Upregulation of apoptosis with dietary restriction: Implications for carcinogenesis and aging

Environmental Health Perspectives

Volumn 106, Issue SUPPL. 1, 1998, Pages 307-312

  James, S Jill ^a,b   Muskhelishvili, Levan ^a   Gaylor, David W ^a   Turturro, Angelo ^a   Hart, Ronald ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Aging; Apoptosis; Cancer; Dietary restriction; Homeostasis; Proliferation

Indexed keywords

AGING; APOPTOSIS; CALORIC INTAKE; CARCINOGENESIS; CELL COUNT; CELL DEATH; CELL PROLIFERATION; CONFERENCE PAPER; DIET RESTRICTION; HOMEOSTASIS; LIVER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0031967803     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.98106s1307     Document Type: Conference Paper

References (51)

1. Meikrantz W, Schlegel R. Apoptosis and the cell cycle. J Cell Biochem 58:160-174 (1995).
2. McDonnell TJ. Cell division versus cell death: a functional model of multistep neoplasia. Mol Carcinog 8:209-213 (1993).
3. Schulte-Hermann R, Grasl-Kraupp B, Bursch W. Tumor development and apoptosis. Int Arch Allergy Immunol 105:363-367 (1994).
4. Kong J, Ringer DP. Quantitative analysis of changes in cell proliferation and apoptosis during preneoplastic and neoplastic stages of hepatocarcinogenesis. Cancer Lett 105:241-248 (1996).
5. Kerr JFR, Searle JA. A suggested explanation for the paradoxically slow growth rate of basal cell carcinomas that contain numerous mitotic figures. J Pathol 107:41-44 (1972).
6. Ishida M, Gomyo Y, Tatebe S, Ohfuji S, Ito H. Apoptosis in human gastric mucosa, chronic gastritis, dysplasia and carcinoma: analysis by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling. Virchows Arch Int J Pathol 428:229-235 (1996).
7. Columbano A, Endoh T, Denda A, Noguchi O, Nakae D, Hasegawa K, Ledda-Columbano GM, Zedda AI, Konishi Y. Effects of cell proliferation and cell death (apoptosis and necrosis) on the early stages of rat hepatocarcinogenesis. Carcinogenesis 17:395-400 (1996).
8. Bursch W, Lauer B, Timmermann-Trosiener I, Barthel G, Schuppler J, Schulte-Hermann R. Controlled cell death (apoptosis) of normal and putative preneoplastic cells in rat liver following withdrawal of tumor promoters. Carcinogenesis 5:453-458 (1984).
9. Ledda-Columbano GM, Columbano A. Apoptosis and hepatocarcinogenesis. In: Apoptosis: The Molecular Basis of Cell Death (Tomei LD, Cope FO, eds). Plainview, NY:Cold Spring Harbor Laboratory Press, 1991;101-119.
10. Schulte-Hermann R, Bursch W, Grasl-Kraupp B, Müllauer L, Ruttkay-Nedecky B. Apoptosis and multistage carcinogenesis in rat liver. Mutat Res 333:81-87 (1995).
11. Schulte-Hermann R, Bursch W, Kraupp-Grasl B, Oberhammer F, Wagner A, Jirtle R. Cell proliferation and apoptosis in normal liver and preneoplastic foci. Environ Health Perspect 101:87-90 (1993).
12. Kolaja KL, Stevenson DE, Walborg EF Jr, Klaunig JE. Dose dependence of phenobarbital promotion of preneoplastic hepatic lesions in F344 rats and B6C3F1 mice: effects on DNA synthesis and apoptosis. Carcinogenesis 17:947-954 (1996).
13. Wörner W, Schrenk D. Influence of liver tumor promoters on apoptosis in rat heparocytes induced by 2-acetylaminofluorene, ultraviolet light, or transforming growth factor β1. Cancer Res 56:1272-1278 (1996).
14. Gill JH, Molloy KJ, Shoesmith KJ, Bayly AC, Roberts RA. The rodent non-genotoxic hepatocarcinogen nafenopin and EGF alter the mitosis/apoptosis balance promoting hepatoma and cell clonal growth. Cell Death Differ 2:211-217 (1995).
15. Hall PA, Lane DP. Genetics of growth arrest and cell death: key determinants of tissue homeostasis. Eur J Cancer 30A:2001-2012 (1994).
16. Goldsworthy TL, Frannson-Steen RL, Moser GJ. Assessing proliferation and apoptosis in liver tumor development. CIIT Act 15:1-8 (1995).
17. Farber E. Cell proliferation as a major risk factor for cancer: a concept of doubtful validity. Cancer Res 55:3759-3762 (1995).
18. Goldsworthy TL, Conolly RB, Fransson-Steen R, Apoptosis and cancer risk assessment. Mutat Res 365:71-90 (1996).
19. Naik P, Karrim J, Hanahan D. The rise and fall of apoptosis during multistage tumorigenesis: down-modulation contributes to tumor progression from angiogenic progenitors. Genes Dev 10:2105-2116 (1996).
20. Marsman DS, Barrett JC. Apoptosis and chemical carcinogenesis. Risk Anal 14:321-326 (1994).
21. Reed JC, Miyashita T, Takayama S, Wang HG, Sato T, Krajewski S, Aimé-Sempé C, Bodrug S, Kitada S, Hanada M. BCL-2 family proteins: regulators of cell death involved in the pathogenesis of cancer and resistance to therapy. J Cell Biochem 60:23-32 (1996).
22. Trosko JE, Goodman JI. Intercellular communication may facilitate apoptosis: implications for tumor promotion. Mol Carcinog 11:8-12 (1994).
23. Carthew P, Nolan BM, Edwards RE, Smith LL, The role of cell death and cell proliferation in the promotion of rat liver tumors by tamoxifen. Cancer Lett 106:163-169 (1996).
24. Constan AA, Benjamin SA, Tessari JD, Baker DC, Yang RSH. Increased rate of apoptosis correlates with hepatocellular proliferation in Fischer 344 rats following long-term exposure to a mixture of ground water contaminants. Toxicol Pathol 24:315-322 (1996).
25. King KL, Cidlowski JA. Cell cycle and apoptosis: common pathways to life and death. J Cell Biochem 58:175-180 (1995).
26. Hoffman B, Liebermann DA. Molecular controls of apoptosis: differentiation/growth arrest primary response genes, proto-oncogenes, and tumor suppressor genes as positive and negative modulators. Oncogene 9:1807-1812 (1994).
27. Green DR, Martin SJ. The killer and the executioner: how apoptosis controls malignancy, Curr Opin Immunol 7:694-703 (1995).
28. Haas-Kogan DA, Kogen SC, Levi D, Dazin P, Fung YK, Isreal MA. Inhibition of apoptosis by the retinoblastoma gene product. EMBO J 14:461-472 (1995).
29. Martin SJ, Green DR. Apoptosis and cancer: the failure of controls on cell death and cell survival. Crit Rev Oncol Hematol 18:137-153 (1995).
30. Fernandez RS, McGowan AJ, Cotter T.G. Mutant H-ras overexpression inhibits drug and UV-induced apoptosis. Anticancer Res 16:1691-1705 (1996).
31. Weindruch R, Albanes D, Kritchevsky D. The role of calories and caloric restriction in carcinogenesis. Hematol Oncol Clin N Am 5:79-89 (1991).
32. Weindruch RH, Walford RL, Fligiel S, Guthrie D. The retardation of aging in mice by dietary restriction: longevity, cancer, immunity, and lifetime energy intake. J Nutr 116:641-654 (1986).
33. Hart RW, Turturro, A. Overview of Cancer and Aging. Exper Gerontol 27:567-574 (1992).
34. Brash DE, Hart RW. Molecular biology of aging. In: The Biology of Aging (Behnke J, ed). New York:Plenum Press, 1977;57-81.
35. Warner HR, Fernandes G, Wang E. A unifying hypothesis to explain the retardation of aging and tumorigenesis by caloric restriction. J Gerontol A Biol Sci Med Sci 50A:B107-B109 (1995).
36. James SJ, Muskhelishvili L. Rates of apoptosis and proliferation vary with caloric intake and may influence incidence of spontaneous hepatoma in B6C3F1 mice. Cancer Res 554:5508-5510 (1994).
37. Muskhelishvili L, Hart RW, Turturro A, James SJ. Age-related changes in the intrinsic rate of apoptosis in livers of diet-restricted and ad libitum-fed B6C3F1 mice. Am J Pathol 147:20-24 (1995).
38. Monti D, Grassilli E, Troiano L, Cossarizza A, Salvioli S, Barbieri D, Agnesini C, Bettuzzi S, Ingletti MC, Corti A et al. Senescence, immortalization, and apoptosis: an intriguing relationship. Ann NY Acad Sci 673:70-82 (1992).
39. Muskhelishvili L, Turturro A, Hart RW, James SJ. Pi-class glutathione S-transferase-positive hepatocytes in aging B6C3F1 mice undergo apoptosis induced by dietary restriction. Am J Pathol 149:1585-1591 (1996).
40. Raff MC, Barres BA, Burne JF, Coles HSR, Ishizaki Y, Jacobson MD. Programmed cell death and the control of cell survival. Philos Trans R Soc Lond B Biol Sci 435:265-268 (1994).
41. Collins MKL, Perkins GR, Rodriguez-Tarduchy G, Nieto MA, Lopez-Rivas A. Growth factors as survival factors: regulation of apoptosis. Bioessays 16:133-138 (1994).
42. Ruggeri BA, Klurfeld DM, Kritchevsky D, Furlanetto RW. Caloric restriction and 7, 12-dimethylbenz(α)anthracene-induced mammary tumor growth in rats: alterations in circulating insulin, insulin-like growth factors I and II, and epidermal growth factor. Cancer Res 49:4130-4134 (1989).
43. Lagopoulos L, Sunahara GI, Wurtzner H, Dombrowsky I, Stalder R. The effects of alternating dietary restriction and ad libitum feeding of mice on the development of diethylnitrosamine-induced liver tumors and its correlation to insulinaemia. Carcinogenesis 12:311-315 (1991).
44. Resnicoff M, Burgaud JL, Rotman HL, Abraham D, Baserga R. Correlation between apoptosis, tumorigenesis, and levels of insulin-like growth factor I receptors. Cancer Res 55:3739-3741 (1995).
45. Resnicoff M, Abraham D, Yutanawiboonchai W, Rotman HL, Rubin R, Zoltick P, Barserga R. The insulin-like growth factor I receptor protects tumor cells from apoptosis in vivo. Cancer Res 55:2463-2469 (1995).
46. Weindruch R. Caloric restriction and aging. Sci Am 274:46-52 (1996).
47. Urao M, Ueda G, Abe M, Kanno K, Hirose S, Shirai T. Food restriction inhibits an autoimmune disease resembling systemic lupus erythematosus in (NZBxNZW) F1 mice. J Nutr 125:2316-2324 (1995).
48. Luan XH, Zhao WG, Chandrasekar BS, Fernandes G. Calorie restriction modulates lymphocyte subset phenotype and increases apoptosis in MRL/lpr mice. Immunol Lett 47:181-186 (1995).
49. Sohal RS, Weindruch R. Oxidative stress, caloric restriction, and aging. Science 273:59-63 (1996).
50. Feuers RJ, Weindruch, R, Hart RW. Caloric restriction, aging and antioxidant enzymes. Mutat Res 295:191-200 (1993).
51. Sorenson CM, Rogers SA, Korsmeyer SJ, Hammerman MR. Fulminant metanephric apoptosis and abnormal kidney development in W-2-deficient mice. Am J Physiol 268:F73-F81 1995).