Regulation of translation initiation by FRAP/mTOR

Genes and Development

Volumn 15, Issue 7, 2001, Pages 807-826

  Gingras, A C ^a   Raught, B ^a   Sonenberg, N ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; PROTEIN FRAP; PROTEIN KINASE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

CANCER INHIBITION; GENE DELETION; GENE EXPRESSION; GENE TARGETING; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION; REVIEW; RNA TRANSLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TRANSLATION INITIATION; TRANSLATION REGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; ANIMALS; ANTINEOPLASTIC AGENTS; BINDING SITES; CARRIER PROTEINS; CELL DIVISION; CHROMONES; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; ENERGY METABOLISM; ENZYME INHIBITORS; EUKARYOTIC CELLS; EUKARYOTIC INITIATION FACTORS; FUNGAL PROTEINS; GENE EXPRESSION REGULATION; INSECT PROTEINS; INSULIN; MACROMOLECULAR SUBSTANCES; MAMMALS; MICE; MORPHOLINES; NEOPLASM PROTEINS; PEPTIDE FRAGMENTS; PEPTIDE INITIATION FACTORS; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN BIOSYNTHESIS; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RNA, MESSENGER; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; SIROLIMUS; SPECIES SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP; TACROLIMUS BINDING PROTEIN 1A; TUMOR SUPPRESSOR PROTEINS;

EID: 0035312747     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.887201     Document Type: Review

References (236)

1. Immunopharmacology of rapamycin
2. Protein kinase activity and identification of a toxic effector domain of the target of rapamycin TOR proteins in yeast
3. A Saccharomyces cerevisiae homologue of mammalian translation initiation factor 4B contributes to RNA helicase activity
4. The Saccharomyces cerevisiae translation initiation factor Tif3 and its mammalian homologue, eIF-4B, have RNA annealing activity
5. HEAT repeats in the Huntington's disease protein
6. A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt
7. 1 progression in yeast
8. The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors
9. A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region
10. Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas
11. Translation initiation on picornavirus RNA
12. The mechanism of action of protein synthesis initiation factors from rabbit reticulocytes
13. Purification and characterization of initiation factors IF-E4 and IF-E6 from rabbit reticulocytes
14. Phosphorylation of eukaryotic protein synthesis initiation factors
15. Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation
16. Rapamycin stimulates viral protein synthesis and augments the shutoff of host protein synthesis upon picornavirus infection
17. Drosophila Thor participates in host immune defense and connects a translational regulator with innate immunity
18. Increased phosphoinositide 3-kinase activity induces a lymphoproliferative disorder and contributes to tumor generation in vivo
19. FAT: A novel domain in PIK-related kinases
20. FDA approves new immunosuppressants
21. Translation initiation factor eIF-4gamma is encoded by an amplified gene and induces an immune response in squamous cell lung carcinoma
22. Environmental control of the cell cycle in Drosophila: Nutrition activates mitotic and endoreplicative cells by distinct mechanisms
23. A signaling pathway to translational control
24. A mammalian protein targeted by G1-arresting rapamycin-receptor complex
25. Control of p70 s6 kinase by kinase activity of FRAP in vivo
26. Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002
27. The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus
28. Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin
29. RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1
30. Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity
31. Yeast TOR (DRR) proteins: Amino-acid sequence alignment and identification of structural motifs
32. Nutrients differentially regulate multiple translation factors and their control by insulin
33. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
34. Oncogenes and signal transduction
35. The TOR signaling cascade regulates gene expression in response to nutrients
36. Cellular internal ribosome entry site elements and the use of cDNA microarrays in their investigation
37. A transient, neuron-wide form of CREB-mediated long-term facilitation can be stabilized at specific synapses by local protein synthesis
38. AKT/PKB and other D3 phosphoinositide-regulated kinases: Kinase activation by phosphoinositide-dependent phosphorylation
39. Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase
40. A putative sirolimus (rapamycin) effector protein
41. Alpha 4 associates with protein phosphatases 2A, 4, and 6
42. AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas
43. Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA
44. Transforming activity and mitosis-related expression of the AKT2 oncogene: Evidence suggesting a link between cell cycle regulation and oncogenesis
45. RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex
46. Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP
47. Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHp
48. Structure of importin-β bound to the IBB domain of importin-α
49. A new yeast translation initiation factor suppresses a mutation in the eIF-4A RNA helicase
50. CLN3 expression is sufficient to restore G1-to-S-phase progression in Saccharomyces cerevisiae mutants defective in translation initiation factor eIF4E
51. eIF4E expression in tumours
52. The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases
53. Target of rapamycin (TOR): Balancing the opposing forces of protein synthesis and degradation
54. Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases
55. The multiple roles of PTEN in tumor suppression
56. Pten is essential for embryonic development and tumour suppression
57. All cyclophilins and FK506 binding proteins are, individually and collectively, dispensable for viability in Saccharomyces cerevisiae
58. Protein kinase B localization and activation differentially affect S6 kinase 1 activity and eukaryotic translation initiation factor 4E-binding protein 1 phosphorylation
59. Regulation of initiation factors during translational repression caused by serum depletion. Covalent modification
60. Translation initiation factor eIF-4A1 mRNA is consistently overexpressed in human melanoma cells in vitro
61. Identification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and rapamycin in rat adipocytes
62. Phosphoinositide kinases
63. Malignant transformation by overproduction of translation initiation factor eIF4G
64. S6 phosphorylation and signal transduction
65. The Cln3 cyclin is down-regulated by translational repression and degradation during the G1 arrest caused by nitrogen deprivation in budding yeast
66. Drosophila PTEN regulates cell growth and proliferation through PI3K-dependent and -independent pathways
67. The effect of CCI-779, a novel macrolide anti-tumor agent, on the growth of human tumor cells in vitro and in nude mouse xenografts in vivo
68. Adenovirus infection inactivates the translational inhibitors 4E-BP1 and 4E-BP2
69. 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway
70. Regulation of 4E-BP1 phosphorylation: A novel two-step mechanism
71. eIF4 initiation factors: Effectors of mRNA recruitment to ribosomes and regulators of translation
72. Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway
73. Peptidyl-prolyl cis-transisomerases, a superfamily of ubiquitous folding catalysts
74. Topological characteristics of helical repeat proteins
75. The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs
76. Regulation of eIF-4E BP1 phosphorylation by mTOR
77. Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism
78. A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase
79. Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins
80. DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product
81. Dissociation of the eukaryotic initiation factor-4E/4E-BP1 complex involves phosphorylation of 4E-BP1 by an mTOR-associated kinase
82. Insulin-stimulated kinase from rat fat cells that phosphorylates initiation factor-4E binding protein 1 on the rapamycin-insensitive site (serine-111)
83. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast
84. FK 506-binding protein proline rotamase is a target for the immunosuppressive agent FK 506 in Saccharomyces cerevisiae
85. TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast
86. The flat-top gene is required for the expansion and regionalization of the telencephalic primordium
87. eIF4G: A multipurpose ribosome adapter?
88. Rapid induction of apoptosis mediated by peptides that bind initiation factor eIF4E
89. Pathway and mechanism of initiation of protein synthesis
90. Translational control and cancer
91. In vivo and in vitro ovarian carcinoma growth inhibition by a phosphatidylinositol 3-kinase inhibitor (LY294002)
92. PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development
93. Amino acid-dependent control of p70(s6k). Involvement of tRNA aminoacylation in the regulation
94. Human eukaryotic translation initiation factor 4G (eIF4G) possesses two separate and independent binding sites for eIF4A
95. Molecular cloning of a cDNA clone encoding a phosphoprotein component related to the Ig receptor-mediated signal transduction
96. Ig receptor binding protein 1 (alpha4) is associated with a rapamycin-sensitive signal transduction in lymphocytes through direct binding to the catalytic subunit of protein phosphatase 2A
97. A comparative view of initiation site selection mechanisms
98. Ribosomal protein S6 phosphorylation and signal transduction
99. Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family
100. Rapamycin suppresses 5′TOP mRNA translation through inhibition of p70s6k
101. Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast
102. Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase
103. Identification of eukaryotic mRNAs that are translated at reduced cap binding complex eIF4F concentrations using a cDNA microarray
104. Efficacy of sirolimus compared with azathioprine for reduction of acute renal allograft rejection: A randomised multicentre study. The Rapamune US Study Group
105. Translational homeostasis: Eukaryotic translation initiation factor 4E control of 4E-binding protein 1 and p70 S6 kinase activities
106. Cytoplasmic-nuclear shuttling of FKBP12-rapamycin-associated protein is involved in rapamycin-sensitive signaling and translation initiation
107. Regulation of translation initiation in mammalian cells by amino acids
108. Leucine regulates translation of specific mRNAs in L6 myoblasts through mTOR-mediated changes in availability of eIF4E and phosphorylation of ribosomal protein S6
109. Regulation of translation initiation factors by signal transduction
110. Construction and characterization of a conditionally active version of the serine/threonine kinase Akt
111. Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerase related to human FK506-binding protein
112. mRNAs containing extensive secondary structure in their 5′ noncoding region translate efficiently in cells overexpressing initiation factor eIF-4E
113. The scanning model for translation: An update
114. An analysis of vertebrate mRNA sequences: Intimations of translational control
115. Functional interaction between RAFT1/FRAP/ mTOR and protein kinase C delta in the regulation of cap-dependent initiation of translation
116. Regulation of the rapamycin and FKBP-target 1/mammalian target of rapamycin and cap-dependent initiation of translation by the c-Ab1 protein-tyrosine kinase
117. Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression
118. HEAT repeats mediate plasma membrane localization of Tor2p in yeast
119. Mapping of functional domains in eukaryotic protein synthesis initiation factor 4G (eIF4G) with picornaviral proteases. Implications for cap-dependent and cap-independent translational initiation
120. Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5′ cap
121. The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth
122. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
123. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome
124. Control of the translational regulators PHAS-I and PHAS-II by insulin and cAMP in 3T3-L1 adipocytes
125. PHAS-I as a link between mitogen-activated protein kinase and translation initiation
126. Control of PHAS-I by insulin in 3T3-L1 adipocytes. Synthesis, degradation, and phosphorylation by a rapamycin-sensitive and mitogen-activated protein kinase-independent pathway
127. Translational control of protein synthesis
128. TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin
129. Constitutive activation of S6 kinase by deletion of amino-terminal autoinhibitory and rapamycin sensitivity domains
130. The immunosuppressive macrolide RAD inhibits growth of human Epstein-Barr virus-transformed B lymphocytes in vitro and in vivo: A potential approach to prevention and treatment of posttransplant lymphoproliferative disorders
131. Insulin induction of ornithine decarboxylase. Importance of mRNA secondary structure and phosphorylation of eucaryotic initiation factors eIF-4B and eIF-4E
132. Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G
133. A conserved HEAT domain within eIF4G directs assembly of the translation initiation machinery
134. Germline mutations in PTEN are present in Bannayan-Zonana syndrome
135. Origins and principles of translational control
136. A region rich in aspartic acid, arginine, tyrosine, and glycine (DRYG) mediates eukaryotic initiation factor 4B (eIF4B) self-association and interaction with eIF3
137. Translational control of TOP mRNAs
138. Translational control of ribosomal protein mRNAs in eukaryotes
139. Isolation of translationally controlled mRNAs by differential screening
140. The translational inhibitor 4EBP is an effector of PI3K/Akt signaling in Drosophila, and regulates cell growth
141. Oncogenic transformation of cells by a conditionally active form of the protein kinase Akt/PKB
142. Drosophila S6 kinase: A regulator of cell size
143. Eukaryotic translation initiation factor 4E (eIF4E) binding site and the middle one-third of eIF4GI constitute the core domain for cap-dependent translation, and the C-terminal one-third functions as a modulatory region
144. Phorbol esters stimulate phosphorylation of eukaryotic initiation factors 3, 4B, and 4F
145. Differential stimulation of phosphorylation of initiation factors eIF-4F, eIF-4B, eIF-3, and ribosomal protein S6 by insulin and phorbol esters
146. Mammalian Target of Rapamycin-dependent phosphorylation of PHAS-I in Four (S/T)P Sites detected by phospho-specific antibodies
147. Multiple mechanisms control phosphorylation of PHAS-I in five (S/T)P sites that govern translational repression
148. Cyclin D expression is controlled post-transcriptionally via a phosphatidylinositol 3-kinase/Akt-dependent pathway
149. B cell receptor-associated protein alpha4 displays rapamycin-sensitive binding directly to the catalytic subunit of protein phosphatase 2A
150. Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines
151. Regulation of protein phosphatase 2A catalytic activity by alpha4 protein and its yeast homolog TAP42
152. Alpha4 protein as a common regulator of type 2A-related serine/threonine protein phosphatases
153. Two structural domains of initiation factor eIF-4B are involved in binding to RNA
154. Mammalian target of rapamycin is a direct target for protein kinase B: Identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation
155. Growth-dependent translation of IGF-II mRNA by a rapamycin-sensitive pathway
156. A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development
157. Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin
158. Bidirectional modulation of insulin action by amino acids
159. Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function
160. Distinct repression of translation by wortmannin and rapamycin
161. Hypoinsulinaemia, glucose intolerance and diminished b-cell size in S6K1-deficient mice
162. Functional dissection of eukaryotic initiation factor 4F: The 4A subunit and the central domain of the 4G subunit are sufficient to mediate internal entry of 43S preinitiation complexes
163. Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycin associated protein
164. FKBP12-rapamycin-associated protein (FRAP) autophosphorylates at serine 2481 under translationally repressive conditions
165. Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems
166. Translational control of the antiapoptotic function of Ras
167. 1 cyclin CLN3 in yeast
168. Regulation of ribosome biogenesis by the rapamycin-sensitive TOR-signaling pathway in Saccharomyces cerevisiae
169. Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase
170. Control of the elongation phase of protein synthesis
171. Phosphorylation and activation of p70s6k by PDK1
172. Gastrin induces phosphorylation of eIF4E binding protein 1 and translation initiation of ornithine decarboxylase mRNA
173. Expression of a translationally regulated, dominant-negative CCAAT/enhancer-binding protein beta isoform and up-regulation of the eukaryotic translation initiation factor 2alpha are correlated with neoplastic transformation of mammary epithelial cells
174. Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI
175. Regulation of ribosomal recruitment in eukaryotes
176. Upregulation of protein synthesis initiation factor eIF-4E is an early event during colon carcinogenesis
177. The eIF4E-binding proteins 1 and 2 are negative regulators of cell growth
178. Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F
179. Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas
180. 2+-dependent pathway independent of phosphatidylinositol 3-kinase/Akt
181. RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs
182. Interaction of RAFT1 with gephyrin required for rapamycin-sensitive signaling
183. Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells
184. Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin
185. TOR, a central controller of cell growth
186. TOR2 is required for organization of the actin cytoskeleton in yeast
187. The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2
188. The Tor nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease
189. Translational control during heat shock
190. Initiation of mammalian protein synthesis. I. Purification and characterization of seven initiation factors
191. p70(S6K) controls selective mRNA translation during oocyte maturation and early embryogenesis in Xenopus laevis
192. Attenuation of mammalian Target of Rapamycin activity by increased cAMP in 3T3-L1 cells
193. Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway
194. Inhibition by rapamycin of ornithine decarboxylase and epithelial cell proliferation in intestinal IEC-6 cells in culture
195. A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells
196. Partitioning the transcriptional program induced by rapamycin among the effectors of the Tor proteins
197. Expression of an ornithine decarboxylase dominant-negative mutant reverses eukaryotic initiation factor 4E-induced cell transformation
198. PIK3CA is implicated as an oncogene in ovarian cancer
199. Regulation of translational effectors by amino acid and mammalian target of rapamycin signaling pathways. Possible involvement of autophagy in cultured hepatoma cells
200. Disruption of the p70S6k/p85S6k gene reveals a small mouse phenotype and a new functional S6 kinase
201. The conserved phosphoinositide 3-kinase pathway determines heart size in mice
202. A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin
203. The cytosolic-binding protein for the immunosuppressant FK-506 is both a ubiquitous and highly conserved peptidyl-prolyl cistrans isomerase
204. Remarks on the mechanism of ribosome binding to eukaryotic mRNAs
205. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
206. The Drosophila p70s6k homolog exhibits conserved regulatory elements and rapamycin sensitivity
207. Evidence that the Rous sarcoma virus transforming gene product phosphorylates phosphatidylinositol and diacylglycerol
208. High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice
209. Rapamycin and wortmannin enhance replication of a defective encephalomyocarditis virus
210. The requirement for eukaryotic initiation factor 4A (eIF4A) in translation is in direct proportion to the degree of mRNA 5′ secondary structure
211. Opposite translational control of GLUT1 and GLUT4 glucose transporter mRNAs in response to insulin. Role of mammalian target of rapamycin, protein kinase B, and phosphatidylinositol 3-kinase in GLUT1 mRNA translation
212. Requirement for Akt (protein kinase B) in insulin-induced activation of glycogen synthase and phosphorylation of 4E-BP1 (PHAS-1)
213. Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins
214. TOR signalling and control of cell growth
215. Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase
216. Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB
217. Structural view of the Ran-Importin beta interaction at 2.3 A resolution
218. Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle
219. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4mor-pholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
220. 4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase
221. The insulin-induced signalling pathway leading to S6 and initiation factor 4E binding protein 1 phosphorylation bifurcates at a rapamycin-sensitive point immediately upstream of p70s6k
222. Amino acid availability regulates p70 S6 kinase and multiple translation factors
223. Regulation of imaginal disc cell size, cell number and organ size by Drosophila class I(A) phosphoinositide 3-kinase and its adaptor
224. Translational induction of the c-myc oncogene via activation of the FRAP/mTOR signalling pathway
225. Signal-dependent translation of a regulatory protein, Bcl-3, in activated human platelets
226. Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation
227. Translational control of developmental decisions
228. FKB1 encodes a nonessential FK 506-binding protein in Saccharomyces cerevisiae and contains regions suggesting homology to the cyclophilins
229. The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway
230. Branched-chain amino acids are essential in the regulation of PHAS-I and p70 S6 kinase by pancreatic beta-cells. A possible role in protein translation and mitogenic signaling
231. Insulin mediates glucose-stimulated phosphorylation of PHAS-I by pancreatic beta cells. An insulin-receptor mechanism for autoregulation of protein synthesis by translation
232. Participation of ATM in insulin signaling through phosphorylation of eIF-4E-binding protein 1
233. Regulation of cellular growth by the Drosophila target of rapamycin dTOR
234. TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin
235. Messenger RNA translation state: The second dimension of high-throughput expression screening