Development of novobiocin analogues that manifest anti-proliferative activity against several cancer cell lines

Journal of Organic Chemistry

Volumn 73, Issue 6, 2008, Pages 2130-2137

  Burlison, Joseph A ^a   Avila, Christopher ^b   Vielhauer, George ^b   Lubbers, Donna J ^a   Holzbeierlein, Jeffrey ^b   Blagg, Brian S J ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER CELL LINES; NOVOBIOCIN ANALOGUES;

BINDING SITES; CONCENTRATION (PROCESS); DNA; ENZYME INHIBITION; TUMORS;

CELLS;

ANTINEOPLASTIC AGENT; BENZAMIDE DERIVATIVE; HEAT SHOCK PROTEIN 90; N [7 (3,4 DIHYDROXY 5 METHOXY 6,6 DIMETHYLTETRAHYDRO 2H PYRAN 2 YLOXY) 8 METHYL 2 OXO 2H CHROMEN 3 YL] 1H INDOLE 3 CARBOXAMIDE; N [7 (3,4 DIHYDROXY 5 METHOXY 6,6 DIMETHYLTETRAHYDRO 2H PYRAN 2 YLOXY) 8 METHYL 2 OXO 2H CHROMEN 3 YL] 2 METHOXYBENZAMIDE; N [7 (3,4 DIHYDROXY 5 METHOXY 6,6 DIMETHYLTETRAHYDRO 2H PYRAN 2 YLOXY) 8 METHYL 2 OXO 2H CHROMEN 3 YL] 6 METHOXYBIPHENYL 3 CARBOXAMIDE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CARBON NUCLEAR MAGNETIC RESONANCE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROGEN BOND; IC 50; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; PROTON NUCLEAR MAGNETIC RESONANCE; SOLVOLYSIS; STRUCTURE ACTIVITY RELATION; SUZUKI REACTION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; BENZAMIDES; CELL LINE, TUMOR; DIMERIZATION; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; NOVOBIOCIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 41849084518     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo702191a     Document Type: Article

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