Structure of TPR domain-peptide complexes: Critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine

Cell

Volumn 101, Issue 2, 2000, Pages 199-210

  Scheufler, Clemens ^a   Brinker, Achim ^a   Bourenkov, Gleb ^b   Pegoraro, Stefano ^a   Moroder, Luis ^a   Bartunik, Hans ^b   Hartl, F Ulrich ^a   Moarefi, Ismail ^a  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b MAX PLANCK UNIT FOR STRUCTURAL MOLECULAR BIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; CHAPERONE; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; POLYPEPTIDE;

ARTICLE; CALORIMETRY; COMPLEX FORMATION; HYDROPHOBICITY; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN STRUCTURE;

HUMULUS;

EID: 0034646511     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)80830-2     Document Type: Article

References (50)

1. The Ccp4 Suite - Programs for protein crystallography
2. Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions
3. Chaperone function of Hsp90-associated proteins
4. Crystallography and NMR system: A new software suite for macromolecular structure determination
5. Hsp90 and Co.- A holding for folding
6. Hsp90's secrets unfold: New insights from structural and functional studies
7. The common tetratricopeptide repeat acceptor site for steroid receptor - Associated immunophilins and hop is located in the dimerization domain of Hsp90
8. In vivo analysis of the Hsp90 cochaperone Sti1 (p60)
9. Hop as an adaptor in the heat shock protein 70 (Hsp70) and hsp90 chaperone machinery
10. Interactions of p60, a mediator of progesterone receptor assembly, with heat shock proteins hsp90 and hsp70
11. Differential interactions of p23 and the TPR-containing proteins Hop, Cyp40, FKBP52 and FKBP51 with Hsp90 mutants
12. The structure of the tetratricopeptide repeats of protein phosphatase 5: Implications for TPR-mediated protein-protein interactions
13. The carboxy-terminal domain of Hsc70 provides binding sites for a distinct set of chaperone cofactors
14. CNS1 encodes an essential p60/Sti1 homolog in Saccharomyces cerevisiae that suppresses cyclophilin 40 mutations and interacts with Hsp90
15. Crystal structures of a complexed and peptide-free membrane protein-binding domain: Molecular basis of peptide recognition by PDZ
16. Further additions to MolScript version 1.4, including reading and contouring of electron-density maps
17. Molecular chaperone machines: Chaperone activities of the cyclophilin Cyp-40 and the steroid aporeceptor-associated protein p23
18. Chaperones get in touch: The Hip-Hop connection
19. Peptide-surface association: The case of PDZ and PTB domains
20. Molecular chaperones in cellular protein folding
21. Molecular cloning and expression of a transformation-sensitive human protein containing the TPR motif and sharing identity to the stress-inducible yeast protein STI1
22. Protein folding in vivo: Unraveling complex pathways
23. Hop modulates Hsp70/Hsp90 interactions in protein folding
24. Improved methods for building protein models in electron-density maps and the location of errors in these models
25. Isolation and characterization of human SGT and identification of homologues in Saccharomyces cerevisiae and Caenorhabditis elegans
26. Modular peptide recognition domains in eukaryotic signaling
27. Tetratrico peptide repeat interactions: To TPR or not to TPR?
28. Stress-inducible, murine protein mSTI1. Characterization of binding domains for heat shock proteins and in vitro phosphorylation by different kinases
29. Cns1 is an essential protein associated with the hsp90 chaperone complex in Saccharomyces cerevisiae that can restore cyclophilin 40-dependent functions in cpr7Delta cells
30. Raster3D: Photorealistic molecular graphics
31. Identification and characterization of two novel tetratricopeptide repeat-containing genes
32. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro
33. Grasp - Graphical representation and analysis of surface properties
34. Processing of X-ray diffraction data collected in oscillation mode
35. A model of protein targeting mediated by immunophilins and other proteins that bind to hsp90 via tetratricopeptide repeat domains
36. Automated protein model building combined with iterative structure refinement
37. The role of the hsp90-based chaperone system in signal transduction by nuclear receptors and receptors signaling via MAP kinase
38. Steroid receptor interactions with heat shock protein and immunophilin chaperones
39. Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone
40. Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones
41. Identification of a 60-kilodalton stress-related protein, p60, which interacts with hsp90 and hsp70
42. Molecular chaperones: Biology and prospects for pharmacological intervention
43. Crystal structure of an Hsp90-geldanamycin complex: Targeting of a protein chaperone by an antitumor agent
44. TTC4, a novel human gene containing the tetratricopeptide repeat and mapping to the region of chromosome 1p31 that is frequently deleted in sporadic breast cancer
45. Identification and cloning of a novel cDNA belonging to tetratricopeptide repeat gene family from Down syndrome-critical region 21q22.2
46. Ligplota program to generate schematic diagrams of protein ligand interactions
47. Rapid measurement of binding constants and heats of binding using a new titration calorimeter
48. The structural basis for 14-3-3: Phosphopeptide binding specificity
49. Specific binding of tetratricopeptide repeat proteins to the C-terminal 12kDa domain of hsp90
50. Isolation and sequencing of the cDNA encoding the 75-kD human sperm protein related to infertility