-
1
-
-
0031873752
-
The 90-kDa molecular chaperone family: Structure, function, and clinical applications. a comprehensive review
-
DOI 10.1016/S0163-7258(98)00013-8, PII S0163725898000138
-
Csermely P, Schnaider T, Soti C, Prohászka Z and Nardai G: The 90-kDa molecular chaperone family: structure, function and clinical applications. a comprehensive review. Pharmacol Ther 79: 129-168, 1998. (Pubitemid 28380440)
-
(1998)
Pharmacology and Therapeutics
, vol.79
, Issue.2
, pp. 129-168
-
-
Csermely, P.1
Schnaider, T.2
Soti, C.3
Prohaszka, Z.4
Nardai, G.5
-
2
-
-
0032924953
-
Hsp90 & Co. - A holding for folding
-
Buchner J: Hsp90 & Co. - a holding for folding. Trends Biochem Sci 24: 136-141, 1999.
-
(1999)
Trends Biochem Sci
, vol.24
, pp. 136-141
-
-
Buchner, J.1
-
3
-
-
4143095430
-
Altered Hsp90 function in cancer: A unique therapeutic opportunity
-
Bagatell R and Whitesell L: Altered Hsp90 function in cancer: a unique therapeutic opportunity. Mol Cancer Ther 3: 1021-1030, 2004. (Pubitemid 39199597)
-
(2004)
Molecular Cancer Therapeutics
, vol.3
, Issue.8
, pp. 1021-1030
-
-
Bagatell, R.1
Whitesell, L.2
-
4
-
-
0037315208
-
Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery
-
Pratt WB and Toft DO: Regulation of signaling protein function and trafficking by the Hsp90/hsp70-based chaperone machinery. Exp Biol Med (Maywood) 228: 111-133, 2003. (Pubitemid 36187918)
-
(2003)
Experimental Biology and Medicine
, vol.228
, Issue.2
, pp. 111-133
-
-
Pratt, W.B.1
Toft, D.O.2
-
5
-
-
44149104599
-
Heat shock proteins: Essential proteins for apoptosis regulation
-
Lanneau D, Brunet M, Frisan E, Solary E, Fontenay M and Garrido C: Heat shock proteins: essential proteins for apoptosis regulation. J Cell Mol Med 12: 743-761, 2008.
-
(2008)
J Cell Mol Med
, vol.12
, pp. 743-761
-
-
Lanneau, D.1
Brunet, M.2
Frisan, E.3
Solary, E.4
Fontenay, M.5
Garrido, C.6
-
6
-
-
0034710542
-
Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxy-geldanamycin, an inhibitor of the Hsp90 molecular chaperone
-
Clarke PA, Hostein I, Banerji U, Stefano FD, Maloney A, Walton M, Judson I and Workman P: Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxy-geldanamycin, an inhibitor of the Hsp90 molecular chaperone. Oncogene 19: 4125-4133, 2000.
-
(2000)
Oncogene
, vol.19
, pp. 4125-4133
-
-
Clarke, P.A.1
Hostein, I.2
Banerji, U.3
Stefano, F.D.4
Maloney, A.5
Walton, M.6
Judson, I.7
Workman, P.8
-
7
-
-
17144377442
-
Hsp90 activation and cell cycle regulation
-
Burrows F, Zhang H and Kamal A: HSP90 activation and cell cycle regulation. Cell Cycle 3: 1530-1536, 2004. (Pubitemid 40521406)
-
(2004)
Cell Cycle
, vol.3
, Issue.12
, pp. 1530-1536
-
-
Burrows, F.1
Zhang, H.2
Kamal, A.3
-
8
-
-
0026749295
-
Unusual expression and locization of heat shock protein in human tumor cells
-
Ferrarini M, Heltai S, Zocchi MR and Rugarli C: Unusual expression and locization of heat shock protein in human tumor cells. Int J Cancer 51: 613-619, 1992.
-
(1992)
Int J Cancer
, vol.51
, pp. 613-619
-
-
Ferrarini, M.1
Heltai, S.2
Zocchi, M.R.3
Rugarli, C.4
-
9
-
-
17444404622
-
Hsp90 and environmental impacts on epigenetic states: A model for the trans-generational effects of diethylstibesterol on uterine development and cancer
-
DOI 10.1093/hmg/ddi103
-
Ruden DM, Xiao L, Garfinkel MD and Lu X: Hsp90 and environmental impacts on epigenetic states: a model for the transgenerational effects of diethylstibesterol on uterine development and cancer. Hum Mol Genet 14: R149-R155, 2005. (Pubitemid 40542631)
-
(2005)
Human Molecular Genetics
, vol.14
, Issue.SPEC. ISS. 1
-
-
Ruden, D.M.1
Xiao, L.2
Garfinkel, M.D.3
Lu, X.4
-
10
-
-
0034603178
-
The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties
-
DOI 10.1074/jbc.275.5.3305
-
Felts SJ, Owen BA, Nguyen P, Trepel J, Donner DB and Toft DO: The Hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties. J Biol Chem 275: 3305-3312, 2000. (Pubitemid 30083032)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.5
, pp. 3305-3312
-
-
Felts, S.J.1
Owen, B.A.L.2
Nguyen, P.3
Trepel, J.4
Donner, D.B.5
Toft, D.O.6
-
11
-
-
0034817255
-
The Hsp90 family of proteins in Arabidopsis thaliana
-
Krishna P and Gloor G: The Hsp90 family of proteins in Arabidopsis thaliana. Cell Stress Chaperon 6: 238-246, 2001.
-
(2001)
Cell Stress Chaperon
, vol.6
, pp. 238-246
-
-
Krishna, P.1
Gloor, G.2
-
12
-
-
0023224123
-
Nucleotide sequence of a cDNA for a member of the human 90-kDa heat-shock protein family
-
Rebbe NF, Ware J, Bertina RM, Modrich P and Stafford DW: Nucleotide sequence of a cDNA for a member of the human 90-kDa heat-shock protein family. Gene 53: 235-245, 1987. (Pubitemid 17116365)
-
(1987)
Gene
, vol.53
, Issue.2-3
, pp. 235-245
-
-
Rebbe, N.F.1
Ware, J.2
Bertina, R.M.3
-
13
-
-
0024214254
-
Heat-shock proteins, Hsp84 and Hsp86, of mice and men: Two related genes encode formerly identified tumour-specific transplantation antigens
-
DOI 10.1016/0378-1119(88)90182-5
-
Hoffmann T and Hovemann B: Heat-shockproteins, Hsp84 and Hsp86, of mice and men: two related genes encode formerly identified tumour-specific transplantation antigens. Gene 74: 491-501, 1988. (Pubitemid 19060663)
-
(1988)
Gene
, vol.74
, Issue.2
, pp. 491-501
-
-
Hoffmann, T.1
Hovemann, B.2
-
14
-
-
28644443855
-
The HSP90 family of genes in the human genome: Insights into their divergence and evolution
-
DOI 10.1016/j.ygeno.2005.08.012, PII S0888754305002430
-
Chen B, Piel WH, Gui L, Bruford E and Monteiro A: The HSP90 family of genes in the human genome: insights into their divergence and evolution. Genomics 86: 627-637, 2005. (Pubitemid 41752943)
-
(2005)
Genomics
, vol.86
, Issue.6
, pp. 627-637
-
-
Chen, B.1
Piel, W.H.2
Gui, L.3
Bruford, E.4
Monteiro, A.5
-
15
-
-
0028171452
-
Hsp 90alpha and Hsp 90beta genes are present in the zebrafish and are differentially regulated in developing embryos
-
DOI 10.1006/bbrc.1994.2522
-
Krone PH and Sass JB: Hsp90a and Hsp90β genes are present in the zebrafish and are differentially regulated on developing embryos. Biochem Biophys Res Commun 204: 746-752, 1994. (Pubitemid 2148355)
-
(1994)
Biochemical and Biophysical Research Communications
, vol.204
, Issue.2
, pp. 746-752
-
-
Krone, P.H.1
Sass, J.B.2
-
16
-
-
2542474337
-
Evolutionary origins of Hsp90 chaperones and a deep paralogy in their bacterial ancestors
-
DOI 10.1111/j.1550-7408.2004.tb00580.x
-
Stechmann A and Cavalier-Smith T: Evolutionary origins of Hsp90 chaperones and a deep paralogy in their bacterial ancestors. J Eukaryot Microbiol 51: 364-373, 2004. (Pubitemid 38689131)
-
(2004)
Journal of Eukaryotic Microbiology
, vol.51
, Issue.3
, pp. 364-373
-
-
Stechmann, A.1
Cavalier-Smith, T.2
-
17
-
-
0028954475
-
Identification of a protein with homology to Hsp90 that binds the type 1 tumor necrosis factor receptor
-
Song HY, Dunbar JD, Zhang YX, Guo D and Donner DB: Identification of a protein with homology to Hsp90 that binds the type 1 tumor necrosis factor receptor. J Bio Chem 270: 3574-3581, 1995.
-
(1995)
J Bio Chem
, vol.270
, pp. 3574-3581
-
-
Song, H.Y.1
Dunbar, J.D.2
Zhang, Y.X.3
Guo, D.4
Donner, D.B.5
-
18
-
-
0037040975
-
The role of Hsp90N, a new member of the Hsp90 family, in signal transduction and neoplastic transformation
-
DOI 10.1074/jbc.M109200200
-
Grammatikakis N, Vultur A, Ramana CV, Siganou A, Schweinfest CW, Watson DK and Raptis L: The role of HSP90N, a new member of the Hsp90 family, in signal transduction and neoplastic transformation. J Bio Chem 277: 8312-8320, 2002. (Pubitemid 34968291)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.10
, pp. 8312-8320
-
-
Grammatikakis, N.1
Vultur, A.2
Ramana, C.V.3
Siganou, A.4
Schweinfest, C.W.5
Watson, D.K.6
Raptis, L.7
-
19
-
-
33750008686
-
Structural analysis of E. coli Hsp90 reveals dramatic nucleotide-dependent conformational rearrangements
-
Shiau AK, Harris SF, Southworth DR and Agard DA: Structural analysis of E. coli Hsp90 reveals dramatic nucleotide-dependent conformational rearrangements. Cell 127: 329-340, 2006.
-
(2006)
Cell
, vol.127
, pp. 329-340
-
-
Shiau, A.K.1
Harris, S.F.2
Southworth, D.R.3
Agard, D.A.4
-
20
-
-
17044403753
-
Structures of the N-terminal and middle domains of E. coli Hsp90 and conformation changes upon ADP binding
-
Huai Q, Wang H, Liu Y, Kim HY, Toft D and Ke H: Structures of the N-terminal and middle domains of E. coli Hsp90 and conformation changes upon ADP binding. Structure 13: 579-590, 2005.
-
(2005)
Structure
, vol.13
, pp. 579-590
-
-
Huai, Q.1
Wang, H.2
Liu, Y.3
Kim, H.Y.4
Toft, D.5
Ke, H.6
-
21
-
-
0031444238
-
Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone
-
DOI 10.1016/S0092-8674(00)80314-1
-
Prodromou C, Roe SM, O'Brien R, Ladbury JE, Piper PW and Pearl LH: Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone. Cell 90: 65-75, 1997. (Pubitemid 28009419)
-
(1997)
Cell
, vol.90
, Issue.1
, pp. 65-75
-
-
Prodromou, C.1
Roe, S.M.2
O'Brien, R.3
Ladbury, J.E.4
Piper, P.W.5
Pearl, L.H.6
-
22
-
-
33646176246
-
Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex
-
Ali MM, Roe SM, Vaughan CK, Meyer P, Panaretou B, Piper PW, Prodromou C and Pearl LH: Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex. Nature 440: 1013-1017, 2006.
-
(2006)
Nature
, vol.440
, pp. 1013-1017
-
-
Ali, M.M.1
Roe, S.M.2
Vaughan, C.K.3
Meyer, P.4
Panaretou, B.5
Piper, P.W.6
Prodromou, C.7
Pearl, L.H.8
-
23
-
-
0031005361
-
Crystal structure of an Hsp90-geldanamycin complex: Targeting of a protein chaperone by an antitumor agent
-
Stebbins CE, Russo AA, Schneider C, Rosen N, Hartl FU and Pavletich NP: Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent. Cell 89: 239-250, 1997. (Pubitemid 27199896)
-
(1997)
Cell
, vol.89
, Issue.2
, pp. 239-250
-
-
Stebbins, C.E.1
Russo, A.A.2
Schneider, C.3
Rosen, N.4
Hartl, F.U.5
Pavletich, N.P.6
-
24
-
-
49649113716
-
Conserved conformational changes in the ATPase cycle of human Hsp 90
-
Richter K, Soroka J, Skalniak L, Leskovar A, Hessling M, Reinstein J and Buchner J: Conserved conformational changes in the ATPase cycle of human Hsp 90. J Biol Chem 283: 17757-17765, 2008.
-
(2008)
J Biol Chem
, vol.283
, pp. 17757-17765
-
-
Richter, K.1
Soroka, J.2
Skalniak, L.3
Leskovar, A.4
Hessling, M.5
Reinstein, J.6
Buchner, J.7
-
25
-
-
18544386399
-
Binding of ATP to heat shock protein 90: Evidence for an ATP-binding site in the C-terminal domain
-
DOI 10.1074/jbc.M111874200
-
Garnier C, Lafitte D, Tsvetkov PO, Barbier P, Leclerc-Devin J, Millot JM, Briand C, Makarov AA, Catelli MG and Peyrot V: Binding of ATP to heat shock protein 90: evidence for an ATP-binding site in the C-terminal domain. J Biol Chem 277: 12208-12214, 2002. (Pubitemid 34952787)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.14
, pp. 12208-12214
-
-
Garnier, C.1
Lafitte, D.2
Tsvetkov, P.O.3
Barbier, P.4
Leclerc-Devin, J.5
Millot, J.-M.6
Briand, C.7
Makarov, A.A.8
Catelli, M.G.9
Peyrot, V.10
-
26
-
-
0027214861
-
The calmodulin-binding domain of the mouse 90-kDa heat shock protein
-
Minami Y, Kawasaki H, Suzuki K and Yahara I: The calmodulin-binding domain of the mouse 90-kDa heat shock protein. J Biol Chem 268: 9604-9610, 1993. (Pubitemid 23146018)
-
(1993)
Journal of Biological Chemistry
, vol.268
, Issue.13
, pp. 9604-9610
-
-
Minami, Y.1
Kawasaki, H.2
Suzuki, K.3
Yahara, I.4
-
27
-
-
0028012587
-
The carboxy-terminal region of mammalian HSP90 is required for its dimerization and function in vivo
-
Minami Y, Kimura Y, Kawasaki H, Suzuki K and Yahara I: The carboxy-terminal region of mammalian HSP90 is required for its dimerization and function in vivo. Mol Cell Biol 14: 1459-1464, 1994. (Pubitemid 24036596)
-
(1994)
Molecular and Cellular Biology
, vol.14
, Issue.2
, pp. 1459-1464
-
-
Minami, Y.1
Kimura, Y.2
Kawasaki, H.3
Suzuki, K.4
Yahara, I.5
-
28
-
-
0031846768
-
Differential interactions of p23 and the TPR-containing proteins Hop, Cyp40, FKBP52 and FKBP51 with Hsp90 mutants
-
DOI 10.1379/1466-1268(1998)003<0118:DIOPAT>2.3.CO;2
-
Chen S, Sullivan WP, Toft DO and Smith DF: Differential interactions of p23 and the TPR-containing proteins Hop, Cyp40, FKBP52 and FKBP51 with Hsp90 mutants. Cell Stress Chaperones 3: 118-129, 1998. (Pubitemid 28327424)
-
(1998)
Cell Stress and Chaperones
, vol.3
, Issue.2
, pp. 118-129
-
-
Chen, S.1
Sullivan, W.P.2
Toft, D.O.3
Smith, D.F.4
-
29
-
-
0033081968
-
Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones
-
DOI 10.1093/emboj/18.3.754
-
Prodromou C, Siligardi G, O'Brien R, Woolfson DN, Regan L, Panaretou B, Ladbury JE, Piper PW and Peral LH: Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones. EMBO J 18: 754-762, 1999. (Pubitemid 29057260)
-
(1999)
EMBO Journal
, vol.18
, Issue.3
, pp. 754-762
-
-
Prodromou, C.1
Siligardi, G.2
O'Brien, R.3
Woolfson, D.N.4
Regan, L.5
Panaretou, B.6
Ladbury, J.E.7
Piper, P.W.8
Pearl, L.H.9
-
30
-
-
0034646511
-
Structure of TPR domain-peptide complexes: Critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine
-
DOI 10.1016/S0092-8674(00)80830-2
-
Scheufler C, Brinker A, Bourenkov G, Pegoraro S, Moroder L, Bartunik H, Harl FU and Moarefi I: Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine. Cell 101: 199-210, 2000. (Pubitemid 32004747)
-
(2000)
Cell
, vol.101
, Issue.2
, pp. 199-210
-
-
Scheufler, C.1
Brinker, A.2
Bourenkov, G.3
Pegoraro, S.4
Moroder, L.5
Bartunik, H.6
Hartl, F.U.7
Moarefi, I.8
-
31
-
-
33750983940
-
The middle domain of Hsp90 acts as a discriminator between different types of client proteins
-
DOI 10.1128/MCB.02188-05
-
Hawl P, Siepmann M, Harst A, Siderius M, Reusch HP and Obermann WM: The middle domain of Hsp90 acts as a discriminator between different types of client proteins. Mol Cell Biol 26: 8385-8395, 2006. (Pubitemid 44748572)
-
(2006)
Molecular and Cellular Biology
, vol.26
, Issue.22
, pp. 8385-8395
-
-
Hawle, P.1
Siepmann, M.2
Harst, A.3
Siderius, M.4
Reusch, H.P.5
Obermann, W.M.J.6
-
32
-
-
18844406200
-
Aha1 competes with Hop, p50 and p23 for binding to the molecular chaperone Hsp90 and contributes to kinase and hormone receptor activation
-
DOI 10.1042/BJ20041283
-
Harst A, Lin H and Obermann WM: Aha1 competes with Hop, p50 and p23 for binding to the molecular chaperone Hsp90 and contributes to kinase and hormone receptor activation. Biochem J 387: 789-796, 2005. (Pubitemid 40685714)
-
(2005)
Biochemical Journal
, vol.387
, Issue.3
, pp. 789-796
-
-
Harst, A.1
Lin, H.2
Obermann, W.M.J.3
-
33
-
-
0037593900
-
Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone
-
DOI 10.1074/jbc.M212761200
-
Lotz GP, Lin H, Harst A and Obermann WM: Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone. J Biol Chem 278: 17228-17235, 2003. (Pubitemid 36799604)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.19
, pp. 17228-17235
-
-
Lotz, G.P.1
Lin, H.2
Harst, A.3
Obermann, W.M.J.4
-
34
-
-
0037352446
-
Structural and functional analysis of the middle segment of Hsp90: Implications for ATP hydrolysis and client protein and cochaperone interactions
-
DOI 10.1016/S1097-2765(03)00065-0
-
Meyer P, Prodromou C, Hu B, Vaughan C, Roe SM, Panaretou B, Piper PW and Pearl LH: Structural and functional analysis of the middle segment of Hsp90: implications for ATP hydrolysis and client protein and cochaperone interactions. Mol Cell 11: 647-658, 2003. (Pubitemid 36385120)
-
(2003)
Molecular Cell
, vol.11
, Issue.3
, pp. 647-658
-
-
Meyer, P.1
Prodromou, C.2
Hu, B.3
Vaughan, C.4
Roe, S.M.5
Panaretou, B.6
Piper, P.W.7
Pearl, L.H.8
-
35
-
-
0036931438
-
Activation of the ATPase activity of Hsp90 by the stress-regulated cochaperone Aha1
-
DOI 10.1016/S1097-2765(02)00785-2
-
Panaretou B, Siligardi G, Meyer P, Maloney A, Sullivan JK, Singh S, Millson SH, Clarke PA, Naaby-Hansen S, Stein R, Cramer R, Mollapour M, Workman P, Piper PW, Pearl LH and Prodromou C: Activation of the ATPase activity of Hsp90 by the stress-regulated cochaperone aha1. Mol Cell 10: 1307-1318, 2002. (Pubitemid 36050873)
-
(2002)
Molecular Cell
, vol.10
, Issue.6
, pp. 1307-1318
-
-
Panaretou, B.1
Siligardi, G.2
Meyer, P.3
Maloney, A.4
Sullivan, J.K.5
Singh, S.6
Millson, S.H.7
Clarke, P.A.8
Naaby-Hansen, S.9
Stein, R.10
Cramer, R.11
Mollapour, M.12
Workman, P.13
Piper, P.W.14
Pearl, L.H.15
Prodromou, C.16
-
36
-
-
0030901877
-
A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone
-
DOI 10.1038/nsb0697-477
-
Prodromou C, Roe SM, Piper PW and Pearl LH: A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone. Nature Struct Biol 4: 477-482, 1997. (Pubitemid 27263601)
-
(1997)
Nature Structural Biology
, vol.4
, Issue.6
, pp. 477-482
-
-
Prodromou, C.1
Roe, S.M.2
Piper, P.W.3
Pearl, L.H.4
-
37
-
-
0030863995
-
The amino-terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation
-
DOI 10.1074/jbc.272.38.23843
-
Grenert JP, Sullivan WP, Fadden P, Haystead TA, Clark J, Mimnaugh E, Krutzsch H, Ochel HJ, Schulte TW, Sausville E, Neckers LM and Toft DO: The amino-terminal domain of heat shock protein90 (Hsp90) that binds Geldanamycin is an ATP/ADP switch domain that regulates Hsp90 conformation. J Biol Chem 272: 23843-23850, 1997. (Pubitemid 27410964)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.38
, pp. 23843-23850
-
-
Grenert, J.P.1
Sullivan, W.P.2
Fadden, P.3
Haystead, T.A.J.4
Clark, J.5
Mimnaugh, E.6
Krutzsch, H.7
Ochel, H.-J.8
Schulte, T.W.9
Sausville, E.10
Neckers, L.M.11
Toft, D.O.12
-
38
-
-
0032538995
-
In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis
-
Obermann WM, Sondermann H, Russo AA, Pavletich NP and Hartl FU: In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis. J Cell Biol 143: 901-910, 1998.
-
(1998)
J Cell Biol
, vol.143
, pp. 901-910
-
-
Obermann, W.M.1
Sondermann, H.2
Russo, A.A.3
Pavletich, N.P.4
Hartl, F.U.5
-
39
-
-
0032541344
-
ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo
-
DOI 10.1093/emboj/17.16.4829
-
Panaretou B, Prodromou C, Roe SM, O'Brien R, Ladbury JE, Piper PW and Pearl LH: ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo. EMBO J 17: 4829-4836, 1998. (Pubitemid 28377183)
-
(1998)
EMBO Journal
, vol.17
, Issue.16
, pp. 4829-4836
-
-
Panaretou, B.1
Prodromou, C.2
Roe, S.M.3
O'Brien, R.4
Ladbury, J.E.5
Piper, P.W.6
Pearl, L.H.7
-
40
-
-
0033741503
-
Dimerization and N-terminal domain proximity underlie the function of the molecular chaperone heat shock protein 90
-
Chadli A, Bouhouche I, Sullivan W, Stensgard B, McMahon N, Catelli MG and Toft DO: Dimerization and N-terminal domain proximity underlie the function of the molecular chaperone heat shock protein 90. Proc Natl Acad Sci USA 97: 12524-12529, 2000.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 12524-12529
-
-
Chadli, A.1
Bouhouche, I.2
Sullivan, W.3
Stensgard, B.4
McMahon, N.5
Catelli, M.G.6
Toft, D.O.7
-
41
-
-
0035939668
-
Hsp90: A specialized but essential protein-folding tool
-
DOI 10.1083/jcb.200104079
-
Young JC, Moarefi I and Hartl FU: Hsp90: a specialized but essential protein-folding tool. J Cell Biol 154: 267-273, 2001. (Pubitemid 34286138)
-
(2001)
Journal of Cell Biology
, vol.154
, Issue.2
, pp. 267-273
-
-
Young, J.C.1
Moarefi, I.2
Ulrich Hartl, F.3
-
42
-
-
0036510547
-
A nucleotide-dependent molecular switch controls ATP binding at the C-terminal domain of Hsp90. N-terminal nucleotide binding unmasks a C-terminal binding pocket
-
DOI 10.1074/jbc.M105568200
-
Söti C, Rácz A and Csermely P: A Nucleotide-dependent molecular switch controls ATP binding at the C-terminal domain of Hsp90. N-terminal nucleotide binding unmasks a C-terminal binding pocket. J Biol Chem 277: 7066-7075, 2002. (Pubitemid 34953095)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.9
, pp. 7066-7075
-
-
Soti, C.1
Racz, A.2
Csermely, P.3
-
43
-
-
33744956564
-
Intrinsic inhibition of the Hsp90 ATPase activity
-
DOI 10.1074/jbc.M510142200
-
Richter K, Moser S, Hagn F, Friedrich R, Hainzl O, Heller M, Schlee S, Kessler H, Reinstein J and Buchner J: Intrinsic inhibition of the Hsp90 ATPase activity. J Biol Chem 281: 11301-11311, 2006. (Pubitemid 43855555)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.16
, pp. 11301-11311
-
-
Richter, K.1
Moser, S.2
Hagn, F.3
Friedrich, R.4
Hainzl, O.5
Heller, M.6
Schlee, S.7
Kessler, H.8
Reinstein, J.9
Buchner, J.10
-
44
-
-
0028064940
-
Inhibition of heat shock protein HSP90-pp60(v-src) heteroprotein complex formation by benzoquinone ansamycins: Essential role for stress proteins in oncogenic transformation
-
Whitesell L, Mimnaugh EG, De Costa B, Myers CE and Neckers LM: Inhibition of heat shock protein HSP90-pp6Ov-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation. Proc Natl Acad Sci USA 91: 8324-8328, 1994. (Pubitemid 24273656)
-
(1994)
Proceedings of the National Academy of Sciences of the United States of America
, vol.91
, Issue.18
, pp. 8324-8328
-
-
Whitesell, L.1
Mimnaugh, E.G.2
De Costa, B.3
Myers, C.E.4
Neckers, L.M.5
-
46
-
-
0029122080
-
Inhibition of the oncogene product p185erbB-2 in vitro and in vivo by geldanamycin and dihydrogeldanamycin derivatives
-
Schnur RC, Corman ML, Gallaschun RJ, et al: Inhibition of the oncogene product p185erbB-2 in vitro and in vivo by geldanamycin and dihydrogeldanamycin derivatives. J Med Chem 38: 3806-3812, 1995.
-
(1995)
J Med Chem
, vol.38
, pp. 3806-3812
-
-
Schnur, R.C.1
Corman, M.L.2
Gallaschun, R.J.3
-
47
-
-
4544337503
-
Synthesis and biological activities of novel 17-aminogeldanamycin derivatives
-
DOI 10.1016/j.bmc.2004.07.053, PII S0968089604005759
-
Tian ZQ, Liu Y, Zhang D, Wang Z, Dong SD, Carreras CW, Zhou Y, Rastelli G, Santi DV and Myles DC: Synthesis and biological activities of novel 17-aminogeldanamycin derivatives. Bioorg Med Chem 12: 5317-5329, 2004. (Pubitemid 39243952)
-
(2004)
Bioorganic and Medicinal Chemistry
, vol.12
, Issue.20
, pp. 5317-5329
-
-
Tian, Z.-Q.1
Liu, Y.2
Zhang, D.3
Wang, Z.4
Dong, S.D.5
Carreras, C.W.6
Zhou, Y.7
Rastelli, G.8
Santi, D.V.9
Myles, D.C.10
-
48
-
-
0031875042
-
The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin
-
DOI 10.1007/s002800050817
-
Schulte TW and Neckers LM: Thebenzoquinone ansamycin 17-allylamino-17- demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin. Cancer Chemother Pharmacol 42: 273-279, 1998. (Pubitemid 28393843)
-
(1998)
Cancer Chemotherapy and Pharmacology
, vol.42
, Issue.4
, pp. 273-279
-
-
Schulte, T.W.1
Neckers, L.M.2
-
49
-
-
37649024109
-
Development and application of Hsp90 inhibitors
-
Solit DB and Chiosis G: Development and application of Hsp90 inhibitors. Drug Discovery Today 13: 38-43, 2008.
-
(2008)
Drug Discovery Today
, vol.13
, pp. 38-43
-
-
Solit, D.B.1
Chiosis, G.2
-
50
-
-
0035872442
-
Inhibition of signal transduction by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin results in cytostasis and apoptosis
-
Hostein I, Robertson D, Di Stefano F, Workman P and Clarke PA: Inhibition of signal transduction by the Hsp90 inhibitor 17-allylamino-17-demethox- ygeldanamycin results in cytostasis and apoptosis. Cancer Res 61: 4003-4009, 2001. (Pubitemid 32720963)
-
(2001)
Cancer Research
, vol.61
, Issue.10
, pp. 4003-4009
-
-
Hostein, I.1
Robertson, D.2
Distefano, F.3
Workman, P.4
Clarke, P.A.5
-
51
-
-
0034886833
-
Modulation of Hsp90 function by ansamycins sensitizes breast cancer cells to chemotherapy-induced apoptosis in an RB- and schedule-dependent manner. See: E.A. Sausville, combining cytotoxics and 17-allylamino, 17-demethoxy- geldanamycin: sequence and tumor biology matters
-
Münster PN, Basso A, Solit D, Norton L and Rosen N: Modulation of Hsp90 function by ansamycins sensitizes breast cancer cells to chemotherapy-induced apoptosis in an RB- and schedule-dependent manner. See: E.A. Sausville, combining cytotoxics and 17-allylamino, 17-demethoxy- geldanamycin: sequence and tumor biology matters. Clin Cancer Res 7: 2155-2158, 2001.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 2155-2158
-
-
Münster, P.N.1
Basso, A.2
Solit, D.3
Norton, L.4
Rosen, N.5
-
52
-
-
33747691089
-
A phase II trial of 17-(Allylamino)-17-demethoxygeldanamycin in patients with papillary and clear cell renal cell carcinoma
-
DOI 10.1007/s10637-006-9208-z
-
Ronnen EA, Kondagunta GV, Ishill N, Sweeney SM, Deluca JK, Schwartz L, Bacik J and Motzer RJ: A phase II trial of 17-(allylamino)-17- demethoxygeldanamycin in patients with papillary and clear cell renal cell carcinoma. Invest New Drugs 24: 543-546, 2006. (Pubitemid 44273031)
-
(2006)
Investigational New Drugs
, vol.24
, Issue.6
, pp. 543-546
-
-
Ronnen, E.A.1
Kondagunta, G.V.2
Ishill, N.3
Sweeney, S.M.4
Deluca, J.K.5
Schwartz, L.6
Bacik, J.7
Motzer, R.J.8
-
53
-
-
0034743361
-
Plasma pharmacokinetics and tissue distribution of 17-(allylamino)-17- demethoxygeldanamycin (NSC 330507) in CD2F1 mice1
-
DOI 10.1007/s002800000242
-
Egorin MJ, Zuhowski EG, Rosen DM, Sentz DL, Covey JM and Eiseman JL: Plasma pharmacokinetics and tissue distribution of 17-(allylamino)-17- demethoxygeldanamycin (NSC330507) in CD2F1 mice1. Cancer Chemother Pharmacol 47: 291-302, 2001. (Pubitemid 32640768)
-
(2001)
Cancer Chemotherapy and Pharmacology
, vol.47
, Issue.4
, pp. 291-302
-
-
Egorin, M.J.1
Zuhowski, E.G.2
Rosen, D.M.3
Sentz, D.L.4
Covey, J.M.5
Eiseman, J.L.6
-
54
-
-
27544446054
-
Formation of 17-allylamino-demethoxygeldanamycin (17-AAG) hydroquinone by NAD(P)H:quinone oxidoreductase 1: Role of 17-AAG hydroquinone in heat shock protein 90 inhibition
-
DOI 10.1158/0008-5472.CAN-05-2029
-
Guo W, Reigan P, Siegel D, Zirrolli J, Gustafson D and Ross D: Formation of 17-allylamino-demethoxy-geldanamycin (17-AAG) hydroquinone by NAD(P)H: quinone oxidoreductase 1: role of 17-AAG hydroquinone in heat shock protein 90 inhibition. Cancer Res 65: 10006-10015, 2005. (Pubitemid 41541482)
-
(2005)
Cancer Research
, vol.65
, Issue.21
, pp. 10006-10015
-
-
Guo, W.1
Reigan, P.2
Siegel, D.3
Zirrolli, J.4
Gustafson, D.5
Ross, D.6
-
55
-
-
33746662241
-
Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90
-
DOI 10.1021/jm0603116
-
Ge J, Normant E, Porter JR, Ali JA, Dembski MS, GaoY, Georges AT, Grenier L, Pak RH, Patterson J, Sydor JR, Tibbitts TT, Tong JK, Adams J and Palombella VJ: Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90. J Med Chem 49: 4606-4615, 2006. (Pubitemid 44162687)
-
(2006)
Journal of Medicinal Chemistry
, vol.49
, Issue.15
, pp. 4606-4615
-
-
Ge, J.1
Normant, E.2
Porter, J.R.3
Ali, J.A.4
Dembski, M.S.5
Gao, Y.6
Georges, A.T.7
Grenier, L.8
Pak, R.H.9
Patterson, J.10
Sydor, J.R.11
Tibbitts, T.T.12
Tong, J.K.13
Adams, J.14
Palombella, V.J.15
-
57
-
-
58149340657
-
PhaseII trial of 17-allylamino-17-demethoxy geldanamycin in patients with metastatic melanoma
-
Solit DB, Osman I, Polsky D, Panageas KS, Daud A, Goydos JS, Teitcher J, Wolchok JD, Germino FJ, Krown SE, Coit D, Rosen N and Chapman PB: PhaseII trial of 17-allylamino-17-demethoxy geldanamycin in patients with metastatic melanoma. Clin Cancer Res 14: 8302-8307, 2008.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 8302-8307
-
-
Solit, D.B.1
Osman, I.2
Polsky, D.3
Panageas, K.S.4
Daud, A.5
Goydos, J.S.6
Teitcher, J.7
Wolchok, J.D.8
Germino, F.J.9
Krown, S.E.10
Coit, D.11
Rosen, N.12
Chapman, P.B.13
-
58
-
-
33745174538
-
Heat shock protein-90 inhibitors: A chronicle from geldanamycin to today's agents
-
Chiosis G, Caldas Lopes E and Solit D: Heat shock protein-90 inhibitors a chronice from geldanamycin to today's agents. Curr Opin Investig Drugs 7: 534-541, 2006. (Pubitemid 43891032)
-
(2006)
Current Opinion in Investigational Drugs
, vol.7
, Issue.6
, pp. 534-541
-
-
Chiosis, G.1
Lopes, E.C.2
Solit, D.3
-
59
-
-
21244466289
-
Comparison of 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17DMAG) and 17-allylamino-17-demethoxygeldanamycin (17AAG) in vitro: Effects on Hsp90 and client proteins in melanoma models
-
DOI 10.1007/s00280-004-0947-2
-
Smith V, Sausville EA, Camalier RF, Fiebig HH and Burger AM: Comparison of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17DMAG) and 17-allylamino-17-demethoxygeldanamycin (17AAG) in vitro: effects on Hsp90 and client proteins in melanoma models. Cancer Chemother Pharmacol 56: 126-137, 2005. (Pubitemid 40884268)
-
(2005)
Cancer Chemotherapy and Pharmacology
, vol.56
, Issue.2
, pp. 126-137
-
-
Smith, V.1
Sausville, E.A.2
Camalier, R.F.3
Fiebig, H.-H.4
Burger, A.M.5
-
60
-
-
21244462689
-
In vivo antitumor efficacy of 17-DMAG (17-dimethylaminoethylamino-17- demethoxygeldanamycinhydrochloride) a water-soluble geldanamycin derivative
-
Hollingshead M, Alley M, Burger AM, Borgel S, Pacula-Cox C, Fiebig HH and Sausville EA: In vivo antitumor efficacy of 17-DMAG (17- dimethylaminoethylamino-17-demethoxygeldanamycinhydrochloride) a water-soluble geldanamycin derivative. Cancer Chemother Pharmacol 56: 115-125, 2005.
-
(2005)
Cancer Chemother Pharmacol
, vol.56
, pp. 115-125
-
-
Hollingshead, M.1
Alley, M.2
Burger, A.M.3
Borgel, S.4
Pacula-Cox, C.5
Fiebig, H.H.6
Sausville, E.A.7
-
61
-
-
29244460610
-
Determination of the heat shock protein 90 inhibitor 17- Dimethylaminoethylamino-17-demethoxygeldanamycin in plasma by liquid chromatography-electrospray mass spectrometry
-
DOI 10.1016/j.jchromb.2005.10.019, PII S1570023205007348
-
Hwang K, Scripture CD, Gutierrez M, Kummar S, Figg WD and Sparreboom A: Determination of the heat shock protein 90 inhibitor 17-dimethyl aminoethylamino-17-demethoxygeldanamycin in plasma by liquid chromatography-electrospray mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 830: 35-40, 2006. (Pubitemid 41831385)
-
(2006)
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
, vol.830
, Issue.1
, pp. 35-40
-
-
Hwang, K.1
Scripture, C.D.2
Gutierrez, M.3
Kummar, S.4
Figg, W.D.5
Sparreboom, A.6
-
62
-
-
0036139023
-
Pharmaco kinetics, tissue distribution and metabolism of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (NSC707545) in CD2F1 mice and Fischer 344 rats
-
Egorin MJ, Lagattuta TF, Hamburger DR, Covey JM, White KD, Musser SM and Eiseman JL: Pharmaco kinetics, tissue distribution and metabolism of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (NSC707545) in CD2F1 mice and Fischer 344 rats. Cancer Chemother Pharmacol 49: 7-19, 2002.
-
(2002)
Cancer Chemother Pharmacol
, vol.49
, pp. 7-19
-
-
Egorin, M.J.1
Lagattuta, T.F.2
Hamburger, D.R.3
Covey, J.M.4
White, K.D.5
Musser, S.M.6
Eiseman, J.L.7
-
63
-
-
26444462561
-
Preclinical toxicity of a geldanamycin analog, 17- (dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG), in rats and dogs: Potential clinical relevance
-
Glaze ER, Lambert AL, Smith AC, Page JG, Johnson WD, McCormick DL, Brown AP, Levine BS, Covey JM, Egorin MJ, Eiseman JL, Holleran JL, Sausville EA and Tomaszewski JE: Preclinical toxicity of a geldanamycin analog, 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG), in rats and dogs: potential clinical relevance. Cancer Chemother Pharmacol 56: 637-647, 2005.
-
(2005)
Cancer Chemother Pharmacol
, vol.56
, pp. 637-647
-
-
Glaze, E.R.1
Lambert, A.L.2
Smith, A.C.3
Page, J.G.4
Johnson, W.D.5
McCormick, D.L.6
Brown, A.P.7
Levine, B.S.8
Covey, J.M.9
Egorin, M.J.10
Eiseman, J.L.11
Holleran, J.L.12
Sausville, E.A.13
Tomaszewski, J.E.14
-
64
-
-
0032101569
-
Metabolism of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) by murine and human hepatic preparations
-
Egorin MJ, Rosen DM, Wolff JH, Callery PS, Musser SM and Eiseman JL: Metabolism of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) by murine and human hepatic preparations. Cancer Res 58: 2385-2396, 1998.
-
(1998)
Cancer Res
, vol.58
, pp. 2385-2396
-
-
Egorin, M.J.1
Rosen, D.M.2
Wolff, J.H.3
Callery, P.S.4
Musser, S.M.5
Eiseman, J.L.6
-
65
-
-
11244337455
-
Pharmacokinetics and pharmacodynamics of 17-demethoxy 17-[[(2- Dimethylamino)ethyl]amino]geldanamycin (17DMAG, NSC 707545) in C.B-17 SCID mice bearing MDA-MB-231 human breast cancer xenografts
-
DOI 10.1007/s00280-004-0865-3
-
Eiseman JL, Lan J, Lagattuta TF, Hamburger DR, Joseph E, Covey JM and Egorin MJ: Pharmacokinetics and pharmacodynamics of 17-demethoxy 17-{[(2-dimethylamino)ethyl]amino} geldanamycin (17DMAG, NSC 707545) in C.B-17 SCID mice bearing MDA-MB-231 human breast cancer xenografts. Cancer Chemother Pharmacol 55: 21-32, 2005. (Pubitemid 40064492)
-
(2005)
Cancer Chemotherapy and Pharmacology
, vol.55
, Issue.1
, pp. 21-32
-
-
Eiseman, J.L.1
Lan, J.2
Lagattuta, T.F.3
Hamburger, D.R.4
Joseph, E.5
Covey, J.M.6
Egorin, M.J.7
-
66
-
-
33751258297
-
Development of 17-allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride (IPI-504), an anti-cancer agent directed against Hsp90
-
DOI 10.1073/pnas.0608372103
-
Sydor JR, Normant E, Pien CS, Porter JR, Ge J, Grenier L, Pak RH, Ali JA, Dembski MS, Hudak J, Patterson J, Penders C, Pink M, Read MA, Sang J, Woodward C, Zhang Y, Grayzel DS, Wright J, Barrett JA, Palombella VJ, Adams J and Tong JK: Development of 17-allylamino-17-demethoxygel-danamycin hydroquinone hydrochloride (IPI-504), an anti-cancer agent directed against Hsp90. Proc Natl Acad Sci USA 103: 17408-17413, 2006. (Pubitemid 44788982)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.46
, pp. 17408-17413
-
-
Sydor, J.R.1
Normant, E.2
Pien, C.S.3
Porter, J.R.4
Ge, J.5
Grenier, L.6
Pak, R.H.7
Ali, J.A.8
Dembski, M.S.9
Hudak, J.10
Patterson, J.11
Penders, C.12
Pink, M.13
Read, M.A.14
Sang, J.15
Woodward, C.16
Zhang, Y.17
Grayzel, D.S.18
Wright, J.19
Barrett, J.A.20
Palombella, V.J.21
Adams, J.22
Tong, J.K.23
more..
-
67
-
-
34248149502
-
Update on phase I clinical trial of IPI-504, a novel, water soluble Hsp90 inhibitor, in patients with relapsed/refractory multiple myeloma
-
(ASH Annual Meeting Abstracts) abs. 3579
-
Siegel D, Jagannath S, Mazumder A, Vesole D, Borrello I, Sydor JR, Wright J, Patterson J, Normant E, Adams J, Anderson KC, Grayzel DS and Richardson PG: Update on phase I clinical trial of IPI-504, a novel, water soluble Hsp90 inhibitor, in patients with relapsed/refractory multiple myeloma. (ASH Annual Meeting Abstracts) Blood 108: abs. 3579, 2006.
-
(2006)
Blood
, vol.108
-
-
Siegel, D.1
Jagannath, S.2
Mazumder, A.3
Vesole, D.4
Borrello, I.5
Sydor, J.R.6
Wright, J.7
Patterson, J.8
Normant, E.9
Adams, J.10
Anderson, K.C.11
Grayzel, D.S.12
Richardson, P.G.13
-
68
-
-
66249099479
-
Potent cytotoxic C-11 modified geldanamycin analogues
-
Tian ZQ, Wang Z, MacMillan KS, Zhou Y, Carreras CW, Mueller T, Myles DC and Liu Y: Potent cytotoxic C-11 modified geldanamycin analogues. J Med Chem 52: 3265-3273, 2009.
-
(2009)
J Med Chem
, vol.52
, pp. 3265-3273
-
-
Tian, Z.Q.1
Wang, Z.2
MacMillan, K.S.3
Zhou, Y.4
Carreras, C.W.5
Mueller, T.6
Myles, D.C.7
Liu, Y.8
-
69
-
-
0034671898
-
Radicicol binds and inhibits mammalian ATP citrate lyase
-
DOI 10.1074/jbc.M006192200
-
Ki SW, Ishigami K, Kitahara T, Kasahara K, Yoshida M and Horinouchi S: Radicicol binds and inhibits mammalian ATP citrate lyase. J Biol Chem 275: 39231-39236, 2000. (Pubitemid 32058941)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.50
, pp. 39231-39236
-
-
Ki, S.W.1
Ishigami, K.2
Kitahara, T.3
Kasahara, K.4
Yoshida, M.5
Horinouchi, S.6
-
70
-
-
0026823291
-
Radicicol, an agent inducing the reversal of transformed phenotypes of src-transformed fibroblasts
-
Kwon HJ, Yoshida M, Abe K, Horinouchi S and Beppu T: Radicicol, an agent inducing the reversal of transformed phenotypes of src-transformed fibroblasts. Biosc Biotech Biochem 56: 538-539, 1992.
-
(1992)
Biosc Biotech Biochem
, vol.56
, pp. 538-539
-
-
Kwon, H.J.1
Yoshida, M.2
Abe, K.3
Horinouchi, S.4
Beppu, T.5
-
71
-
-
0027081145
-
Potent and specific inhibition of p60(v-src) protein kinase both in vivo and in vitro by radicicol
-
Kwon HJ, Yoshida M, Fukui Y, Horinouchi S and Beppu T: Potent and specific inhibition of p60v-src protein kinase both in vivo and in vitro by radicicol. Cancer Res 52: 6926-6930, 1992. (Pubitemid 23006300)
-
(1992)
Cancer Research
, vol.52
, Issue.24
, pp. 6926-6930
-
-
Ho Jeong, K.1
Yoshida, M.2
Fukui, Y.3
Horinouchi, S.4
Beppu, T.5
-
72
-
-
0029122654
-
Morphology of ras-transformed cells becomes apparently normal again with tyrosine kinase inhibitors without a decrease in the ras-GTP complex
-
Kwon HJ, Yoshida M, Muroya K, Hattori S, Nishida E, Fukui Y, Beppu T and Horinouchi S: Morphology of ras-transformed cells becomes apparently normal again with tyrosine kinase inhibitors without a decrease in the ras-GTP complex. J Biochem 118: 221-228, 1995.
-
(1995)
J Biochem
, vol.118
, pp. 221-228
-
-
Kwon, H.J.1
Yoshida, M.2
Muroya, K.3
Hattori, S.4
Nishida, E.5
Fukui, Y.6
Beppu, T.7
Horinouchi, S.8
-
73
-
-
0028923306
-
Radicicol, a protein tyrosine kinase inhibitor, suppresses the expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide and in experimental glomerulonephritis
-
Chanmugam P, Feng L, Liou S, Lee JH, Jang BC, Boudreau M, Yu G, Kwon HJ, Beppu T, Yoshida M, Xia Y, Wilson CB and Hwang D: Radicicol, a protein tyrosine kinase inhibitor, suppresses the expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide and in experimental glomerulonephritis. J Biol Chem 270: 5418-5426, 1995.
-
(1995)
J Biol Chem
, vol.270
, pp. 5418-5426
-
-
Chanmugam, P.1
Feng, L.2
Liou, S.3
Lee, J.H.4
Jang, B.C.5
Boudreau, M.6
Yu, G.7
Kwon, H.J.8
Beppu, T.9
Yoshida, M.10
Xia, Y.11
Wilson, C.B.12
Hwang, D.13
-
74
-
-
0027242297
-
Radicicol, a microbial cell differentiation modulator, inhibits in vivo angiogenesis
-
Oikawa T, Ito H, Ashino H, Toi M, Tominaga T, Morita I and Murota S: Radicicol, a microbial cell differentiation modulator, inhibits in vivo angiogenesis. Eur J Pharmacol 241: 221-227, 1993. (Pubitemid 23272883)
-
(1993)
European Journal of Pharmacology
, vol.241
, Issue.2-3
, pp. 221-227
-
-
Oikawa, T.1
Ito, H.2
Ashino, H.3
Toi, M.4
Tominaga, T.5
Morita, I.6
Murota, S.7
-
75
-
-
0032959590
-
Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin
-
DOI 10.1021/jm980403y
-
Roe SM, Prodromou C, O'Brien R, Ladbury JE, Piper PW and Pearl LH: Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin. J Med Chem 42: 260-266, 1999. (Pubitemid 29069861)
-
(1999)
Journal of Medicinal Chemistry
, vol.42
, Issue.2
, pp. 260-266
-
-
Roe, S.M.1
Prodromou, C.2
O'Brien, R.3
Ladbury, J.E.4
Piper, P.W.5
Pearl, L.H.6
-
76
-
-
0031984520
-
Radicicol leads to selective depletion of Raf kinase and disrupts K- Ras-activated aberrant signaling pathway
-
DOI 10.1074/jbc.273.2.822
-
Soga S, Kozawa T, Narumi H, Akinaga S, Irie K, Matsumoto K, Sharma SV, Nakano H, Mizukami T and Hara M: Radicicol leads to selective depletion of raf kinase and disrupts K-ras-activated aberrant signaling pathway. J Biol Chem 273: 822-828, 1998. (Pubitemid 28049172)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.2
, pp. 822-828
-
-
Soga, S.1
Kozawa, T.2
Narumi, H.3
Akinaga, S.4
Irie, K.5
Matsumoto, K.6
Sharma, S.V.7
Nakano, H.8
Mizukami, T.9
Hara, M.10
-
77
-
-
0031844350
-
Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin
-
DOI 10.1379/1466-1268(1998)003<0100:ARBTTN>2.3.CO;2
-
Schulte TW, Akinaga S, Soga S, Sullivan W, Stensgard B, Toft D and Neckers LM: The antibiotic radicicol to the N-terminal domain of Hsp90 and shares important biological activities with geldanamycin. Cell Stress Chaperones 3: 100-108, 1998. (Pubitemid 28327422)
-
(1998)
Cell Stress and Chaperones
, vol.3
, Issue.2
, pp. 100-108
-
-
Schulte, T.W.1
Akinaga, S.2
Soga, S.3
Sullivan, W.4
Stensgard, B.5
Toft, D.6
Neckers, L.M.7
-
78
-
-
0032554763
-
Targeting of the protein chaperone, HSP90, by the transformation suppressing agent, radicicol
-
Sharma SV, Agatsuma T and Nakano H: Targeting of the protein chaperone, Hsp90, by the transformation suppressing agent, radicicol. Oncogene 16: 2639-2645, 1998. (Pubitemid 28264041)
-
(1998)
Oncogene
, vol.16
, Issue.20
, pp. 2639-2645
-
-
Sharma, S.V.1
Agatsuma, T.2
Nakano, H.3
-
79
-
-
0033564430
-
KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules
-
Soga S, Neckers LM, Schulte TW, Shiotsu Y, Akasaka K Narumi H, Agatsuma T, Ikuina Y, Murakata C, Tamaoki T and Akinaga S: KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules. Cancer Res 59: 2931-2938, 1999. (Pubitemid 29283134)
-
(1999)
Cancer Research
, vol.59
, Issue.12
, pp. 2931-2938
-
-
Soga, S.1
Neckers, L.M.2
Schulte, T.W.3
Shiotsu, Y.4
Akasaka, K.5
Narumi, H.6
Agatsuma, T.7
Ikuina, Y.8
Murakata, C.9
Tamaoki, T.10
Akinaga, S.11
-
80
-
-
0034665760
-
Novel oxime derivatives of radicicol induce erythroid differentiation associated with preferential G1 phase accumulation against chronic myelogenous leukemia cells through destabilization of Bcr-Abl with Hsp90 complex
-
Shiotsu Y, Neckers LM, Wortman I, An WG, Schulte TW, Soga S, Murakata C, Tamaoki T and Akinaga S: Novel oxime derivatives of radicicol induce erythroid differentiation associated with preferential G1 phase accumulation against chronic myelogenous leukemia cells through destabilization of Bcr-Abl with Hsp90 complex. Blood 96: 2284-2291, 2000.
-
(2000)
Blood
, vol.96
, pp. 2284-2291
-
-
Shiotsu, Y.1
Neckers, L.M.2
Wortman, I.3
An, W.G.4
Schulte, T.W.5
Soga, S.6
Murakata, C.7
Tamaoki, T.8
Akinaga, S.9
-
81
-
-
0030714117
-
Suppression of morphological transformation by radicicol is accompanied by enhanced gelsolin expression
-
Kwon HJ, Yoshida M, Nagaoka R, Obinata T, Beppu T and Horinouchi S: Suppression of morphological transformation by radicicol is accompanied by enhanced gelsolin expression. Oncogene 15: 2625-2631, 1997. (Pubitemid 27507254)
-
(1997)
Oncogene
, vol.15
, Issue.21
, pp. 2625-2631
-
-
Kwon, H.J.1
Yoshida, M.2
Nagaoka, R.3
Obinata, T.4
Beppu, T.5
Horinouchi, S.6
-
82
-
-
0036836678
-
Halohydrin and oxime derivatives of radicicol: Synthesis and antitumor activities
-
Agatsuma T, Ogawa H, Akasaka K, Asai A, Yamashita Y, Mizukami T, Akinaga S and Saitoh Y: Halohydrin and oxime derivatives of radicicol: synthesis and antitumor activities. Bioorg Med Chem 10: 3445-3454, 2002.
-
(2002)
Bioorg Med Chem
, vol.10
, pp. 3445-3454
-
-
Agatsuma, T.1
Ogawa, H.2
Akasaka, K.3
Asai, A.4
Yamashita, Y.5
Mizukami, T.6
Akinaga, S.7
Saitoh, Y.8
-
83
-
-
0037528210
-
Pochonins A-F, new antiviral and antiparasitic resorcylic acid lactones from Pochonia chlamydosporia var. catenulata
-
Hellwig V, Mayer-Bartschmid A, Muelle H, Greif G, Kleymann G, Zitzmann W, Tichy HV and Stadler M: Pochonins A-F, new antiviral and antiparasitic resorcylic acid lactones from Pochonia chlamydosporia var. catenulata. J Nat Prod 66: 829-837, 2003.
-
(2003)
J Nat Prod
, vol.66
, pp. 829-837
-
-
Hellwig, V.1
Mayer-Bartschmid, A.2
Muelle, H.3
Greif, G.4
Kleymann, G.5
Zitzmann, W.6
Tichy, H.V.7
Stadler, M.8
-
85
-
-
10044237881
-
Design, synthesis and evaluation of a radicicol and geldanamycin chimera radamide
-
Clevenger RC and Blagg BS: Design, synthesis and evaluation of a radicicol and geldanamycin chimera radamide. Org Lett 6: 4459-4462, 2004.
-
(2004)
Org Lett
, vol.6
, pp. 4459-4462
-
-
Clevenger, R.C.1
Blagg, B.S.2
-
86
-
-
33644979098
-
Radanamycin, a macrocyclic chimera of radicicol and geldanamycin
-
Wang M, Shen G and Blagg BS: Radanamycin, a macrocyclic chimera of radicicol and geldanamycin. Bioorg Med Chem Lett 16: 2459-12262, 2006.
-
(2006)
Bioorg Med Chem Lett
, vol.16
, pp. 2459-12262
-
-
Wang, M.1
Shen, G.2
Blagg, B.S.3
-
87
-
-
67649586399
-
Synthesis and evaluation of radamide analogues, a chimera of radicicol and geldanamycin
-
Hadden MK and Blagg BS: Synthesis and evaluation of radamide analogues, a chimera of radicicol and geldanamycin. J Org Chem 74: 4697-4704, 2009.
-
(2009)
J Org Chem
, vol.74
, pp. 4697-4704
-
-
Hadden, M.K.1
Blagg, B.S.2
-
88
-
-
0020360025
-
Effects of novobiocin, coumermycin A1, clorobiocin and their analogs on Escherichia coli DNA gyrase and bacterial growth
-
Hooper DC, Wolfson JS, McHugh GL, Winters MB and Swartz MN: Effects of novobiocin, coumermycin A1, clorobiocin and their analogs on Escherichia coli DNA gyrase and bacterial growth. Antimicrob Agents Chemother 22: 662-671, 1982.
-
(1982)
Antimicrob Agents Chemother
, vol.22
, pp. 662-671
-
-
Hooper, D.C.1
Wolfson, J.S.2
McHugh, G.L.3
Winters, M.B.4
Swartz, M.N.5
-
89
-
-
4644248307
-
Synthesis and antibacterial activity of novel and potent DNA gyrase inhibitors with azole ring
-
DOI 10.1016/j.bmc.2004.08.010, PII S0968089604006133
-
Tanitame A, Oyamada Y, Ofuji K, Fujimoto M, Suzuki K, Ueda T, Terauchi H, Kawasaki M, Nagai K, Wachi M and Yamagishi J: Synthesis and antibacterial activity of novel and potent DNA gyrase inhibitors with azole ring. Bioorg Med Chem 12: 5515-5524, 2004. (Pubitemid 39304051)
-
(2004)
Bioorganic and Medicinal Chemistry
, vol.12
, Issue.21
, pp. 5515-5524
-
-
Tanitame, A.1
Oyamada, Y.2
Ofuji, K.3
Fujimoto, M.4
Suzuki, K.5
Ueda, T.6
Terauchi, H.7
Kawasaki, M.8
Nagai, K.9
Wachi, M.10
Yamagishi, J.-I.11
-
90
-
-
0033523612
-
Structure-activity relationship in two series of aminoalkyl substituted coumarin inhibitors of gyrase B
-
DOI 10.1016/S0960-894X(99)00492-8, PII S0960894X99004928
-
Laurin P, Ferroud D, Schio L, Klich M, Dupuis-Hamelin C, Mauvais P, Lassaigne P, Bonnefoy A and Musicki B: Structure-activity relationship in two series of aminoalkyl substituted coumarin inhibitors of gyrase B. Bioorg Med Chem Lett 9: 2875-2880, 1999. (Pubitemid 29481181)
-
(1999)
Bioorganic and Medicinal Chemistry Letters
, vol.9
, Issue.19
, pp. 2875-2880
-
-
Laurin, P.1
Ferroud, D.2
Schio, L.3
Klich, M.4
Dupuis-Hamelin, C.5
Mauvais, P.6
Lassaigne, P.7
Bonnefoy, A.8
Musicki, B.9
-
91
-
-
0027419771
-
The 43-kilodalton N-terminal fragment of the DNA gyrase B protein hydro-lyzes ATP and binds coumarin drugs
-
Ali JA, Jackson AP, Howells AJ and Maxwell A: The 43-kilodalton N-terminal fragment of the DNA gyrase B protein hydro-lyzes ATP and binds coumarin drugs. Biochemistry 32: 2717-2724, 1993.
-
(1993)
Biochemistry
, vol.32
, pp. 2717-2724
-
-
Ali, J.A.1
Jackson, A.P.2
Howells, A.J.3
Maxwell, A.4
-
92
-
-
0030987132
-
An atypical topoisomerase II from archaea with implications for meiotic recombination
-
DOI 10.1038/386414a0
-
Bergerat A, De Massy B, Gadelle D, Varoutas PC, Nicolas A and Forterre P: An atypical topoisomerase II from Archaea with implications for meiotic recombination. Nature 386: 414-417, 1997. (Pubitemid 27154484)
-
(1997)
Nature
, vol.386
, Issue.6623
, pp. 414-417
-
-
Bergerat, A.1
De Massy, B.2
Gadelle, D.3
Varoutas, P.-C.4
Nicolas, A.5
Forterre, P.6
-
93
-
-
0033305209
-
Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones
-
Schulte TW, Akinaga S, Murakata T, Agatsuma T, Sugimoto S, Nakano H, Lee YS, Simen BB, Argon Y, Felts S, Toft DO, Neckers LM and Sharma SV: Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones. Mol Endocrinol 13: 1435-1448, 1999. (Pubitemid 30650587)
-
(1999)
Molecular Endocrinology
, vol.13
, Issue.9
, pp. 1435-1448
-
-
Schulte, T.W.1
Akinaga, S.2
Murakata, T.3
Agatsuma, T.4
Sugimoto, S.5
Nakano, H.6
Lee, Y.S.7
Simen, B.B.8
Argon, Y.9
Felts, S.10
Toft, D.O.11
Neckers, L.M.12
Sharma, S.V.13
-
94
-
-
0034594644
-
Novobiocin and related coumarins and depletion of heat shock protein 90-dependent signaling proteins
-
Marcu MG, Schulte TW and Neckers L: Novobiocin and related coumarins and depletion of heat shock protein 90-dependent signaling proteins. J Natl Cancer Inst 92: 242-248, 2000.
-
(2000)
J Natl Cancer Inst
, vol.92
, pp. 242-248
-
-
Marcu, M.G.1
Schulte, T.W.2
Neckers, L.3
-
95
-
-
33646371009
-
Modulation of chaperone function and cochaperone interaction by novobiocin in the C-terminal domain of Hsp90
-
Allan RK, Mok D, Ward BK and Ratajczak T: Modulation of chaperone function and cochaperone interaction by novobiocin in the C-terminal domain of Hsp90. J Biol Chem 281: 7161-7171, 2006.
-
(2006)
J Biol Chem
, vol.281
, pp. 7161-7171
-
-
Allan, R.K.1
Mok, D.2
Ward, B.K.3
Ratajczak, T.4
-
96
-
-
25144435448
-
Hsp90 inhibitors identified from a library of novobiocin analogues
-
DOI 10.1021/ja0535864
-
Yu XM, Shen G, Neckers L, Blake H, Holzbeierlein J, Cronk B and Blagg BS: Hsp90 inhibitors identified from a library of novobiocin analogues. J Am Chem Soc 127: 12778-12779, 2005. (Pubitemid 41339147)
-
(2005)
Journal of the American Chemical Society
, vol.127
, Issue.37
, pp. 12778-12779
-
-
Yu, X.M.1
Shen, G.2
Neckers, L.3
Blake, H.4
Holzbeierlein, J.5
Cronk, B.6
Blagg, B.S.J.7
-
97
-
-
33845306864
-
Novobiocin: Redesigning a DNA gyrase inhibitor for selective inhibition of Hsp90
-
DOI 10.1021/ja065793p
-
Burlison JA, Neckers L, Smith AB, Maxwell A and Blagg BS: Novobiocin: redesigning a DNA gyrase inhibitor for selective inhibition of Hsp90. J Am Chem Soc 128: 15529-15536, 2006. (Pubitemid 44876029)
-
(2006)
Journal of the American Chemical Society
, vol.128
, Issue.48
, pp. 15529-15536
-
-
Burlison, J.A.1
Neckers, L.2
Smith, A.B.3
Maxwell, A.4
Blagg, B.S.J.5
-
98
-
-
0034711270
-
The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone
-
DOI 10.1074/jbc.M003701200
-
Marcu MG, Chadli A, Bouhouche I, Catelli M and Neckers LM: The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone. J Biol Chem 275: 37181-37186, 2000. (Pubitemid 32002137)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.47
, pp. 37181-37186
-
-
Marcu, M.G.1
Chadli, A.2
Bouhouche, I.3
Catelli, M.4
Neckers, L.M.5
-
99
-
-
33750357639
-
Synthesis and evaluation of coumermycin A1 analogues that inhibit the Hsp90 protein folding machinery
-
Burlison JA and Blagg BS: Synthesis and evaluation of coumermycin A1 analogues that inhibit the Hsp90 protein folding machinery. Org Lett 8: 4855-4858, 2006.
-
(2006)
Org Lett
, vol.8
, pp. 4855-4858
-
-
Burlison, J.A.1
Blagg, B.S.2
-
100
-
-
41849084518
-
Development of novobiocin analogues that manifest anti-proliferative activity against several cancer cell lines
-
DOI 10.1021/jo702191a
-
Burlison JA, Avila C, Vielhauer G, Lubbers DJ, Holzbeierlein J and Blagg BS: Development of novobiocin analogues that manifest anti-proliferative activity against several cancer cell lines. J Org Chem 73: 2130-2137, 2008. (Pubitemid 351497740)
-
(2008)
Journal of Organic Chemistry
, vol.73
, Issue.6
, pp. 2130-2137
-
-
Burlison, J.A.1
Avila, C.2
Vielhauer, G.3
Lubbers, D.J.4
Holzbeierlein, J.5
Blagg, B.S.J.6
-
101
-
-
34248569319
-
A library of noviosylated coumarin analogues
-
Huang YT and Blagg BS: A library of noviosylated coumarin analogues. J Org Chem 72: 3609-3613, 2007.
-
(2007)
J Org Chem
, vol.72
, pp. 3609-3613
-
-
Huang, Y.T.1
Blagg, B.S.2
-
102
-
-
37849037720
-
New novobiocin analogues as antiproliferative agents in breast cancer cells and potential inhibitors of heat shock protein 90
-
Le Bras G, Radanyi C, Peyrat JF, Brion JD, Alami M, Marsaud V, Stella B and Renoir JM: New novobiocin analogues as antiproliferative agents in breast cancer cells and potential inhibitors of heat shock protein 90. J Med Chem 50: 6189-6200, 2007.
-
(2007)
J Med Chem
, vol.50
, pp. 6189-6200
-
-
Le Bras, G.1
Radanyi, C.2
Peyrat, J.F.3
Brion, J.D.4
Alami, M.5
Marsaud, V.6
Stella, B.7
Renoir, J.M.8
-
103
-
-
41349108858
-
Synthesis and biological activity of simplified denoviose-coumarins related to novobiocin as potent inhibitors of heat-shock protein 90 (Hsp90)
-
Radanyi C, Le Bras G, Messaoudi S, Bouclier C, Peyrat JF, Brion JD, Marsaud V, Renoir JM and Alami M: Synthesis and biological activity of simplified denoviose-coumarins related to novobiocin as potent inhibitors of heat-shock protein 90 (Hsp90). Bioorg Med Chem Lett 18: 2495-2498, 2008.
-
(2008)
Bioorg Med Chem Lett
, vol.18
, pp. 2495-2498
-
-
Radanyi, C.1
Le Bras, G.2
Messaoudi, S.3
Bouclier, C.4
Peyrat, J.F.5
Brion, J.D.6
Marsaud, V.7
Renoir, J.M.8
Alami, M.9
-
104
-
-
0032730946
-
Two stages of cancer prevention with green tea
-
DOI 10.1007/s004320050321
-
Fujiki H: Two stages of cancer prevention with green tea. J Cancer Res Clin Oncol 125: 589-597, 1999. (Pubitemid 29502339)
-
(1999)
Journal of Cancer Research and Clinical Oncology
, vol.125
, Issue.11
, pp. 589-597
-
-
Fujiki, H.1
-
105
-
-
16344364163
-
Epigallocatechin gallate inhibits aryl hydrocarbon receptor gene transcription through an indirect mechanism involving binding to a 90-kDa heat shock protein
-
Palermo CM, Westlake CA and Gasiewicz TA: Epigallocatechin gallate inhibits aryl hydrocarbon receptor gene transcription through an indirect mechanism involving binding to a 90-kDa heat shock protein. Biochemistry 44: 5041-5052, 2005.
-
(2005)
Biochemistry
, vol.44
, pp. 5041-5052
-
-
Palermo, C.M.1
Westlake, C.A.2
Gasiewicz, T.A.3
-
106
-
-
68249097417
-
(-)- Epigallocatechin-3-gallate inhibits Hsp90 function by impairing Hsp90 association with cochaperones in pancreatic cancer cell line Mia Paca-2
-
Li Y, Zhang T, Jiang Y, Lee HF, Schwartz SJ and Sun D: (-)- Epigallocatechin-3-gallate inhibits Hsp90 function by impairing Hsp90 association with cochaperones in pancreatic cancer cell line Mia Paca-2. Mol Pharm 6: 1152-1159, 2009.
-
(2009)
Mol Pharm
, vol.6
, pp. 1152-1159
-
-
Li, Y.1
Zhang, T.2
Jiang, Y.3
Lee, H.F.4
Schwartz, S.J.5
Sun, D.6
-
107
-
-
0024438369
-
Isolation and characterization of an antimalarial agent of the neem tree Azadirachta indica
-
Khalid SA, Duddeck H and Gonzalez-Sierra M: Isolation and characterization of an antimalarial agent of the neem tree Azadirachta indica. J Nat Prod 52: 922-926, 1989.
-
(1989)
J Nat Prod
, vol.52
, pp. 922-926
-
-
Khalid, S.A.1
Duddeck, H.2
Gonzalez-Sierra, M.3
-
108
-
-
32544453259
-
Effect of neem limonoids on lactate dehydrogenase (LDH) of the rice leaf holder, C naphalocrocismedinalis (Guenee) (Insecta: Lepidoptera: Pyralidae)
-
Nathan SS, Kalaivani K, Chang PG and Murugan K: Effect of neem limonoids on lactate dehydrogenase (LDH) of the rice leaf holder, C naphalocrocismedinalis (Guenee) (Insecta: Lepidoptera: Pyralidae). Chemosphere 62: 1388-1393, 2006.
-
(2006)
Chemosphere
, vol.62
, pp. 1388-1393
-
-
Nathan, S.S.1
Kalaivani, K.2
Chang, P.G.3
Murugan, K.4
-
109
-
-
34547692945
-
Gedunin, a limonoid from Xylocarpus granatum, inhibits the growth of CaCo-2 colon cancer cell line in vitro
-
Uddin SJ, Nahar L, Shilpi JA, Shoeb M, Borkowski T, Gibbons S, Middleton M, Byres M and Sarker SD: Gedunin, a limonoid from Xylocarpus granatum, inhibits the growth of CaCo-2 colon cancer cell line in vitro. Phytother Res 21: 757-761, 2007.
-
(2007)
Phytother Res
, vol.21
, pp. 757-761
-
-
Uddin, S.J.1
Nahar, L.2
Shilpi, J.A.3
Shoeb, M.4
Borkowski, T.5
Gibbons, S.6
Middleton, M.7
Byres, M.8
Sarker, S.D.9
-
110
-
-
1542344495
-
Anti-inflammatory compounds of plant origin. Part II: Modulation of pro-inflammatory cytokines, chemokines and adhesion molecules
-
Calixto JB, Campos MM, Otuki MF and Santos AR: Anti-inflammatory compounds of plant origin. Part II: modulation of pro-inflammatory cytokines, chemokines and adhesion molecules. Planta Med 70: 93-103, 2004.
-
(2004)
Planta Med
, vol.70
, pp. 93-103
-
-
Calixto, J.B.1
Campos, M.M.2
Otuki, M.F.3
Santos, A.R.4
-
111
-
-
0019374043
-
Tripterygium wilfordii Hook f in rheumatoid arthritis and ankylosing spondylitis. Preliminary report
-
Guo JL, Yuan SX, Wang XC, Xu SX and Li DD: Tripterygium wilfordii Hook f in rheumatoid arthritis and ankylosing spondylitis. Preliminary report. Chin Med J (Engl) 94: 405-412, 1981.
-
(1981)
Chin Med J (Engl)
, vol.94
, pp. 405-412
-
-
Guo, J.L.1
Yuan, S.X.2
Wang, X.C.3
Xu, S.X.4
Li, D.D.5
-
112
-
-
2842616065
-
Apoptosis induction in HL-60 cells and inhibition of topoisomerase II by triterpene celastrol
-
Nagase M, Oto J, Sugiyama S, Yube K, Takaishi Y and Sakato N: Apoptosis induction in HL-60 cells and inhibition of topoisomerase II by triterpene celastrol. Biosci Biotechnol Biochem 67: 1883-1887, 2003.
-
(2003)
Biosci Biotechnol Biochem
, vol.67
, pp. 1883-1887
-
-
Nagase, M.1
Oto, J.2
Sugiyama, S.3
Yube, K.4
Takaishi, Y.5
Sakato, N.6
-
113
-
-
33646406554
-
Celastrol, a triterpene extracted from the Chinese 'Thunder of God Vine' is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice
-
Yang H, Chen D, Cui QC, Yuan X and Dou QP: Celastrol, a triterpene extracted from the Chinese 'Thunder of God Vine' is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice. Cancer Res 66: 4758-4765, 2006.
-
(2006)
Cancer Res
, vol.66
, pp. 4758-4765
-
-
Yang, H.1
Chen, D.2
Cui, Q.C.3
Yuan, X.4
Dou, Q.P.5
-
114
-
-
33749335282
-
The connectivity map: Using gene expression signatures to connect small molecules, genes and disease
-
Lamb J, Crawford ED, Peck D, Modell JW, Blat IC, Wrobel MJ, Lerner J, Brunet JP, Subramanian A, Ross KN, Reich M, Hieronymus H, Wei G, Armstrong SA, Haggarty SJ, Clemons PA, Wei R, Carr SA, Lander ES and Golub TR: The connectivity map: using gene expression signatures to connect small molecules, genes and disease. Science 313: 1929-1935, 2006.
-
(2006)
Science
, vol.313
, pp. 1929-1935
-
-
Lamb, J.1
Crawford, E.D.2
Peck, D.3
Modell, J.W.4
Blat, I.C.5
Wrobel, M.J.6
Lerner, J.7
Brunet, J.P.8
Subramanian, A.9
Ross, K.N.10
Reich, M.11
Hieronymus, H.12
Wei, G.13
Armstrong, S.A.14
Haggarty, S.J.15
Clemons, P.A.16
Wei, R.17
Carr, S.A.18
Lander, E.S.19
Golub, T.R.20
more..
-
115
-
-
33749433916
-
Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators
-
DOI 10.1016/j.ccr.2006.09.005, PII S1535610806002820
-
Hieronymus H, Lamb J, Ross KN, Peng XP, Clement C, Rodina A, Nieto M, Du J, Stegmaier K, Raj SM, Maloney KN, Clardy J, Hahn WC, Chiosis G and Golub TR: Gene expression signature based chemical genomic prediction identifies a novel class of HSP90 pathway modulators. Cancer Cell 10: 321-330, 2006. (Pubitemid 44512193)
-
(2006)
Cancer Cell
, vol.10
, Issue.4
, pp. 321-330
-
-
Hieronymus, H.1
Lamb, J.2
Ross, K.N.3
Peng, X.P.4
Clement, C.5
Rodina, A.6
Nieto, M.7
Du, J.8
Stegmaier, K.9
Raj, S.M.10
Maloney, K.N.11
Clardy, J.12
Hahn, W.C.13
Chiosis, G.14
Golub, T.R.15
-
116
-
-
38349153572
-
A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37complex against pancreatic cancer cells
-
Zhang T, Hamza A, Cao X, Wang B, Yu S, Zhan CG and Sun D: A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37complex against pancreatic cancer cells. Mol Cancer Ther 7: 162-170, 2008.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 162-170
-
-
Zhang, T.1
Hamza, A.2
Cao, X.3
Wang, B.4
Yu, S.5
Zhan, C.G.6
Sun, D.7
-
117
-
-
70349921403
-
Molecular mechanism of inhibition of the human protein complex Hsp90-Cdc37, a kinome chaperone-cochaperone, by triterpene celastrol
-
Sreeramulu S, Gande SL, Göbel M and Schwalbe H: Molecular mechanism of inhibition of the human protein complex Hsp90-Cdc37, a kinome chaperone-cochaperone, by triterpene celastrol. Angew Chem Int Ed Engl 48: 5853-5855, 2009.
-
(2009)
Angew Chem Int Ed Engl
, vol.48
, pp. 5853-5855
-
-
Sreeramulu, S.1
Gande, S.L.2
Göbel, M.3
Schwalbe, H.4
-
118
-
-
38349059089
-
Derrubone, an inhibitor of the Hsp90 protein folding machinery
-
Hadden MK, Galam L, Gestwicki JE, Matts RL and Blagg BS: Derrubone, an inhibitor of the Hsp90 protein folding machinery. J Nat Prod 70: 2014-2018, 2007.
-
(2007)
J Nat Prod
, vol.70
, pp. 2014-2018
-
-
Hadden, M.K.1
Galam, L.2
Gestwicki, J.E.3
Matts, R.L.4
Blagg, B.S.5
-
119
-
-
40949091876
-
Synthesis and evaluation of derrubone and select analogues
-
Hastings JM, Hadden MK and Blagg BS: Synthesis and evaluation of derrubone and select analogues. J Org Chem 73: 369-373, 2008.
-
(2008)
J Org Chem
, vol.73
, pp. 369-373
-
-
Hastings, J.M.1
Hadden, M.K.2
Blagg, B.S.3
-
120
-
-
0035071607
-
A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells
-
Chiosis G, Timaul MN, Lucas B, Munster PN, Zheng FF, Sepp-Lorenzino L and Rosen N: A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells. Chem Biol 8: 289-299, 2001.
-
(2001)
Chem Biol
, vol.8
, pp. 289-299
-
-
Chiosis, G.1
Timaul, M.N.2
Lucas, B.3
Munster, P.N.4
Zheng, F.F.5
Sepp-Lorenzino, L.6
Rosen, N.7
-
121
-
-
0036836964
-
Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase
-
Chiosis G, Lucas B, Shtil A, Huezo H and Rosen N: Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase. Bioorg Med Chem 10: 3555-3564, 2002.
-
(2002)
Bioorg Med Chem
, vol.10
, pp. 3555-3564
-
-
Chiosis, G.1
Lucas, B.2
Shtil, A.3
Huezo, H.4
Rosen, N.5
-
122
-
-
3042553538
-
Targeting wide-range oncogenic transformation via PU24FCl, a specific inhibitor of tumor Hsp90
-
Vilenchik M, Solit D, Basso A, Huezo H, Lucas B, He H, Rosen N, Spampinato C, Modrich P and Chiosis G: Targeting wide-range oncogenic transformation via PU24FCl, a specific inhibitor of tumor Hsp90. Chem Biol 11: 787-797, 2004.
-
(2004)
Chem Biol
, vol.11
, pp. 787-797
-
-
Vilenchik, M.1
Solit, D.2
Basso, A.3
Huezo, H.4
Lucas, B.5
He, H.6
Rosen, N.7
Spampinato, C.8
Modrich, P.9
Chiosis, G.10
-
123
-
-
17444416142
-
Evaluation of 8-arylsulfanyl, 8-arylsulfoxyl, and 8-arylsulfonyl adenine derivatives as inhibitors of the heat shock protein 90
-
Llauger L, He H, Kim J, Aguirre J, Rosen N, Peters U, Davies P and Chiosis G: Evaluation of 8-arylsulfanyl, 8-arylsulfoxyl, and 8-arylsulfonyl adenine derivatives as inhibitors of the heat shock protein 90. J Med Chem 48: 2892-2905, 2005.
-
(2005)
J Med Chem
, vol.48
, pp. 2892-2905
-
-
Llauger, L.1
He, H.2
Kim, J.3
Aguirre, J.4
Rosen, N.5
Peters, U.6
Davies, P.7
Chiosis, G.8
-
124
-
-
31544433450
-
Orally active purine-based inhibitors of Hsp90
-
Biamonte MA, Shi J, Hong K, Hurst DC, Zhang L, Fan J, Busch DJ, Karjian PL, Maldonado AA, Sensintaffar JL, Yang YC, Kamal A, Lough RE, Lundgren K, Burrows FJ, Timony GA, Boehm MF and Kasibhatla SR: Orally active purine-based inhibitors of Hsp90. J Med Chem 49: 817-828, 2006.
-
(2006)
J Med Chem
, vol.49
, pp. 817-828
-
-
Biamonte, M.A.1
Shi, J.2
Hong, K.3
Hurst, D.C.4
Zhang, L.5
Fan, J.6
Busch, D.J.7
Karjian, P.L.8
Maldonado, A.A.9
Sensintaffar, J.L.10
Yang, Y.C.11
Kamal, A.12
Lough, R.E.13
Lundgren, K.14
Burrows, F.J.15
Timony, G.A.16
Boehm, M.F.17
Kasibhatla, S.R.18
-
125
-
-
30444447639
-
Identification of potent water soluble purine scaffold inhibitors of the heat shock protein 90
-
He H, Zatorska D, Kim J, Aguirre J, Llauger L, She Y, Wu N, Immormino RM, Gewirth DT and Chiosis G: Identification of potent water soluble purine scaffold inhibitors of the heat shock protein 90. J Med Chem 49: 381-390, 2006.
-
(2006)
J Med Chem
, vol.49
, pp. 381-390
-
-
He, H.1
Zatorska, D.2
Kim, J.3
Aguirre, J.4
Llauger, L.5
She, Y.6
Wu, N.7
Immormino, R.M.8
Gewirth, D.T.9
Chiosis, G.10
-
126
-
-
51449093764
-
Targeting Hsp90: Small-molecule inhibitors and their clinical development
-
Taldone T, Gozman A, Maharaj R and Chiosis G: Targeting Hsp90: small-molecule inhibitors and their clinical development. Curr Opin Pharmacol 8: 370-374, 2008.
-
(2008)
Curr Opin Pharmacol
, vol.8
, pp. 370-374
-
-
Taldone, T.1
Gozman, A.2
Maharaj, R.3
Chiosis, G.4
-
127
-
-
66449094961
-
BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90
-
Lundgren K, Zhang H, Brekken J, Huser N, Powell RE, Timple N, Busch DJ, Neely L, Sensintaffar JL, Yang YC, McKenzie A, Friedman J, Scannevin R, Kamal A, Hong K, Kasibhatla SR, Boehm MF and Burrows FJ: BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90. Mol Cancer Ther 8: 921-929, 2009.
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 921-929
-
-
Lundgren, K.1
Zhang, H.2
Brekken, J.3
Huser, N.4
Powell, R.E.5
Timple, N.6
Busch, D.J.7
Neely, L.8
Sensintaffar, J.L.9
Yang, Y.C.10
McKenzie, A.11
Friedman, J.12
Scannevin, R.13
Kamal, A.14
Hong, K.15
Kasibhatla, S.R.16
Boehm, M.F.17
Burrows, F.J.18
-
128
-
-
74049091229
-
BIIB021, a novel Hsp90 inhibitor, sensitizes head and neck squamous cell carcinoma to radiotherapy
-
Yin X, Zhang H, Lundgren K, Wilson L, Burrows F and Shores CG: BIIB021, a novel Hsp90 inhibitor, sensitizes head and neck squamous cell carcinoma to radiotherapy. Int J Cancer 126: 1216-1225, 2010.
-
(2010)
Int J Cancer
, vol.126
, pp. 1216-1225
-
-
Yin, X.1
Zhang, H.2
Lundgren, K.3
Wilson, L.4
Burrows, F.5
Shores, C.G.6
-
129
-
-
74049114496
-
BIIB021, a synthetic Hsp90 inhibitor, has broad application against tumors with acquired multidrug resistance
-
Zhang H, Neely L, Lundgren K, Yang YC, Lough R, Timple N and Burrows F: BIIB021, a synthetic Hsp90 inhibitor, has broad application against tumors with acquired multidrug resistance. Int J Cancer 126: 1226-1234, 2010.
-
(2010)
Int J Cancer
, vol.126
, pp. 1226-1234
-
-
Zhang, H.1
Neely, L.2
Lundgren, K.3
Yang, Y.C.4
Lough, R.5
Timple, N.6
Burrows, F.7
-
130
-
-
55249118494
-
BIIB021, an oral, synthetic non-ansamycin Hsp90 inhibitor: Phase I experience
-
abs. 2503
-
Elfiky A, Saif MW, Beeram M, Brien SO, Lammanna N, Castro JE, Woodworth J, Perea R, Storgard C and von Hoff DD: BIIB021, an oral, synthetic non-ansamycin Hsp90 inhibitor: phase I experience. J Clin Oncol 26: abs. 2503, 2008.
-
(2008)
J Clin Oncol
, vol.26
-
-
Elfiky, A.1
Saif, M.W.2
Beeram, M.3
Brien, S.O.4
Lammanna, N.5
Castro, J.E.6
Woodworth, J.7
Perea, R.8
Storgard, C.9
Von Hoff, D.D.10
-
131
-
-
1642503079
-
High-throughput screening assay for inhibitors of heat-shock protein 90 ATPase activity
-
DOI 10.1016/j.ab.2003.10.038, PII S0003269703007541
-
Rowlands MG, Newbatt YM, Prodromou C, Pearl LH, Workman P and Aherne W: High-throughput screening assay for inhibitors of heat-shock protein 90 ATPase activity. Anal Biochem 327: 176-183, 2004. (Pubitemid 38402186)
-
(2004)
Analytical Biochemistry
, vol.327
, Issue.2
, pp. 176-183
-
-
Rowlands, M.G.1
Newbatt, Y.M.2
Prodromou, C.3
Pearl, L.H.4
Workman, P.5
Aherne, W.6
-
132
-
-
20644448390
-
The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors
-
Cheung KM, Matthews TP, James K, Rowlands MG, Boxall KJ, Sharp SY, Maloney A, Roe SM, Prodromou C, Pearl LH, Aherne GW, McDonald E and Workman P: The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors. Bioorg Med Chem Lett 15: 3338-3343, 2005.
-
(2005)
Bioorg Med Chem Lett
, vol.15
, pp. 3338-3343
-
-
Cheung, K.M.1
Matthews, T.P.2
James, K.3
Rowlands, M.G.4
Boxall, K.J.5
Sharp, S.Y.6
Maloney, A.7
Roe, S.M.8
Prodromou, C.9
Pearl, L.H.10
Aherne, G.W.11
McDonald, E.12
Workman, P.13
-
133
-
-
13944270580
-
Crystal structures of human HSP90 alpha-complexed with dihydroxyphenylpyrazoles
-
Kreusch A, Han S, Brinker A, Zhou V, Choi HS, He Y, Lesley SA, Caldwell J and Gu XJ: Crystal structures of human HSP90 alpha-complexed with dihydroxyphenylpyrazoles. Bioorg Med Chem Lett 15: 1475-1478, 2005.
-
(2005)
Bioorg Med Chem Lett
, vol.15
, pp. 1475-1478
-
-
Kreusch, A.1
Han, S.2
Brinker, A.3
Zhou, V.4
Choi, H.S.5
He, Y.6
Lesley, S.A.7
Caldwell, J.8
Gu, X.J.9
-
134
-
-
33947210121
-
In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors
-
Sharp SY, Boxall K, Rowlands M, Prodromou C, Roe SM, Maloney A, Powers M, Clarke PA, Box G, Sanderson S, Patterson L, Matthews TP, Cheung KM, Ball K, Hayes A, Raynaud F, Marais R, Pearl L, Eccles S, Aherne W, McDonald E and Workman P: In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors. Cancer Res 67: 2206-2216, 2007.
-
(2007)
Cancer Res
, vol.67
, pp. 2206-2216
-
-
Sharp, S.Y.1
Boxall, K.2
Rowlands, M.3
Prodromou, C.4
Roe, S.M.5
Maloney, A.6
Powers, M.7
Clarke, P.A.8
Box, G.9
Sanderson, S.10
Patterson, L.11
Matthews, T.P.12
Cheung, K.M.13
Ball, K.14
Hayes, A.15
Raynaud, F.16
Marais, R.17
Pearl, L.18
Eccles, S.19
Aherne, W.20
McDonald, E.21
Workman, P.22
more..
-
135
-
-
21244505104
-
Novel, potent small molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design
-
Dymock BW, Barril X, Brough PA, Cansfield JE, Massey A, McDonald E, Hubbard RE, Surgenor A, Roughley SD, Webb P, Workman P, Wright L and Drysdale MJ: Novel, potent small molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design. J Med Chem 48: 4212-4215, 2005.
-
(2005)
J Med Chem
, vol.48
, pp. 4212-4215
-
-
Dymock, B.W.1
Barril, X.2
Brough, P.A.3
Cansfield, J.E.4
Massey, A.5
McDonald, E.6
Hubbard, R.E.7
Surgenor, A.8
Roughley, S.D.9
Webb, P.10
Workman, P.11
Wright, L.12
Drysdale, M.J.13
-
136
-
-
38349157746
-
4,5-Diarylisoxazole Hsp90 chaperone inhibitors: Potential therapeutic agents for the treatment of cancer
-
Brough PA, Aherne W, Barril X, Borgognoni J, Boxall K, Cansfield JE, Cheung KM, Collins I, Davies NG, Drysdale MJ, Dymock B, Eccles SA, Finch H, Fink A, Hayes A, Howes R, Hubbard RE, James K, Jordan AM, Lockie A, Martins V, Massey A, Matthews TP, McDonald E, Northfield CJ, Pearl LH, Prodromou C, Ray S, Raynaud FI, Roughley SD, Sharp SY, Surgenor A, Walmsley DL, Webb P, Wood M, Workman P and Wright L: 4,5-Diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer. J Med Chem 51: 196-218, 2008.
-
(2008)
J Med Chem
, vol.51
, pp. 196-218
-
-
Brough, P.A.1
Aherne, W.2
Barril, X.3
Borgognoni, J.4
Boxall, K.5
Cansfield, J.E.6
-
137
-
-
0344851702
-
Positron emission tomography (PET): Expanding the horizons of oncology drug development
-
Hammond LA, Denis L, Salman U, Jerabek P, Thomas CR Jr and Kuhn JG: Positron emission tomography (PET): expanding the horizons of oncology drug development. Invest New Drugs 21: 309-340, 2003.
-
(2003)
Invest New Drugs
, vol.21
, pp. 309-340
-
-
Hammond, L.A.1
Denis, L.2
Salman, U.3
Jerabek, P.4
Thomas Jr., C.R.5
Kuhn, J.G.6
-
138
-
-
40749103835
-
SNX2112, a synthetic heat shock protein 90 inhibitor, has potent antitumor activity against HER kinase dependent cancers
-
Chandarlapaty S, Sawai A, Ye Q, Scott A, Silinski M, Huang K, Fadden P, Partdrige J, Hall S, Steed P, Norton L, Rosen N and Solit DB: SNX2112, a synthetic heat shock protein 90 inhibitor, has potent antitumor activity against HER kinase dependent cancers. Clin Cancer Res 14: 240-248, 2008.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 240-248
-
-
Chandarlapaty, S.1
Sawai, A.2
Ye, Q.3
Scott, A.4
Silinski, M.5
Huang, K.6
Fadden, P.7
Partdrige, J.8
Hall, S.9
Steed, P.10
Norton, L.11
Rosen, N.12
Solit, D.B.13
-
139
-
-
59649086503
-
SNX-2112, a selective Hsp90 inhibitor, potently inhibits tumor cell growth, angiogenesis, and osteoclastogenesis in multiple myeloma and other hematologic tumors by abrogating signaling via Akt and ERK
-
Okawa Y, Hideshima T, Steed P, Vallet S, Hall S, Huang K, Rice J, Barabasz A, Foley B, Ikeda H, Raje N, Kiziltepe T, Yasui H, Enatsu S and Anderson KC: SNX-2112, a selective Hsp90 inhibitor, potently inhibits tumor cell growth, angiogenesis, and osteoclastogenesis in multiple myeloma and other hematologic tumors by abrogating signaling via Akt and ERK. Blood 113: 846-855, 2009.
-
(2009)
Blood
, vol.113
, pp. 846-855
-
-
Okawa, Y.1
Hideshima, T.2
Steed, P.3
Vallet, S.4
Hall, S.5
Huang, K.6
Rice, J.7
Barabasz, A.8
Foley, B.9
Ikeda, H.10
Raje, N.11
Kiziltepe, T.12
Yasui, H.13
Enatsu, S.14
Anderson, K.C.15
-
140
-
-
67349255247
-
Transcriptomic and proteomic approach to studying SNX-2112-induced K562 cells apoptosis and anti-leukemia activity in K562-NOD/SCID mice
-
Jin L, Xiao CL, Lu CH, Xia M, Xing GW, Xiong S, Liu QY, Liu H, Li YC, Ge F, Wang QD, He QY and Wang YF: Transcriptomic and proteomic approach to studying SNX-2112-induced K562 cells apoptosis and anti-leukemia activity in K562-NOD/SCID mice. FEBS Lett 583: 1859-1866, 2009.
-
(2009)
FEBS Lett
, vol.583
, pp. 1859-1866
-
-
Jin, L.1
Xiao, C.L.2
Lu, C.H.3
Xia, M.4
Xing, G.W.5
Xiong, S.6
Liu, Q.Y.7
Liu, H.8
Li, Y.C.9
Ge, F.10
Wang, Q.D.11
He, Q.Y.12
Wang, Y.F.13
-
141
-
-
52049125709
-
The novel HSP90 inhibitor STA-9090 exhibits activity against kit-dependent and -independent malignant mast cell tumors
-
Lin TY, Bear M, Du Z, Foley KP, Ying W, Barsoum J and London C: The novel HSP90 inhibitor STA-9090 exhibits activity against kit-dependent and -independent malignant mast cell tumors. Exp Hematol 36: 1266-1277, 2008.
-
(2008)
Exp Hematol
, vol.36
, pp. 1266-1277
-
-
Lin, T.Y.1
Bear, M.2
Du, Z.3
Foley, K.P.4
Ying, W.5
Barsoum, J.6
London, C.7
-
142
-
-
70350108239
-
The novel HSP90 inhibitor STA-1474 exhibits biologic activity against osteosarcoma cell lines
-
McCleese JK, Bear MD, Fossey SL, Mihalek RM, Foley KP, Ying W, Barsoum J and London CA: The novel HSP90 inhibitor STA-1474 exhibits biologic activity against osteosarcoma cell lines. Int J Cancer 125: 2792-2801, 2009.
-
(2009)
Int J Cancer
, vol.125
, pp. 2792-2801
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-
McCleese, J.K.1
Bear, M.D.2
Fossey, S.L.3
Mihalek, R.M.4
Foley, K.P.5
Ying, W.6
Barsoum, J.7
London, C.A.8
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