Synthesis and biological activity of simplified denoviose-coumarins related to novobiocin as potent inhibitors of heat-shock protein 90 (hsp90)

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 7, 2008, Pages 2495-2498

  Radanyi, Christine ^a   Le Bras, Gaëlle ^a   Messaoudi, Samir ^a   Bouclier, Céline ^a   Peyrat, Jean François ^a   Brion, Jean Daniel ^a   Marsaud, Véronique ^a   Renoir, Jack Michel ^a   Alami, Mouâd ^a  

^a UNIVERSITÉ PARIS SACLAY   (France)

Author keywords

Anti tumour; Coumarin inhibitors; hsp90; Novobiocin; Steroid receptors

Indexed keywords

4 TOSYLCYCLONOVOBIOCIC ACID; COUMARIN DERIVATIVE; DENOVIOSE; ESTRADIOL; HEAT SHOCK PROTEIN 90 INHIBITOR; NOVOBIOCIN; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; BREAST CANCER; CANCER CELL; CELL PROLIFERATION; PROTEIN DEGRADATION; PROTEIN SYNTHESIS;

ANTIBIOTICS, ANTINEOPLASTIC; BINDING SITES; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; COUMARINS; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; ESTRADIOL; HSP90 HEAT-SHOCK PROTEINS; HUMANS; NOVOBIOCIN; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION, GENETIC;

EID: 41349108858     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.01.128     Document Type: Article

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