메뉴 건너뛰기




Volumn 71, Issue 8, 2007, Pages 771-777

Inhibition of the mammalian target of rapamycin impedes lymphangiogenesis

Author keywords

Lymphangiogenesis; Lymphangioma; Lymphatic endothelial cells; mTOR; Sirolimus; VEGF C

Indexed keywords

PROTEIN KINASE; PROTEIN KINASE P70S6; RAPAMYCIN; UNCLASSIFIED DRUG; VASCULOTROPIN A; VASCULOTROPIN C;

EID: 34247279338     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/sj.ki.5002112     Document Type: Article
Times cited : (169)

References (23)
  • 1
    • 2942668041 scopus 로고    scopus 로고
    • Lymphatic vasculature: Development molecular regulation and role in tumor metastasis and inflammation
    • Saharinen P, Tammela T, Karkkainen MJ, Alitalo K. Lymphatic vasculature: development molecular regulation and role in tumor metastasis and inflammation. Trends Immunol 2004; 25: 387-395.
    • (2004) Trends Immunol , vol.25 , pp. 387-395
    • Saharinen, P.1    Tammela, T.2    Karkkainen, M.J.3    Alitalo, K.4
  • 2
    • 0034842967 scopus 로고    scopus 로고
    • Concurrent induction of lymphangiogenesis, angiogenesis, and macrophage recruitment by vascular endothelial growth factor-C in melanoma
    • Skobe M, Hamberg LM, Hawighorst T et al. Concurrent induction of lymphangiogenesis, angiogenesis, and macrophage recruitment by vascular endothelial growth factor-C in melanoma. Am J Pathol 2001; 159: 893-903.
    • (2001) Am J Pathol , vol.159 , pp. 893-903
    • Skobe, M.1    Hamberg, L.M.2    Hawighorst, T.3
  • 3
    • 0034693879 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptors in the regulation of angiogenesis and lymphangiogenesis
    • Karkkainen MJ, Petrova TV. Vascular endothelial growth factor receptors in the regulation of angiogenesis and lymphangiogenesis. Oncogene 2000; 19: 5598-5605.
    • (2000) Oncogene , vol.19 , pp. 5598-5605
    • Karkkainen, M.J.1    Petrova, T.V.2
  • 4
    • 0037312604 scopus 로고    scopus 로고
    • Sirolimus and lymphocele formation after kidney transplantation: An immunosuppressive medication as co-factor for a surgical problem?
    • Giessing M, Budde K. Sirolimus and lymphocele formation after kidney transplantation: an immunosuppressive medication as co-factor for a surgical problem? Nephrol Dial Transplant 2003; 18: 448-449.
    • (2003) Nephrol Dial Transplant , vol.18 , pp. 448-449
    • Giessing, M.1    Budde, K.2
  • 5
    • 1942471969 scopus 로고    scopus 로고
    • Lymphedema associated with sirolimus in renal transplant recipients
    • Aboujaoude W, Milgrom ML, Govani MV. Lymphedema associated with sirolimus in renal transplant recipients. Transplantation 2004; 77: 1094-1096.
    • (2004) Transplantation , vol.77 , pp. 1094-1096
    • Aboujaoude, W.1    Milgrom, M.L.2    Govani, M.V.3
  • 6
    • 33646545659 scopus 로고    scopus 로고
    • Patterns of pulmonary complications associated with sirolimus
    • Chhajed PN, Dickenmann M, Bubendorf L et al. Patterns of pulmonary complications associated with sirolimus. Respiration 2006; 73: 367-374.
    • (2006) Respiration , vol.73 , pp. 367-374
    • Chhajed, P.N.1    Dickenmann, M.2    Bubendorf, L.3
  • 7
    • 17844373853 scopus 로고    scopus 로고
    • Immunosuppressive therapy with everolimus can be associated with potentially life-threatening lingual angioedema
    • Fuchs U, Zittermann A, Berthold HK et al. Immunosuppressive therapy with everolimus can be associated with potentially life-threatening lingual angioedema. Transplantation 2005; 79: 981-983.
    • (2005) Transplantation , vol.79 , pp. 981-983
    • Fuchs, U.1    Zittermann, A.2    Berthold, H.K.3
  • 8
    • 20044379939 scopus 로고    scopus 로고
    • Cutaneous adverse events in renal transplant recipients receiving sirolimus-based therapy
    • Mahe E, Morelon E, Lechaton S et al. Cutaneous adverse events in renal transplant recipients receiving sirolimus-based therapy. Transplantation 2005; 79: 476-482.
    • (2005) Transplantation , vol.79 , pp. 476-482
    • Mahe, E.1    Morelon, E.2    Lechaton, S.3
  • 10
    • 8344281974 scopus 로고    scopus 로고
    • Targeting the molecular target of rapamycin (mTOR)
    • Rowinsky EK. Targeting the molecular target of rapamycin (mTOR). Curr Opin Oncol 2004; 16: 564-575.
    • (2004) Curr Opin Oncol , vol.16 , pp. 564-575
    • Rowinsky, E.K.1
  • 11
    • 0036174289 scopus 로고    scopus 로고
    • Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: Involvement of vascular endothelial growth factor
    • Guba M, von Breitenbuch P, Steinbauer M et al. Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor. Nat Med 2002; 8: 128-135.
    • (2002) Nat Med , vol.8 , pp. 128-135
    • Guba, M.1    von Breitenbuch, P.2    Steinbauer, M.3
  • 12
    • 21144443076 scopus 로고    scopus 로고
    • Rapamycin induces tumor-specific thrombosis via tissue factor in the presence of VEGF
    • Guba M, Yezhelyev M, Eichhorn ME et al. Rapamycin induces tumor-specific thrombosis via tissue factor in the presence of VEGF. Blood 2005; 105: 4463-4469.
    • (2005) Blood , vol.105 , pp. 4463-4469
    • Guba, M.1    Yezhelyev, M.2    Eichhorn, M.E.3
  • 13
    • 0033080517 scopus 로고    scopus 로고
    • Lymphatic endothelial tumors induced by intraperitoneal injection of incomplete Freund's adjuvant
    • Mancardi S, Stanta G, Dusetti N, Bestagno M et al. Lymphatic endothelial tumors induced by intraperitoneal injection of incomplete Freund's adjuvant. Exp Cell Res 1999; 246: 368-375.
    • (1999) Exp Cell Res , vol.246 , pp. 368-375
    • Mancardi, S.1    Stanta, G.2    Dusetti, N.3    Bestagno, M.4
  • 14
    • 1642334756 scopus 로고    scopus 로고
    • Impact of cyclosporine on the development of immunosuppressive therapy
    • Fritsche L, Dragun D, Neumayer HH, Budde K. Impact of cyclosporine on the development of immunosuppressive therapy. Transplant Proc 2004; 36: 130S-134S.
    • (2004) Transplant Proc , vol.36
    • Fritsche, L.1    Dragun, D.2    Neumayer, H.H.3    Budde, K.4
  • 15
    • 0034899437 scopus 로고    scopus 로고
    • Lymphangiogenesis and tumor metastasis: Myth or reality?
    • Pepper MS. Lymphangiogenesis and tumor metastasis: myth or reality? Clin Cancer Res 2001; 7: 462-468.
    • (2001) Clin Cancer Res , vol.7 , pp. 462-468
    • Pepper, M.S.1
  • 16
    • 20144367584 scopus 로고    scopus 로고
    • Sirolimus for Kaposi's sarcoma in renal-transplant recipients
    • Stallone G, Schena A, Infante B et al. Sirolimus for Kaposi's sarcoma in renal-transplant recipients. N Engl J Med 2005; 352: 1317-1323.
    • (2005) N Engl J Med , vol.352 , pp. 1317-1323
    • Stallone, G.1    Schena, A.2    Infante, B.3
  • 17
    • 0033023309 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor receptor-3 and podoplanin suggests a lymphatic endothelial cell origin of Kaposi's sarcoma tumor cells
    • Weninger W, Partanen TA, Breiteneder-Geleff S et al. Expression of vascular endothelial growth factor receptor-3 and podoplanin suggests a lymphatic endothelial cell origin of Kaposi's sarcoma tumor cells. Lab Invest 1999; 79: 243-251.
    • (1999) Lab Invest , vol.79 , pp. 243-251
    • Weninger, W.1    Partanen, T.A.2    Breiteneder-Geleff, S.3
  • 18
    • 0036959853 scopus 로고    scopus 로고
    • Insights into the molecular pathogenesis and targeted treatment of lymphedema
    • Saaristo A, Karkkainen MJ, Alitalo K. Insights into the molecular pathogenesis and targeted treatment of lymphedema. Ann N Y Acad Sci 2002; 979: 94-110.
    • (2002) Ann N Y Acad Sci , vol.979 , pp. 94-110
    • Saaristo, A.1    Karkkainen, M.J.2    Alitalo, K.3
  • 19
    • 9444229297 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-C gene therapy restores lymphatic flow across incision wounds
    • Saaristo A, Tammela T, Timonen J et al. Vascular endothelial growth factor-C gene therapy restores lymphatic flow across incision wounds. FASEB J 2004; 18: 1707-1709.
    • (2004) FASEB J , vol.18 , pp. 1707-1709
    • Saaristo, A.1    Tammela, T.2    Timonen, J.3
  • 20
    • 0026495179 scopus 로고
    • A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factor
    • Passaniti A, Taylor RM, Pili R et al. A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factor. Lab Invest 1992; 67: 519-528.
    • (1992) Lab Invest , vol.67 , pp. 519-528
    • Passaniti, A.1    Taylor, R.M.2    Pili, R.3
  • 21
    • 0035793086 scopus 로고    scopus 로고
    • A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt
    • Aoki M, Blazek E, Vogt PK. A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt. Proc Natl Acad Sci USA 2001; 98: 136-141.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 136-141
    • Aoki, M.1    Blazek, E.2    Vogt, P.K.3
  • 22
    • 0032549572 scopus 로고    scopus 로고
    • A recombinant mutant vascular endothelial growth factor-C that has lost vascular endothelial growth factor receptor-2 binding, activation, and vascular permeability activities
    • Joukov V, Kumar V, Sorsa T et al. A recombinant mutant vascular endothelial growth factor-C that has lost vascular endothelial growth factor receptor-2 binding, activation, and vascular permeability activities. J Biol Chem 1998; 273: 6599-6602.
    • (1998) J Biol Chem , vol.273 , pp. 6599-6602
    • Joukov, V.1    Kumar, V.2    Sorsa, T.3
  • 23
    • 17744396472 scopus 로고    scopus 로고
    • Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice
    • Veikkola T, Jussila L, Makinen T et al. Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice. EMBO J 2001; 20: 1223-1231.
    • (2001) EMBO J , vol.20 , pp. 1223-1231
    • Veikkola, T.1    Jussila, L.2    Makinen, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.