Crystal structures of human HSP90α-complexed with dihydroxyphenylpyrazoles

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 5, 2005, Pages 1475-1478

  Kreusch, Andreas ^a   Han, Shulin ^a   Brinker, Achim ^a   Zhou, Vicki ^a   Choi, Ha Soon ^a   He, Yun ^a   Lesley, Scott A ^a   Caldwell, Jeremy ^a   Gu, Xiang Ju ^a  

^a GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

Author keywords

3D structure; Co crystal; Dihydroxyphenylpyrazole; Hsp90; Pyrazole; Structure based drug design

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; G 3129; G 3130; HEAT SHOCK PROTEIN 90; HYDROXYL GROUP; PROTEIN INHIBITOR; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; COMPLEX FORMATION; CONCENTRATION RESPONSE; CRYSTAL STRUCTURE; DRUG EFFECT; DRUG PROTEIN BINDING; HYDROGEN BOND; PROTEIN DEGRADATION; PROTEIN DOMAIN; STRUCTURE ANALYSIS;

EID: 13944270580     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.12.087     Document Type: Article

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