-
1
-
-
0029028792
-
Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: Implications for drug delivery and activity in cancer chemotherapy
-
Wacher V.J., Wu C.Y.,Benet L.Z. - Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy. - Mol Carcinog, 13, 129-134, 1995.
-
(1995)
Mol Carcinog
, vol.13
, pp. 129-134
-
-
Wacher, V.J.1
Wu, C.Y.2
Benet, L.Z.3
-
2
-
-
0035854830
-
The Leishmania ATP-binding Cassette Protein PGPA is an Intracellular Metal-Thiol Transporter ATPase
-
DOI 10.1074/jbc.M102351200
-
Legare D., Richard D., Mukhopadhyay R., Stierhof Y.D., Rosen B.P., Haimeur A., Papadopoulou B., Ouellette M. - The Leishmania ATP-binding cassette protein PGPA is an intracellular metal-thiol transporter ATPase. - J Biol Chem, 276, 26301-26307, 2001. (Pubitemid 37412846)
-
(2001)
Journal of Biological Chemistry
, vol.276
, Issue.28
, pp. 26301-26307
-
-
Legare, D.1
Richard, D.2
Mukhopadhyay, R.3
Stierhof, Y.-D.4
Rosen, B.P.5
Haimeur, A.6
Papadopoulou, B.7
Ouellette, M.8
-
3
-
-
0030014846
-
Membrane topology and glycosylation of the human multidrug resistance- Associated protein
-
DOI 10.1074/jbc.271.21.12322
-
Bakos E., Hegedus T., Hollo Z., Welker E., Tusnady G.E., Zaman G.J., Flens M.J., Varadi A., Sarkadi B. - Membrane topology and glycosylation of the human multidrug resistance-associated protein. - J Biol Chem, 271, 12322-12326, 1996. (Pubitemid 26160897)
-
(1996)
Journal of Biological Chemistry
, vol.271
, Issue.21
, pp. 12322-12326
-
-
Bakos, E.1
Hegedus, T.2
Hollo, Z.3
Welker, E.4
Tusnady, G.E.5
Zaman, G.J.R.6
Flens, M.J.7
Varadi, A.8
Sarkadi, B.9
-
4
-
-
0030863293
-
Membrane topology of the multidrug resistance protein (MRP). a study of glycosylation-site mutants reveals an extracytosolic NH2 terminus
-
Hipfner D.R., Almquist K.C., Leslie E.M., Gerlach J.H., Grant C.E., Deeley R.G., Cole S.P. - Membrane topology of the multidrug resistance protein (MRP). A study of glycosylation-site mutants reveals an extracytosolic NH2 terminus. - J Biol Chem, 272, 23623-23630, 1997.
-
(1997)
J Biol Chem
, vol.272
, pp. 23623-23630
-
-
Hipfner, D.R.1
Almquist, K.C.2
Leslie, E.M.3
Gerlach, J.H.4
Grant, C.E.5
Deeley, R.G.6
Cole, S.P.7
-
5
-
-
0030685129
-
Topology mapping of the amino-terminal half of multidrug resistance- Associated protein by epitope insertion and immunofluorescence
-
DOI 10.1074/jbc.272.42.26479
-
Kast C., Gros P. - Topology mapping of the amino-terminal half of multidrug resistance-associated protein by epitope insertion and immunofluorescence. - J Biol Chem, 272, 26479-26487, 1997. (Pubitemid 27458867)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.42
, pp. 26479-26487
-
-
Kast, C.1
Grost, P.2
-
6
-
-
0037050736
-
Dominant-negative inhibition of breast cancer resistance protein as drug efflux pump through the inhibition of S-S dependent homodimerization
-
DOI 10.1002/ijc.10100
-
Kage K., Tsukahara S., Sugiyama T., Asada S., Ishikawa E., Tsuruo T., Sugimoto Y. - Dominant-negative inhibition of breast cancer resistance protein as drug efflux pump through the inhibition of S-S dependent homodimerization. - Int J Cancer, 97, 626-630, 2002. (Pubitemid 34087801)
-
(2002)
International Journal of Cancer
, vol.97
, Issue.5
, pp. 626-630
-
-
Kage, K.1
Tsukahara, S.2
Sugiyama, T.3
Asada, S.4
Ishikawa, E.5
Tsuruo, T.6
Sugimoto, Y.7
-
7
-
-
0028786395
-
Both P-glycoprotein nucleotide-binding sites are catalytically active
-
Urbatsch I.L., Sankaran B., Bhagat S.,Senior A.E. - Both P-glycoprotein nucleotide-binding sites are catalytically active. - J Biol Chem, 270, 26956-26961, 1995.
-
(1995)
J Biol Chem
, vol.270
, pp. 26956-26961
-
-
Urbatsch, I.L.1
Sankaran, B.2
Bhagat, S.3
Senior, A.E.4
-
8
-
-
33645830172
-
A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants
-
Juliano R.L.,Ling V. - A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. - Biochim Biophys Acta, 455, 152-162, 1976.
-
(1976)
Biochim Biophys Acta
, vol.455
, pp. 152-162
-
-
Juliano, R.L.1
Ling, V.2
-
9
-
-
22844451077
-
Role of efflux pumps and metabolising enzymes in drug delivery
-
Katragadda S., Budda B., Anand B.S.,Mitra A.K. - Role of efflux pumps and metabolising enzymes in drug delivery. - Expert Opin Drug Deliv, 2, 683-705, 2005.
-
(2005)
Expert Opin Drug Deliv
, vol.2
, pp. 683-705
-
-
Katragadda, S.1
Budda, B.2
Anand, B.S.3
Mitra, A.K.4
-
10
-
-
0037457802
-
Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: An overview
-
Schinkel A.H.,Jonker J.W. - Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview. - Adv Drug Deliv Rev, 55, 3-29, 2003.
-
(2003)
Adv Drug Deliv Rev
, vol.55
, pp. 3-29
-
-
Schinkel, A.H.1
Jonker, J.W.2
-
11
-
-
0344825356
-
P-glycoprotein: From genomics to mechanism
-
Ambudkar S.V., Kimchi-Sarfaty C., Sauna Z.E., Gottesman M.M. - P-glycoprotein: from genomics to mechanism. - Oncogene, 22, 7468-7485, 2003.
-
(2003)
Oncogene
, vol.22
, pp. 7468-7485
-
-
Ambudkar, S.V.1
Kimchi-Sarfaty, C.2
Sauna, Z.E.3
Gottesman, M.M.4
-
12
-
-
0023447098
-
Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues
-
Thiebaut F., Tsuruo T., Hamada H., Gottesman M.M., Pastan I., Willingham M.C. - Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues. - Proc Natl Acad Sci USA, 84, 7735-7738, 1987.
-
(1987)
Proc Natl Acad Sci USA
, vol.84
, pp. 7735-7738
-
-
Thiebaut, F.1
Tsuruo, T.2
Hamada, H.3
Gottesman, M.M.4
Pastan, I.5
Willingham, M.C.6
-
13
-
-
0000712439
-
Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites
-
Cordon-Cardo C., O'brien J.P., Casals D., Rittman-Grauer L., Biedler J.L., Melamed M.R.,Bertino J.R. - Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites. - Proc Natl Acad Sci USA, 86, 695-698, 1989.
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, pp. 695-698
-
-
Cordon-Cardo, C.1
O'Brien, J.P.2
Casals, D.3
Rittman-Grauer, L.4
Biedler, J.L.5
Melamed, M.R.6
Bertino, J.R.7
-
14
-
-
0023889448
-
Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK 16
-
Sugawara I., Kataoka I., Morishita Y., Hamada H., Tsuruo T., Itoyama S., Mori S. - Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK 16. - Cancer Res, 48, 1926-1929, 1988.
-
(1988)
Cancer Res
, vol.48
, pp. 1926-1929
-
-
Sugawara, I.1
Kataoka, I.2
Morishita, Y.3
Hamada, H.4
Tsuruo, T.5
Itoyama, S.6
Mori, S.7
-
15
-
-
0037624566
-
Multidrug resistance 1 gene (P-glycoprotein 170): An important determinant in gastrointestinal disease?
-
Ho G.T., Moodie F.M., Satsangi J. - Multidrug resistance 1 gene (P-glycoprotein 170): an important determinant in gastrointestinal disease? - Gut, 52, 759-766, 2003.
-
(2003)
Gut
, vol.52
, pp. 759-766
-
-
Ho, G.T.1
Moodie, F.M.2
Satsangi, J.3
-
16
-
-
0027181852
-
Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. Kinetics of vinblastine secretion and interaction with modulators
-
Hunter J., Jepson M.A., Tsuruo T., Simmons N.L., Hirst B.H. - Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. Kinetics of vinblastine secretion and interaction with modulators. - J Biol Chem, 268, 14991-14997, 1993. (Pubitemid 23206648)
-
(1993)
Journal of Biological Chemistry
, vol.268
, Issue.20
, pp. 14991-14997
-
-
Hunter, J.1
Jepson, M.A.2
Tsuruo, T.3
Simmons, N.L.4
Hirst, B.H.5
-
17
-
-
0027180795
-
Drug absorption limited by P-glycoprotein-mediated secretory drug transport in human intestinal epithelial Caco-2 cell layers
-
DOI 10.1023/A:1018972102702
-
Hunter J., Hirst B.H.Simmons N.L. - Drug absorption limited by P-glycoprotein-mediated secretory drug transport in human intestinal epithelial Caco-2 cell layers. - Pharm Res, 10, 743-749, 1993. (Pubitemid 23152323)
-
(1993)
Pharmaceutical Research
, vol.10
, Issue.5
, pp. 743-749
-
-
Hunter, J.1
Hirst, B.H.2
Simmons, N.L.3
-
18
-
-
12644278301
-
Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine
-
DOI 10.1073/pnas.94.5.2031
-
Sparreboom A., Van Asperen J., Mayer U., Schinkel A.H., Smit J.W., Meijer D.K., Borst P., Nooijen W.J., Beijnen J.H., Van Tellingen O. - Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine. - Proc Natl Acad Sci USA, 94, 2031-2035, 1997. (Pubitemid 27113956)
-
(1997)
Proceedings of the National Academy of Sciences of the United States of America
, vol.94
, Issue.5
, pp. 2031-2035
-
-
Sparreboom, A.1
Van Asperen, J.2
Mayer, U.3
Schinkel, A.H.4
Smit, J.W.5
Meijer, D.K.F.6
Borst, P.7
Nooijen, W.J.8
Beijnen, J.H.9
Van Tellingen, O.10
-
19
-
-
0032518290
-
The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors
-
Kim R.B., Fromm M.F., Wandel C., Leake B., Wood A.J., Roden D.M., Wilkinson G.R. - The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors. - J Clin Invest, 101, 289-294, 1998. (Pubitemid 28067324)
-
(1998)
Journal of Clinical Investigation
, vol.101
, Issue.2
, pp. 289-294
-
-
Kim, R.B.1
Fromm, M.F.2
Wandel, C.3
Leake, B.4
Wood, A.J.J.5
Roden, D.M.6
Wilkinson, G.R.7
-
20
-
-
0029800447
-
Active secretion of drugs from the small intestinal epithelium in rats by P-glycoprotein functioning as an absorption barrier
-
Terao T., Hisanaga E., Sai Y., Tamai I., Tsuji A. - Active secretion of drugs from the small intestinal epithelium in rats by P-glycoprotein functioning as an absorption barrier. - J Pharm Pharmacol, 48, 1083-1089, 1996. (Pubitemid 26400301)
-
(1996)
Journal of Pharmacy and Pharmacology
, vol.48
, Issue.10
, pp. 1083-1089
-
-
Terao, T.1
Hisanaga, E.2
Sai, Y.3
Tamai, I.4
Tsuji, A.5
-
21
-
-
0041837255
-
Blood-brain barrier efflux transport
-
Golden P.L., Pollack G.M. - Blood-brain barrier efflux transport. - J Pharm Sci, 92, 1739-1753, 2003.
-
(2003)
J Pharm Sci
, vol.92
, pp. 1739-1753
-
-
Golden, P.L.1
Pollack, G.M.2
-
22
-
-
2942723107
-
The role of P-glycoprotein in cerebral amyloid angiopathy; implications for the early pathogenesis of Alzheimer's disease
-
Vogelgesang S., Warzok R.W., Cascorbi I., Kunert-Keil C., Schroeder E., Kroemer H.K., Siegmund W., Walker L.C., Pahnke J. - The role of P-glycoprotein in cerebral amyloid angiopathy; implications for the early pathogenesis of Alzheimer's disease. - Curr Alzheimer Res, 1, 121-125, 2004.
-
(2004)
Curr Alzheimer Res
, vol.1
, pp. 121-125
-
-
Vogelgesang, S.1
Warzok, R.W.2
Cascorbi, I.3
Kunert-Keil, C.4
Schroeder, E.5
Kroemer, H.K.6
Siegmund, W.7
Walker, L.C.8
Pahnke, J.9
-
23
-
-
0035167174
-
In vivo evidence for P-glycoprotein-mediated transport of phenytoin at the blood-brain barrier of rats
-
Potschka H.,Loscher W. - In vivo evidence for P-glycoprotein-mediated transport of phenytoin at the blood-brain barrier of rats. - Epilepsia, 42, 1231-1240, 2001.
-
(2001)
Epilepsia
, vol.42
, pp. 1231-1240
-
-
Potschka, H.1
Loscher, W.2
-
24
-
-
0028567035
-
The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump
-
Zaman G.J., Flens M.J., Van Leusden M.R., De Haas M., Mulder H.S., Lankelma J., Pinedo H.M., Scheper R.J., Baas F., Broxterman H.J., et al. - The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump. - Proc Natl Acad Sci USA, 91, 8822-8826, 1994.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 8822-8826
-
-
Zaman, G.J.1
Flens, M.J.2
Van Leusden, M.R.3
De Haas, M.4
Mulder, H.S.5
Lankelma, J.6
Pinedo, H.M.7
Scheper, R.J.8
Baas, F.9
Broxterman, H.J.10
-
25
-
-
0027249710
-
The MRP gene associated with a non-P-glycoprotein multidrug resistance encodes a 190-kDa membrane bound glycoprotein
-
Krishnamachary N., Center M.S. - The MRP gene associated with a non-P-glycoprotein multidrug resistance encodes a 190-kDa membrane bound glycoprotein. - Cancer Res, 53, 3658-3661, 1993.
-
(1993)
Cancer Res
, vol.53
, pp. 3658-3661
-
-
Krishnamachary, N.1
Center, M.S.2
-
26
-
-
0030950351
-
Characterization of a clonal human colon adenocarcinoma line intrinsically resistant to doxorubicin
-
Dolfini E., Dasdia T., Arancia G., Molinari A., Calcabrini A., Scheper R.J., Flens M.J., Gariboldi M.B., Monti E. - Characterization of a clonal human colon adenocarcinoma line intrinsically resistant to doxorubicin. - Br J Cancer, 76, 67-76, 1997. (Pubitemid 27250078)
-
(1997)
British Journal of Cancer
, vol.76
, Issue.1
, pp. 67-76
-
-
Dolfini, E.1
Dasdia, T.2
Arancia, G.3
Molinari, A.4
Calcabrini, A.5
Scheper, R.J.6
Flens, M.J.7
Gariboldi, M.B.8
Monti, E.9
-
27
-
-
0032946239
-
ATP-Dependent efflux of CPT-11 and SN-38 by the multidrug resistance protein (MRP) and its inhibition by PAK-104P
-
Chen Z.S., Furukawa T., Sumizawa T., Ono K., Ueda K., Seto K.,Akiyama S.I. - ATP-Dependent efflux of CPT-11 and SN-38 by the multidrug resistance protein (MRP) and its inhibition by PAK-104P. - Mol Pharmacol, 55, 921-928, 1999.
-
(1999)
Mol Pharmacol
, vol.55
, pp. 921-928
-
-
Chen, Z.S.1
Furukawa, T.2
Sumizawa, T.3
Ono, K.4
Ueda, K.5
Seto, K.6
Akiyama, S.I.7
-
28
-
-
0027095653
-
Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line
-
Cole S.P., Bhardwaj G., Gerlach J.H., Mackie J.E., Grant C.E., Almquist K.C., Stewart A.J., Kurz E.U., Duncan A.M., Deeley R.G. - Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. - Science, 258, 1650-1654, 1992. (Pubitemid 23012438)
-
(1992)
Science
, vol.258
, Issue.5088
, pp. 1650-1654
-
-
Cole, S.P.C.1
Bhardwaj, G.2
Gerlach, J.H.3
Mackie, J.E.4
Grant, C.E.5
Almquist, K.C.6
Stewart, A.J.7
Kurz, E.U.8
Duncan, A.M.V.9
Deeley, R.G.10
-
29
-
-
0027960078
-
Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells
-
Cole S.P., Sparks K.E., Fraser K., Loe D.W., Grant C.E., Wilson G.M., Deeley R.G. - Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells. - Cancer Res, 54, 5902-5910, 1994. (Pubitemid 24375226)
-
(1994)
Cancer Research
, vol.54
, Issue.22
, pp. 5902-5910
-
-
Cole, S.P.C.1
Sparks, K.E.2
Fraser, K.3
Loe, D.W.4
Grant, C.E.5
Wilson, G.M.6
Deeley, R.G.7
-
30
-
-
0029995238
-
Basolateral localization and export activity of the human multidrug resistance-associated protein in polarized pig kidney cells
-
Evers R., Zaman G.J., Van Deemter L., Jansen H., Calafat J., Oomen L.C., Oude Elferink R.P., Borst P., Schinkel A.H. - Basolateral localization and export activity of the human multidrug resistance-associated protein in polarized pig kidney cells. - J Clin Invest, 97, 1211-1218, 1996. (Pubitemid 26085476)
-
(1996)
Journal of Clinical Investigation
, vol.97
, Issue.5
, pp. 1211-1218
-
-
Evers, R.1
Zaman, G.J.R.2
Van Deemter, L.3
Jansen, H.4
Calafat, J.5
Oomen, L.C.J.M.6
Elferink, R.P.J.O.7
Borst, P.8
Schinkel, A.H.9
-
31
-
-
9244261944
-
Tissue distribution of the multidrug resistance protein
-
Flens M.J., Zaman G.J., Van Der Valk P., Izquierdo M.A., Schroeijers A.B., Scheffer G.L., Van Der Groep P., De Haas M., Meijer C.J., Scheper R.J. - Tissue distribution of the multidrug resistance protein. - Am J Pathol, 148, 1237-1247, 1996. (Pubitemid 26111082)
-
(1996)
American Journal of Pathology
, vol.148
, Issue.4
, pp. 1237-1247
-
-
Flens, M.J.1
Zaman, G.J.R.2
Van Der Valk, P.3
Izquierdo, M.A.4
Schroeijers, A.B.5
Scheffer, G.L.6
Van Der Groep, P.7
De Haas, M.8
Meijer, C.J.L.M.9
Scheper, R.J.10
-
32
-
-
0030962253
-
ATP-dependent transport of aflatoxin B1 and its glutathione conjugates by the product of the multidrug resistance protein (MRP) gene
-
Loe D.W., Stewart R.K., Massey T.E., Deeley R.G., Cole S.P. - ATP-dependent transport of aflatoxin B1 and its glutathione conjugates by the product of the multidrug resistance protein (MRP) gene. - Mol Pharmacol, 51, 1034-1041, 1997.
-
(1997)
Mol Pharmacol
, vol.51
, pp. 1034-1041
-
-
Loe, D.W.1
Stewart, R.K.2
Massey, T.E.3
Deeley, R.G.4
Cole, S.P.5
-
33
-
-
0036122824
-
Increased expression of multidrug resistance-associated protein 1 (mrp1) in hepatocyte basolateral membrane and renal tubular epithelia after bile duct ligation in rats
-
Pei Q.L., Kobayashi Y., Tanaka Y., Taguchi Y., Higuchi K., Kaito M., Ma N., Semba R., Kamisako T.,Adachi Y. - Increased expression of multidrug resistance-associated protein 1 (mrp1) in hepatocyte basolateral membrane and renal tubular epithelia after bile duct ligation in rats. - Hepatol Res, 22, 58-64, 2002.
-
(2002)
Hepatol Res
, vol.22
, pp. 58-64
-
-
Pei, Q.L.1
Kobayashi, Y.2
Tanaka, Y.3
Taguchi, Y.4
Higuchi, K.5
Kaito, M.6
Ma, N.7
Semba, R.8
Kamisako, T.9
Adachi, Y.10
-
34
-
-
0029133131
-
Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes
-
Mayer R., Kartenbeck J., Buchler M., Jedlitschky G., Leier I.,Keppler D. - Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes. - J Cell Biol, 131, 137-150, 1995.
-
(1995)
J Cell Biol
, vol.131
, pp. 137-150
-
-
Mayer, R.1
Kartenbeck, J.2
Buchler, M.3
Jedlitschky, G.4
Leier, I.5
Keppler, D.6
-
35
-
-
0032781499
-
Enhanced transport of anticancer agents and leukotriene C4 by the human canalicular multispecific organic anion transporter (cMOAT/MRP2)
-
Kawabe T., Chen Z.S., Wada M., Uchiumi T., Ono M., Akiyama S.,Kuwano M. - Enhanced transport of anticancer agents and leukotriene C4 by the human canalicular multispecific organic anion transporter (cMOAT/MRP2). - FEBS Lett, 456, 327-331, 1999.
-
(1999)
FEBS Lett
, vol.456
, pp. 327-331
-
-
Kawabe, T.1
Chen, Z.S.2
Wada, M.3
Uchiumi, T.4
Ono, M.5
Akiyama, S.6
Kuwano, M.7
-
36
-
-
0345299165
-
Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells
-
Cui Y., Konig J., Buchholz J.K., Spring H., Leier I.,Keppler D. - Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells. - Mol Pharmacol, 55, 929-937, 1999.
-
(1999)
Mol Pharmacol
, vol.55
, pp. 929-937
-
-
Cui, Y.1
Konig, J.2
Buchholz, J.K.3
Spring, H.4
Leier, I.5
Keppler, D.6
-
37
-
-
0037963557
-
Differential modulation of the human liver conjugate transporters MRP2 and MRP3 by bile acids and organic anions
-
DOI 10.1074/jbc.M303515200
-
Bodo A., Bakos E., Szeri F., Varadi A.,Sarkadi B. - Differential modulation of the human liver conjugate transporters MRP2 and MRP3 by bile acids and organic anions. - J Biol Chem, 278, 23529-23537, 2003. (Pubitemid 36830172)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.26
, pp. 23529-23537
-
-
Bodso, A.1
Bakos, E.2
Szeri, F.3
Varadi, A.4
Sarkadi, B.5
-
38
-
-
0027305406
-
Glutathione-associated cis-diamminedichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells. Molecular characterization of glutathione-platinum complex and its biological significance
-
Ishikawa T.,Ali-Osman F. - Glutathione-associated cis- diamminedichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells. Molecular characterization of glutathione-platinum complex and its biological significance. - J Biol Chem, 268, 20116-20125, 1993.
-
(1993)
J Biol Chem
, vol.268
, pp. 20116-20125
-
-
Ishikawa, T.1
Ali-Osman, F.2
-
39
-
-
0032765899
-
Interactions of HIV protease inhibitors with ATP-dependent drug export proteins
-
Gutmann H., Fricker G., Drewe J., Toeroek M.,Miller D.S. - Interactions of HIV protease inhibitors with ATP-dependent drug export proteins. - Mol Pharmacol, 56, 383-389, 1999.
-
(1999)
Mol Pharmacol
, vol.56
, pp. 383-389
-
-
Gutmann, H.1
Fricker, G.2
Drewe, J.3
Toeroek, M.4
Miller, D.S.5
-
40
-
-
0034765470
-
Nucleoside phosphonate interactions with multiple organic anion transporters in renal proximal tubule
-
Miller D.S. - Nucleoside phosphonate interactions with multiple organic anion transporters in renal proximal tubule. - J Pharmacol Exp Ther, 299, 567-574, 2001.
-
(2001)
J Pharmacol Exp Ther
, vol.299
, pp. 567-574
-
-
Miller, D.S.1
-
41
-
-
0036186107
-
The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: Putative efflux pump for urinary cAMP and cGMP
-
Van Aubel R.A., Smeets P.H., Peters J.G., Bindeis R.J.,Russel F.G. - The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP. - J Am Soc Nephrol, 13, 595-603, 2002.
-
(2002)
J Am Soc Nephrol
, vol.13
, pp. 595-603
-
-
Van Aubel, R.A.1
Smeets, P.H.2
Peters, J.G.3
Bindeis, R.J.4
Russel, F.G.5
-
42
-
-
0036146666
-
Involvement of multidrug resistance-associated protein 2 in intestinal secretion of grepafloxacin in rats
-
DOI 10.1128/AAC.46.2.344-349.2002
-
Naruhashi K., Tamai I., Inoue N., Muraoka H., Sai Y., Suzuki N., Tsuji A. - Involvement of multidrug resistance-associated protein 2 in intestinal secretion of grepafloxacin in rats. - Antimicrob Agents Chemother, 46, 344-349, 2002. (Pubitemid 34087178)
-
(2002)
Antimicrobial Agents and Chemotherapy
, vol.46
, Issue.2
, pp. 344-349
-
-
Naruhashi, K.1
Tamai, I.2
Inoue, N.3
Muraoka, H.4
Sai, Y.5
Suzuki, N.6
Tsuji, A.7
-
43
-
-
0034119967
-
Expression and localization of multidrug resistant protein mrp2 in rat small intestine
-
Mottino A.D., Hoffman T., Jennes L., Vore M. - Expression and localization of multidrug resistant protein mrp2 in rat small intestine. - J Pharmacol Exp Ther, 293, 717-723, 2000. (Pubitemid 30417835)
-
(2000)
Journal of Pharmacology and Experimental Therapeutics
, vol.293
, Issue.3
, pp. 717-723
-
-
Mottino, A.D.1
Hoffman, T.2
Jennes, L.3
Vore, M.4
-
44
-
-
0037464458
-
Comparison of in vitro P-glycoprotein screening assays: Recommendations for their use in drug discovery
-
Schwab D., Fischer H., Tabatabaei A., Poli S.,Huwyler J. - Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. - J Med Chem, 46, 1716-1725, 2003.
-
(2003)
J Med Chem
, vol.46
, pp. 1716-1725
-
-
Schwab, D.1
Fischer, H.2
Tabatabaei, A.3
Poli, S.4
Huwyler, J.5
-
45
-
-
0033681486
-
Expression of members of the multidrug resistance protein family in human term placenta
-
St-Pierre M.V., Serrano M.A., Macias R.I., Dubs U., Hoechli M., Lauper U., Meier P.J.,Marin J.J. - Expression of members of the multidrug resistance protein family in human term placenta. - Am J Physiol Regul Integr Comp Physiol, 279, R1495-1503, 2000.
-
(2000)
Am J Physiol Regul Integr Comp Physiol
, vol.279
-
-
St-Pierre, M.V.1
Serrano, M.A.2
Macias, R.I.3
Dubs, U.4
Hoechli, M.5
Lauper, U.6
Meier, P.J.7
Marin, J.J.8
-
46
-
-
0034811602
-
Correlation of gene expression of ten drug efflux proteins of the atp-binding cassette transporter family in normal human jejunum and in human intestinal epithelial Caco-2 cell monolayers
-
Taipalensuu J., Tornblom H., Lindberg G., Einarsson C., Sjoqvist F., Melhus H., Garberg R., Sjostrom B., Lundgren B.,Artursson P. - Correlation of gene expression of ten drug efflux proteins of the ATP-binding cassette transporter family in normal human jejunum and in human intestinal epithelial Caco-2 cell monolayers. - J Pharmacol Exp Ther, 299, 164-170, 2001. (Pubitemid 32905131)
-
(2001)
Journal of Pharmacology and Experimental Therapeutics
, vol.299
, Issue.1
, pp. 164-170
-
-
Taipalensuu, J.1
Tornblom, H.2
Lindberg, G.3
Einarsson, C.4
Sjoqvist, F.5
Melhus, H.6
Garberg, P.7
Sjostrom, B.8
Lundgren, B.O.9
Artursson, P.10
-
47
-
-
0037131880
-
Single nucleotide polymorphisms in multidrug resistance associated protein 2 (MRP2/ABCC2): Its impact on drug disposition
-
Suzuki H.,Sugiyama Y. - Single nucleotide polymorphisms in multidrug resistance associated protein 2 (MRP2/ABCC2): its impact on drug disposition. - Adv Drug Deliv Rev, 54, 1311-1331, 2002.
-
(2002)
Adv Drug Deliv Rev
, vol.54
, pp. 1311-1331
-
-
Suzuki, H.1
Sugiyama, Y.2
-
48
-
-
34047258853
-
Molecular evidence and functional expression of a novel drug efflux pump (ABCC2) in human corneal epithelium and rabbit cornea and its role in ocular drug efflux
-
DOI 10.1016/j.ijpharm.2006.11.031, PII S037851730600980X
-
Karla P.K., Pal D., Quinn T.,Mitra A.K. - Molecular evidence and functional expression of a novel drug efflux pump (ABCC2) in human corneal epithelium and rabbit cornea and its role in ocular drug efflux. - Int J Pharm, 336, 12-21, 2007. (Pubitemid 46551552)
-
(2007)
International Journal of Pharmaceutics
, vol.336
, Issue.1
, pp. 12-21
-
-
Karla, P.K.1
Pal, D.2
Quinn, T.3
Mitra, A.K.4
-
49
-
-
0031838805
-
CDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3)
-
Kiuchi Y., Suzuki H., Hirohashi T., Tyson C.A., Sugiyama Y. - cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3). - FEBS Lett, 433, 149-152, 1998.
-
(1998)
FEBS Lett
, vol.433
, pp. 149-152
-
-
Kiuchi, Y.1
Suzuki, H.2
Hirohashi, T.3
Tyson, C.A.4
Sugiyama, Y.5
-
50
-
-
0032926354
-
Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane
-
Konig J., Rost D., Cui Y.,Keppler D. - Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane. - Hepatology, 29, 1156-1163, 1999.
-
(1999)
Hepatology
, vol.29
, pp. 1156-1163
-
-
Konig, J.1
Rost, D.2
Cui, Y.3
Keppler, D.4
-
51
-
-
0032545019
-
Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins
-
Belinsky M.G., Bain L.J., Balsara B.B., Testa J.R.,Kruh G.D. - Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins. - J Natl Cancer Inst, 90, 1735-1741, 1998.
-
(1998)
J Natl Cancer Inst
, vol.90
, pp. 1735-1741
-
-
Belinsky, M.G.1
Bain, L.J.2
Balsara, B.B.3
Testa, J.R.4
Kruh, G.D.5
-
52
-
-
0036171510
-
Tissue distribution and induction of human multidrug resistant protein 3
-
Scheffer G.L., Kool M., De Haas M., De Vree J.M., Pijnenborg A.C., Bosman D.K., Elferink R.P., Van Der Valk P., Borst P.,Scheper R.J. - Tissue distribution and induction of human multidrug resistant protein 3. - Lab Invest, 82, 193-201, 2002.
-
(2002)
Lab Invest
, vol.82
, pp. 193-201
-
-
Scheffer, G.L.1
Kool, M.2
De Haas, M.3
De Vree, J.M.4
Pijnenborg, A.C.5
Bosman, D.K.6
Elferink, R.P.7
Van Der Valk, P.8
Borst, P.9
Scheper, R.J.10
-
53
-
-
13044294031
-
MRP3, an organic anion transporter able to transport anti-cancer drugs
-
Kool M., Van Der Linden M., De Haas M., Scheffer G.L., De Vree J.M., Smith A.J., Jansen G., Peters G.J., Ponne N., Scheper R.J., Elferink R.P., Baas F.,Borst P. - MRP3, an organic anion transporter able to transport anti-cancer drugs. - Proc Natl Acad Sci USA, 96, 6914-6919, 1999.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 6914-6919
-
-
Kool, M.1
Van Der Linden, M.2
De Haas, M.3
Scheffer, G.L.4
De Vree, J.M.5
Smith, A.J.6
Jansen, G.7
Peters, G.J.8
Ponne, N.9
Scheper, R.J.10
Elferink, R.P.11
Baas, F.12
Borst, P.13
-
54
-
-
0035823559
-
Transport of cyclic nucleotides and estradiol 17-beta-D-glucuronide by multidrug resistance protein 4. Resistance to 6-mercaptopurine and 6-thioguanine
-
DOI 10.1074/jbc.M104833200
-
Chen Z.S., Lee K.,Kruh G.D. - Transport of cyclic nucleotides and estradiol 17-beta-D-glucuronide by multidrug resistance protein 4. Resistance to 6-mercaptopurine and 6-thioguanine. - J Biol Chem, 276, 33747-33754, 2001. (Pubitemid 37384594)
-
(2001)
Journal of Biological Chemistry
, vol.276
, Issue.36
, pp. 33747-33754
-
-
Chen, Z.-S.1
Lee, K.2
Kruh, G.D.3
-
55
-
-
0034614112
-
Analysis of the MRP4 drug resistance profile in transfected NIH3T3 cells
-
Lee K., Klein-Szanto A. J., Kruh G.D. - Analysis of the MRP4 drug resistance profile in transfected NIH3T3 cells. - J Natl Cancer Inst, 92, 1934-1940, 2000.
-
(2000)
J Natl Cancer Inst
, vol.92
, pp. 1934-1940
-
-
Lee, K.1
Klein-Szanto, A.J.2
Kruh, G.D.3
-
56
-
-
0036229673
-
Immunolocalization of multidrug resistance protein 5 in the human genitourinary system
-
Nies A.T., Spring H., Thon W.F., Keppler D.,Jedlitschky G. - Immunolocalization of multidrug resistance protein 5 in the human genitourinary system. - J Urol, 167, 2271-2275, 2002.
-
(2002)
J Urol
, vol.167
, pp. 2271-2275
-
-
Nies, A.T.1
Spring, H.2
Thon, W.F.3
Keppler, D.4
Jedlitschky, G.5
-
57
-
-
68149176787
-
Expression of multidrug resistance associated protein 5 (MRP5) on cornea and its role in drug efflux
-
Karla P.K., Quinn T.L., Herndon B.L., Thomas P., Pal D.,Mitra A. - Expression of multidrug resistance associated protein 5 (MRP5) on cornea and its role in drug efflux. - J Ocul Pharmacol Ther, 25, 121-132, 2009.
-
(2009)
J Ocul Pharmacol Ther
, vol.25
, pp. 121-132
-
-
Karla, P.K.1
Quinn, T.L.2
Herndon, B.L.3
Thomas, P.4
Pal, D.5
Mitra, A.6
-
58
-
-
2442451598
-
MRP8, a new member of ABC transporter superfamily, identified by EST database mining and gene prediction program, is highly expressed in breast cancer
-
Bera T.K., Lee S., Salvatore G., Lee B.,Pastan I. - MRP8, a new member of ABC transporter superfamily, identified by EST database mining and gene prediction program, is highly expressed in breast cancer. - Mol Med, 7, 509-516, 2001.
-
(2001)
Mol Med
, vol.7
, pp. 509-516
-
-
Bera, T.K.1
Lee, S.2
Salvatore, G.3
Lee, B.4
Pastan, I.5
-
59
-
-
0035948584
-
Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12
-
Tammur J., Prades C., Arnould I., Rzhetsky A., Hutchinson A., Adachi M., Schuetz J.D., Swoboda K.J., Ptacek L.J., Rosier M., Dean M.,Allikmets R. - Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12. - Gene, 273, 89-96, 2001.
-
(2001)
Gene
, vol.273
, pp. 89-96
-
-
Tammur, J.1
Prades, C.2
Arnould, I.3
Rzhetsky, A.4
Hutchinson, A.5
Adachi, M.6
Schuetz, J.D.7
Swoboda, K.J.8
Ptacek, L.J.9
Rosier, M.10
Dean, M.11
Allikmets, R.12
-
60
-
-
0032893268
-
Expression of human MRP6, a homologue of the multidrug resistance protein gene MRP1, in tissues and cancer cells
-
Kool M., Van Der Linden M., De Haas M., Baas F.,Borst P. - Expression of human MRP6, a homologue of the multidrug resistance protein gene MRP1, in tissues and cancer cells. - Cancer Res, 59, 175-182, 1999.
-
(1999)
Cancer Res
, vol.59
, pp. 175-182
-
-
Kool, M.1
Van Der Linden, M.2
De Haas, M.3
Baas, F.4
Borst, P.5
-
61
-
-
0035951692
-
Analysis of the structure and expression pattern of MRP7 (ABCC10), a new member of the MRP subfamily
-
DOI 10.1016/S0304-3835(00)00646-7, PII S0304383500006467
-
Hopper E., Belinsky M.G., Zeng H., Tosolini A., Testa J.R.,Kruh G.D. - Analysis of the structure and expression pattern of MRP7 (ABCC10), a new member of the MRP subfamily. - Cancer Lett, 162, 181-191, 2001. (Pubitemid 32056287)
-
(2001)
Cancer Letters
, vol.162
, Issue.2
, pp. 181-191
-
-
Hopper, E.1
Belinsky, M.G.2
Zeng, H.3
Tosolini, A.4
Testa, J.R.5
Kruh, G.D.6
-
62
-
-
0034081847
-
The multidrug-resistant phenotype associated with overexpression of the new ABC half-transporter, MXR (ABCG2)
-
Litman T., Brangi M., Hudson E., Fetsch P., Abati A., Ross D.D., Miyake K., Resau J.H.,Bates S.E. - The multidrug-resistant phenotype associated with overexpression of the new ABC half-transporter, MXR (ABCG2). - J Cell Sci, 113 (Pt 11), 2011-2021, 2000. (Pubitemid 30386505)
-
(2000)
Journal of Cell Science
, vol.113
, Issue.11
, pp. 2011-2021
-
-
Litman, T.1
Brangi, M.2
Hudson, E.3
Fetsch, P.4
Abati, A.5
Ross, D.D.6
Miyake, K.7
Resau, J.H.8
Bates, S.E.9
-
63
-
-
0034728768
-
The product of the ABC half-transporter gene ABCG2 (BCRP/MXR/ABCP) is expressed in the plasma membrane
-
DOI 10.1006/bbrc.2000.2590
-
Rocchi E., Khodjakov A., Volk E.L., Yang C.H., Litman T., Bates S.E., Schneider E. - The product of the ABC half-transporter gene ABCG2 (BCRP/MXR/ABCP) is expressed in the plasma membrane. - Biochem Biophys Res Commun, 271, 42-46, 2000. (Pubitemid 30444853)
-
(2000)
Biochemical and Biophysical Research Communications
, vol.271
, Issue.1
, pp. 42-46
-
-
Rocchi, E.1
Khodjakov, A.2
Volk, E.L.3
Yang, C.-H.4
Litman, T.5
Bates, S.E.6
Schneider, E.7
-
64
-
-
18744421466
-
Breast cancer resistance protein is localized at the plasma membrane in mitoxantrone- And topotecan-resistant cell lines
-
Scheffer G.L., Maliepaard M., Pijnenborg A.C., Van Gastelen M.A., De Jong M.C., Schroeijers A.B., Van Der Kolk D.M., Allen J.D., Ross D.D., Van Der Valk P., Dalton W.S., Schellens J.H.,Scheper R.J. - Breast cancer resistance protein is localized at the plasma membrane in mitoxantrone- and topotecan-resistant cell lines. - Cancer Res, 60, 2589-2593, 2000.
-
(2000)
Cancer Res
, vol.60
, pp. 2589-2593
-
-
Scheffer, G.L.1
Maliepaard, M.2
Pijnenborg, A.C.3
Van Gastelen, M.A.4
De Jong, M.C.5
Schroeijers, A.B.6
Van Der Kolk, D.M.7
Allen, J.D.8
Ross, D.D.9
Van Der Valk, P.10
Dalton, W.S.11
Schellens, J.H.12
Scheper, R.J.13
-
65
-
-
0037117313
-
Genetic defects in hepatobiliary transport
-
Elferink R.O.,Groen A.K. - Genetic defects in hepatobiliary transport. - Biochim Biophys Acta, 1586, 129-145, 2002.
-
(2002)
Biochim Biophys Acta
, vol.1586
, pp. 129-145
-
-
Elferink, R.O.1
Groen, A.K.2
-
66
-
-
0023134061
-
Improved corneal penetration of timolol by prodrugs as a means to reduce systemic drug load
-
Chang S.C., Bundgaard H., Buur A.,Lee V.H. - Improved corneal penetration of timolol by prodrugs as a means to reduce systemic drug load. - Invest Ophthalmol Vis Sci, 28, 487-491, 1987.
-
(1987)
Invest Ophthalmol Vis Sci
, vol.28
, pp. 487-491
-
-
Chang, S.C.1
Bundgaard, H.2
Buur, A.3
Lee, V.H.4
-
67
-
-
0024380916
-
Prodrugs of 5-iodo-2′-deoxyuridine for enhanced ocular transport
-
Narurkar M.M.,Mitra A.K. - Prodrugs of 5-iodo-2′-deoxyuridine for enhanced ocular transport. - Pharm Res, 6, 887-891, 1989.
-
(1989)
Pharm Res
, vol.6
, pp. 887-891
-
-
Narurkar, M.M.1
Mitra, A.K.2
-
68
-
-
0025614271
-
Rate limiting barrier to the penetration of ocular hypotensive beta blockers across the corneal epithelium in the pigmented rabbit
-
Shih R.L.,Lee V.H. - Rate limiting barrier to the penetration of ocular hypotensive beta blockers across the corneal epithelium in the pigmented rabbit. - J Ocul Pharmacol, 6, 329-336, 1990.
-
(1990)
J Ocul Pharmacol
, vol.6
, pp. 329-336
-
-
Shih, R.L.1
Lee, V.H.2
-
69
-
-
0037151547
-
Biodistribution studies of BSA loaded gelatin microspheres after peroral application
-
Mladenovska K., Janevik I., Glavas D., Kumbaradzi F., Goracinova K. - Biodistribution studies of BSA loaded gelatin microspheres after peroral application. - Int J Pharm, 242, 251-253, 2002.
-
(2002)
Int J Pharm
, vol.242
, pp. 251-253
-
-
Mladenovska, K.1
Janevik, I.2
Glavas, D.3
Kumbaradzi, F.4
Goracinova, K.5
-
70
-
-
0030471901
-
Gastrointestinal uptake of biodegradable microparticles: Effect of particle size
-
Desai M.P., Labhasetwar V., Amidon G.L.,Levy R.J. - Gastrointestinal uptake of biodegradable microparticles: effect of particle size. - Pharm Res, 13, 1838-1845, 1996.
-
(1996)
Pharm Res
, vol.13
, pp. 1838-1845
-
-
Desai, M.P.1
Labhasetwar, V.2
Amidon, G.L.3
Levy, R.J.4
-
71
-
-
0030474006
-
Particle uptake and translocation across epithelial membranes
-
Thomas N.W., Jenkins P.G., Howard K.A., Smith M.W., Lavelle E.C., Holland J., Davis S.S. - Particle uptake and translocation across epithelial membranes. - J Anat, 189 (Pt 3), 487-490, 1996. (Pubitemid 27011000)
-
(1996)
Journal of Anatomy
, vol.189
, Issue.3
, pp. 487-490
-
-
Thomas, N.W.1
Jenkins, P.G.2
Howard, K.A.3
Smith, M.W.4
Lavelle, E.C.5
Holland, J.6
Davis, S.S.7
-
72
-
-
0029031427
-
Uptake and translocation of microparticles in small intestine. Morphology and quantification of particle distribution
-
Hodges G.M., Carr E.A., Hazzard R.A., Carr K.E. - Uptake and translocation of microparticles in small intestine. Morphology and quantification of particle distribution. - Dig Dis Sci, 40, 967-975, 1995.
-
(1995)
Dig Dis Sci
, vol.40
, pp. 967-975
-
-
Hodges, G.M.1
Carr, E.A.2
Hazzard, R.A.3
Carr, K.E.4
-
73
-
-
0345055299
-
Comparison of the effect of different chitosan salts and N-trimethyl chitosan chloride on the permeability of intestinal epithelial cells (Caco-2)
-
Kotze A.F., Luessen H.L., De Leeuw B.J., De Boer A.G., Verhoef J.C.,Junginger H.E. - Comparison of the effect of different chitosan salts and N-trimethyl chitosan chloride on the permeability of intestinal epithelial cells (Caco-2). - J Control Release, 51, 35-46, 1998.
-
(1998)
J Control Release
, vol.51
, pp. 35-46
-
-
Kotze, A.F.1
Luessen, H.L.2
De Leeuw, B.J.3
De Boer, A.G.4
Verhoef, J.C.5
Junginger, H.E.6
-
74
-
-
0032917517
-
Effect of chitosan on epithelial permeability and structure
-
Dodane V., Amin Khan M.,Merwin J.R. - Effect of chitosan on epithelial permeability and structure. - Int J Pharm, 182, 21-32, 1999.
-
(1999)
Int J Pharm
, vol.182
, pp. 21-32
-
-
Dodane, V.1
Amin Khan, M.2
Merwin, J.R.3
-
75
-
-
0037043094
-
Effects of superporous hydrogels on paracellular drug permeability and cytotoxicity studies in Caco-2 cell monolayers
-
DOI 10.1016/S0378-5173(02)00115-1, PII S0378517302001151
-
Dorkoosh F.A., Setyaningsih D., Borchard G., Rafiee-Tehrani M., Verhoef J.C.,Junginger H.E. - Effects of superporous hydrogels on paracellular drug permeability and cytotoxicity studies in Caco-2 cell monolayers. - Int J Pharm, 241, 35-45, 2002. (Pubitemid 34667064)
-
(2002)
International Journal of Pharmaceutics
, vol.241
, Issue.1
, pp. 35-45
-
-
Dorkoosh, F.A.1
Setyaningsih, D.2
Borchard, G.3
Rafiee-Tehrani, M.4
Verhoef, J.C.5
Junginger, H.E.6
-
76
-
-
1542619707
-
Transport of Octreotide and Evaluation of Mechanism of Opening the Paracellular Tight Junctions using Superporous Hydrogel Polymers in Caco-2 Cell Monolayers
-
DOI 10.1002/jps.10570
-
Dorkoosh F.A., Broekhuizen C.A., Borchard G., Rafiee-Tehrani M., Verhoef J.C.,Junginger H.E. - Transport of octreotide and evaluation of mechanism of opening the paracellular tight junctions using superporous hydrogel polymers in Caco-2 cell monolayers. - J Pharm Sci, 93, 743-752, 2004. (Pubitemid 38332306)
-
(2004)
Journal of Pharmaceutical Sciences
, vol.93
, Issue.3
, pp. 743-752
-
-
Dorkoosh, F.A.1
Broekhuizen, C.A.N.2
Borchard, G.3
Rafiee-Tehrani, M.4
Verhoef, J.C.5
Junginger, H.E.6
-
77
-
-
0028137062
-
Cyclodextrins as mucosal absorption promoters of insulin. II. Effects of beta-cyclodextrin derivatives on alpha-chymotryptic degradation and enteral absorption of insulin in rats
-
Shao Z., Li Y., Chermak T.,Mitra A.K. - Cyclodextrins as mucosal absorption promoters of insulin. II. Effects of beta-cyclodextrin derivatives on alpha-chymotryptic degradation and enteral absorption of insulin in rats. - Pharm Res, 11, 1174-1179, 1994.
-
(1994)
Pharm Res
, vol.11
, pp. 1174-1179
-
-
Shao, Z.1
Li, Y.2
Chermak, T.3
Mitra, A.K.4
-
78
-
-
0036678569
-
Current prodrug strategies via membrane transporters/receptors
-
Anand B.S., Dey S.,Mitra A.K. - Current prodrug strategies via membrane transporters/receptors. - Expert Opin Biol Ther, 2, 607-620, 2002.
-
(2002)
Expert Opin Biol Ther
, vol.2
, pp. 607-620
-
-
Anand, B.S.1
Dey, S.2
Mitra, A.K.3
-
79
-
-
1442351172
-
Peptide transporters: Structure, function, regulation and application for drug delivery
-
Terada T.,Inui K. - Peptide transporters: structure, function, regulation and application for drug delivery. - Curr Drug Metab, 5, 85-94, 2004.
-
(2004)
Curr Drug Metab
, vol.5
, pp. 85-94
-
-
Terada, T.1
Inui, K.2
-
80
-
-
48749131090
-
Peptide transporters and their roles in physiological processes and drug disposition
-
Rubio-Aliaga I.,Daniel H. - Peptide transporters and their roles in physiological processes and drug disposition. - Xenobiotica, 38, 1022-1042, 2008.
-
(2008)
Xenobiotica
, vol.38
, pp. 1022-1042
-
-
Rubio-Aliaga, I.1
Daniel, H.2
-
81
-
-
0036710840
-
Mammalian peptide transporters as targets for drug delivery
-
Rubio-Aliaga I.,Daniel H. - Mammalian peptide transporters as targets for drug delivery. - Trends Pharmacol Sci, 23, 434-440, 2002.
-
(2002)
Trends Pharmacol Sci
, vol.23
, pp. 434-440
-
-
Rubio-Aliaga, I.1
Daniel, H.2
-
82
-
-
0032853619
-
Intestinal peptide transport systems and oral drug availability
-
Yang C.Y., Dantzig A.H.,Pidgeon C - Intestinal peptide transport systems and oral drug availability. - Pharm Res, 16, 1331-1343, 1999.
-
(1999)
Pharm Res
, vol.16
, pp. 1331-1343
-
-
Yang, C.Y.1
Dantzig, A.H.2
Pidgeon, C.3
-
83
-
-
0033659819
-
Physiological and pharmacological implications of peptide transporters, PEPT1 and PEPT2
-
Inui K., Terada T., Masuda S.,Saito H. - Physiological and pharmacological implications of peptide transporters, PEPT1 and PEPT2. - Nephrol Dial Transplant, 15, Suppl 6, 11-13, 2000.
-
(2000)
Nephrol Dial Transplant
, vol.15
, Issue.SUPPL. 6
, pp. 11-13
-
-
Inui, K.1
Terada, T.2
Masuda, S.3
Saito, H.4
-
84
-
-
0037530341
-
Di/tri-peptide transporters as drug delivery targets: Regulation of transport under physiological and patho-physiological conditions
-
Nielsen C.U.,Brodin B. - Di/tri-peptide transporters as drug delivery targets: regulation of transport under physiological and patho-physiological conditions. - Curr Drug Targets, 4, 373-388, 2003.
-
(2003)
Curr Drug Targets
, vol.4
, pp. 373-388
-
-
Nielsen, C.U.1
Brodin, B.2
-
85
-
-
0035289188
-
Prodrug based optimal drug delivery via membrane transporter/receptor
-
Yang C., Tirucherai G.S.,Mitra A.K. - Prodrug based optimal drug delivery via membrane transporter/receptor. - Expert Opin Biol Ther, 1, 159-175, 2001.
-
(2001)
Expert Opin Biol Ther
, vol.1
, pp. 159-175
-
-
Yang, C.1
Tirucherai, G.S.2
Mitra, A.K.3
-
86
-
-
50249154146
-
Interaction of dipeptide prodrugs of saquinavir with multidrug resistance protein-2 (MRP-2): Evasion of MRP-2 mediated efflux
-
Jain R., Agarwal S., Mandava N.K., Sheng Y.,Mitra A.K. - Interaction of dipeptide prodrugs of saquinavir with multidrug resistance protein-2 (MRP-2): evasion of MRP-2 mediated efflux. - Int J Pharm, 362, 44-51, 2008.
-
(2008)
Int J Pharm
, vol.362
, pp. 44-51
-
-
Jain, R.1
Agarwal, S.2
Mandava, N.K.3
Sheng, Y.4
Mitra, A.K.5
-
87
-
-
34247567472
-
Intestinal absorption of novel-dipeptide prodrugs of saquinavir in rats
-
Jain R., Duwuri S., Kansara V., Mandava N.K.,Mitra A.K. - Intestinal absorption of novel-dipeptide prodrugs of saquinavir in rats. - Int J Pharm, 336, 233-240, 2007.
-
(2007)
Int J Pharm
, vol.336
, pp. 233-240
-
-
Jain, R.1
Duwuri, S.2
Kansara, V.3
Mandava, N.K.4
Mitra, A.K.5
-
88
-
-
50249124852
-
Pharmacokinetics of amino acid ester prodrugs of acyclovir after oral administration: Interaction with the transporters on Caco-2 cells
-
Katragadda S., Jain R., Kwatra D., Hariharan S.,Mitra A.K. - Pharmacokinetics of amino acid ester prodrugs of acyclovir after oral administration: interaction with the transporters on Caco-2 cells. - Int J Pharm, 362, 93-101, 2008.
-
(2008)
Int J Pharm
, vol.362
, pp. 93-101
-
-
Katragadda, S.1
Jain, R.2
Kwatra, D.3
Hariharan, S.4
Mitra, A.K.5
-
89
-
-
44749093484
-
Peptide prodrugs: Improved oral absorption of lopinavir, a HIV protease inhibitor
-
Agarwal S., Boddu S.H., Jain R., Samanta S., Pal D.,Mitra A.K. - Peptide prodrugs: improved oral absorption of lopinavir, a HIV protease inhibitor. - Int J Pharm, 359, 7-14, 2008.
-
(2008)
Int J Pharm
, vol.359
, pp. 7-14
-
-
Agarwal, S.1
Boddu, S.H.2
Jain, R.3
Samanta, S.4
Pal, D.5
Mitra, A.K.6
-
90
-
-
30544437062
-
Dipeptide monoester ganciclovir prodrugs for treating HSV-1-induced corneal epithelial and stromal keratitis: In vitro and in vivo evaluations
-
DOI 10.1089/jop.2005.21.463
-
Majumdar S., Nashed Y.E., Patel K., Jain R., Itahashi M., Neumann D.M., Hill J.M.,Mitra A.K. - Dipeptide monoester ganciclovir prodrugs for treating HSV-1-induced corneal epithelial and stromal keratitis: in vitro and in vivo evaluations. - J Ocul Pharmacol Ther, 21, 463-474, 2005. (Pubitemid 43083338)
-
(2005)
Journal of Ocular Pharmacology and Therapeutics
, vol.21
, Issue.6
, pp. 463-474
-
-
Majumdar, S.1
Nashed, Y.E.2
Patel, K.3
Jain, R.4
Itahashi, M.5
Neumann, D.M.6
Hill, J.M.7
Mitra, A.K.8
-
91
-
-
6344288793
-
Pharmacokinetics of novel dipeptide ester prodrugs of acyclovir after oral administration: Intestinal absorption and liver metabolism
-
Anand B.S., Katragadda S.,Mitra A.K. - Pharmacokinetics of novel dipeptide ester prodrugs of acyclovir after oral administration: intestinal absorption and liver metabolism. - J Pharmacol Exp Ther, 311, 659-667, 2004.
-
(2004)
J Pharmacol Exp Ther
, vol.311
, pp. 659-667
-
-
Anand, B.S.1
Katragadda, S.2
Mitra, A.K.3
-
92
-
-
35848953208
-
Dipeptide monoester ganciclovir prodrugs for transscleral drug delivery: Targeting the oligopeptide transporter on rabbit retina
-
DOI 10.1089/jop.2006.0150
-
Kansara V., Hao Y.,Mitra A.K. - Dipeptide monoester ganciclovir prodrugs for transscleral drug delivery: targeting the oligopeptide transporter on rabbit retina. - J Ocul Pharmacol Ther, 23, 321-334, 2007. (Pubitemid 350195056)
-
(2007)
Journal of Ocular Pharmacology and Therapeutics
, vol.23
, Issue.4
, pp. 321-334
-
-
Kansara, V.1
Hao, Y.I.2
Mitra, A.K.3
-
93
-
-
0036018543
-
Transport of peptidomimetic drugs by the intestinal di/tri-peptide transporter, PepT1
-
DOI 10.1034/j.1600-0773.2002.900601.x
-
Brodin B., Nielsen C.U., Steffansen B.,Frokjaer S. - Transport of peptidomimetic drugs by the intestinal Di/tri-peptide transporter, PepT1. - Pharmacol Toxicol, 90, 285-296, 2002. (Pubitemid 34713193)
-
(2002)
Pharmacology and Toxicology
, vol.90
, Issue.6
, pp. 285-296
-
-
Brodin, B.1
Nielsen, C.U.2
Steffansen, B.3
Frokjaer, S.4
-
94
-
-
0037319276
-
Drug delivery to the retina: Challenges and opportunities
-
Duwuri S., Majumdar S.,Mitra A.K. - Drug delivery to the retina: challenges and opportunities. - Expert Opin Biol Ther, 3, 45-56, 2003.
-
(2003)
Expert Opin Biol Ther
, vol.3
, pp. 45-56
-
-
Duwuri, S.1
Majumdar, S.2
Mitra, A.K.3
-
95
-
-
1342329764
-
Mechanism of a model dipeptide transport across blood-ocular barriers following systemic administration
-
Atluri H., Anand B.S., Patel J.,Mitra A.K. - Mechanism of a model dipeptide transport across blood-ocular barriers following systemic administration. - Exp Eye Res, 78, 815-822, 2004.
-
(2004)
Exp Eye Res
, vol.78
, pp. 815-822
-
-
Atluri, H.1
Anand, B.S.2
Patel, J.3
Mitra, A.K.4
-
96
-
-
33846294417
-
Corneal absorption and anterior chamber pharmacokinetics of dipeptide monoester prodrugs of ganciclovir (GCV): In vivo comparative evaluation of these prodrugs with val-GCV and GCV in rabbits
-
DOI 10.1089/jop.2006.22.465
-
Gunda S., Hariharan S., Mitra A.K. - Corneal absorption and anterior chamber pharmacokinetics of dipeptide monoester prodrugs of ganciclovir (GCV): in vivo comparative evaluation of these prodrugs with Val-GCV and GCV in rabbits. - J Ocul Pharmacol Ther, 22, 465-476, 2006. (Pubitemid 46110643)
-
(2006)
Journal of Ocular Pharmacology and Therapeutics
, vol.22
, Issue.6
, pp. 465-476
-
-
Gunda, S.1
Hariharan, S.2
Mitra, A.K.3
-
97
-
-
0036689265
-
Mechanism of corneal permeation of L-valyl ester of acyclovir: Targeting the oligopeptide transporter on the rabbit cornea
-
Anand B.S.,Mitra A.K. - Mechanism of corneal permeation of L-valyl ester of acyclovir: targeting the oligopeptide transporter on the rabbit cornea. - Pharm Res, 19, 1194-1202, 2002.
-
(2002)
Pharm Res
, vol.19
, pp. 1194-1202
-
-
Anand, B.S.1
Mitra, A.K.2
-
98
-
-
0037308045
-
Interactions of the dipeptide ester prodrugs of acyclovir with the intestinal oligopeptide transporter: Competitive inhibition of glycylsarcosine transport in human intestinal cell line-Caco-2
-
Anand B.S., Patel J.,Mitra A.K. - Interactions of the dipeptide ester prodrugs of acyclovir with the intestinal oligopeptide transporter: competitive inhibition of glycylsarcosine transport in human intestinal cell line-Caco-2. - J Pharmacol Exp Ther, 304, 781-791, 2003.
-
(2003)
J Pharmacol Exp Ther
, vol.304
, pp. 781-791
-
-
Anand, B.S.1
Patel, J.2
Mitra, A.K.3
-
99
-
-
0013298520
-
Novel dipeptide prodrugs of acyclovir for ocular herpes infections: Bioreversion, antiviral activity and transport across rabbit cornea
-
Anand B., Nashed Y.,Mitra A. - Novel dipeptide prodrugs of acyclovir for ocular herpes infections: Bioreversion, antiviral activity and transport across rabbit cornea. - Curr Eye Res, 26, 151-163, 2003.
-
(2003)
Curr Eye Res
, vol.26
, pp. 151-163
-
-
Anand, B.1
Nashed, Y.2
Mitra, A.3
-
100
-
-
23844497838
-
Quantitative assessment of HIV-1 protease inhibitor interactions with drug efflux transporters in the blood-brain barrier
-
Bachmeier C.J., Spitzenberger T.J., Elmquist W.F.,Miller D.W. - Quantitative assessment of HIV-1 protease inhibitor interactions with drug efflux transporters in the blood-brain barrier. - Pharm Res, 22, 1259-1268, 2005.
-
(2005)
Pharm Res
, vol.22
, pp. 1259-1268
-
-
Bachmeier, C.J.1
Spitzenberger, T.J.2
Elmquist, W.F.3
Miller, D.W.4
-
101
-
-
0018800293
-
Active carrier-mediated transport of melphalan by two separate amino acid transport systems in LPC-1 plasmacytoma cells in vitro
-
Goldenberg G.J., Lam H.Y.,Begleiter A. - Active carrier-mediated transport of melphalan by two separate amino acid transport systems in LPC-1 plasmacytoma cells in vitro. - J Biol Chem, 254, 1057-1064, 1979.
-
(1979)
J Biol Chem
, vol.254
, pp. 1057-1064
-
-
Goldenberg, G.J.1
Lam, H.Y.2
Begleiter, A.3
-
102
-
-
0025347918
-
The transport of thyroxine into mouse neuroblastoma cells, NB41A3: The effect of L-system amino acids
-
Lakshmanan M., Goncalves E., Lessly G., Foti D.,Robbins J. - The transport of thyroxine into mouse neuroblastoma cells, NB41A3: the effect of L-system amino acids. - Endocrinology, 126, 3245-3250, 1990.
-
(1990)
Endocrinology
, vol.126
, pp. 3245-3250
-
-
Lakshmanan, M.1
Goncalves, E.2
Lessly, G.3
Foti, D.4
Robbins, J.5
-
103
-
-
0028986069
-
Transport of gabapentin, a gamma-amino acid drug, by system I alpha-amino acid transporters: A comparative study in astrocytes, synaptosomes, and CHO cells
-
Su T.Z., Lunney E., Campbell G.,Oxender D.L. - Transport of gabapentin, a gamma-amino acid drug, by system I alpha-amino acid transporters: a comparative study in astrocytes, synaptosomes, and CHO cells. - J Neurochem, 64, 2125-2131, 1995.
-
(1995)
J Neurochem
, vol.64
, pp. 2125-2131
-
-
Su, T.Z.1
Lunney, E.2
Campbell, G.3
Oxender, D.L.4
-
104
-
-
62649129250
-
Detection and regulation of cationic amino acid transporters in healthy and diseased ocular surface
-
Jager K., Bonisch U., Risch M., Worlitzsch D.,Paulsen F. - Detection and regulation of cationic amino acid transporters in healthy and diseased ocular surface. - Invest Ophthalmol Vis Sci, 50, 1112-1121, 2009.
-
(2009)
Invest Ophthalmol Vis Sci
, vol.50
, pp. 1112-1121
-
-
Jager, K.1
Bonisch, U.2
Risch, M.3
Worlitzsch, D.4
Paulsen, F.5
-
105
-
-
22844449962
-
Reabsorption of neutral amino acids mediated by amino acid transporter LAT2 and TAT1 in the basolateral membrane of proximal tubule
-
Park S.Y., Kim J.K., Kim I.J., Choi B.K., Jung K.Y., Lee S., Park K.J., Chairoungdua A., Kanai Y., Endou H., Kim D.K. - Reabsorption of neutral amino acids mediated by amino acid transporter LAT2 and TAT1 in the basolateral membrane of proximal tubule. - Arch Pharm Res, 28, 421-432, 2005.
-
(2005)
Arch Pharm Res
, vol.28
, pp. 421-432
-
-
Park, S.Y.1
Kim, J.K.2
Kim, I.J.3
Choi, B.K.4
Jung, K.Y.5
Lee, S.6
Park, K.J.7
Chairoungdua, A.8
Kanai, Y.9
Endou, H.10
Kim, D.K.11
-
106
-
-
31344475734
-
Cellular distribution of glutamate transporters in the gastrointestinal tract of mice. An immunohistochemical and in situ hybridization approach
-
DOI 10.2220/biomedres.26.271
-
Iwanaga T, Goto M., Watanabe M. - Cellular distribution of glutamate transporters in the gastrointestinal tract of mice: an immunohistochemical and in situ hybridization approach. - Biomed Res, 26, 271-278, 2005. (Pubitemid 43137334)
-
(2006)
Biomedical Research
, vol.26
, Issue.6
, pp. 271-278
-
-
Iwanaga, T.1
Goto, M.2
Watanabe, M.3
-
107
-
-
31544435477
-
+-dependent neutral amino acid transporter, ASCT1, in rabbit corneal epithelial cell culture and rabbit cornea
-
DOI 10.1080/02713680500306439, PII K338H6P17087J878
-
+-dependent neutral amino acid transporter, ASCT1, in rabbit corneal epithelial cell culture and rabbit cornea. - Curr Eye Res, 30, 989-1002, 2005. (Pubitemid 43154693)
-
(2005)
Current Eye Research
, vol.30
, Issue.11
, pp. 989-1002
-
-
Katragadda, S.1
Talluri, R.S.2
Pal, D.3
Mitra, A.K.4
-
108
-
-
0027734068
-
Review of research leading to new anti-herpesvirus agents in clinical development: Valaciclovir hydrochloride (256U, the L-valyl ester of acyclovir) and 882C, a specific agent for varicella zoster virus
-
Purifoy D.J., Beauchamp L.M., De Miranda P., Ertl P., Lacey S., Roberts G., Rahim S.G., Darby G., Krenitsky TA.,Powell K.L. - Review of research leading to new anti-herpesvirus agents in clinical development: valaciclovir hydrochloride (256U, the L-valyl ester of acyclovir) and 882C, a specific agent for varicella zoster virus. - J Med Virol, Suppl 1, 139-145, 1993.
-
(1993)
J Med Virol
, Issue.SUPPL. 1
, pp. 139-145
-
-
Purifoy, D.J.1
Beauchamp, L.M.2
De Miranda, P.3
Ertl, P.4
Lacey, S.5
Roberts, G.6
Rahim, S.G.7
Darby, G.8
Krenitsky, T.A.9
Powell, K.L.10
-
109
-
-
0027768955
-
Pharmacokinetics of the acyclovir pro-drug valaciclovir after escalating single- And multiple-dose administration to normal volunteers
-
Weiler S., Blum M.R., Doucette M., Burnette T., Cederberg D.M., De Miranda P., Smiley M.L. - Pharmacokinetics of the acyclovir pro-drug valaciclovir after escalating single- and multiple-dose administration to normal volunteers. - Clin Pharmacol Ther, 54, 595-605, 1993. (Pubitemid 24028442)
-
(1993)
Clinical Pharmacology and Therapeutics
, vol.54
, Issue.6
, pp. 595-605
-
-
Weller, S.1
Blum, M.R.2
Doucette, M.3
Burnette, T.4
Cederberg, D.M.5
De Miranda, P.6
Smiley, M.L.7
-
110
-
-
1342329731
-
0,+ and Expression of the Transporter in Tissues Amenable for Drug Delivery
-
DOI 10.1124/jpet.103.057109
-
0,+ and expression of the transporter in tissues amenable for drug delivery. - J Pharmacol Exp Ther, 308, 1138-1147, 2004. (Pubitemid 38263991)
-
(2004)
Journal of Pharmacology and Experimental Therapeutics
, vol.308
, Issue.3
, pp. 1138-1147
-
-
Hatanaka, T.1
Haramura, M.2
Fei, Y.-J.3
Miyauchi, S.4
Bridges, C.C.5
Ganapathy, P.S.6
Smith, S.B.7
Ganapathy, V.8
Ganapathy, M.E.9
-
111
-
-
0031662109
-
5′-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter
-
Han H., De Vrueh R.L., Rhie J.K., Covitz K.M., Smith P.L., Lee C.P., Oh D.M., Sadee W.,Amidon G.L. - 5′-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter. - Pharm Res, 15, 1154-1159, 1998.
-
(1998)
Pharm Res
, vol.15
, pp. 1154-1159
-
-
Han, H.1
De Vrueh, R.L.2
Rhie, J.K.3
Covitz, K.M.4
Smith, P.L.5
Lee, C.P.6
Oh, D.M.7
Sadee, W.8
Amidon, G.L.9
-
112
-
-
1842789741
-
+)-independent large neutral amino acid transporter (LAT2) on ARPE-19 cells
-
+)-independent large neutral amino acid transporter (LAT2) on ARPE-19 cells. - Int J Pharm, 275, 189-200, 2004.
-
(2004)
Int J Pharm
, vol.275
, pp. 189-200
-
-
Gandhi, M.D.1
Pal, D.2
Mitra, A.K.3
-
113
-
-
24944561003
-
0,+), in human and rabbit cornea
-
0,+), in human and rabbit cornea. - Mol Pharm, 1, 338-346, 2004.
-
(2004)
Mol Pharm
, vol.1
, pp. 338-346
-
-
Jain-Vakkalagadda, B.1
Pal, D.2
Gunda, S.3
Nashed, Y.4
Ganapathy, V.5
Mitra, A.K.6
-
114
-
-
3242683504
-
0,+)
-
0,+). - Pharm Res, 21, 1303-1310, 2004.
-
(2004)
Pharm Res
, vol.21
, pp. 1303-1310
-
-
Umapathy, N.S.1
Ganapathy, V.2
Ganapathy, M.E.3
-
115
-
-
42949091493
-
Characterization and astrocytic modulation of system L transporters in brain microvasculature endothelial cells
-
Omidi Y., Barar J., Ahmadian S., Heidari H.R.,Gumbleton M. - Characterization and astrocytic modulation of system L transporters in brain microvasculature endothelial cells. - Cell Biochem Funct, 26, 381-391, 2008.
-
(2008)
Cell Biochem Funct
, vol.26
, pp. 381-391
-
-
Omidi, Y.1
Barar, J.2
Ahmadian, S.3
Heidari, H.R.4
Gumbleton, M.5
-
116
-
-
39749166269
-
Large neutral amino acid transporter enables brain drug delivery via prodrugs
-
Gynther M., Laine K., Ropponen J., Leppanen J., Mannila A., Nevalainen T., Savolainen J., Jarvinen T.,Rautio J. - Large neutral amino acid transporter enables brain drug delivery via prodrugs. - J Med Chem, 51, 932-936, 2008.
-
(2008)
J Med Chem
, vol.51
, pp. 932-936
-
-
Gynther, M.1
Laine, K.2
Ropponen, J.3
Leppanen, J.4
Mannila, A.5
Nevalainen, T.6
Savolainen, J.7
Jarvinen, T.8
Rautio, J.9
-
117
-
-
0033853560
-
Enhancement of transport of D-melphalan analogue by conjugation with L-glutamate across bovine brain microvessel endothelial cell monolayers
-
Sakaeda T., Siahaan T.J., Audus K.L., Stella V.J. - Enhancement of transport of D-melphalan analogue by conjugation with L-glutamate across bovine brain microvessel endothelial cell monolayers. - J Drug Target, 8, 195-204, 2000. (Pubitemid 30609587)
-
(2000)
Journal of Drug Targeting
, vol.8
, Issue.3
, pp. 195-204
-
-
Sakaeda, T.1
Siahaan, T.J.2
Audus, K.L.3
Stella, V.J.4
-
119
-
-
0035042563
-
Chemical stability, enzymatic hydrolysis, and nasal uptake of amino acid ester prodrugs of acyclovir
-
DOI 10.1002/1520-6017(200105)90:5<617::AID-JPS1018>3.0.CO;2-5
-
Yang C., Gao H.,Mitra A.K. - Chemical stability, enzymatic hydrolysis, and nasal uptake of amino acid ester prodrugs of acyclovir. - J Pharm Sci, 90, 617-624, 2001. (Pubitemid 32378383)
-
(2001)
Journal of Pharmaceutical Sciences
, vol.90
, Issue.5
, pp. 617-624
-
-
Yang, C.1
Gao, H.2
Mitra, A.K.3
-
120
-
-
0033569442
-
The proton-linked monocarboxylate transporter (MCT) family: Structure, function and regulation
-
Halestrap A.P.,Price N.T. - The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. - Biochem J, 343, Pt 2, 281-299, 1999.
-
(1999)
Biochem J
, vol.343
, Issue.PART 2
, pp. 281-299
-
-
Halestrap, A.P.1
Price, N.T.2
-
121
-
-
0035662969
-
MCT1-mediated transport of L-lactic acid at the inner blood-retinal barrier: A possible route for delivery of monocarboxylic acid drugs to the retina
-
DOI 10.1023/A:1013310210710
-
Hosoya K., Kondo T., Tomi M., Takanaga H., Ohtsuki S., Terasaki T. - MCT1-mediated transport of L-lactic acid at the inner blood-retinal barrier: a possible route for delivery of monocarboxylic acid drugs to the retina. - Pharm Res, 18, 1669-1676, 2001. (Pubitemid 34020421)
-
(2001)
Pharmaceutical Research
, vol.18
, Issue.12
, pp. 1669-1676
-
-
K-i, H.1
Kondo, T.2
Tomi, M.3
Takanaga, H.4
Ohtsuki, S.5
Terasaki, T.6
-
122
-
-
2942612987
-
Membrane transporter/receptor-targeted prodrug design: Strategies for human and veterinary drug development
-
DOI 10.1016/j.addr.2004.02.006, PII S0169409X04000699, Veterinary Drug Delivery: Part VI
-
Majumdar S., Duwuri S., Mitra A.K. - Membrane transporter/receptor- targeted prodrug design: strategies for human and veterinary drug development. - Adv Drug Deliv Rev, 56, 1437-1452, 2004. (Pubitemid 38748825)
-
(2004)
Advanced Drug Delivery Reviews
, vol.56
, Issue.10
, pp. 1437-1452
-
-
Majumdar, S.1
Duvvuri, S.2
Mitra, A.K.3
-
123
-
-
59149090614
-
Monocarboxylate transporters: Past, present, and future
-
Merezhinskaya N., Fishbein W.N. -Monocarboxylate transporters: past, present, and future. - Histol Histopathol, 24, 243-264, 2009.
-
(2009)
Histol Histopathol
, vol.24
, pp. 243-264
-
-
Merezhinskaya, N.1
Fishbein, W.N.2
-
124
-
-
51249118120
-
Sodium-coupled monocarboxylate transporters in normal tissues and in cancer
-
Ganapathy V., Thangaraju M., Gopal E., Martin P.M., Itagaki S., Miyauchi S., Prasad P.D. - Sodium-coupled monocarboxylate transporters in normal tissues and in cancer. - AAPS J, 10, 193-199, 2008.
-
(2008)
AAPS J
, vol.10
, pp. 193-199
-
-
Ganapathy, V.1
Thangaraju, M.2
Gopal, E.3
Martin, P.M.4
Itagaki, S.5
Miyauchi, S.6
Prasad, P.D.7
-
125
-
-
48749086146
-
The SLC16 monocaboxylate transporter family
-
Meredith D., Christian H.C. - The SLC16 monocaboxylate transporter family. - Xenobiotica, 38, 1072-1106, 2008.
-
(2008)
Xenobiotica
, vol.38
, pp. 1072-1106
-
-
Meredith, D.1
Christian, H.C.2
-
126
-
-
34249978112
-
Thyroid hormone transport by monocarboxylate transporters
-
Visser W.E., Friesema E.C., Jansen J.,Visser T.J. - Thyroid hormone transport by monocarboxylate transporters. - Best Pract Res Clin Endocrinol Metab, 21, 223-236, 2007.
-
(2007)
Best Pract Res Clin Endocrinol Metab
, vol.21
, pp. 223-236
-
-
Visser, W.E.1
Friesema, E.C.2
Jansen, J.3
Visser, T.J.4
-
127
-
-
0031775697
-
Monocarboxylate transporter MCT1 is located in the apical membrane and MCT3 in the basal membrane of rat RPE
-
Philp N.J., Yoon H., Grollman E.F. - Monocarboxylate transporter MCT1 is located in the apical membrane and MCT3 in the basal membrane of rat RPE. - Am J Physiol, 274, R1824-1828, 1998. (Pubitemid 28304302)
-
(1998)
American Journal of Physiology - Regulatory Integrative and Comparative Physiology
, vol.274
, Issue.6
-
-
Philp, N.J.1
Yoon, H.2
Grollman, E.F.3
-
128
-
-
0037377965
-
Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells
-
Philp N.J., Wang D., Yoon H.,Hjelmeland L.M. - Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells. - Invest Ophthalmol Vis Sci, 44, 1716-1721, 2003.
-
(2003)
Invest Ophthalmol Vis Sci
, vol.44
, pp. 1716-1721
-
-
Philp, N.J.1
Wang, D.2
Yoon, H.3
Hjelmeland, L.M.4
-
129
-
-
0033591422
-
+-dependent multivitamin transporter: Cloning, functional expression, gene structure, and chromosomal localization
-
+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization. - J Biol Chem, 274, 14875-14883, 1999. (Pubitemid 129518818)
-
(1999)
Journal of Biological Chemistry
, vol.274
, Issue.21
, pp. 14875-14883
-
-
Wang, H.1
Huang, W.2
Fei, Y.-J.3
Xia, H.4
Yang-Feng, T.L.5
Leibach, F.H.6
Devoe, L.D.7
Ganapathy, V.8
Prasad, P.D.9
-
130
-
-
58649097285
-
Cell and molecular aspects of human intestinal biotin absorption
-
Said H.M. - Cell and molecular aspects of human intestinal biotin absorption. - J Nutr, 139, 158-162, 2009.
-
(2009)
J Nutr
, vol.139
, pp. 158-162
-
-
Said, H.M.1
-
131
-
-
0038001512
-
Biotin uptake by human intestinal and liver epithelial cells: Role of the SMVT system
-
Balamurugan K., Ortiz A., Said H.M. - Biotin uptake by human intestinal and liver epithelial cells: role of the SMVT system. - Am J Physiol Gastrointest Liver Physiol, 285, G73-77, 2003. (Pubitemid 36736390)
-
(2003)
American Journal of Physiology - Gastrointestinal and Liver Physiology
, vol.285
, Issue.1
-
-
Balamurugan, K.1
Ortiz, A.2
Said, H.M.3
-
132
-
-
0345269747
-
Transport of biotin in human keratinocytes
-
Grafe F, Wohlrab W., Neubert R.H.,Brandsch M. - Transport of biotin in human keratinocytes. - J Invest Dermatol, 120, 428-433, 2003.
-
(2003)
J Invest Dermatol
, vol.120
, pp. 428-433
-
-
Grafe, F.1
Wohlrab, W.2
Neubert, R.H.3
Brandsch, M.4
-
133
-
-
33750074733
-
Biotin uptake by rabbit corneal epithelial cells: Role of sodium-dependent multivitamin transporter (SMVT)
-
Janoria K.G., Hariharan S., Paturi D., Pal D.,Mitra A.K. - Biotin uptake by rabbit corneal epithelial cells: role of sodium-dependent multivitamin transporter (SMVT). - Curr Eye Res, 31, 797-809, 2006.
-
(2006)
Curr Eye Res
, vol.31
, pp. 797-809
-
-
Janoria, K.G.1
Hariharan, S.2
Paturi, D.3
Pal, D.4
Mitra, A.K.5
-
134
-
-
33645031361
-
Biotin uptake and cellular translocation in human derived retinoblastoma cell line (Y-79): A role of hSMVT system
-
Kansara V., Luo S., Balasubrahmanyam B., Pal D., Mitra A.K. - Biotin uptake and cellular translocation in human derived retinoblastoma cell line (Y-79): a role of hSMVT system. - Int J Pharm, 312, 43-52, 2006.
-
(2006)
Int J Pharm
, vol.312
, pp. 43-52
-
-
Kansara, V.1
Luo, S.2
Balasubrahmanyam, B.3
Pal, D.4
Mitra, A.K.5
-
135
-
-
0034868135
-
Targeting the sodium-dependent multivitamin transporter (SMVT) for improving the oral absorption properties of a retro-inverso Tat nonapeptide
-
Ramanathan S., Pooyan S., Stein S., Prasad P.D., Wang J., Leibowitz M.J., Ganapathy V.,Sinko P.J. - Targeting the sodium-dependent multivitamin transporter (SMVT) for improving the oral absorption properties of a retro-inverso Tat nonapeptide. - Pharm Res, 18, 950-956, 2001.
-
(2001)
Pharm Res
, vol.18
, pp. 950-956
-
-
Ramanathan, S.1
Pooyan, S.2
Stein, S.3
Prasad, P.D.4
Wang, J.5
Leibowitz, M.J.6
Ganapathy, V.7
Sinko, P.J.8
-
136
-
-
0035856813
-
Targeted PEG-based bioconjugates enhance the cellular uptake and transport of a HIV-1 TAT nonapeptide
-
DOI 10.1016/S0168-3659(01)00474-6, PII S0168365901004746
-
Ramanathan S., Qiu B., Pooyan S., Zhang G., Stein S., Leibowitz M.J., Sinko P.J. - Targeted PEG-based bioconjugates enhance the cellular uptake and transport of a HIV-1 TAT nonapeptide. - J Control Release, 77, 199-212, 2001. (Pubitemid 33145472)
-
(2001)
Journal of Controlled Release
, vol.77
, Issue.3
, pp. 199-212
-
-
Ramanathan, S.1
Qiu, B.2
Pooyan, S.3
Zhang, G.4
Stein, S.5
Leibowitz, M.J.6
Sinko, P.J.7
-
137
-
-
0036354863
-
Enhancing the anticancer efficacy of camptothecin using biotinylated polyethylene glycol conjugates in sensitive and multidrug-resistant human ovarian carcinoma cells
-
Minko T., Paranjpe RV, Qiu B., Lalloo A., Won R., Stein S.,Sinko P.J. - Enhancing the anticancer efficacy of camptothecin using biotinylated polyethylene glycol) conjugates in sensitive and multidrug-resistant human ovarian carcinoma cells. - Cancer Chemother Pharmacol, 50, 143-150, 2002.
-
(2002)
Cancer Chemother Pharmacol
, vol.50
, pp. 143-150
-
-
Minko, T.1
Paranjpe, R.V.2
Qiu, B.3
Lalloo, A.4
Won, R.5
Stein, S.6
Sinko, P.J.7
-
138
-
-
33745795950
-
Functional characterization of sodium-dependent multivitamin transporter in MDCK-MDR1 cells and its utilization as a target for drug delivery
-
Luo S., Kansara V.S., Zhu X., Mandava N.K., Pal D.,Mitra A.K. - Functional characterization of sodium-dependent multivitamin transporter in MDCK-MDR1 cells and its utilization as a target for drug delivery. - Mol Pharm, 3, 329-339, 2006.
-
(2006)
Mol Pharm
, vol.3
, pp. 329-339
-
-
Luo, S.1
Kansara, V.S.2
Zhu, X.3
Mandava, N.K.4
Pal, D.5
Mitra, A.K.6
-
139
-
-
70350335365
-
Receptor mediated gene delivery by folate conjugated N-trimethyl chitosan in vitro
-
Zheng Y., Cai Z., Song X., Yu B., Bi Y., Chen Q., Zhao D., Xu J., Hou S. - Receptor mediated gene delivery by folate conjugated N-trimethyl chitosan in vitro. - Int J Pharm, 382, 262-269, 2009.
-
(2009)
Int J Pharm
, vol.382
, pp. 262-269
-
-
Zheng, Y.1
Cai, Z.2
Song, X.3
Yu, B.4
Bi, Y.5
Chen, Q.6
Zhao, D.7
Xu, J.8
Hou, S.9
-
140
-
-
77950623295
-
Preparation and characterization of folate-poly(ethylene glycol)-grafted-trimethylchitosan for intracellular transport of protein through folate receptor-mediated endocytosis
-
Zheng Y., Song X., Darby M., Liang Y., He L., Cai Z., Chen Q., Bi Y., Yang X., Xu J., Li Y., Sun Y.,Hou S. - Preparation and characterization of folate-poly(ethylene glycol)-grafted-trimethylchitosan for intracellular transport of protein through folate receptor-mediated endocytosis. - J Biotechnol, 2009.
-
(2009)
J Biotechnol
-
-
Zheng, Y.1
Song, X.2
Darby, M.3
Liang, Y.4
He, L.5
Cai, Z.6
Chen, Q.7
Bi, Y.8
Yang, X.9
Xu, J.10
Li, Y.11
Sun, Y.12
Hou, S.13
-
141
-
-
65949114852
-
Tumor cell targeting using folate-conjugated fluorescent quantum dots and receptor-mediated endocytosis
-
Song E.Q., Zhang Z.L., Luo Q.Y., Lu W., Shi Y.B.,Pang D.W. - Tumor cell targeting using folate-conjugated fluorescent quantum dots and receptor-mediated endocytosis. - Clin Chem, 55, 955-963, 2009.
-
(2009)
Clin Chem
, vol.55
, pp. 955-963
-
-
Song, E.Q.1
Zhang, Z.L.2
Luo, Q.Y.3
Lu, W.4
Shi, Y.B.5
Pang, D.W.6
-
142
-
-
67649849650
-
Folate-targeted therapeutic and imaging agents for cancer
-
Low P.S.,Kularatne S.A. - Folate-targeted therapeutic and imaging agents for cancer. - Curr Opin Chem Biol, 13, 256-262, 2009.
-
(2009)
Curr Opin Chem Biol
, vol.13
, pp. 256-262
-
-
Low, P.S.1
Kularatne, S.A.2
-
143
-
-
0036336471
-
Folate receptor targeted delivery of liposomal daunorubicin into tumor cells
-
Ni S., Stephenson S.M.,Lee R.J. - Folate receptor targeted delivery of liposomal daunorubicin into tumor cells. - Anticancer Res, 22, 2131-2135, 2002.
-
(2002)
Anticancer Res
, vol.22
, pp. 2131-2135
-
-
Ni, S.1
Stephenson, S.M.2
Lee, R.J.3
-
144
-
-
0142072936
-
Novel shielded transferrin-polyethylene glycol-polyethylenimine/DNA complexes for systemic tumor-targeted gene transfer
-
DOI 10.1021/bc0256087
-
Kursa M., Walker G.F., Roessler V., Ogris M., Roedl W., Kircheis R., Wagner E. - Novel shielded transferrin-polyethylene glycolpolyethylenimine/DNA complexes for systemic tumor-targeted gene transfer. - Bioconjug Chem, 14, 222-231, 2003. (Pubitemid 36169036)
-
(2003)
Bioconjugate Chemistry
, vol.14
, Issue.1
, pp. 222-231
-
-
Kursa, M.1
Walker, G.F.2
Roessler, V.3
Ogris, M.4
Roedl, W.5
Kircheis, R.6
Wagner, E.7
-
145
-
-
0038812123
-
Systemic tumor-targeted gene delivery by anti-transferrin receptor scFv-immunoliposomes
-
Xu L., Huang C.C., Huang W., Tang W.H., Rait A., Yin Y.Z., Cruz I., Xiang L.M., Pirollo K.F.,Chang E.H. - Systemic tumor-targeted gene delivery by anti-transferrin receptor scFv-immunoliposomes. - Mol Cancer Ther, 1, 337-346, 2002.
-
(2002)
Mol Cancer Ther
, vol.1
, pp. 337-346
-
-
Xu, L.1
Huang, C.C.2
Huang, W.3
Tang, W.H.4
Rait, A.5
Yin, Y.Z.6
Cruz, I.7
Xiang, L.M.8
-
146
-
-
0029334731
-
Vitamin B12 mediated oral delivery systems for granulocyte-colony stimulating factor and erythropoietin
-
Russell-Jones G.J., Westwood S.W.,Habberfield A.D. - Vitamin B12 mediated oral delivery systems for granulocyte-colony stimulating factor and erythropoietin. - Bioconjug Chem, 6, 459-465, 1995.
-
(1995)
Bioconjug Chem
, vol.6
, pp. 459-465
-
-
Russell-Jones, G.J.1
Westwood, S.W.2
Habberfield, A.D.3
-
147
-
-
0029205005
-
Synthesis of LHRH antagonists suitable for oral administration via the vitamin B12 uptake system
-
Russell-Jones G.J., Westwood S.W., Farnworth P.G., Findlay J.K.,Burger H.G. - Synthesis of LHRH antagonists suitable for oral administration via the vitamin B12 uptake system. - Bioconjug Chem, 6, 34-42, 1995.
-
(1995)
Bioconjug Chem
, vol.6
, pp. 34-42
-
-
Russell-Jones, G.J.1
Westwood, S.W.2
Farnworth, P.G.3
Findlay, J.K.4
Burger, H.G.5
-
148
-
-
55049110160
-
Targeted delivery of macromolecular drugs: Asialoglycoprotein receptor (ASGPR) expression by selected hepatoma cell lines used in antiviral drug development
-
Li Y, Huang G., Diakur J.,Wiebe L.I. - Targeted delivery of macromolecular drugs: asialoglycoprotein receptor (ASGPR) expression by selected hepatoma cell lines used in antiviral drug development. - Curr Drug Deliv, 5, 299-302, 2008.
-
(2008)
Curr Drug Deliv
, vol.5
, pp. 299-302
-
-
Li, Y.1
Huang, G.2
Diakur, J.3
Wiebe, L.I.4
-
149
-
-
27144475378
-
Interaction with blood components plays a crucial role in asialoglycoprotein receptor-mediated in vivo gene transfer by galactosylated lipoplex
-
DOI 10.1124/jpet.105.089516
-
Fumoto S., Kawakami S., Shigeta K., Higuchi Y., Yamashita F.,Hashida M. - Interaction with blood components plays a crucial role in asialoglycoprotein receptor-mediated in vivo gene transfer by galactosylated lipoplex. - J Pharmacol Exp Ther, 315, 484-493, 2005. (Pubitemid 41500711)
-
(2005)
Journal of Pharmacology and Experimental Therapeutics
, vol.315
, Issue.2
, pp. 484-493
-
-
Fumoto, S.1
Kawakami, S.2
Shigeta, K.3
Higuchi, Y.4
Yamashita, F.5
Hashida, M.6
|