Schmidt, A.1
Bickle, M.2
Beck, T.3
Hall, M.N.4
-
113
-
-
0035475321
-
Paxillin: A focal adhesionassociated adaptor protein
-
Schaller MD. Paxillin: a focal adhesionassociated adaptor protein. Oncogene. 2001; 20:6459-6472
-
(2001)
Oncogene
, vol.20
, pp. 6459-6472
-
-
Schaller, M.D.1
-
114
-
-
34548151890
-
P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration
-
Hernandez-Negrete I, Carretero-Ortega J, Rosenfeldt H, Hernandez-Garcia R, Calderon-Salinas JV, Reyes-Cruz G, Gutkind JS, Vazquez-Prado J. P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration. J Biol Chem. 2007;282:23708-23715
-
(2007)
J Biol Chem
, vol.282
, pp. 23708-23715
-
-
Hernandez-Negrete, I.1
Carretero-Ortega, J.2
Rosenfeldt, H.3
Hernandez-Garcia, R.4
Calderon-Salinas, J.V.5
Reyes-Cruz, G.6
Gutkind, J.S.7
Vazquez-Prado, J.8
-
115
-
-
19344367393
-
Rapamycin inhibits fi bronectin-induced migration of the human arterial smooth muscle line (E47) through the mammalian target of rapamycin
-
Sakakibara K, Liu B, Hollenbeck S, Kent KC. Rapamycin inhibits fi bronectin-induced migration of the human arterial smooth muscle line (E47) through the mammalian target of rapamycin. Am J Physiol Heart Circ Physiol. 2005;288:H2861-8.
-
(2005)
Am J Physiol Heart Circ Physiol
, vol.288
-
-
Sakakibara, K.1
Liu, B.2
Hollenbeck, S.3
Kent, K.C.4
-
116
-
-
33750858427
-
Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways
-
Liu L, Li F, Cardelli JA, Martin KA, Blenis J, Huang S. Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways. Oncogene. 2006;25: 7029-7040
-
(2006)
Oncogene
, vol.25
, pp. 7029-7040
-
-
Liu, L.1
Li, F.2
Cardelli, J.A.3
Martin, K.A.4
Blenis, J.5
Huang, S.6
-
117
-
-
50649123206
-
Rapamycin inhibits F-actin reorganization and phosphorylation of focal adhesion proteins
-
Liu L, Chen L, Chung J, Huang S. Rapamycin inhibits F-actin reorganization and phosphorylation of focal adhesion proteins. Oncogene. 2008;27:4998-5010.
-
(2008)
Oncogene
, vol.27
, pp. 4998-5010
-
-
Liu, L.1
Chen, L.2
Chung, J.3
Huang, S.4
-
118
-
-
0030901145
-
Insulin like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivo
-
Brooks PC, Klemke RL, Schon S, Lewis JM, Schwartz MA, Cheresh DA. Insulin like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivo. J Clin Invest. 1997;99: 390-398
-
(1997)
J Clin Invest
, vol.99
, pp. 390-398
-
-
Brooks, P.C.1
Klemke, R.L.2
Schon, S.3
Lewis, J.M.4
Schwartz, M.A.5
Cheresh, D.A.6
-
119
-
-
0033603879
-
The activated insulin-like growth factor i receptor induces depolarization in breast epithelial cells characterized by actin fi lament disassembly and tyrosine dephosphorylation of FAK, Cas, and paxillin
-
Guvakova MA, Surmacz E. The activated insulin-like growth factor I receptor induces depolarization in breast epithelial cells characterized by actin fi lament disassembly and tyrosine dephosphorylation of FAK, Cas, and paxillin. Exp Cell Res. 1999;251:244-255
-
(1999)
Exp Cell Res.
, vol.251
, pp. 244-255
-
-
Guvakova, M.A.1
Surmacz, E.2
-
120
-
-
0033231070
-
Epidermal growth factor promotes MDA-MB-231 breast cancer cell migration through a phosphatidylinositol 3-kinase and phospholipase C-dependent mechanism
-
Price JT, Tiganis T, Agarwal A, Djakiew D, Thompson EW. Epidermal growth factor promotes MDA-MB-231 breast cancer cell migration through a phosphatidylinositol 3-kinase and phospholipase C-dependent mechanism. Cancer Res. 1999;59:5475-5478
-
(1999)
Cancer Res
, vol.59
, pp. 5475-5478
-
-
Price, J.T.1
Tiganis, T.2
Agarwal, A.3
Djakiew, D.4
Thompson, E.W.5
-
121
-
-
0035913613
-
Epidermal growth factor receptor signaling and the invasive phenotype of ovarian carcinoma cells
-
Alper O, Bergmann-Leitner ES, Bennett TA, Hacker NF, Stromberg K, Stetler Stevenson WG. Epidermal growth factor receptor signaling and the invasive phenotype of ovarian carcinoma cells. J Natl Cancer Inst. 2001;93:1375-1384
-
(2001)
J Natl Cancer Inst
, vol.93
, pp. 1375-1384
-
-
Alper, O.1
Bergmann-Leitner, E.S.2
Bennett, T.A.3
Hacker, N.F.4
Stromberg, K.5
Stetler Stevenson, W.G.6
-
122
-
-
0029845013
-
Rapamycin inhibits vascular smooth muscle cell migration
-
Poon M, Marx SO, Gallo R, Badimon JJ, Taubman MB, Marks AR. Rapamycin inhibits vascular smooth muscle cell migration. J Clin Invest. 1996;98:2277-2283
-
(1996)
J Clin Invest
, vol.98
, pp. 2277-2283
-
-
Poon, M.1
Marx, S.O.2
Gallo, R.3
Badimon, J.J.4
Taubman, M.B.5
Marks, A.R.6
-
123
-
-
0035912863
-
Role for p27(Kip1) in vascular smooth muscle cell migration
-
Sun J, Marx SO, Chen HJ, Poon M, Marks AR, Rabbani LE. Role for p27(Kip1) in vascular smooth muscle cell migration. Circulation. 2001;103:2967-2972
-
(2001)
Circulation
, vol.103
, pp. 2967-2972
-
-
Sun, J.1
Marx, S.O.2
Chen, H.J.3
Poon, M.4
Marks, A.R.5
Rabbani, L.E.6
-
124
-
-
0033747214
-
Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3-kinase-, rho-, and rac-dependent signaling pathways
-
Attoub S, Noe V, Pirola L, Bruyneel E, Chastre E, Mareel M, Wymann MP, Gespach C. Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3-kinase-, rho-, and rac-dependent signaling pathways. FASEB J. 2000;14:2329-2338
-
(2000)
FASEB J
, vol.14
, pp. 2329-2338
-
-
Attoub, S.1
Noe, V.2
Pirola, L.3
Bruyneel, E.4
Chastre, E.5
Mareel, M.6
Wymann, M.P.7
Gespach, C.8
-
125
-
-
0142102521
-
Rapamycin inhibits GM-CSF-induced neutrophil migration
-
Gomez-Cambronero J. Rapamycin inhibits GM-CSF-induced neutrophil migration. FEBS Lett. 2003;550:94-100.
-
(2003)
FEBS Lett
, vol.550
, pp. 94-100
-
-
Gomez-Cambronero, J.1
-
126
-
-
4043054354
-
Progressive changes in Met-dependent signaling in a human ovarian surface epithelial model of malignant transformation
-
Wong AS, Roskelley CD, Pelech S, Miller D, Leung PC, Auersperg N. Progressive changes in Met-dependent signaling in a human ovarian surface epithelial model of malignant transformation. Exp Cell Res. 2004;299:248-256
-
(2004)
Exp Cell Res
, vol.299
, pp. 248-256
-
-
Wong, A.S.1
Roskelley, C.D.2
Pelech, S.3
Miller, D.4
Leung, P.C.5
Auersperg, N.6
-
127
-
-
13944281689
-
Inhibitory effect of rapamycin on corneal neovascularization in vitro and in vivo
-
Kwon YS, Hong HS, Kim JC, Shin JS, Son Y. Inhibitory effect of rapamycin on corneal neovascularization in vitro and in vivo. Invest Ophthalmol Vis Sci. 2005;46:454-460
-
(2005)
Invest Ophthalmol Vis Sci
, vol.46
, pp. 454-460
-
-
Kwon, Y.S.1
Hong, H.S.2
Kim, J.C.3
Shin, J.S.4
Son, Y.5
-
128
-
-
0025837327
-
Mitogen-activated 70K S6 kinase. Identifi cation of in vitro 40 S ribosomal S6 phosphorylation sites
-
Ferrari S, Bandi HR, Hofsteenge J, Bussian BM, Thomas G. Mitogen-activated 70K S6 kinase. Identifi cation of in vitro 40 S ribosomal S6 phosphorylation sites. J Biol Chem. 1991;266:22770-22775
-
(1991)
J Biol Chem
, vol.266
, pp. 22770-22775
-
-
Ferrari, S.1
Bandi, H.R.2
Hofsteenge, J.3
Bussian, B.M.4
Thomas, G.5
-
129
-
-
0031557653
-
Regulation of thrombin-induced stress fi bre formation in Swiss 3T3 cells by the 70-kDa S6 kinase
-
Crouch MF. Regulation of thrombin-induced stress fi bre formation in Swiss 3T3 cells by the 70-kDa S6 kinase. Biochem Biophys Res Commun. 1997;233:193-199
-
(1997)
Biochem Biophys Res Commun
, vol.233
, pp. 193-199
-
-
Crouch, M.F.1
-
130
-
-
33645856178
-
Activation of p70S6K induces expression of matrix metallopro teinase 9 associated with hepatocyte growth factormediated invasion in human ovarian cancer cells
-
Zhou HY, Wong AS. Activation of p70S6K induces expression of matrix metallopro teinase 9 associated with hepatocyte growth factormediated invasion in human ovarian cancer cells. Endocrinology. 2006;147:2557-2566
-
(2006)
Endocrinology
, vol.147
, pp. 2557-2566
-
-
Zhou, H.Y.1
Wong, A.S.2
-
131
-
-
0028172867
-
Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin
-
Nourse J, Firpo E, Flanagan WM, Coats S, Polyak K, Lee MH, Massague J, Crabtree GR, Roberts JM. Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin. Nature. 1994;372:570 3.
-
(1994)
Nature
, vol.372
, Issue.570
, pp. 3
-
-
Nourse, J.1
Firpo, E.2
Flanagan, W.M.3
Coats, S.4
Polyak, K.5
Lee, M.H.6
Massague, J.7
Crabtree, G.R.8
Roberts, J.M.9
-
132
-
-
0029977949
-
Rapamycin resistance tied to defective regulation of p27Kip1
-
Luo Y, Marx SO, Kiyokawa H, Koff A, Massague J, Marks AR. Rapamycin resistance tied to defective regulation of p27Kip1. Mol Cell Biol. 1996;16:6744-6751
-
(1996)
Mol Cell Biol
, vol.16
, pp. 6744-6751
-
-
Luo, Y.1
Marx, S.O.2
Kiyokawa, H.3
Koff, A.4
Massague, J.5
Marks, A.R.6
-
133
-
-
2942594770
-
The rapamycin derivative RAD inhibits mesangial cell migration through the CDK-inhibitor p27KIP1
-
Daniel C, Pippin J, Shankland SJ, Hugo C. The rapamycin derivative RAD inhibits mesangial cell migration through the CDK-inhibitor p27KIP1. Lab Invest. 2004;84:588-596
-
(2004)
Lab Invest
, vol.84
, pp. 588-596
-
-
Daniel, C.1
Pippin, J.2
Shankland, S.J.3
Hugo, C.4
-
134
-
-
0346725862
-
Regulation of IGF-I receptor signaling in tumor cells
-
OConnor R. Regulation of IGF-I receptor signaling in tumor cells. Horm Metab Res. 2003;35:771-777
-
(2003)
Horm Metab Res
, vol.35
, pp. 771-777
-
-
Oconnor, R.1
-
136
-
-
0345267246
-
Endothelial cell response to human head and neck squamous cell carcinomas involves downregulation of protein phosphatases-1/2A, cytoskeletal depolymerization and increased motility
-
Benefi eld J, Meisinger J, Petruzzelli GJ, Young MR. Endothelial cell response to human head and neck squamous cell carcinomas involves downregulation of protein phosphatases-1/2A, cytoskeletal depolymerization and increased motility. Invasion Metastasis. 1997;17:210-220
-
(1997)
Invasion Metastasis
, vol.17
, pp. 210-220
-
-
Benefi Eld, J.1
Meisinger, J.2
Petruzzelli, G.J.3
Young, M.R.4
-
137
-
-
0038199833
-
Protein phosphatase- 2A regulates protein tyrosine phosphatase activity in Lewis lung carcinoma tumor variants
-
Jackson JL, Young MR. Protein phosphatase- 2A regulates protein tyrosine phosphatase activity in Lewis lung carcinoma tumor variants. Clin Exp Metastasis. 2003;20:357-364
-
(2003)
Clin Exp Metastasis
, vol.20
, pp. 357-364
-
-
Jackson, J.L.1
Young, M.R.2
-
138
-
-
41449089311
-
MTORC1 signaling can regulate growth factor activation of p44/42 mitogen-activated protein kinases through protein phosphatase 2A
-
Harwood FC, Shu L, Houghton PJ. mTORC1 signaling can regulate growth factor activation of p44/42 mitogen-activated protein kinases through protein phosphatase 2A. J Biol Chem. 2008;283:2575-2585
-
(2008)
J Biol Chem
, vol.283
, pp. 2575-2585
-
-
Harwood, F.C.1
Shu, L.2
Houghton, P.J.3
-
139
-
-
0036174289
-
Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: Involvement of vascular endothelial growth factor
-
Guba M, von Breitenbuch P, Steinbauer M, Koehl G, Flegel S, Hornung M, Bruns CJ, Zuelke C, Farkas S, Anthuber M, Jauch KW, Geissler EK. Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor. Nat Med. 2002;8:128-135
-
(2002)
Nat Med
, vol.8
, pp. 128-135
-
-
Guba, M.1
Von Breitenbuch, P.2
Steinbauer, M.3
Koehl, G.4
Flegel, S.5
Hornung, M.6
Bruns, C.J.7
Zuelke, C.8
Farkas, S.9
Anthuber, M.10
Jauch, K.W.11
Geissler, E.K.12
-
140
-
-
0037182139
-
Rapamycin blocks tumor progression: Unlinking immunosuppression from antitumor effi cacy
-
Luan FL, Hojo M, Maluccio M, Yamaji K, Suthanthiran M. Rapamycin blocks tumor progression: unlinking immunosuppression from antitumor effi cacy. Transplantation. 2002;73:1565-1572
-
(2002)
Transplantation
, vol.73
, pp. 1565-1572
-
-
Luan, F.L.1
Hojo, M.2
Maluccio, M.3
Yamaji, K.4
Suthanthiran, M.5
-
141
-
-
0037336853
-
Rapamycin is an effective inhibitor of human renal cancer metastasis
-
Luan FL, Ding R, Sharma VK, Chon WJ, Lagman M, Suthanthiran M. Rapamycin is an effective inhibitor of human renal cancer metastasis. Kidney Int. 2003;63:917-926
-
(2003)
Kidney Int
, vol.63
, pp. 917-926
-
-
Luan, F.L.1
Ding, R.2
Sharma, V.K.3
Chon, W.J.4
Lagman, M.5
Suthanthiran, M.6
-
142
-
-
0032918414
-
TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development
-
Yin JJ, Selander K, Chirgwin JM, Dallas M, Grubbs BG, Wieser R, Massague J, Mundy GR, Guise TA. TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development. J Clin Invest. 1999;103:197-206.
-
(1999)
J Clin Invest
, vol.103
, pp. 197-206
-
-
Yin, J.J.1
Selander, K.2
Chirgwin, J.M.3
Dallas, M.4
Grubbs, B.G.5
Wieser, R.6
Massague, J.7
Mundy, G.R.8
Guise, T.A.9
-
143
-
-
1642576127
-
Rapamycin inhibits the growth and metastatic progression of non-small cell lung cancer
-
Boffa DJ, Luan F, Thomas D, Yang H, Sharma VK, Lagman M, Suthanthiran M. Rapamycin inhibits the growth and metastatic progression of non-small cell lung cancer. Clin Cancer Res. 2004;10:293-300.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 293-300
-
-
Boffa, D.J.1
Luan, F.2
Thomas, D.3
Yang, H.4
Sharma, V.K.5
Lagman, M.6
Suthanthiran, M.7
-
144
-
-
16844366544
-
Rapamycin inhibits ezrin-mediated metastatic behavior in a murine model of osteosarcoma
-
Wan X, Mendoza A, Khanna C, Helman LJ. Rapamycin inhibits ezrin-mediated metastatic behavior in a murine model of osteosarcoma. Cancer Res. 2005;65:2406 11.
-
(2005)
Cancer Res
, vol.65
, Issue.2406
, pp. 11
-
-
Wan, X.1
Mendoza, A.2
Khanna, C.3
Helman, L.J.4
-
145
-
-
0024814175
-
cDNA cloning and sequencing of the protein-tyrosine kinase substrate, ezrin, reveals homology to band 4.1
-
Gould KL, Bretscher A, Esch FS, Hunter T. cDNA cloning and sequencing of the protein-tyrosine kinase substrate, ezrin, reveals homology to band 4.1. EMBO J. 1989;8:4133-4142
-
(1989)
EMBO J
, vol.8
, pp. 4133-4142
-
-
Gould, K.L.1
Bretscher, A.2
Esch, F.S.3
Hunter, T.4
-
146
-
-
0027196725
-
The ezrin-like family of tyrosine kinase substrates: Receptorspecifi c pattern of tyrosine phosphorylation and relationship to malignant transformation
-
Fazioli F, Wong WT, Ullrich SJ, Sakaguchi K, Appella E, Di Fiore PP. The ezrin-like family of tyrosine kinase substrates: receptorspecifi c pattern of tyrosine phosphorylation and relationship to malignant transformation. Oncogene. 1993;8:1335-45.
-
(1993)
Oncogene
, vol.8
, pp. 1335-1345
-
-
Fazioli, F.1
Wong, W.T.2
Ullrich, S.J.3
Sakaguchi, K.4
Appella, E.5
Di Fiore, P.P.6
-
147
-
-
0028229539
-
ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons
-
Tsukita S, Oishi K, Sato N, Sagara J, Kawai A, Tsukita S. ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons. J Cell Biol. 1994;126:391-401.
-
(1994)
J Cell Biol
, vol.126
, pp. 391-401
-
-
Tsukita, S.1
Oishi, K.2
Sato, N.3
Sagara, J.4
Kawai, A.5
Tsukita, S.6
-
148
-
-
34247279338
-
Inhibition of the mammalian target of rapamycin impedes lymphangiogenesis
-
Huber S, Bruns CJ, Schmid G, Hermann PC, Conrad C, Niess H, Huss R, Graeb C, Jauch KW, Heeschen C, Guba M. Inhibition of the mammalian target of rapamycin impedes lymphangiogenesis. Kidney Int. 2007;71:771-777
-
(2007)
Kidney Int
, vol.71
, pp. 771-777
-
-
Huber, S.1
Bruns, C.J.2
Schmid, G.3
Hermann, P.C.4
Conrad, C.5
Niess, H.6
Huss, R.7
Graeb, C.8
Jauch, K.W.9
Heeschen, C.10
Guba, M.11
-
149
-
-
34147121375
-
Rapamycin, a specifi c inhibitor of the mammalian target of rapamycin, suppresses lymphangiogenesis and lymphatic metastasis
-
Kobayashi S, Kishimoto T, Kamata S, Otsuka M, Miyazaki M, Ishikura H. Rapamycin, a specifi c inhibitor of the mammalian target of rapamycin, suppresses lymphangiogenesis and lymphatic metastasis. Cancer Sci. 2007;98:726-733
-
(2007)
Cancer Sci
, vol.98
, pp. 726-733
-
-
Kobayashi, S.1
Kishimoto, T.2
Kamata, S.3
Otsuka, M.4
Miyazaki, M.5
Ishikura, H.6
-
150
-
-
23044501991
-
Inhibition of lymphogenous metastasis using adeno-associated virus-mediated gene transfer of a soluble VEGFR-3 decoy receptor
-
Lin J, Lalani AS, Harding TC, Gonzalez M, Wu WW, Luan B, Tu GH, Koprivnikar K, VanRoey MJ, He Y, Alitalo K, Jooss K. Inhibition of lymphogenous metastasis using adeno-associated virus-mediated gene transfer of a soluble VEGFR-3 decoy receptor. Cancer Res. 2005;65:6901-6909
-
(2005)
Cancer Res
, vol.65
, pp. 6901-6909
-
-
Lin, J.1
Lalani, A.S.2
Harding, T.C.3
Gonzalez, M.4
Wu, W.W.5
Luan, B.6
Tu, G.H.7
Koprivnikar, K.8
Vanroey, M.J.9
He, Y.10
Alitalo, K.11
Jooss, K.12
-
151
-
-
33645046619
-
Inhibition of VEGFR-3 activation with the antagonistic antibody more potently suppresses lymph node and distant metastases than inactivation of VEGFR-2
-
Roberts N, Kloos B, Cassella M, Podgrabinska S, Persaud K, Wu Y, Pytowski B, Skobe M. Inhibition of VEGFR-3 activation with the antagonistic antibody more potently suppresses lymph node and distant metastases than inactivation of VEGFR-2. Cancer Res. 2006;66:2650-2657
-
(2006)
Cancer Res
, vol.66
, pp. 2650-2657
-
-
Roberts, N.1
Kloos, B.2
Cassella, M.3
Podgrabinska, S.4
Persaud, K.5
Wu, Y.6
Pytowski, B.7
Skobe, M.8
-
152
-
-
33745550002
-
The balance of VEGF-C and VEGFR-3 mRNA is a predictor of lymph node metastasis in non-small cell lung cancer
-
Takizawa H, Kondo K, Fujino H, Kenzaki K, Miyoshi T, Sakiyama S, Tangoku A. The balance of VEGF-C and VEGFR-3 mRNA is a predictor of lymph node metastasis in non-small cell lung cancer. Br J Cancer. 2006;95:75-79
-
(2006)
Br J Cancer
, vol.95
, pp. 75-79
-
-
Takizawa, H.1
Kondo, K.2
Fujino, H.3
Kenzaki, K.4
Miyoshi, T.5
Sakiyama, S.6
Tangoku, A.7
-
153
-
-
34447257690
-
Tumour-derived fi broblast growth factor-2 exerts lymphangiogenic effects through Akt/mTOR/p70S6kinase pathway in rat lymphatic endothelial cells
-
Matsuo M, Yamada S, Koizumi K, Sakurai H, Saiki I. Tumour-derived fi broblast growth factor-2 exerts lymphangiogenic effects through Akt/mTOR/p70S6kinase pathway in rat lymphatic endothelial cells. Eur J Cancer. 2007;43:1748-1754
-
(2007)
Eur J Cancer
, vol.43
, pp. 1748-1754
-
-
Matsuo, M.1
Yamada, S.2
Koizumi, K.3
Sakurai, H.4
Saiki, I.5
-
154
-
-
67349226686
-
IL-20 activates human lymphatic endothelial cells causing cell signalling and tube formation
-
Mar 9. [Epub ahead of print]. Cited in PubMed PMID: 19281830
-
Hammer T, Tritsaris K, Hubschmann MV, Gibson J, Nisato RE, Pepper MS, Dissing S. IL-20 activates human lymphatic endothelial cells causing cell signalling and tube formation. Microvasc Res. 2009 Mar 9. [Epub ahead of print]. Cited in PubMed; PMID: 19281830.
-
(2009)
Microvasc Res
-
-
Hammer, T.1
Tritsaris, K.2
Hubschmann, M.V.3
Gibson, J.4
Nisato, R.E.5
Pepper, M.S.6
Dissing, S.7
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