mTORC1 signaling can regulate growth factor activation of p44/42 mitogen-activated protein kinases through protein phosphatase 2A

Journal of Biological Chemistry

Volumn 283, Issue 5, 2008, Pages 2575-2585

  Harwood, Franklin C ^a   Shu, Lili ^a   Houghton, Peter J ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINATION; AMINES; AMINO ACIDS; ANTIBIOTICS; BIOACTIVITY; CELL CULTURE; DISSOCIATION; GROWTH (MATERIALS); GROWTH KINETICS; HORMONES; INSULIN; MAMMALS; ORGANIC ACIDS; PEPTIDES; PHOSPHORYLATION;

ACTIVATED PROTEIN KINASES; ACTIVATED PROTEINS; CANCER CELL LINES; CATALYTIC SUBUNITS; COMPLEX REGULATIONS; DEPHOSPHORYLATION; EFFECTS OF AMINO ACIDS; EPIDERMAL GROWTH FACTORS; GROWTH FACTOR ACTIVATIONS; GROWTH FACTORS; HIGHER CONCENTRATIONS; INDUCED DISSOCIATIONS; KINASE ACTIVITIES; LOW CONCENTRATIONS; MAMMALIAN TARGET OF RAPAMYCIN (MTOR); MITOGEN; OKADAIC ACIDS; PROTEIN PHOSPHATASES; RAPAMYCIN; STIMULATED PHOSPHORYLATIONS; TUBEROUS SCLEROSES;

CHEMICAL REACTIONS;

AMINO ACID; EPIDERMAL GROWTH FACTOR; GROWTH FACTOR; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE 2A; RAPAMYCIN; SOMATOMEDIN C; THREONINE; TYROSINE; DNA; MTORC1 PROTEIN, HUMAN; PHOSPHOPROTEIN PHOSPHATASE 2; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DOWNSTREAM PROCESSING; DRUG MECHANISM; ENZYME INHIBITION; ENZYME REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; RAPTOR; SIGNAL TRANSDUCTION; UPREGULATION; AMINO ACID SEQUENCE; BIOLOGICAL MODEL; DRUG EFFECT; GENETICS; KINETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHOSPHORYLATION; TUMOR CELL LINE;

MAMMALIA; RAPTORES;

AMINO ACID SEQUENCE; BASE SEQUENCE; CELL LINE, TUMOR; DNA; EPIDERMAL GROWTH FACTOR; HUMANS; INSULIN; INSULIN-LIKE GROWTH FACTOR I; KINETICS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; OKADAIC ACID; PHOSPHORYLATION; PROTEIN PHOSPHATASE 2; SIGNAL TRANSDUCTION; SIROLIMUS; TRANSCRIPTION FACTORS;

EID: 41449089311     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M706173200     Document Type: Article

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