Endothelial cell response to human head and neck squamous cell carcinomas involves downregulation of protein phosphatases-1/2A, cytoskeletal depolymerization and increased motility

Invasion and Metastasis

Volumn 17, Issue 4, 1998, Pages 210-220

  Benefield, Janet ^a,b   Meisinger, Jeremy ^a   Petruzzelli, Guy J ^b   Young, M Rita I ^a,b,c  

^a VA Hospital   (United States)

^b LOYOLA UNIVERSITY CHICAGO   (United States)

^c HINES VA HOSPITAL   (United States)

Author keywords

Angiogenesis; Endothelial cells; Migration; Protein phosphatases 1 2; Squamous carcinoma, head and neck

Indexed keywords

ANGIOGENIC FACTOR; CELL PROTEIN; CYTOSKELETON PROTEIN; F ACTIN; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 2A; TUBULIN;

ACTIN FILAMENT; ANGIOGENESIS; ARTICLE; CELL MIGRATION; CELL MOTILITY; CELL PROLIFERATION; CONTROLLED STUDY; CYTOSKELETON; DEPOLYMERIZATION; DOWN REGULATION; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME INHIBITION; HEAD AND NECK CARCINOMA; HUMAN; HUMAN CELL; MICROTUBULE;

ACTINS; CARCINOMA, SQUAMOUS CELL; CELL MOVEMENT; CYTOSKELETON; DOWN-REGULATION; ENDOTHELIUM, VASCULAR; HEAD AND NECK NEOPLASMS; HUMANS; PHOSPHOPROTEIN PHOSPHATASE; TUMOR CELLS, CULTURED;

EID: 0345267246     PISSN: 02511789     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Bernstein LR, Liotta LA: Molecular mediators of interactions with extracellular matrix components in metastasis and angiogenesis. Curr Opin Oncol 1994;6:106-113.
2. Fidler IJ, Ellis LM: The implications of angiogenesis for the biology and therapy of cancer metastasis. Cell 1994;79:185-188.
3. Folkman J: The role of angiogenesis in tumor growth. Semin Cancer Biol 1992;3:65-71.
4. Jackson CJ, Knop CJ, Giles I, Jenkins K, Schrieber L: VLA-2 mediates the interaction of collagen with endothelium during in vitro vascular tube formation. Cell Biol Int 1994;18:859-867.
5. Davis GE, Camarillo CW: Regulation of endothelial cell morphogenesis by integrins, mechanical forces, and matrix guidance pathways. Exp Cell Res 1995;216:113-123.
6. Claffey KP, Brown LF, del Anguila LF, Tognazzi K, Yeo K-T, Manseau EJ, Dvorak HF: Expression of vascular permeability factor/vascular endothelial growth factor by melanoma cells increases tumor growth, angiogenesis, and experimental metastasis. Cancer Res 1996;56:172-181.
7. Ito N, Kawata S, Tamura S, Shirai Y, Kiso S, Tsushima H, Matsuzawa Y: Positive correlation of plasma transforming growth factor-β1 levels with tumor vascularity in hepatocellular carcinoma. Cancer Lett 1995; 89:45-48.
8. Pandey A, Shao H, Marks RM, Polverini PJ, Dixit VM: Role of B61, the ligand for the eck receptor tyrosine kinase, in TNF-α-induced angiogenesis. Science 1995;268:567-569.
9. Strieter RM, Polverini PJ, Arenberg DA, Walz A, Opdenakker G, Van Damme J, Kunkel SL: Role of C-X-C chemokines as regulators of angiogenesis in lung cancer. J Leukoc Biol 1995;57:752-762.
10. Battegay EJ: Angiogenesis: Mechanistic insights, neovascular diseases, and therapeutic prospects. J Mol Med 1995;73:333-346.
11. Ito K, Abe T, Tomita M, Morimoto A, Kohno K, Mori T, Ono M, Sugenoya A, Nishihira T, Kuwano M: Anti-angiogenic activity of arachidonic acid metabolism inhibitors in angiogenesis model systems involving human microvascular endothelial cells and neovascularization in mice. Int J Cancer 1993;55:660-666.
12. Albo D, Granick MS, Jhala N, Atkinson B, Solomon MP: The relationship of angiogenesis to biological activity in human squamous cell carcinomas of the head and neck. Ann Plast Surg 1994;32:588-594.
13. Benefield J, Petruzzelli GJ, Fowler S, Taitz A, Young MRI: Regulation of the steps of angiogenesis by human head and neck squamous cell carcinomas. Invasion Metastasis 1996;16:291-301.
14. Petruzzelli GJ, Benefield J, Taitz A, Fowler S, Kalkanis J, Scobercea S, West D, Young MRI: Heparin binding growth factor(s) derived from head and neck squamous cell carcinomas induce endothelial cell proliferation. Head Neck 1997;19:576-582.
15. 3 coupled to a decline in protein kinase A activity and an increase in cytoskeletal organization. Clin Exp Metastasis 1997; 15:102-110.
16. Pokorna E, Jordan PW, O'Neill CH, Zicha D, Gilbert CS, Vesely P: Actin cytoskeleton and motility in rat sarcoma cell populations with different metastatic potential. Cell Motil Cytoskeleton 1994;28:25-33.
17. Lakshmi MS, Parker C, Sherbet GV: Metastasis and associated MTSl and NM23 genes affect tubulin polymerisation in B16 melanomas: A possible mechanism of their regulation of metastatic behaviour of tumours. Anticancer Res 1993;13: 299-303.
18. Scott G, Liang H:pp125FAK in human melanocytes and melanoma: Expression and phosphorylation. Exp Cell Res 1995;219:197-203.
19. Trachsel S, Keller HU: Selective responses (actin polymerization, shape changes, locomotion, pinocytosis) to the PKC inhibitor Ro 31-8220 suggest that PKC discriminately regulates functions of human blood lymphocytes. J Leukoc Biol 1995;57:587-591.
20. Goldenring JR, Vallano ML, DeLorenzo RJ: Phosphorylation of microtubule-associated protein 2 at distinct sites by calmodulin-dependent and cyclic-AMP-dependent kinases. J Neurochem 1985;45:900-905.
21. 2+/calmodulin-dependent protein kinase II. J Neurosci Res 1993;34:642-647.
22. Gurland G, Gundersen GG: Protein phosphatase inhibitors induce the selective breakdown of stable microtubules in fibroblasts and epithelial cells. Proc Natl Acad Sci USA 1993; 90:8827-8831.
23. Shinoki N, Sakon M, Kambayashi J, Ikeda M, Oiki E, Okuyama M, Fujitani K, Yano Y, Kawasaki T, Monden M: Involvement of protein phosphatase-1 in cytoskeletal organization of cultured endothelial cells. J Cell Biochem 1995;59:368-375.
24. Meisinger J, Patel S, Vellody K, Bergstrom R, Benefield J, Lozano Y, Young MRI: Protein phosphatase-2A association with microtubules and its role in restricting the invasiveness of human head and neck squamous cell carcinoma cells. Cancer Lett 1997;111:87-95.
25. 3 and ceramide reduce the invasion of tumor cells through extracellular matrix components by elevating protein phosphatase-2A. Invasion Metastasis 1997;16:280-290.
26. 2-protein kinase A signaling and protein phosphatases-1 and -2 A regulate human head and neck squamous cell carcinoma motility, adherence to extracellular matrix components, and cytoskeletal organization. Prostaglandins 1996;51:35-48.
27. Maier GD, Wright MA, Lozano Y, Djordjevic A, Matthews JP, Young MRI: Regulation of cytoskeletal organization in tumor cells by protein phosphatases-1 and -2A. Int J Cancer 1995;61:51-54.
28. Ades EW, Candal FJ, Swerlick RA, George VG, Summers S, Bosse DC, Lawley TJ: HMEC-1: Establishment of an immortalized human microvascular endothelial cell line. J Invest Dermatol 1992;99:683-690.
29. Young MRI, Montpetit M, Lozano Y, Djordjevic A, Devata S, Matthews JP, Yedavalli S, Cheijfec G: Lewis lung carcinoma transfectants that either overexpress or have defective protein kinase A activity have a respective high or low capacity to invade and metastasize in vivo. Int J Cancer 1995;64:104-109.
30. Hardie DG, Haystead AJ, Sim ATR: Use of okadaic acid to inhibit protein phosphatases in intact cells. Methods Enzymol 1991;201:469-476.
31. Favre B, Zolnierowicz S, Turowski P, Hemmings BA: The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo. J Biol Chem 1994;269:16311-16317.
32. Young MR: Protein phosphatases-1 and -2A regulate tumor cell migration, invasion and cytoskeletal organization. Adv Exp Med Biol 1997; 407:311-318.
33. Young MRI, Lozano Y, Djordjevic A, Maier D: Protein phosphatases limit tumor motility. Int J Cancer 1993;54:1036-1041.
34. Kumar R, Yoneda J, Bucana CD, Fidler IJ: Regulation of distinct steps of angiogenesis by different angiogenic molecules. Int J Oncol 1998;12:749-757.
35. Cohen P: The structure and regulation of protein phosphatases. Annu Rev Biochem 1989;58:453-508.