Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin

Cell Stress and Chaperones

Volumn 3, Issue 2, 1998, Pages 100-108

  Schulte, Theodor W ^a   Akinaga, Shiro ^b   Soga, Shiro ^b   Sullivan, William ^c   Stensgard, Bridget ^c   Toft, David ^c   Neckers, Leonard M ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b KYOWA HAKKO KOGYO CO LTD   (Japan)

^c MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; ANTIFUNGAL AGENT; CHAPERONE; GELDANAMYCIN; HEAT SHOCK PROTEIN 90; MACROCYCLIC COMPOUND; RADICICOL; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; DRUG PROTEIN BINDING; PRIORITY JOURNAL;

ANIMALS; ANTIBIOTICS, ANTIFUNGAL; ANTIBIOTICS, ANTINEOPLASTIC; BENZOQUINONES; BINDING SITES; BINDING, COMPETITIVE; BREAST NEOPLASMS; CELL DIVISION; CHICKENS; CHROMATOGRAPHY, AFFINITY; FEMALE; HSP90 HEAT-SHOCK PROTEINS; HUMANS; LACTAMS, MACROCYCLIC; LACTONES; MACROLIDES; MOLECULAR STRUCTURE; QUINONES; TUMOR CELLS, CULTURED;

EID: 0031844350     PISSN: 13558145     EISSN: None     Source Type: Journal    
DOI: 10.1379/1466-1268(1998)003<0100:ARBTTN>2.3.CO;2     Document Type: Article

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