-
1
-
-
0027251913
-
Correlation of the survival of ovarian cancer patients with mRNA expression of the 60kDa heat shock protein Hsp60
-
Kimura E, Erns RE, Alcaraz JE, Arboleda J, Slamon DJ, Howell SB. Correlation of the survival of ovarian cancer patients with mRNA expression of the 60kDa heat shock protein Hsp60. J Clin Oncol 1993; 11:891-8.
-
(1993)
J. Clin. Oncol.
, vol.11
, pp. 891-898
-
-
Kimura, E.1
Erns, R.E.2
Alcaraz, J.E.3
Arboleda, J.4
Slamon, D.J.5
Howell, S.B.6
-
2
-
-
0027503365
-
Heat shock protein Hsp70 in patients with axillary lymph node-negative breast cancer: Prognostic implications
-
Ciocca DR, Clark GM, Tandon AK, Fuqua SAW, Welch WJ, McGuire WL. Heat shock protein Hsp70 in patients with axillary lymph node-negative breast cancer: prognostic implications. J Natl Cancer Inst 1993; 85:570-4.
-
(1993)
J. Natl. Cancer Inst.
, vol.85
, pp. 570-574
-
-
Ciocca, D.R.1
Clark, G.M.2
Tandon, A.K.3
Fuqua, S.A.W.4
Welch, W.J.5
McGuire, W.L.6
-
3
-
-
0032058966
-
Autoantibodies to the 90kDa heat shock protein and poor survival in breast cancer patients
-
Conroy SE, Sasieni PD, Fentiman I, Latchman DS. Autoantibodies to the 90kDa heat shock protein and poor survival in breast cancer patients. Eur J Cancer 1998;34:942-3.
-
(1998)
Eur. J. Cancer
, vol.34
, pp. 942-943
-
-
Conroy, S.E.1
Sasieni, P.D.2
Fentiman, I.3
Latchman, D.S.4
-
4
-
-
0028970484
-
r 70,000 heat shock protein in normal, premalignant, and malignant human uterine cervix
-
r 70,000 heat shock protein in normal, premalignant, and malignant human uterine cervix. Clin Cancer Res 1995;1:1217-22.
-
(1995)
Clin. Cancer Res.
, vol.1
, pp. 1217-1722
-
-
Ralhan, R.1
Kaur, J.2
-
5
-
-
0029642276
-
Differential expression of 70-kDa heat shock-protein in human oral tumorigenesis
-
Kaur J, Ralhan R. Differential expression of 70-kDa heat shock-protein in human oral tumorigenesis. Int J Cancer 1995;63:774-9.
-
(1995)
Int. J. Cancer
, vol.63
, pp. 774-779
-
-
Kaur, J.1
Ralhan, R.2
-
6
-
-
0030750217
-
Expression of heat shock protein 72 in renal cell carcinoma: Possible role as prognostic implications in cancer patients
-
Santarosa M, Favaro D, Quaia M, Galligioni E. Expression of heat shock protein 72 in renal cell carcinoma: possible role as prognostic implications in cancer patients. Eur J Cancer 1997;33:873-7.
-
(1997)
Eur. J. Cancer
, vol.33
, pp. 873-877
-
-
Santarosa, M.1
Favaro, D.2
Quaia, M.3
Galligioni, E.4
-
7
-
-
1642471825
-
Heat-shock proteins as regulators of apoptosis
-
Takayama S, Reed JC, Homma S. Heat-shock proteins as regulators of apoptosis. Oncogene 2003;22:9041-7.
-
(2003)
Oncogene
, vol.22
, pp. 9041-9047
-
-
Takayama, S.1
Reed, J.C.2
Homma, S.3
-
8
-
-
3542995049
-
Stress-inducible responses and heat shock proteins: New pharmacologic targets for cytoprotection
-
Morimoto RI, Santoro MG. Stress-inducible responses and heat shock proteins: new pharmacologic targets for cytoprotection. Nat Biotechnol 1998;16:833-8.
-
(1998)
Nat. Biotechnol.
, vol.16
, pp. 833-838
-
-
Morimoto, R.I.1
Santoro, M.G.2
-
9
-
-
0031018610
-
Heat shock response - Pathophysiological implications
-
Leppa S, Sistonen L. Heat shock response - pathophysiological implications. Ann Med 1997;29:73-8.
-
(1997)
Ann. Med.
, vol.29
, pp. 73-78
-
-
Leppa, S.1
Sistonen, L.2
-
10
-
-
0034605446
-
Role of the heat shock response and molecular chaperones in oncogenesis and cell death
-
Jolly C, Morimoto RI. Role of the heat shock response and molecular chaperones in oncogenesis and cell death. J Natl Cancer Inst 2000; 92:1564-72.
-
(2000)
J. Natl. Cancer Inst.
, vol.92
, pp. 1564-1572
-
-
Jolly, C.1
Morimoto, R.I.2
-
11
-
-
0032416104
-
Molecular chaperones: Biology and prospects for pharmacological intervention
-
Smith DF, Whitesell L, Katsanis E. Molecular chaperones: biology and prospects for pharmacological intervention. Pharmacol Rev 1998;50: 493-513.
-
(1998)
Pharmacol. Rev.
, vol.50
, pp. 493-513
-
-
Smith, D.F.1
Whitesell, L.2
Katsanis, E.3
-
12
-
-
0032924953
-
Hsp90 & co.-a holding for folding
-
Buchner J. Hsp90 & co.-a holding for folding. Trends Biochem Sci 1999;24:136-41.
-
(1999)
Trends Biochem. Sci.
, vol.24
, pp. 136-141
-
-
Buchner, J.1
-
13
-
-
0031873752
-
The 90-kDa molecular chaperone family: Structure, function, and clinical applications. A comprehensive review
-
Csermely P, Schneider T, Soti C, Prohaskka Z, Nardai G. The 90-kDa molecular chaperone family: structure, function, and clinical applications. A comprehensive review. Pharmacol Ther 1998;79:129-68.
-
(1998)
Pharmacol. Ther.
, vol.79
, pp. 129-168
-
-
Csermely, P.1
Schneider, T.2
Soti, C.3
Prohaskka, Z.4
Nardai, G.5
-
14
-
-
0037315208
-
Regulation of signaling protein function and trafficking by the Hsp90/Hsp70-based chaperone machinery
-
Pratt WB, Toft DO. Regulation of signaling protein function and trafficking by the Hsp90/Hsp70-based chaperone machinery. Exp Biol Med (Maywood) 2003;228:111-33.
-
(2003)
Exp. Biol. Med. (Maywood)
, vol.228
, pp. 111-133
-
-
Pratt, W.B.1
Toft, D.O.2
-
15
-
-
0043288724
-
Heat shock protein 90 as a molecular target for cancer therapeutics
-
Isaacs JS, Xu W, Neckers L. Heat shock protein 90 as a molecular target for cancer therapeutics. Cancer Cell 2003;3:213-7.
-
(2003)
Cancer Cell
, vol.3
, pp. 213-217
-
-
Isaacs, J.S.1
Xu, W.2
Neckers, L.3
-
17
-
-
0029011834
-
Analysis of heat shock protein expression in myeloid leukemia cells by flow cytometry
-
Chant ID, Rose PE, Morris AG. Analysis of heat shock protein expression in myeloid leukemia cells by flow cytometry. Br J Haematol 1995;90:163-8.
-
(1995)
Br. J. Haematol.
, vol.90
, pp. 163-168
-
-
Chant, I.D.1
Rose, P.E.2
Morris, A.G.3
-
18
-
-
0026664393
-
High constitutive expression of heat shock protein 90a in human acute leukemia cells
-
Yufu Y, Nishimura J, Nawata H. High constitutive expression of heat shock protein 90a in human acute leukemia cells. Leuk Res 1992;16: 597-605.
-
(1992)
Leuk. Res.
, vol.16
, pp. 597-605
-
-
Yufu, Y.1
Nishimura, J.2
Nawata, H.3
-
19
-
-
0026544498
-
Clinical and biological significance of Hsp90a in human breastcancer
-
Jameel A, Skilton RA, Campbell TA, Chander SK, Coombes RC, Luqmani YA. Clinical and biological significance of Hsp90a in human breastcancer. Int J Cancer 1992;50:409-15.
-
(1992)
Int. J. Cancer
, vol.50
, pp. 409-415
-
-
Jameel, A.1
Skilton, R.A.2
Campbell, T.A.3
Chander, S.K.4
Coombes, R.C.5
Luqmani, Y.A.6
-
20
-
-
0029849363
-
Expression and roles of heat shock proteins in human breast cancer
-
Yano M, Naito Z, Tanaka S, Asano G. Expression and roles of heat shock proteins in human breast cancer. Jpn J Cancer Res 1996;87: 908-15.
-
(1996)
Jpn. J. Cancer Res.
, vol.87
, pp. 908-915
-
-
Yano, M.1
Naito, Z.2
Tanaka, S.3
Asano, G.4
-
21
-
-
0031733457
-
Prognostic significance of heat shock proteins Hsp70 and Hsp90 in enclometrial carcinomas
-
Nanbu K, Konishi I, Mandai M, et al. Prognostic significance of heat shock proteins Hsp70 and Hsp90 in enclometrial carcinomas. Cancer Detect Prev 1998;22:549-55.
-
(1998)
Cancer Detect. Prev.
, vol.22
, pp. 549-555
-
-
Nanbu, K.1
Konishi, I.2
Mandai, M.3
-
22
-
-
0033988478
-
Antibodies to heat shock protein 90 in osteosarcoma patients correlate with response to neoadjuvant chemotherapy
-
Trieb K, Gerth R, Holzer G, Grohs JG, Berger P, Kotz R. Antibodies to heat shock protein 90 in osteosarcoma patients correlate with response to neoadjuvant chemotherapy. Br J Cancer 2000;82:85-7.
-
(2000)
Br. J. Cancer
, vol.82
, pp. 85-87
-
-
Trieb, K.1
Gerth, R.2
Holzer, G.3
Grohs, J.G.4
Berger, P.5
Kotz, R.6
-
23
-
-
0038668000
-
Escaping cell death: Survival proteins in cancer
-
Jaattela M. Escaping cell death: survival proteins in cancer. Exp Cell Res 1999;248:30-43.
-
(1999)
Exp. Cell Res.
, vol.248
, pp. 30-43
-
-
Jaattela, M.1
-
24
-
-
0030999750
-
Apoptosis and the dilemma of cancer chemotherapy
-
Hannun Y. Apoptosis and the dilemma of cancer chemotherapy. Blood 1997;89:1845-53.
-
(1997)
Blood
, vol.89
, pp. 1845-1853
-
-
Hannun, Y.1
-
25
-
-
0030016274
-
Drug resistance against gemcitabine and topotecan mediated by constitutive Hsp70 overexpression in vitro: Implication of quercetin as sensitizer in chemotherapy
-
Sliutz G, Karlseder J, Tempfer C, Orel L, Holzer G, Simon MM. Drug resistance against gemcitabine and topotecan mediated by constitutive Hsp70 overexpression in vitro: implication of quercetin as sensitizer in chemotherapy. Br J Cancer 1996;74:172-7.
-
(1996)
Br. J. Cancer
, vol.74
, pp. 172-177
-
-
Sliutz, G.1
Karlseder, J.2
Tempfer, C.3
Orel, L.4
Holzer, G.5
Simon, M.M.6
-
26
-
-
0034253533
-
Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome
-
Beere HM, Wolf BB, Cain K, et al. Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome. Nat Cell Biol 2000;2:469-75.
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 469-475
-
-
Beere, H.M.1
Wolf, B.B.2
Cain, K.3
-
27
-
-
0034253474
-
Negative regulation of the Apaf-1 apoptosome by Hsp70
-
Saleh A, Srinivasula SM, Balkir L, Robbins PD, Alnemri ES. Negative regulation of the Apaf-1 apoptosome by Hsp70. Nat Cell Biol 2000;2: 476-83.
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 476-483
-
-
Saleh, A.1
Srinivasula, S.M.2
Balkir, L.3
Robbins, P.D.4
Alnemri, E.S.5
-
28
-
-
0033830374
-
The chaperone function of Hsp70 is required for protection against stress-induced apoptosis
-
Mosser DD, Caron AW, Bourget L, et al. The chaperone function of Hsp70 is required for protection against stress-induced apoptosis. Mol Cell Biol 2000;20:7146-59.
-
(2000)
Mol. Cell Biol.
, vol.20
, pp. 7146-7159
-
-
Mosser, D.D.1
Caron, A.W.2
Bourget, L.3
-
29
-
-
0034608892
-
Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses bcl-2
-
Nylandsted J, Rohde M, Brand K, Bastholm L, Elling F, Jaattela M. Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses bcl-2. Proc Natl Acad Sci USA 2000;97:7871-6.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 7871-7876
-
-
Nylandsted, J.1
Rohde, M.2
Brand, K.3
Bastholm, L.4
Elling, F.5
Jaattela, M.6
-
30
-
-
0037131187
-
Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and cdc37 and is destabilized by inhibitors of Hsp90 function
-
Basso AD, Solit DB, Chiosis G, Giri B, Tsichlis P, Rosen N. Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and cdc37 and is destabilized by inhibitors of Hsp90 function. J Biol Chem 2002;277:39858-66.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 39858-39866
-
-
Basso, A.D.1
Solit, D.B.2
Chiosis, G.3
Giri, B.4
Tsichlis, P.5
Rosen, N.6
-
31
-
-
0037458627
-
Disruption of Hsp90 function reverts tumor necrosis factor-induced necrosis to apoptosis
-
Vanden Berghe T, Kalai M, van Loo G, Declercq W, Vandenabeele P. Disruption of Hsp90 function reverts tumor necrosis factor-induced necrosis to apoptosis. J Biol Chem 2003;278:5622-9.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 5622-5629
-
-
Vanden Berghe, T.1
Kalai, M.2
van Loo, G.3
Declercq, W.4
Vandenabeele, P.5
-
32
-
-
0036187476
-
TNF-induce recruitment and activation of the IKK complex require cdc37 and Hsp90
-
Chen G, Cao P, Goeddel DV. TNF-induce recruitment and activation of the IKK complex require cdc37 and Hsp90. Mol Cell 2002;9:401-10.
-
(2002)
Mol. Cell
, vol.9
, pp. 401-410
-
-
Chen, G.1
Cao, P.2
Goeddel, D.V.3
-
33
-
-
0030667932
-
In vivo functions of the Saccharomyces cerevisiae Hsp90 chaperone
-
Nathan DE, Vos MH, Lindquist S. In vivo functions of the Saccharomyces cerevisiae Hsp90 chaperone. Proc Natl Acad Sci USA 1997;94:12949-56.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 12949-12956
-
-
Nathan, D.E.1
Vos, M.H.2
Lindquist, S.3
-
34
-
-
0031895351
-
The Hsp90-based chaperone system: Involvement in signal transduction from a variety of hormone and growth factor receptors
-
Pratt WB. The Hsp90-based chaperone system: involvement in signal transduction from a variety of hormone and growth factor receptors. Proc Soc Exp Biol Med 1998;217:420-31.
-
(1998)
Proc. Soc. Exp. Biol. Med.
, vol.217
, pp. 420-431
-
-
Pratt, W.B.1
-
35
-
-
0037047429
-
Dynamic remodeling of transcription complexes by molecular chaperones
-
Morimoto RI. Dynamic remodeling of transcription complexes by molecular chaperones. Cell 2002;110:281-4.
-
(2002)
Cell
, vol.110
, pp. 281-284
-
-
Morimoto, R.I.1
-
36
-
-
0037150683
-
Disassembly of transcriptional regulatory complexes by molecular chaperones
-
Freeman BC, Yamamoto KR. Disassembly of transcriptional regulatory complexes by molecular chaperones. Science 2002;296:2232-5.
-
(2002)
Science
, vol.296
, pp. 2232-2235
-
-
Freeman, B.C.1
Yamamoto, K.R.2
-
37
-
-
0027484097
-
Dynamics of heat shock protein 90-progesterone receptor binding and the disactivation loop model for steroid receptor complexes
-
Smith DF. Dynamics of heat shock protein 90-progesterone receptor binding and the disactivation loop model for steroid receptor complexes. Mol Endocrinol 1993;7:1418-29.
-
(1993)
Mol. Endocrinol.
, vol.7
, pp. 1418-1429
-
-
Smith, D.F.1
-
38
-
-
0028064940
-
Inhibition of heat shock protein Hsp90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: Essential role for stress proteins in oncogenic transformation
-
Whitesell L, Mimnaugh EG, De Costa B, Myers CE, Neckers LM. Inhibition of heat shock protein Hsp90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation. Proc Natl Acad Sci USA 1994;91:8324-8.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 8324-8328
-
-
Whitesell, L.1
Mimnaugh, E.G.2
De Costa, B.3
Myers, C.E.4
Neckers, L.M.5
-
39
-
-
0031909866
-
The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an Hsp90-binding agent
-
Whitesell L, Sutphin PD, Pulcini EJ, Martinez JD, Cook PH. The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an Hsp90-binding agent. Mol Cell Biol 1998;18:1517-24.
-
(1998)
Mol. Cell Biol.
, vol.18
, pp. 1517-1524
-
-
Whitesell, L.1
Sutphin, P.D.2
Pulcini, E.J.3
Martinez, J.D.4
Cook, P.H.5
-
41
-
-
15844363948
-
Heat shock protein 84 forms a complex with mutant p53 protein predominantly within a cytoplasmic compartment of the cell
-
Sepehrnia B, Paz IB, Dasgupta G, Momand J. Heat shock protein 84 forms a complex with mutant p53 protein predominantly within a cytoplasmic compartment of the cell. J Biol Chem 1996;271:15084-90.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 15084-15090
-
-
Sepehrnia, B.1
Paz, I.B.2
Dasgupta, G.3
Momand, J.4
-
42
-
-
0141819961
-
Genes and proteins governing the cellular sensitivity to Hsp90 inhibitors: A mechanistic perspective
-
Maloney A, Clarke PA, Workman P. Genes and proteins governing the cellular sensitivity to Hsp90 inhibitors: a mechanistic perspective. Curr Cancer Drug Targets 2003;3:331-41.
-
(2003)
Curr. Cancer Drug Targets
, vol.3
, pp. 331-341
-
-
Maloney, A.1
Clarke, P.A.2
Workman, P.3
-
43
-
-
0036931438
-
Activation of the ATPase activity of Hsp90 by the stress-regulated cochaperone aha1
-
Panaretou B, Siligardi G, Meyer P, et al. Activation of the ATPase activity of Hsp90 by the stress-regulated cochaperone aha1. Mol Cell 2002;10:1307-18.
-
(2002)
Mol. Cell
, vol.10
, pp. 1307-1318
-
-
Panaretou, B.1
Siligardi, G.2
Meyer, P.3
-
44
-
-
0344010691
-
Tumor tactics
-
Kitano H. Tumor tactics. Nature 2003;426:125.
-
(2003)
Nature
, vol.426
, pp. 125
-
-
Kitano, H.1
-
45
-
-
0033592960
-
The onset and extent of genomic instability in sporadic colorectal tumor progression
-
Stoler DL, Chen N, Basik M, et al. The onset and extent of genomic instability in sporadic colorectal tumor progression. Proc Natl Acad Sci USA 1999;96:15121-6.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 15121-15126
-
-
Stoler, D.L.1
Chen, N.2
Basik, M.3
-
46
-
-
0036561908
-
Modeling the molecular circuitry of cancer
-
Hahn WC, Weinberg RA. Modeling the molecular circuitry of cancer. Nat Rev Cancer 2002;2:331-41.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 331-341
-
-
Hahn, W.C.1
Weinberg, R.A.2
-
47
-
-
0141988694
-
An evolutionary model of carcinogenesis
-
Gatenby RA, Vincent TL. An evolutionary model of carcinogenesis. Cancer Res 2003;63:6212-20.
-
(2003)
Cancer Res.
, vol.63
, pp. 6212-6220
-
-
Gatenby, R.A.1
Vincent, T.L.2
-
48
-
-
0032569851
-
Hsp90 as a capacitor for morphological evolution
-
Rutherford SL, Lindquist S. Hsp90 as a capacitor for morphological evolution. Nature 1998;396:336-42.
-
(1998)
Nature
, vol.396
, pp. 336-342
-
-
Rutherford, S.L.1
Lindquist, S.2
-
49
-
-
0037030713
-
Hsp90 as a capacitor of phenotypic variation
-
Queitsch C, Sangster TA, Lindquist S. Hsp90 as a capacitor of phenotypic variation. Nature 2002;417:618-24.
-
(2002)
Nature
, vol.417
, pp. 618-624
-
-
Queitsch, C.1
Sangster, T.A.2
Lindquist, S.3
-
50
-
-
0037379626
-
Between genotype and phenotype: Protein chaperones and evolvability
-
Rutherford SL. Between genotype and phenotype: protein chaperones and evolvability. Nat Rev Genet 2003;4:263-74.
-
(2003)
Nat. Rev. Genet.
, vol.4
, pp. 263-274
-
-
Rutherford, S.L.1
-
51
-
-
0141819958
-
The stress response: Implications for the clinical development of Hsp90 inhibitors
-
Whitesell L, Bagatell R, Falsey R. The stress response: implications for the clinical development of Hsp90 inhibitors. Curr Cancer Drug Targets 2003;3:349-58.
-
(2003)
Curr. Cancer Drug Targets
, vol.3
, pp. 349-358
-
-
Whitesell, L.1
Bagatell, R.2
Falsey, R.3
-
52
-
-
0037228526
-
Evidence for an epigenetic mechanism by which Hsp90 acts as a capacitor for morphological evolution
-
Sollars V, Lu X, Xiao L, Wang X, Garfinkel MD, Ruden DM. Evidence for an epigenetic mechanism by which Hsp90 acts as a capacitor for morphological evolution. Nat Genet 2003;33:70-4.
-
(2003)
Nat. Genet.
, vol.33
, pp. 70-74
-
-
Sollars, V.1
Lu, X.2
Xiao, L.3
Wang, X.4
Garfinkel, M.D.5
Ruden, D.M.6
-
54
-
-
0141484615
-
A high affinity conformation of Hsp90 confers tumor selectivity on Hsp90 inhibitors
-
Kamal A, Thao L, Sensintaffar J, et al. A high affinity conformation of Hsp90 confers tumor selectivity on Hsp90 inhibitors. Nature 2003;425: 407-10.
-
(2003)
Nature
, vol.425
, pp. 407-410
-
-
Kamal, A.1
Thao, L.2
Sensintaffar, J.3
-
55
-
-
0035718899
-
Structure, function, and mechanism of the Hsp90 molecular chaperone
-
Pearl LH, Prodromou C. Structure, function, and mechanism of the Hsp90 molecular chaperone. Adv Protein Chem 2001;59:157-86.
-
(2001)
Adv. Protein Chem.
, vol.59
, pp. 157-186
-
-
Pearl, L.H.1
Prodromou, C.2
-
57
-
-
0037040975
-
The role of Hsp90n, a new member of the Hsp90 family, in signal transduction and neoplastic transformation
-
Grammatikakis N, Vultur A, Ramana CV, et al. The role of Hsp90n, a new member of the Hsp90 family, in signal transduction and neoplastic transformation. J Biol Chem 2002;277:8312-20.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 8312-8320
-
-
Grammatikakis, N.1
Vultur, A.2
Ramana, C.V.3
-
58
-
-
0033985080
-
GHKL, an emergent ATPase/kinase superfamily
-
Dutta R, Inouye M. GHKL, an emergent ATPase/kinase superfamily. Trends Biochem Sci 2000;25:24-8.
-
(2000)
Trends Biochem. Sci.
, vol.25
, pp. 24-28
-
-
Dutta, R.1
Inouye, M.2
-
59
-
-
0032959590
-
Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin
-
Roe SM, Prodromou C, O'Brien R, Ladbury JE, Piper PW, Pearl LH. Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin. J Med Chem 1999; 42:260-6.
-
(1999)
J. Med. Chem.
, vol.42
, pp. 260-266
-
-
Roe, S.M.1
Prodromou, C.2
O'Brien, R.3
Ladbury, J.E.4
Piper, P.W.5
Pearl, L.H.6
-
60
-
-
0036789884
-
Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-erbB2/neu
-
Xu W, Marcu M, Yuan X, Mimnaugh E, Patterson C, Neckers L. Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-erbB2/neu. Proc Natl Acad Sci USA 2002;99:12847-52.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 12847-12852
-
-
Xu, W.1
Marcu, M.2
Yuan, X.3
Mimnaugh, E.4
Patterson, C.5
Neckers, L.6
-
61
-
-
0037352446
-
Structural and functional analysis of the middle segment of Hsp90: Implications for ATP hydrolysis and client: Protein and cochaperone interactions
-
Meyer P, Prodromou C, Hu B, et al. Structural and functional analysis of the middle segment of Hsp90: implications for ATP hydrolysis and client: protein and cochaperone interactions. Mol Cell 2003;11:647-58.
-
(2003)
Mol. Cell
, vol.11
, pp. 647-658
-
-
Meyer, P.1
Prodromou, C.2
Hu, B.3
-
62
-
-
0036510547
-
A nucleotide-dependent molecular switch controls ATP binding at the C-terminal domain of Hsp90
-
Soti C, Racz A, Csermely P. A nucleotide-dependent molecular switch controls ATP binding at the C-terminal domain of Hsp90. J Biol Chem 2002;277:7066-75.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 7066-7075
-
-
Soti, C.1
Racz, A.2
Csermely, P.3
-
63
-
-
0034594644
-
Novobiocin and related coumarins and depletion of heat shock protein 90-dependent signaling proteins
-
Marcu MG, Schulte TW, Neckers L. Novobiocin and related coumarins and depletion of heat shock protein 90-dependent signaling proteins. J Natl Cancer Inst 2000;92:242-8.
-
(2000)
J. Natl. Cancer Inst.
, vol.92
, pp. 242-248
-
-
Marcu, M.G.1
Schulte, T.W.2
Neckers, L.3
-
64
-
-
0034711270
-
The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the C-terminus of the chaperone
-
Marcu MG, Chadli A, Bouhouche I, Catelli M, Neckers LM. The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the C-terminus of the chaperone. J Biol Chem 2000;275:37181-6.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 37181-37186
-
-
Marcu, M.G.1
Chadli, A.2
Bouhouche, I.3
Catelli, M.4
Neckers, L.M.5
-
65
-
-
0033231024
-
A novel chaperone-activity-reducing mechanism of the 90-kDa molecular chaperone Hsp90
-
Itoh H, Ogura M, Komatsuda A, Wakui H, Miura A, Tashima Y. A novel chaperone-activity-reducing mechanism of the 90-kDa molecular chaperone Hsp90. Biochem J 1999;343:697-703.
-
(1999)
Biochem. J.
, vol.343
, pp. 697-703
-
-
Itoh, H.1
Ogura, M.2
Komatsuda, A.3
Wakui, H.4
Miura, A.5
Tashima, Y.6
-
66
-
-
10744220096
-
The heat shock protein 90-targeting drug cisplatin selectively inhibits steroid receptor activation
-
Rosenhagen MC, Soti C, Schmidt U, et al. The heat shock protein 90-targeting drug cisplatin selectively inhibits steroid receptor activation. Mol Endocrinol 2003;17:1991-2001.
-
(2003)
Mol. Endocrinol.
, vol.17
, pp. 1991-2001
-
-
Rosenhagen, M.C.1
Soti, C.2
Schmidt, U.3
-
67
-
-
0034646511
-
Structure of TPR domain-peptide complexes: Critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine
-
Scheufler C, Brinker A, Bourenkov G, et al. Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine. Cell 2000;101:199-210.
-
(2000)
Cell
, vol.101
, pp. 199-210
-
-
Scheufler, C.1
Brinker, A.2
Bourenkov, G.3
-
68
-
-
0033081968
-
Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones
-
Prodromou C, Siligardi G, O'Brien R, et al. Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones. EMBO J 1999;18:754-62.
-
(1999)
EMBO J.
, vol.18
, pp. 754-762
-
-
Prodromou, C.1
Siligardi, G.2
O'Brien, R.3
-
70
-
-
0042885973
-
The Hsp90 chaperone complex as a novel target for cancer therapy
-
Goetz MP, Toft DO, Ames MM, Erlichman C. The Hsp90 chaperone complex as a novel target for cancer therapy. Ann Oncol 2003;14: 1169-76.
-
(2003)
Ann. Oncol.
, vol.14
, pp. 1169-1176
-
-
Goetz, M.P.1
Toft, D.O.2
Ames, M.M.3
Erlichman, C.4
-
71
-
-
0033524442
-
Maturation of the tyrosine kinase c-src as a kinase and as a substrate depends on the molecular chaperone Hsp90
-
Jan 5
-
Xu Y, Singer MA, Lindquist S. Maturation of the tyrosine kinase c-src as a kinase and as a substrate depends on the molecular chaperone Hsp90. Proc Natl Acad Sci USA 1999 Jan 5;96:109-14.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 109-114
-
-
Xu, Y.1
Singer, M.A.2
Lindquist, S.3
-
72
-
-
0032980876
-
Genetic analysis of viable Hsp90 alleles reveals a critical role in Drosophila spermatogenesis
-
Mar
-
Yue L, Karr TL, Nathan DF, Swift H, Srinivasan S, Lindquist S. Genetic analysis of viable Hsp90 alleles reveals a critical role in Drosophila spermatogenesis. Genetics 1999 Mar;151:1065-79.
-
(1999)
Genetics
, vol.151
, pp. 1065-1079
-
-
Yue, L.1
Karr, T.L.2
Nathan, D.F.3
Swift, H.4
Srinivasan, S.5
Lindquist, S.6
-
73
-
-
0036735298
-
Proteasome inhibitor PS-341 inhibits human myeloma cell growth in vivo and prolongs survival in a murine model
-
LeBlanc R, Catley LP, Hideshima T, et al. Proteasome inhibitor PS-341 inhibits human myeloma cell growth in vivo and prolongs survival in a murine model. Cancer Res 2002;62:4996-5000.
-
(2002)
Cancer Res.
, vol.62
, pp. 4996-5000
-
-
LeBlanc, R.1
Catley, L.P.2
Hideshima, T.3
-
74
-
-
1142273472
-
Altered states: Selectively drugging the Hsp90 cancer chaperone
-
Workman P. Altered states: selectively drugging the Hsp90 cancer chaperone. Trends Mol Med 2004;10:47-51.
-
(2004)
Trends Mol. Med.
, vol.10
, pp. 47-51
-
-
Workman, P.1
-
75
-
-
0034710542
-
Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin, an inhibitor of the Hsp90 molecular chaperone
-
Clarke PA, Hostein I, Banerji U, et al. Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin, an inhibitor of the Hsp90 molecular chaperone. Oncogene 2000;19:4125-33.
-
(2000)
Oncogene
, vol.19
, pp. 4125-4133
-
-
Clarke, P.A.1
Hostein, I.2
Banerji, U.3
-
76
-
-
0029664590
-
Cell-cycle arrest and p53 accumulation induced by geldanamycin in human ovarian tumor cells
-
McIlwrath AJ, Brunton VG, Brown R. Cell-cycle arrest and p53 accumulation induced by geldanamycin in human ovarian tumor cells. Cancer Chemother Pharmacol 1996;37:423-8.
-
(1996)
Cancer Chemother. Pharmacol.
, vol.37
, pp. 423-428
-
-
McIlwrath, A.J.1
Brunton, V.G.2
Brown, R.3
-
78
-
-
0035872442
-
Inhibition of signal transduction by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin results in cytostatis and apoptosis
-
Hostein I, Robertson D, DiStefano F, Workman P, Clarke PA. Inhibition of signal transduction by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin results in cytostatis and apoptosis. Cancer Res 2001;61: 4003-9.
-
(2001)
Cancer Res.
, vol.61
, pp. 4003-7009
-
-
Hostein, I.1
Robertson, D.2
DiStefano, F.3
Workman, P.4
Clarke, P.A.5
-
79
-
-
0034890377
-
Modulation of Hsp90 function by ansamycins sensitizes breast cancer cells to chemotherapy-induced apoptosis in an RB- and schedule-dependent manner [see Sausville EA. Combining cytotoxics and 17-allylamino,17-demethoxygeldanamycin: Sequence and tumor biology matters. Clin. Cancer Res. 2001;7:2155-8]
-
Munster PN, Basso A, Solit D, Norton L, Rosen N. Modulation of Hsp90 function by ansamycins sensitizes breast cancer cells to chemotherapy-induced apoptosis in an RB- and schedule-dependent manner [see Sausville EA. Combining cytotoxics and 17-allylamino,17-demethoxygeldanamycin: sequence and tumor biology matters. Clin Cancer Res 2001;7:2155-8]. Clin Cancer Res 2001;7:2228-36.
-
(2001)
Clin. Cancer Res.
, vol.7
, pp. 2228-2236
-
-
Munster, P.N.1
Basso, A.2
Solit, D.3
Norton, L.4
Rosen, N.5
-
80
-
-
0037075232
-
Ansamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that overexpress HER2
-
Basso AD, Solit DB, Munster PN, Rosen N. Ansamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that overexpress HER2. Oncogene 2002;21:1159-66.
-
(2002)
Oncogene
, vol.21
, pp. 1159-1166
-
-
Basso, A.D.1
Solit, D.B.2
Munster, P.N.3
Rosen, N.4
-
81
-
-
0037108448
-
Bcr-abl point mutants isolated from patients with imatinib mesylate-resistant chronic myeloid leukemia remain sensitive to inhibitors of the bcr-abl chaperone heat shock protein 90
-
Gorre ME, Ellwood-Yen K, Chiosis G, Rosen N, Sawyers CL. Bcr-abl point mutants isolated from patients with imatinib mesylate-resistant chronic myeloid leukemia remain sensitive to inhibitors of the bcr-abl chaperone heat shock protein 90. Blood 2002;100:3041-4.
-
(2002)
Blood
, vol.100
, pp. 3041-3044
-
-
Gorre, M.E.1
Ellwood-Yen, K.2
Chiosis, G.3
Rosen, N.4
Sawyers, C.L.5
-
82
-
-
0036494113
-
Nucleophosmin-anaplastic lymphoma kinase (npm-alk), a novel Hsp90-client tyrosine kinase: Down-regulation of NPM-ALK expression and tyrosine phosphorylation in ALK(+) CD30(+) lymphoma cells by the Hsp90 antagonist 17-allylamino, 17-demethoxygeldanamycin
-
Bonvini P, Gastaldi T, Falini B, Rosolen A. Nucleophosmin-anaplastic lymphoma kinase (npm-alk), a novel Hsp90-client tyrosine kinase: down-regulation of NPM-ALK expression and tyrosine phosphorylation in ALK(+) CD30(+) lymphoma cells by the Hsp90 antagonist 17-allylamino, 17-demethoxygeldanamycin. Cancer Res 2002;62:1559-66.
-
(2002)
Cancer Res.
, vol.62
, pp. 1559-1566
-
-
Bonvini, P.1
Gastaldi, T.2
Falini, B.3
Rosolen, A.4
-
83
-
-
0142188139
-
Hormone-refractory breast cancer remains sensitive to the antitumor activity of heat shock protein 90 inhibitors
-
Beliakoff J, Bagatell R, Paine-Murrieta G, Taylor CW, Lykkesfeldt AE, Whitesell L. Hormone-refractory breast cancer remains sensitive to the antitumor activity of heat shock protein 90 inhibitors. Clin Cancer Res 2003;9:4961-71.
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 4961-4971
-
-
Beliakoff, J.1
Bagatell, R.2
Paine-Murrieta, G.3
Taylor, C.W.4
Lykkesfeldt, A.E.5
Whitesell, L.6
-
84
-
-
0036091221
-
17-Allylamino-17-demethoxygeldanamycin induces the degradation of androgen receptor and HER-2/ neu and inhibits the growth of prostate cancer xenografts
-
Solit DB, Zheng FF, Drobnjak M, et al. 17-Allylamino-17-demethoxygeldanamycin induces the degradation of androgen receptor and HER-2/ neu and inhibits the growth of prostate cancer xenografts. Clin Cancer Res 2002;8:986-93.
-
(2002)
Clin. Cancer Res.
, vol.8
, pp. 986-993
-
-
Solit, D.B.1
Zheng, F.F.2
Drobnjak, M.3
-
85
-
-
0036606332
-
Degradation of HER2 by ansamycins induces growth arrest and apoptosis in cells with HER2 overexpression via a HER3, phosphatidylinositol 3′-kinase-akt-dependent pathway
-
Munster PN, Marchion DC, Basso AD, Rosen N. Degradation of HER2 by ansamycins induces growth arrest and apoptosis in cells with HER2 overexpression via a HER3, phosphatidylinositol 3′ -kinase-akt-dependent pathway. Cancer Res 2002;62:3132-7.
-
(2002)
Cancer Res.
, vol.62
, pp. 3132-3137
-
-
Munster, P.N.1
Marchion, D.C.2
Basso, A.D.3
Rosen, N.4
-
86
-
-
0038404927
-
Inhibition of heat shock protein 90 function down-regulates Akt kinase and sensitizes tumors to taxol
-
Solit DB, Basso AD, Olshen AB, Scher HI, Rosen N. Inhibition of heat shock protein 90 function down-regulates Akt kinase and sensitizes tumors to taxol. Cancer Res 2003;63:2139-44.
-
(2003)
Cancer Res.
, vol.63
, pp. 2139-2144
-
-
Solit, D.B.1
Basso, A.D.2
Olshen, A.B.3
Scher, H.I.4
Rosen, N.5
-
87
-
-
0033890818
-
Induction of a heat shock factor 1-dependent stress response alters the cytotoxic activity of Hsp90 binding agents
-
Bagatell R, Paine-Murrieta G, Taylor C, et al. Induction of a heat shock factor 1-dependent stress response alters the cytotoxic activity of Hsp90 binding agents. Clin Cancer Res 2000;6:3312-8.
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 3312-3318
-
-
Bagatell, R.1
Paine-Murrieta, G.2
Taylor, C.3
-
88
-
-
0033579175
-
DT-diaphorase expression and tumor cell sensitivity to 17-allylamino,17-demethoxygeldanamycin, an inhibitor of heat shock protein 90
-
Kelland LR, Sharp SY, Rogers PM, Myers TG, Workman P. DT-diaphorase expression and tumor cell sensitivity to 17-allylamino,17-demethoxygeldanamycin, an inhibitor of heat shock protein 90. J Natl Cancer Inst 1999;91:1940-9.
-
(1999)
J. Natl. Cancer Inst.
, vol.91
, pp. 1940-1949
-
-
Kelland, L.R.1
Sharp, S.Y.2
Rogers, P.M.3
Myers, T.G.4
Workman, P.5
-
89
-
-
0034743361
-
Plasma pharmacokinetics and tissue distribution of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) in CD2F1 mice1
-
Egorin MJ, Zuhowski EG, Rosen DM, Sentz DL, Covey JM, Eiseman JL. Plasma pharmacokinetics and tissue distribution of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) in CD2F1 mice1. Cancer Chemother Pharmacol 2001;47:291-302.
-
(2001)
Cancer Chemother. Pharmacol.
, vol.47
, pp. 291-302
-
-
Egorin, M.J.1
Zuhowski, E.G.2
Rosen, D.M.3
Sentz, D.L.4
Covey, J.M.5
Eiseman, J.L.6
-
90
-
-
0346995281
-
Combination treatment with 17-n-allylamino-17-demethoxy geldanamycin and acute irradiation produces supra-additive growth suppression in human prostate carcinoma spheroids
-
Enmon R, Yang WH, Ballangrud AM, et al. Combination treatment with 17-n-allylamino-17-demethoxy geldanamycin and acute irradiation produces supra-additive growth suppression in human prostate carcinoma spheroids. Cancer Res 2003;63:8393-9.
-
(2003)
Cancer Res.
, vol.63
, pp. 8393-8399
-
-
Enmon, R.1
Yang, W.H.2
Ballangrud, A.M.3
-
91
-
-
9144261127
-
Geldanamycin and 17-allylamino-17-demethoxygeldanamycin potentiate the in vitro and in vivo radiation response of cervical tumor cells via the heat shock protein 90-mediated intracellular signaling and cytotoxicity
-
Bisht KS, Bradbury CM, Mattson D, et al. Geldanamycin and 17-allylamino-17-demethoxygeldanamycin potentiate the in vitro and in vivo radiation response of cervical tumor cells via the heat shock protein 90-mediated intracellular signaling and cytotoxicity. Cancer Res 2003;63: 8984-95.
-
(2003)
Cancer Res.
, vol.63
, pp. 8984-8995
-
-
Bisht, K.S.1
Bradbury, C.M.2
Mattson, D.3
-
92
-
-
4143105237
-
Geldanamycin enhances cisplatin cytotoxicity through loss of Akt activation in A549 cells
-
McCollum A, Taft DO, Erlichman C. Geldanamycin enhances cisplatin cytotoxicity through loss of Akt activation in A549 cells. Clin Cancer Res 2003;9 Suppl:6178s.
-
(2003)
Clin. Cancer Res.
, vol.9
, Issue.SUPPL.
-
-
McCollum, A.1
Taft, D.O.2
Erlichman, C.3
-
93
-
-
0038069088
-
Geldanamycin and its 17-allylamino-17-demethoxy analogue antagonize the action of cisplatin in human colon adenocarcinoma cells: Differential caspase activation as a basis for interaction
-
Vasilevskaya IA, Rakitina TV, O'Dwyer PJ. Geldanamycin and its 17-allylamino-17-demethoxy analogue antagonize the action of cisplatin in human colon adenocarcinoma cells: differential caspase activation as a basis for interaction. Cancer Res 2003;63:3241-6.
-
(2003)
Cancer Res.
, vol.63
, pp. 3241-3246
-
-
Vasilevskaya, I.A.1
Rakitina, T.V.2
O'Dwyer, P.J.3
-
94
-
-
4143068615
-
Targeting the HspO molecular chaperone while inhibiting proteosomal proteolysis promotes protein ubiquitination, produces prominent ER-derived cytosolic vacuolization and provokes additive antitumor activity
-
Mimnaugh EG, Xu W, Vos M, Neckers LM. Targeting the HspO molecular chaperone while inhibiting proteosomal proteolysis promotes protein ubiquitination, produces prominent ER-derived cytosolic vacuolization and provokes additive antitumor activity. Clin Cancer Res 2003;9 Suppl:6245s.
-
(2003)
Clin. Cancer Res.
, vol.9
, Issue.SUPPL.
-
-
Mimnaugh, E.G.1
Xu, W.2
Vos, M.3
Neckers, L.M.4
-
95
-
-
0242670014
-
Novel biologically based therapies for Waldenstrom's macroglobulinemia
-
Mitsiades CS, Mitsiades N, Richardson PG, Treon SP, Anderson KC. Novel biologically based therapies for Waldenstrom's macroglobulinemia. Semin Oncol 2003;30:309-12.
-
(2003)
Semin. Oncol.
, vol.30
, pp. 309-312
-
-
Mitsiades, C.S.1
Mitsiades, N.2
Richardson, P.G.3
Treon, S.P.4
Anderson, K.C.5
-
96
-
-
0345734267
-
Coadministration of the heat shock protein 90 antagonist 17-allylamino-17-demethoxygeldanamycin with suberoylanilide hydroxamic acid or sodium butyrate synergistically induces apoptosis in human leukemia cells
-
Rahmani M, Yu C, Dai Y, et al. Coadministration of the heat shock protein 90 antagonist 17-allylamino-17-demethoxygeldanamycin with suberoylanilide hydroxamic acid or sodium butyrate synergistically induces apoptosis in human leukemia cells. Cancer Res 2003;63:8420-7.
-
(2003)
Cancer Res.
, vol.63
, pp. 8420-8427
-
-
Rahmani, M.1
Yu, C.2
Dai, Y.3
-
97
-
-
0037012344
-
Modulation of p53, erbB1, erbB2, and raf-1 expression in lung cancer cells by depsipeptide FR901228
-
Yu X, Guo ZS, Marcu MG, et al. Modulation of p53, erbB1, erbB2, and raf-1 expression in lung cancer cells by depsipeptide FR901228. J Natl Cancer Inst 2002;94:504-13.
-
(2002)
J. Natl. Cancer Inst.
, vol.94
, pp. 504-513
-
-
Yu, X.1
Guo, Z.S.2
Marcu, M.G.3
-
98
-
-
0347360283
-
Adenine derived inhibitors of the molecular chaperone Hsp90-SAR explained through multiple X-ray structures
-
Dymock B, Barril X, Beswick M, et al. Adenine derived inhibitors of the molecular chaperone Hsp90-SAR explained through multiple X-ray structures. Bioorg Med Chem Lett 2004;14:325-8.
-
(2004)
Bioorg. Med. Chem. Lett.
, vol.14
, pp. 325-328
-
-
Dymock, B.1
Barril, X.2
Beswick, M.3
-
99
-
-
4444266873
-
Discovery of a novel synthetic inhibitor of the hsp90 molecular chaperone
-
AACR Annual Meeting Washington, DC
-
Aherne W, Maloney A, Sharp S, et al. Discovery of a novel synthetic inhibitor of the hsp90 molecular chaperone. AACR Annual Meeting; 2003; Washington, DC.
-
(2003)
-
-
Aherne, W.1
Maloney, A.2
Sharp, S.3
-
100
-
-
4143089911
-
Discovery of novel small molecule hsp90 complex inhibitors using a forward chemical genetics approach
-
Barbosa JA, Elkin L, Darrow J, et al. Discovery of novel small molecule hsp90 complex inhibitors using a forward chemical genetics approach. Clin Cancer Res 2003;9 Suppl:6176s.
-
(2003)
Clin. Cancer Res.
, vol.9
, Issue.SUPPL.
-
-
Barbosa, J.A.1
Elkin, L.2
Darrow, J.3
-
101
-
-
0034608532
-
Synthesis and evaluation of geldanamycin-testosterone hybrids
-
Kuduk SD, Harris TC, Zheng FF, et al. Synthesis and evaluation of geldanamycin-testosterone hybrids. Bioorg Med Chem Lett 2000; 10:1303-6.
-
(2000)
Bioorg. Med. Chem. Lett.
, vol.10
, pp. 1303-1306
-
-
Kuduk, S.D.1
Harris, T.C.2
Zheng, F.F.3
-
102
-
-
0034655207
-
Identification of a geldanamycin dimer that induces the selective degradation of HER-family tyrosine kinases
-
Zheng FF, Kuduk SD, Chiosis G, et al. Identification of a geldanamycin dimer that induces the selective degradation of HER-family tyrosine kinases. Cancer Res 2000;60:2090-4.
-
(2000)
Cancer Res.
, vol.60
, pp. 2090-2094
-
-
Zheng, F.F.1
Kuduk, S.D.2
Chiosis, G.3
-
103
-
-
0033564430
-
KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules
-
Soga S, Neckers LM, Schulte TW, et al. KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules. Cancer Res 1999;59:2931-8.
-
(1999)
Cancer Res.
, vol.59
, pp. 2931-2938
-
-
Soga, S.1
Neckers, L.M.2
Schulte, T.W.3
-
104
-
-
0036836964
-
Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of HER2 tyrosine kinase
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Chiosis G, Lucas B, Shtil A, Huezo H, Rosen N. Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of HER2 tyrosine kinase. Bioorg Med Chem 2002;10:3555-64.
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(2002)
Bioorg. Med. Chem.
, vol.10
, pp. 3555-3564
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Chiosis, G.1
Lucas, B.2
Shtil, A.3
Huezo, H.4
Rosen, N.5
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