Modulation of chaperone function and cochaperone interaction by novobiocin in the C-terminal domain of Hsp90: Evidence that coumarin antibiotics disrupt Hsp90 dimerization

Journal of Biological Chemistry

Volumn 281, Issue 11, 2006, Pages 7161-7171

  Allan, Rudi K ^a   Mok, Danny ^a   Ward, Bryan K ^a   Ratajczak, Thomas ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; COMPLEXATION; CONFORMATIONS; DIMERIZATION; ENZYME KINETICS; ENZYMES; HYDROPHOBICITY;

CHAPERONE; COCHAPERONE; COUMARIN; NOVOBIOCIN;

MOLECULAR BIOLOGY;

CHAPERONE; COUMAMYCIN A1; GLUCOCORTICOID RECEPTOR; HEAT SHOCK PROTEIN 90; IMMUNOPHILIN; NOVOBIOCIN; NUCLEOTIDE; PROTEIN KINASE; PROTEIN P50; RECOMBINANT PROTEIN; STEROID RECEPTOR; ALANINE; AMINOCOUMARIN DERIVATIVE; ANTIINFECTIVE AGENT; COMPLEMENTARY DNA; COUMAMYCIN; COUMARIN; COUMARIN DERIVATIVE; ENZYME INHIBITOR; FK 506 BINDING PROTEIN; GLUTATHIONE TRANSFERASE; STEROID; TACROLIMUS BINDING PROTEIN 5;

ALLOSTERISM; ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DIMERIZATION; DRUG INHIBITION; HELA CELL; HUMAN; HUMAN CELL; HYDROPHOBICITY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN MOTIF; AMINO ACID SEQUENCE; CHEMISTRY; CONFORMATION; DOSE RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME SPECIFICITY; METABOLISM; MOLECULAR GENETICS; MUTATION; PLASMID; POINT MUTATION; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SITE DIRECTED MUTAGENESIS; TIME;

ALANINE; AMINO ACID SEQUENCE; AMINOCOUMARINS; ANTI-BACTERIAL AGENTS; BINDING SITES; COUMARINS; DIMERIZATION; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GLUTATHIONE TRANSFERASE; HELA CELLS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; IMMUNOPHILINS; MOLECULAR CHAPERONES; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; NOVOBIOCIN; PLASMIDS; POINT MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; STEROIDS; SUBSTRATE SPECIFICITY; TACROLIMUS BINDING PROTEINS; TIME FACTORS;

EID: 33646371009     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M512406200     Document Type: Article

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