Epidermal growth factor receptor signalling and the invasive phenotype of ovarian carcinoma cells

Journal of the National Cancer Institute

Volumn 93, Issue 18, 2001, Pages 1375-1384

  Alper, Özge ^a   Bergmann Leitner, Elke S ^b   Bennett, Teresa A ^b   Hacker, Neville F ^c   Stromberg, Kurt ^d   Stetler Stevenson, William G ^b,d  

^a GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c ROYAL HOSPITAL FOR WOMEN   (Australia)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (3 BROMOANILINO) 6,7 DIMETHOXYQUINAZOLINE; COMPLEMENTARY DNA; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE; INTEGRIN; LAMININ; LAMININ RECEPTOR; MATRIX METALLOPROTEINASE; TISSUE INHIBITOR OF METALLOPROTEINASE;

ARTICLE; ASSAY; CANCER INVASION; CARCINOMA CELL; CELL ADHESION; CELL MIGRATION; CELL STRUCTURE; CELL SURFACE; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME ACTIVITY; EXPRESSION VECTOR; EXTRACELLULAR MATRIX; FLOW CYTOMETRY; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYPOTHESIS; MICROSCOPY; OVARY CARCINOMA; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STATISTICAL ANALYSIS; VECTOR CONTROL; ZYMOGRAPHY;

EID: 0035913613     PISSN: 00278874     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnci/93.18.1375     Document Type: Article

References (49)

1. The EGF receptor is an actin-binding protein
2. The expression of EGF receptors, EGF-like factors and c-myc in ovarian and cervical carcinomas and their potential clinical significance
3. Growth factors and cancer
4. Invasion and metastases in gastric cancer: In vivo and in vitro models with clinical correlations
5. Characterization of growth factors in human ovarian carcinomas
6. Transforming growth factor-alpha acts as an autocrine growth factor in ovarian carcinoma cell lines
7. Epidermal growth factor receptor (EGFR) antisense transfection reduces the expression of EGFR and suppresses the malignant phenotype of a human ovarian cancer cell line
8. Anti-sense suppression of epidermal growth factor receptor expression alters cellular proliferation, cell-adhesion and tumorigenicity in ovarian cancer cells
9. Molecular mechanisms of cancer invasion and metastasis
10. Regulation of tissue injury responses by the exposure of matricryptic sites within extracellular matrix molecules
11. Expression of alpha 6 and beta 4 integrins in serous ovarian carcinoma correlates with expression of basement membrane protein laminin
12. Reciprocal interactions between betal-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: A different perspective in epithelial biology
13. Signaling by epidermal growth factor differentially affects integrin-mediated adhesion of tumor cells to extracellular matrix proteins
14. Prevention of EGF-modulated adhesion of tumor cells to matrix protein by specific EGF receptor inhibition
15. Integrin activation by R-ras
16. Suppression of integrin activation: A novel function of a Ras/Raf-initiated MAP kinase pathway
17. Integrin signaling and cell growth control
18. Laminin receptors: Achieving specificity through cooperation
19. Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival
20. Desmosomes and hemidesmosomes: Structure and function of molecular components
21. Epithelial detachment due to absence of hemidesmosomes in integrin β 4 null mice
22. 4 integrin promotes carcinoma invasion
23. 4 functions in carcinoma cell migration on laminin-1 by mediating the formation and stabilization of actin-containing motility structures
24. Alpha 6 beta 4 and alpha 6 beta 1 integrins associate with ErbB-2 in human carcinoma cell lines
25. Alpha 3A beta 1 integrin localizes to focal contacts in response to diverse extracellular matrix proteins
26. α3β1 integrin is required for normal development of the epidermal basement membrane
27. Effect of epidermal growth factor on prostate cancer cell line PC3 growth and invasion
28. Induction of growth factor-receptor and metalloproteinase genes by epidermal growth factor and/or transforming growth factor-alpha in human gastric carcinoma cell lines MKN-28
29. Growth factor-regulated proteases and extracellular matrix remodeling during mammalian development
30. Epidermal growth factor stimulates the synthesis of cell-attachment proteins in the human beast cancer cell line PMC42
31. Cell movement elicited by epidermal growth factor receptor requires kinase and autophosphorylation but is separable from mitogenesis
32. Epidermal growth factor receptor-mediated cell motility: Phospholipase C activity is required, but mitogen-activated protein kinase activity is not sufficient for induced cell movement
33. Proteinase requirements of epidermal growth factor-induced ovarian cancer cell invasion
34. Epidermal growth factor (EGF)- and scatter factor/hepatocyte growth factor (SF/HGF)-mediated keratinocyte migration is coincident with induction of matrix metalloproteinase (MMP)-9
35. Role of the plasminogen activator and matrix metalloproteinase systems in epidermal growth factor- and scatter factor-stimulated invasion of carcinoma cells
36. Protein kinase A-Iα subunit-directed antisense inhibition of ovarian cancer cell growth: Crosstalk with tyrosine kinase signaling pathway
37. A specific inhibitor of the epidermal growth factor receptor tyrosine kinase
38. Tissue inhibitor of metalloproteinases-2 inhibits bFGF-induced human microvascular endothelial cell proliferation
39. Quantitative zymography: Detection of picogram quantities of gelatinases
40. Quantitative reverse zymography: Analysis of picogram amounts of metalloproteinase inhibitors using gelatinase A and B reverse zymograms
41. Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN
42. A rapid in vitro assay for quantitating the invasive potential of tumor cells
43. Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5
44. Phosphatidylinositol 3-kinase activity in epidermal growth factor-stimulated matrix metalloproteinase-9 production and cell surface association
45. Rapid effects of EGF on cytoskeletal structures and adhesive properties of highly metastatic rat mammary adenocarcinoma cells
46. Polarization of the alpha 6 beta 4 integrin in ovarian carcinomas
47. Stimulation of beta1-integrin function by epidermal growth factor and heregulin-beta has distinct requirements for erbB2 but a similar dependence on phosphoinositide 3-OH kinase
48. Fibronectin secretion from human peritoneal tissue induces Mr 92,000 type IV collagenase expression and invasion in ovarian cancer cell lines
49. The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells