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Volumn 20, Issue 2, 2010, Pages 89-99

Transporter targeted drug delivery

Author keywords

ATP binding cassette; Bioavailability; Efflux proteins; Multi drug resistance; Pro drug; Substrate; Transporter; Transporter targeted drug delivery

Indexed keywords

ABC TRANSPORTER; ACICLOVIR; AMINO ACID TRANSPORTER; BIOTIN; BREAST CANCER RESISTANCE PROTEIN; CARBAMAZEPINE; ELACRIDAR; GABAPENTIN; GANCICLOVIR; GLYCOPROTEIN P; LAMOTRIGINE; LAT PROTEIN; MONOCARBOXYLATE TRANSPORTER 1; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; MULTIDRUG RESISTANCE PROTEIN 4; MULTIDRUG RESISTANCE PROTEIN 5; MULTIDRUG RESISTANCE PROTEIN 6; PEPTIDE TRANSPORTER 1; PEPTIDE TRANSPORTER 2; PHENYTOIN; PRODRUG; PROTEINASE INHIBITOR; SAQUINAVIR; TOPIRAMATE; UNINDEXED DRUG; VALACICLOVIR; VALGANCICLOVIR;

EID: 77950598764     PISSN: 17732247     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1773-2247(10)50012-1     Document Type: Review
Times cited : (8)

References (149)
  • 1
    • 0029028792 scopus 로고
    • Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: Implications for drug delivery and activity in cancer chemotherapy
    • Wacher V.J., Wu C.Y.,Benet L.Z. - Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy. - Mol Carcinog, 13, 129-134, 1995.
    • (1995) Mol Carcinog , vol.13 , pp. 129-134
    • Wacher, V.J.1    Wu, C.Y.2    Benet, L.Z.3
  • 4
    • 0030863293 scopus 로고    scopus 로고
    • Membrane topology of the multidrug resistance protein (MRP). a study of glycosylation-site mutants reveals an extracytosolic NH2 terminus
    • Hipfner D.R., Almquist K.C., Leslie E.M., Gerlach J.H., Grant C.E., Deeley R.G., Cole S.P. - Membrane topology of the multidrug resistance protein (MRP). A study of glycosylation-site mutants reveals an extracytosolic NH2 terminus. - J Biol Chem, 272, 23623-23630, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 23623-23630
    • Hipfner, D.R.1    Almquist, K.C.2    Leslie, E.M.3    Gerlach, J.H.4    Grant, C.E.5    Deeley, R.G.6    Cole, S.P.7
  • 5
    • 0030685129 scopus 로고    scopus 로고
    • Topology mapping of the amino-terminal half of multidrug resistance- Associated protein by epitope insertion and immunofluorescence
    • DOI 10.1074/jbc.272.42.26479
    • Kast C., Gros P. - Topology mapping of the amino-terminal half of multidrug resistance-associated protein by epitope insertion and immunofluorescence. - J Biol Chem, 272, 26479-26487, 1997. (Pubitemid 27458867)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.42 , pp. 26479-26487
    • Kast, C.1    Grost, P.2
  • 6
    • 0037050736 scopus 로고    scopus 로고
    • Dominant-negative inhibition of breast cancer resistance protein as drug efflux pump through the inhibition of S-S dependent homodimerization
    • DOI 10.1002/ijc.10100
    • Kage K., Tsukahara S., Sugiyama T., Asada S., Ishikawa E., Tsuruo T., Sugimoto Y. - Dominant-negative inhibition of breast cancer resistance protein as drug efflux pump through the inhibition of S-S dependent homodimerization. - Int J Cancer, 97, 626-630, 2002. (Pubitemid 34087801)
    • (2002) International Journal of Cancer , vol.97 , Issue.5 , pp. 626-630
    • Kage, K.1    Tsukahara, S.2    Sugiyama, T.3    Asada, S.4    Ishikawa, E.5    Tsuruo, T.6    Sugimoto, Y.7
  • 7
    • 0028786395 scopus 로고
    • Both P-glycoprotein nucleotide-binding sites are catalytically active
    • Urbatsch I.L., Sankaran B., Bhagat S.,Senior A.E. - Both P-glycoprotein nucleotide-binding sites are catalytically active. - J Biol Chem, 270, 26956-26961, 1995.
    • (1995) J Biol Chem , vol.270 , pp. 26956-26961
    • Urbatsch, I.L.1    Sankaran, B.2    Bhagat, S.3    Senior, A.E.4
  • 8
    • 33645830172 scopus 로고
    • A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants
    • Juliano R.L.,Ling V. - A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. - Biochim Biophys Acta, 455, 152-162, 1976.
    • (1976) Biochim Biophys Acta , vol.455 , pp. 152-162
    • Juliano, R.L.1    Ling, V.2
  • 10
    • 0037457802 scopus 로고    scopus 로고
    • Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: An overview
    • Schinkel A.H.,Jonker J.W. - Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview. - Adv Drug Deliv Rev, 55, 3-29, 2003.
    • (2003) Adv Drug Deliv Rev , vol.55 , pp. 3-29
    • Schinkel, A.H.1    Jonker, J.W.2
  • 12
  • 14
    • 0023889448 scopus 로고
    • Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK 16
    • Sugawara I., Kataoka I., Morishita Y., Hamada H., Tsuruo T., Itoyama S., Mori S. - Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK 16. - Cancer Res, 48, 1926-1929, 1988.
    • (1988) Cancer Res , vol.48 , pp. 1926-1929
    • Sugawara, I.1    Kataoka, I.2    Morishita, Y.3    Hamada, H.4    Tsuruo, T.5    Itoyama, S.6    Mori, S.7
  • 15
    • 0037624566 scopus 로고    scopus 로고
    • Multidrug resistance 1 gene (P-glycoprotein 170): An important determinant in gastrointestinal disease?
    • Ho G.T., Moodie F.M., Satsangi J. - Multidrug resistance 1 gene (P-glycoprotein 170): an important determinant in gastrointestinal disease? - Gut, 52, 759-766, 2003.
    • (2003) Gut , vol.52 , pp. 759-766
    • Ho, G.T.1    Moodie, F.M.2    Satsangi, J.3
  • 16
    • 0027181852 scopus 로고
    • Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. Kinetics of vinblastine secretion and interaction with modulators
    • Hunter J., Jepson M.A., Tsuruo T., Simmons N.L., Hirst B.H. - Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. Kinetics of vinblastine secretion and interaction with modulators. - J Biol Chem, 268, 14991-14997, 1993. (Pubitemid 23206648)
    • (1993) Journal of Biological Chemistry , vol.268 , Issue.20 , pp. 14991-14997
    • Hunter, J.1    Jepson, M.A.2    Tsuruo, T.3    Simmons, N.L.4    Hirst, B.H.5
  • 17
    • 0027180795 scopus 로고
    • Drug absorption limited by P-glycoprotein-mediated secretory drug transport in human intestinal epithelial Caco-2 cell layers
    • DOI 10.1023/A:1018972102702
    • Hunter J., Hirst B.H.Simmons N.L. - Drug absorption limited by P-glycoprotein-mediated secretory drug transport in human intestinal epithelial Caco-2 cell layers. - Pharm Res, 10, 743-749, 1993. (Pubitemid 23152323)
    • (1993) Pharmaceutical Research , vol.10 , Issue.5 , pp. 743-749
    • Hunter, J.1    Hirst, B.H.2    Simmons, N.L.3
  • 20
    • 0029800447 scopus 로고    scopus 로고
    • Active secretion of drugs from the small intestinal epithelium in rats by P-glycoprotein functioning as an absorption barrier
    • Terao T., Hisanaga E., Sai Y., Tamai I., Tsuji A. - Active secretion of drugs from the small intestinal epithelium in rats by P-glycoprotein functioning as an absorption barrier. - J Pharm Pharmacol, 48, 1083-1089, 1996. (Pubitemid 26400301)
    • (1996) Journal of Pharmacy and Pharmacology , vol.48 , Issue.10 , pp. 1083-1089
    • Terao, T.1    Hisanaga, E.2    Sai, Y.3    Tamai, I.4    Tsuji, A.5
  • 21
    • 0041837255 scopus 로고    scopus 로고
    • Blood-brain barrier efflux transport
    • Golden P.L., Pollack G.M. - Blood-brain barrier efflux transport. - J Pharm Sci, 92, 1739-1753, 2003.
    • (2003) J Pharm Sci , vol.92 , pp. 1739-1753
    • Golden, P.L.1    Pollack, G.M.2
  • 23
    • 0035167174 scopus 로고    scopus 로고
    • In vivo evidence for P-glycoprotein-mediated transport of phenytoin at the blood-brain barrier of rats
    • Potschka H.,Loscher W. - In vivo evidence for P-glycoprotein-mediated transport of phenytoin at the blood-brain barrier of rats. - Epilepsia, 42, 1231-1240, 2001.
    • (2001) Epilepsia , vol.42 , pp. 1231-1240
    • Potschka, H.1    Loscher, W.2
  • 25
    • 0027249710 scopus 로고
    • The MRP gene associated with a non-P-glycoprotein multidrug resistance encodes a 190-kDa membrane bound glycoprotein
    • Krishnamachary N., Center M.S. - The MRP gene associated with a non-P-glycoprotein multidrug resistance encodes a 190-kDa membrane bound glycoprotein. - Cancer Res, 53, 3658-3661, 1993.
    • (1993) Cancer Res , vol.53 , pp. 3658-3661
    • Krishnamachary, N.1    Center, M.S.2
  • 27
    • 0032946239 scopus 로고    scopus 로고
    • ATP-Dependent efflux of CPT-11 and SN-38 by the multidrug resistance protein (MRP) and its inhibition by PAK-104P
    • Chen Z.S., Furukawa T., Sumizawa T., Ono K., Ueda K., Seto K.,Akiyama S.I. - ATP-Dependent efflux of CPT-11 and SN-38 by the multidrug resistance protein (MRP) and its inhibition by PAK-104P. - Mol Pharmacol, 55, 921-928, 1999.
    • (1999) Mol Pharmacol , vol.55 , pp. 921-928
    • Chen, Z.S.1    Furukawa, T.2    Sumizawa, T.3    Ono, K.4    Ueda, K.5    Seto, K.6    Akiyama, S.I.7
  • 29
    • 0027960078 scopus 로고
    • Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells
    • Cole S.P., Sparks K.E., Fraser K., Loe D.W., Grant C.E., Wilson G.M., Deeley R.G. - Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells. - Cancer Res, 54, 5902-5910, 1994. (Pubitemid 24375226)
    • (1994) Cancer Research , vol.54 , Issue.22 , pp. 5902-5910
    • Cole, S.P.C.1    Sparks, K.E.2    Fraser, K.3    Loe, D.W.4    Grant, C.E.5    Wilson, G.M.6    Deeley, R.G.7
  • 32
    • 0030962253 scopus 로고    scopus 로고
    • ATP-dependent transport of aflatoxin B1 and its glutathione conjugates by the product of the multidrug resistance protein (MRP) gene
    • Loe D.W., Stewart R.K., Massey T.E., Deeley R.G., Cole S.P. - ATP-dependent transport of aflatoxin B1 and its glutathione conjugates by the product of the multidrug resistance protein (MRP) gene. - Mol Pharmacol, 51, 1034-1041, 1997.
    • (1997) Mol Pharmacol , vol.51 , pp. 1034-1041
    • Loe, D.W.1    Stewart, R.K.2    Massey, T.E.3    Deeley, R.G.4    Cole, S.P.5
  • 33
    • 0036122824 scopus 로고    scopus 로고
    • Increased expression of multidrug resistance-associated protein 1 (mrp1) in hepatocyte basolateral membrane and renal tubular epithelia after bile duct ligation in rats
    • Pei Q.L., Kobayashi Y., Tanaka Y., Taguchi Y., Higuchi K., Kaito M., Ma N., Semba R., Kamisako T.,Adachi Y. - Increased expression of multidrug resistance-associated protein 1 (mrp1) in hepatocyte basolateral membrane and renal tubular epithelia after bile duct ligation in rats. - Hepatol Res, 22, 58-64, 2002.
    • (2002) Hepatol Res , vol.22 , pp. 58-64
    • Pei, Q.L.1    Kobayashi, Y.2    Tanaka, Y.3    Taguchi, Y.4    Higuchi, K.5    Kaito, M.6    Ma, N.7    Semba, R.8    Kamisako, T.9    Adachi, Y.10
  • 34
    • 0029133131 scopus 로고
    • Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes
    • Mayer R., Kartenbeck J., Buchler M., Jedlitschky G., Leier I.,Keppler D. - Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes. - J Cell Biol, 131, 137-150, 1995.
    • (1995) J Cell Biol , vol.131 , pp. 137-150
    • Mayer, R.1    Kartenbeck, J.2    Buchler, M.3    Jedlitschky, G.4    Leier, I.5    Keppler, D.6
  • 35
    • 0032781499 scopus 로고    scopus 로고
    • Enhanced transport of anticancer agents and leukotriene C4 by the human canalicular multispecific organic anion transporter (cMOAT/MRP2)
    • Kawabe T., Chen Z.S., Wada M., Uchiumi T., Ono M., Akiyama S.,Kuwano M. - Enhanced transport of anticancer agents and leukotriene C4 by the human canalicular multispecific organic anion transporter (cMOAT/MRP2). - FEBS Lett, 456, 327-331, 1999.
    • (1999) FEBS Lett , vol.456 , pp. 327-331
    • Kawabe, T.1    Chen, Z.S.2    Wada, M.3    Uchiumi, T.4    Ono, M.5    Akiyama, S.6    Kuwano, M.7
  • 36
    • 0345299165 scopus 로고    scopus 로고
    • Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells
    • Cui Y., Konig J., Buchholz J.K., Spring H., Leier I.,Keppler D. - Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells. - Mol Pharmacol, 55, 929-937, 1999.
    • (1999) Mol Pharmacol , vol.55 , pp. 929-937
    • Cui, Y.1    Konig, J.2    Buchholz, J.K.3    Spring, H.4    Leier, I.5    Keppler, D.6
  • 37
    • 0037963557 scopus 로고    scopus 로고
    • Differential modulation of the human liver conjugate transporters MRP2 and MRP3 by bile acids and organic anions
    • DOI 10.1074/jbc.M303515200
    • Bodo A., Bakos E., Szeri F., Varadi A.,Sarkadi B. - Differential modulation of the human liver conjugate transporters MRP2 and MRP3 by bile acids and organic anions. - J Biol Chem, 278, 23529-23537, 2003. (Pubitemid 36830172)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.26 , pp. 23529-23537
    • Bodso, A.1    Bakos, E.2    Szeri, F.3    Varadi, A.4    Sarkadi, B.5
  • 38
    • 0027305406 scopus 로고
    • Glutathione-associated cis-diamminedichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells. Molecular characterization of glutathione-platinum complex and its biological significance
    • Ishikawa T.,Ali-Osman F. - Glutathione-associated cis- diamminedichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells. Molecular characterization of glutathione-platinum complex and its biological significance. - J Biol Chem, 268, 20116-20125, 1993.
    • (1993) J Biol Chem , vol.268 , pp. 20116-20125
    • Ishikawa, T.1    Ali-Osman, F.2
  • 39
    • 0032765899 scopus 로고    scopus 로고
    • Interactions of HIV protease inhibitors with ATP-dependent drug export proteins
    • Gutmann H., Fricker G., Drewe J., Toeroek M.,Miller D.S. - Interactions of HIV protease inhibitors with ATP-dependent drug export proteins. - Mol Pharmacol, 56, 383-389, 1999.
    • (1999) Mol Pharmacol , vol.56 , pp. 383-389
    • Gutmann, H.1    Fricker, G.2    Drewe, J.3    Toeroek, M.4    Miller, D.S.5
  • 40
    • 0034765470 scopus 로고    scopus 로고
    • Nucleoside phosphonate interactions with multiple organic anion transporters in renal proximal tubule
    • Miller D.S. - Nucleoside phosphonate interactions with multiple organic anion transporters in renal proximal tubule. - J Pharmacol Exp Ther, 299, 567-574, 2001.
    • (2001) J Pharmacol Exp Ther , vol.299 , pp. 567-574
    • Miller, D.S.1
  • 41
    • 0036186107 scopus 로고    scopus 로고
    • The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: Putative efflux pump for urinary cAMP and cGMP
    • Van Aubel R.A., Smeets P.H., Peters J.G., Bindeis R.J.,Russel F.G. - The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP. - J Am Soc Nephrol, 13, 595-603, 2002.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 595-603
    • Van Aubel, R.A.1    Smeets, P.H.2    Peters, J.G.3    Bindeis, R.J.4    Russel, F.G.5
  • 42
    • 0036146666 scopus 로고    scopus 로고
    • Involvement of multidrug resistance-associated protein 2 in intestinal secretion of grepafloxacin in rats
    • DOI 10.1128/AAC.46.2.344-349.2002
    • Naruhashi K., Tamai I., Inoue N., Muraoka H., Sai Y., Suzuki N., Tsuji A. - Involvement of multidrug resistance-associated protein 2 in intestinal secretion of grepafloxacin in rats. - Antimicrob Agents Chemother, 46, 344-349, 2002. (Pubitemid 34087178)
    • (2002) Antimicrobial Agents and Chemotherapy , vol.46 , Issue.2 , pp. 344-349
    • Naruhashi, K.1    Tamai, I.2    Inoue, N.3    Muraoka, H.4    Sai, Y.5    Suzuki, N.6    Tsuji, A.7
  • 44
    • 0037464458 scopus 로고    scopus 로고
    • Comparison of in vitro P-glycoprotein screening assays: Recommendations for their use in drug discovery
    • Schwab D., Fischer H., Tabatabaei A., Poli S.,Huwyler J. - Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. - J Med Chem, 46, 1716-1725, 2003.
    • (2003) J Med Chem , vol.46 , pp. 1716-1725
    • Schwab, D.1    Fischer, H.2    Tabatabaei, A.3    Poli, S.4    Huwyler, J.5
  • 47
    • 0037131880 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms in multidrug resistance associated protein 2 (MRP2/ABCC2): Its impact on drug disposition
    • Suzuki H.,Sugiyama Y. - Single nucleotide polymorphisms in multidrug resistance associated protein 2 (MRP2/ABCC2): its impact on drug disposition. - Adv Drug Deliv Rev, 54, 1311-1331, 2002.
    • (2002) Adv Drug Deliv Rev , vol.54 , pp. 1311-1331
    • Suzuki, H.1    Sugiyama, Y.2
  • 48
    • 34047258853 scopus 로고    scopus 로고
    • Molecular evidence and functional expression of a novel drug efflux pump (ABCC2) in human corneal epithelium and rabbit cornea and its role in ocular drug efflux
    • DOI 10.1016/j.ijpharm.2006.11.031, PII S037851730600980X
    • Karla P.K., Pal D., Quinn T.,Mitra A.K. - Molecular evidence and functional expression of a novel drug efflux pump (ABCC2) in human corneal epithelium and rabbit cornea and its role in ocular drug efflux. - Int J Pharm, 336, 12-21, 2007. (Pubitemid 46551552)
    • (2007) International Journal of Pharmaceutics , vol.336 , Issue.1 , pp. 12-21
    • Karla, P.K.1    Pal, D.2    Quinn, T.3    Mitra, A.K.4
  • 49
    • 0031838805 scopus 로고    scopus 로고
    • CDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3)
    • Kiuchi Y., Suzuki H., Hirohashi T., Tyson C.A., Sugiyama Y. - cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3). - FEBS Lett, 433, 149-152, 1998.
    • (1998) FEBS Lett , vol.433 , pp. 149-152
    • Kiuchi, Y.1    Suzuki, H.2    Hirohashi, T.3    Tyson, C.A.4    Sugiyama, Y.5
  • 50
    • 0032926354 scopus 로고    scopus 로고
    • Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane
    • Konig J., Rost D., Cui Y.,Keppler D. - Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane. - Hepatology, 29, 1156-1163, 1999.
    • (1999) Hepatology , vol.29 , pp. 1156-1163
    • Konig, J.1    Rost, D.2    Cui, Y.3    Keppler, D.4
  • 51
    • 0032545019 scopus 로고    scopus 로고
    • Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins
    • Belinsky M.G., Bain L.J., Balsara B.B., Testa J.R.,Kruh G.D. - Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins. - J Natl Cancer Inst, 90, 1735-1741, 1998.
    • (1998) J Natl Cancer Inst , vol.90 , pp. 1735-1741
    • Belinsky, M.G.1    Bain, L.J.2    Balsara, B.B.3    Testa, J.R.4    Kruh, G.D.5
  • 54
    • 0035823559 scopus 로고    scopus 로고
    • Transport of cyclic nucleotides and estradiol 17-beta-D-glucuronide by multidrug resistance protein 4. Resistance to 6-mercaptopurine and 6-thioguanine
    • DOI 10.1074/jbc.M104833200
    • Chen Z.S., Lee K.,Kruh G.D. - Transport of cyclic nucleotides and estradiol 17-beta-D-glucuronide by multidrug resistance protein 4. Resistance to 6-mercaptopurine and 6-thioguanine. - J Biol Chem, 276, 33747-33754, 2001. (Pubitemid 37384594)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.36 , pp. 33747-33754
    • Chen, Z.-S.1    Lee, K.2    Kruh, G.D.3
  • 55
    • 0034614112 scopus 로고    scopus 로고
    • Analysis of the MRP4 drug resistance profile in transfected NIH3T3 cells
    • Lee K., Klein-Szanto A. J., Kruh G.D. - Analysis of the MRP4 drug resistance profile in transfected NIH3T3 cells. - J Natl Cancer Inst, 92, 1934-1940, 2000.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1934-1940
    • Lee, K.1    Klein-Szanto, A.J.2    Kruh, G.D.3
  • 56
    • 0036229673 scopus 로고    scopus 로고
    • Immunolocalization of multidrug resistance protein 5 in the human genitourinary system
    • Nies A.T., Spring H., Thon W.F., Keppler D.,Jedlitschky G. - Immunolocalization of multidrug resistance protein 5 in the human genitourinary system. - J Urol, 167, 2271-2275, 2002.
    • (2002) J Urol , vol.167 , pp. 2271-2275
    • Nies, A.T.1    Spring, H.2    Thon, W.F.3    Keppler, D.4    Jedlitschky, G.5
  • 57
    • 68149176787 scopus 로고    scopus 로고
    • Expression of multidrug resistance associated protein 5 (MRP5) on cornea and its role in drug efflux
    • Karla P.K., Quinn T.L., Herndon B.L., Thomas P., Pal D.,Mitra A. - Expression of multidrug resistance associated protein 5 (MRP5) on cornea and its role in drug efflux. - J Ocul Pharmacol Ther, 25, 121-132, 2009.
    • (2009) J Ocul Pharmacol Ther , vol.25 , pp. 121-132
    • Karla, P.K.1    Quinn, T.L.2    Herndon, B.L.3    Thomas, P.4    Pal, D.5    Mitra, A.6
  • 58
    • 2442451598 scopus 로고    scopus 로고
    • MRP8, a new member of ABC transporter superfamily, identified by EST database mining and gene prediction program, is highly expressed in breast cancer
    • Bera T.K., Lee S., Salvatore G., Lee B.,Pastan I. - MRP8, a new member of ABC transporter superfamily, identified by EST database mining and gene prediction program, is highly expressed in breast cancer. - Mol Med, 7, 509-516, 2001.
    • (2001) Mol Med , vol.7 , pp. 509-516
    • Bera, T.K.1    Lee, S.2    Salvatore, G.3    Lee, B.4    Pastan, I.5
  • 60
    • 0032893268 scopus 로고    scopus 로고
    • Expression of human MRP6, a homologue of the multidrug resistance protein gene MRP1, in tissues and cancer cells
    • Kool M., Van Der Linden M., De Haas M., Baas F.,Borst P. - Expression of human MRP6, a homologue of the multidrug resistance protein gene MRP1, in tissues and cancer cells. - Cancer Res, 59, 175-182, 1999.
    • (1999) Cancer Res , vol.59 , pp. 175-182
    • Kool, M.1    Van Der Linden, M.2    De Haas, M.3    Baas, F.4    Borst, P.5
  • 61
    • 0035951692 scopus 로고    scopus 로고
    • Analysis of the structure and expression pattern of MRP7 (ABCC10), a new member of the MRP subfamily
    • DOI 10.1016/S0304-3835(00)00646-7, PII S0304383500006467
    • Hopper E., Belinsky M.G., Zeng H., Tosolini A., Testa J.R.,Kruh G.D. - Analysis of the structure and expression pattern of MRP7 (ABCC10), a new member of the MRP subfamily. - Cancer Lett, 162, 181-191, 2001. (Pubitemid 32056287)
    • (2001) Cancer Letters , vol.162 , Issue.2 , pp. 181-191
    • Hopper, E.1    Belinsky, M.G.2    Zeng, H.3    Tosolini, A.4    Testa, J.R.5    Kruh, G.D.6
  • 65
    • 0037117313 scopus 로고    scopus 로고
    • Genetic defects in hepatobiliary transport
    • Elferink R.O.,Groen A.K. - Genetic defects in hepatobiliary transport. - Biochim Biophys Acta, 1586, 129-145, 2002.
    • (2002) Biochim Biophys Acta , vol.1586 , pp. 129-145
    • Elferink, R.O.1    Groen, A.K.2
  • 66
    • 0023134061 scopus 로고
    • Improved corneal penetration of timolol by prodrugs as a means to reduce systemic drug load
    • Chang S.C., Bundgaard H., Buur A.,Lee V.H. - Improved corneal penetration of timolol by prodrugs as a means to reduce systemic drug load. - Invest Ophthalmol Vis Sci, 28, 487-491, 1987.
    • (1987) Invest Ophthalmol Vis Sci , vol.28 , pp. 487-491
    • Chang, S.C.1    Bundgaard, H.2    Buur, A.3    Lee, V.H.4
  • 67
    • 0024380916 scopus 로고
    • Prodrugs of 5-iodo-2′-deoxyuridine for enhanced ocular transport
    • Narurkar M.M.,Mitra A.K. - Prodrugs of 5-iodo-2′-deoxyuridine for enhanced ocular transport. - Pharm Res, 6, 887-891, 1989.
    • (1989) Pharm Res , vol.6 , pp. 887-891
    • Narurkar, M.M.1    Mitra, A.K.2
  • 68
    • 0025614271 scopus 로고
    • Rate limiting barrier to the penetration of ocular hypotensive beta blockers across the corneal epithelium in the pigmented rabbit
    • Shih R.L.,Lee V.H. - Rate limiting barrier to the penetration of ocular hypotensive beta blockers across the corneal epithelium in the pigmented rabbit. - J Ocul Pharmacol, 6, 329-336, 1990.
    • (1990) J Ocul Pharmacol , vol.6 , pp. 329-336
    • Shih, R.L.1    Lee, V.H.2
  • 69
    • 0037151547 scopus 로고    scopus 로고
    • Biodistribution studies of BSA loaded gelatin microspheres after peroral application
    • Mladenovska K., Janevik I., Glavas D., Kumbaradzi F., Goracinova K. - Biodistribution studies of BSA loaded gelatin microspheres after peroral application. - Int J Pharm, 242, 251-253, 2002.
    • (2002) Int J Pharm , vol.242 , pp. 251-253
    • Mladenovska, K.1    Janevik, I.2    Glavas, D.3    Kumbaradzi, F.4    Goracinova, K.5
  • 70
    • 0030471901 scopus 로고    scopus 로고
    • Gastrointestinal uptake of biodegradable microparticles: Effect of particle size
    • Desai M.P., Labhasetwar V., Amidon G.L.,Levy R.J. - Gastrointestinal uptake of biodegradable microparticles: effect of particle size. - Pharm Res, 13, 1838-1845, 1996.
    • (1996) Pharm Res , vol.13 , pp. 1838-1845
    • Desai, M.P.1    Labhasetwar, V.2    Amidon, G.L.3    Levy, R.J.4
  • 72
    • 0029031427 scopus 로고
    • Uptake and translocation of microparticles in small intestine. Morphology and quantification of particle distribution
    • Hodges G.M., Carr E.A., Hazzard R.A., Carr K.E. - Uptake and translocation of microparticles in small intestine. Morphology and quantification of particle distribution. - Dig Dis Sci, 40, 967-975, 1995.
    • (1995) Dig Dis Sci , vol.40 , pp. 967-975
    • Hodges, G.M.1    Carr, E.A.2    Hazzard, R.A.3    Carr, K.E.4
  • 73
    • 0345055299 scopus 로고    scopus 로고
    • Comparison of the effect of different chitosan salts and N-trimethyl chitosan chloride on the permeability of intestinal epithelial cells (Caco-2)
    • Kotze A.F., Luessen H.L., De Leeuw B.J., De Boer A.G., Verhoef J.C.,Junginger H.E. - Comparison of the effect of different chitosan salts and N-trimethyl chitosan chloride on the permeability of intestinal epithelial cells (Caco-2). - J Control Release, 51, 35-46, 1998.
    • (1998) J Control Release , vol.51 , pp. 35-46
    • Kotze, A.F.1    Luessen, H.L.2    De Leeuw, B.J.3    De Boer, A.G.4    Verhoef, J.C.5    Junginger, H.E.6
  • 74
    • 0032917517 scopus 로고    scopus 로고
    • Effect of chitosan on epithelial permeability and structure
    • Dodane V., Amin Khan M.,Merwin J.R. - Effect of chitosan on epithelial permeability and structure. - Int J Pharm, 182, 21-32, 1999.
    • (1999) Int J Pharm , vol.182 , pp. 21-32
    • Dodane, V.1    Amin Khan, M.2    Merwin, J.R.3
  • 76
    • 1542619707 scopus 로고    scopus 로고
    • Transport of Octreotide and Evaluation of Mechanism of Opening the Paracellular Tight Junctions using Superporous Hydrogel Polymers in Caco-2 Cell Monolayers
    • DOI 10.1002/jps.10570
    • Dorkoosh F.A., Broekhuizen C.A., Borchard G., Rafiee-Tehrani M., Verhoef J.C.,Junginger H.E. - Transport of octreotide and evaluation of mechanism of opening the paracellular tight junctions using superporous hydrogel polymers in Caco-2 cell monolayers. - J Pharm Sci, 93, 743-752, 2004. (Pubitemid 38332306)
    • (2004) Journal of Pharmaceutical Sciences , vol.93 , Issue.3 , pp. 743-752
    • Dorkoosh, F.A.1    Broekhuizen, C.A.N.2    Borchard, G.3    Rafiee-Tehrani, M.4    Verhoef, J.C.5    Junginger, H.E.6
  • 77
    • 0028137062 scopus 로고
    • Cyclodextrins as mucosal absorption promoters of insulin. II. Effects of beta-cyclodextrin derivatives on alpha-chymotryptic degradation and enteral absorption of insulin in rats
    • Shao Z., Li Y., Chermak T.,Mitra A.K. - Cyclodextrins as mucosal absorption promoters of insulin. II. Effects of beta-cyclodextrin derivatives on alpha-chymotryptic degradation and enteral absorption of insulin in rats. - Pharm Res, 11, 1174-1179, 1994.
    • (1994) Pharm Res , vol.11 , pp. 1174-1179
    • Shao, Z.1    Li, Y.2    Chermak, T.3    Mitra, A.K.4
  • 78
    • 0036678569 scopus 로고    scopus 로고
    • Current prodrug strategies via membrane transporters/receptors
    • Anand B.S., Dey S.,Mitra A.K. - Current prodrug strategies via membrane transporters/receptors. - Expert Opin Biol Ther, 2, 607-620, 2002.
    • (2002) Expert Opin Biol Ther , vol.2 , pp. 607-620
    • Anand, B.S.1    Dey, S.2    Mitra, A.K.3
  • 79
    • 1442351172 scopus 로고    scopus 로고
    • Peptide transporters: Structure, function, regulation and application for drug delivery
    • Terada T.,Inui K. - Peptide transporters: structure, function, regulation and application for drug delivery. - Curr Drug Metab, 5, 85-94, 2004.
    • (2004) Curr Drug Metab , vol.5 , pp. 85-94
    • Terada, T.1    Inui, K.2
  • 80
    • 48749131090 scopus 로고    scopus 로고
    • Peptide transporters and their roles in physiological processes and drug disposition
    • Rubio-Aliaga I.,Daniel H. - Peptide transporters and their roles in physiological processes and drug disposition. - Xenobiotica, 38, 1022-1042, 2008.
    • (2008) Xenobiotica , vol.38 , pp. 1022-1042
    • Rubio-Aliaga, I.1    Daniel, H.2
  • 81
    • 0036710840 scopus 로고    scopus 로고
    • Mammalian peptide transporters as targets for drug delivery
    • Rubio-Aliaga I.,Daniel H. - Mammalian peptide transporters as targets for drug delivery. - Trends Pharmacol Sci, 23, 434-440, 2002.
    • (2002) Trends Pharmacol Sci , vol.23 , pp. 434-440
    • Rubio-Aliaga, I.1    Daniel, H.2
  • 82
    • 0032853619 scopus 로고    scopus 로고
    • Intestinal peptide transport systems and oral drug availability
    • Yang C.Y., Dantzig A.H.,Pidgeon C - Intestinal peptide transport systems and oral drug availability. - Pharm Res, 16, 1331-1343, 1999.
    • (1999) Pharm Res , vol.16 , pp. 1331-1343
    • Yang, C.Y.1    Dantzig, A.H.2    Pidgeon, C.3
  • 83
    • 0033659819 scopus 로고    scopus 로고
    • Physiological and pharmacological implications of peptide transporters, PEPT1 and PEPT2
    • Inui K., Terada T., Masuda S.,Saito H. - Physiological and pharmacological implications of peptide transporters, PEPT1 and PEPT2. - Nephrol Dial Transplant, 15, Suppl 6, 11-13, 2000.
    • (2000) Nephrol Dial Transplant , vol.15 , Issue.SUPPL. 6 , pp. 11-13
    • Inui, K.1    Terada, T.2    Masuda, S.3    Saito, H.4
  • 84
    • 0037530341 scopus 로고    scopus 로고
    • Di/tri-peptide transporters as drug delivery targets: Regulation of transport under physiological and patho-physiological conditions
    • Nielsen C.U.,Brodin B. - Di/tri-peptide transporters as drug delivery targets: regulation of transport under physiological and patho-physiological conditions. - Curr Drug Targets, 4, 373-388, 2003.
    • (2003) Curr Drug Targets , vol.4 , pp. 373-388
    • Nielsen, C.U.1    Brodin, B.2
  • 85
    • 0035289188 scopus 로고    scopus 로고
    • Prodrug based optimal drug delivery via membrane transporter/receptor
    • Yang C., Tirucherai G.S.,Mitra A.K. - Prodrug based optimal drug delivery via membrane transporter/receptor. - Expert Opin Biol Ther, 1, 159-175, 2001.
    • (2001) Expert Opin Biol Ther , vol.1 , pp. 159-175
    • Yang, C.1    Tirucherai, G.S.2    Mitra, A.K.3
  • 86
    • 50249154146 scopus 로고    scopus 로고
    • Interaction of dipeptide prodrugs of saquinavir with multidrug resistance protein-2 (MRP-2): Evasion of MRP-2 mediated efflux
    • Jain R., Agarwal S., Mandava N.K., Sheng Y.,Mitra A.K. - Interaction of dipeptide prodrugs of saquinavir with multidrug resistance protein-2 (MRP-2): evasion of MRP-2 mediated efflux. - Int J Pharm, 362, 44-51, 2008.
    • (2008) Int J Pharm , vol.362 , pp. 44-51
    • Jain, R.1    Agarwal, S.2    Mandava, N.K.3    Sheng, Y.4    Mitra, A.K.5
  • 87
    • 34247567472 scopus 로고    scopus 로고
    • Intestinal absorption of novel-dipeptide prodrugs of saquinavir in rats
    • Jain R., Duwuri S., Kansara V., Mandava N.K.,Mitra A.K. - Intestinal absorption of novel-dipeptide prodrugs of saquinavir in rats. - Int J Pharm, 336, 233-240, 2007.
    • (2007) Int J Pharm , vol.336 , pp. 233-240
    • Jain, R.1    Duwuri, S.2    Kansara, V.3    Mandava, N.K.4    Mitra, A.K.5
  • 88
    • 50249124852 scopus 로고    scopus 로고
    • Pharmacokinetics of amino acid ester prodrugs of acyclovir after oral administration: Interaction with the transporters on Caco-2 cells
    • Katragadda S., Jain R., Kwatra D., Hariharan S.,Mitra A.K. - Pharmacokinetics of amino acid ester prodrugs of acyclovir after oral administration: interaction with the transporters on Caco-2 cells. - Int J Pharm, 362, 93-101, 2008.
    • (2008) Int J Pharm , vol.362 , pp. 93-101
    • Katragadda, S.1    Jain, R.2    Kwatra, D.3    Hariharan, S.4    Mitra, A.K.5
  • 89
    • 44749093484 scopus 로고    scopus 로고
    • Peptide prodrugs: Improved oral absorption of lopinavir, a HIV protease inhibitor
    • Agarwal S., Boddu S.H., Jain R., Samanta S., Pal D.,Mitra A.K. - Peptide prodrugs: improved oral absorption of lopinavir, a HIV protease inhibitor. - Int J Pharm, 359, 7-14, 2008.
    • (2008) Int J Pharm , vol.359 , pp. 7-14
    • Agarwal, S.1    Boddu, S.H.2    Jain, R.3    Samanta, S.4    Pal, D.5    Mitra, A.K.6
  • 90
    • 30544437062 scopus 로고    scopus 로고
    • Dipeptide monoester ganciclovir prodrugs for treating HSV-1-induced corneal epithelial and stromal keratitis: In vitro and in vivo evaluations
    • DOI 10.1089/jop.2005.21.463
    • Majumdar S., Nashed Y.E., Patel K., Jain R., Itahashi M., Neumann D.M., Hill J.M.,Mitra A.K. - Dipeptide monoester ganciclovir prodrugs for treating HSV-1-induced corneal epithelial and stromal keratitis: in vitro and in vivo evaluations. - J Ocul Pharmacol Ther, 21, 463-474, 2005. (Pubitemid 43083338)
    • (2005) Journal of Ocular Pharmacology and Therapeutics , vol.21 , Issue.6 , pp. 463-474
    • Majumdar, S.1    Nashed, Y.E.2    Patel, K.3    Jain, R.4    Itahashi, M.5    Neumann, D.M.6    Hill, J.M.7    Mitra, A.K.8
  • 91
    • 6344288793 scopus 로고    scopus 로고
    • Pharmacokinetics of novel dipeptide ester prodrugs of acyclovir after oral administration: Intestinal absorption and liver metabolism
    • Anand B.S., Katragadda S.,Mitra A.K. - Pharmacokinetics of novel dipeptide ester prodrugs of acyclovir after oral administration: intestinal absorption and liver metabolism. - J Pharmacol Exp Ther, 311, 659-667, 2004.
    • (2004) J Pharmacol Exp Ther , vol.311 , pp. 659-667
    • Anand, B.S.1    Katragadda, S.2    Mitra, A.K.3
  • 92
    • 35848953208 scopus 로고    scopus 로고
    • Dipeptide monoester ganciclovir prodrugs for transscleral drug delivery: Targeting the oligopeptide transporter on rabbit retina
    • DOI 10.1089/jop.2006.0150
    • Kansara V., Hao Y.,Mitra A.K. - Dipeptide monoester ganciclovir prodrugs for transscleral drug delivery: targeting the oligopeptide transporter on rabbit retina. - J Ocul Pharmacol Ther, 23, 321-334, 2007. (Pubitemid 350195056)
    • (2007) Journal of Ocular Pharmacology and Therapeutics , vol.23 , Issue.4 , pp. 321-334
    • Kansara, V.1    Hao, Y.I.2    Mitra, A.K.3
  • 93
    • 0036018543 scopus 로고    scopus 로고
    • Transport of peptidomimetic drugs by the intestinal di/tri-peptide transporter, PepT1
    • DOI 10.1034/j.1600-0773.2002.900601.x
    • Brodin B., Nielsen C.U., Steffansen B.,Frokjaer S. - Transport of peptidomimetic drugs by the intestinal Di/tri-peptide transporter, PepT1. - Pharmacol Toxicol, 90, 285-296, 2002. (Pubitemid 34713193)
    • (2002) Pharmacology and Toxicology , vol.90 , Issue.6 , pp. 285-296
    • Brodin, B.1    Nielsen, C.U.2    Steffansen, B.3    Frokjaer, S.4
  • 94
    • 0037319276 scopus 로고    scopus 로고
    • Drug delivery to the retina: Challenges and opportunities
    • Duwuri S., Majumdar S.,Mitra A.K. - Drug delivery to the retina: challenges and opportunities. - Expert Opin Biol Ther, 3, 45-56, 2003.
    • (2003) Expert Opin Biol Ther , vol.3 , pp. 45-56
    • Duwuri, S.1    Majumdar, S.2    Mitra, A.K.3
  • 95
    • 1342329764 scopus 로고    scopus 로고
    • Mechanism of a model dipeptide transport across blood-ocular barriers following systemic administration
    • Atluri H., Anand B.S., Patel J.,Mitra A.K. - Mechanism of a model dipeptide transport across blood-ocular barriers following systemic administration. - Exp Eye Res, 78, 815-822, 2004.
    • (2004) Exp Eye Res , vol.78 , pp. 815-822
    • Atluri, H.1    Anand, B.S.2    Patel, J.3    Mitra, A.K.4
  • 96
    • 33846294417 scopus 로고    scopus 로고
    • Corneal absorption and anterior chamber pharmacokinetics of dipeptide monoester prodrugs of ganciclovir (GCV): In vivo comparative evaluation of these prodrugs with val-GCV and GCV in rabbits
    • DOI 10.1089/jop.2006.22.465
    • Gunda S., Hariharan S., Mitra A.K. - Corneal absorption and anterior chamber pharmacokinetics of dipeptide monoester prodrugs of ganciclovir (GCV): in vivo comparative evaluation of these prodrugs with Val-GCV and GCV in rabbits. - J Ocul Pharmacol Ther, 22, 465-476, 2006. (Pubitemid 46110643)
    • (2006) Journal of Ocular Pharmacology and Therapeutics , vol.22 , Issue.6 , pp. 465-476
    • Gunda, S.1    Hariharan, S.2    Mitra, A.K.3
  • 97
    • 0036689265 scopus 로고    scopus 로고
    • Mechanism of corneal permeation of L-valyl ester of acyclovir: Targeting the oligopeptide transporter on the rabbit cornea
    • Anand B.S.,Mitra A.K. - Mechanism of corneal permeation of L-valyl ester of acyclovir: targeting the oligopeptide transporter on the rabbit cornea. - Pharm Res, 19, 1194-1202, 2002.
    • (2002) Pharm Res , vol.19 , pp. 1194-1202
    • Anand, B.S.1    Mitra, A.K.2
  • 98
    • 0037308045 scopus 로고    scopus 로고
    • Interactions of the dipeptide ester prodrugs of acyclovir with the intestinal oligopeptide transporter: Competitive inhibition of glycylsarcosine transport in human intestinal cell line-Caco-2
    • Anand B.S., Patel J.,Mitra A.K. - Interactions of the dipeptide ester prodrugs of acyclovir with the intestinal oligopeptide transporter: competitive inhibition of glycylsarcosine transport in human intestinal cell line-Caco-2. - J Pharmacol Exp Ther, 304, 781-791, 2003.
    • (2003) J Pharmacol Exp Ther , vol.304 , pp. 781-791
    • Anand, B.S.1    Patel, J.2    Mitra, A.K.3
  • 99
    • 0013298520 scopus 로고    scopus 로고
    • Novel dipeptide prodrugs of acyclovir for ocular herpes infections: Bioreversion, antiviral activity and transport across rabbit cornea
    • Anand B., Nashed Y.,Mitra A. - Novel dipeptide prodrugs of acyclovir for ocular herpes infections: Bioreversion, antiviral activity and transport across rabbit cornea. - Curr Eye Res, 26, 151-163, 2003.
    • (2003) Curr Eye Res , vol.26 , pp. 151-163
    • Anand, B.1    Nashed, Y.2    Mitra, A.3
  • 100
    • 23844497838 scopus 로고    scopus 로고
    • Quantitative assessment of HIV-1 protease inhibitor interactions with drug efflux transporters in the blood-brain barrier
    • Bachmeier C.J., Spitzenberger T.J., Elmquist W.F.,Miller D.W. - Quantitative assessment of HIV-1 protease inhibitor interactions with drug efflux transporters in the blood-brain barrier. - Pharm Res, 22, 1259-1268, 2005.
    • (2005) Pharm Res , vol.22 , pp. 1259-1268
    • Bachmeier, C.J.1    Spitzenberger, T.J.2    Elmquist, W.F.3    Miller, D.W.4
  • 101
    • 0018800293 scopus 로고
    • Active carrier-mediated transport of melphalan by two separate amino acid transport systems in LPC-1 plasmacytoma cells in vitro
    • Goldenberg G.J., Lam H.Y.,Begleiter A. - Active carrier-mediated transport of melphalan by two separate amino acid transport systems in LPC-1 plasmacytoma cells in vitro. - J Biol Chem, 254, 1057-1064, 1979.
    • (1979) J Biol Chem , vol.254 , pp. 1057-1064
    • Goldenberg, G.J.1    Lam, H.Y.2    Begleiter, A.3
  • 102
    • 0025347918 scopus 로고
    • The transport of thyroxine into mouse neuroblastoma cells, NB41A3: The effect of L-system amino acids
    • Lakshmanan M., Goncalves E., Lessly G., Foti D.,Robbins J. - The transport of thyroxine into mouse neuroblastoma cells, NB41A3: the effect of L-system amino acids. - Endocrinology, 126, 3245-3250, 1990.
    • (1990) Endocrinology , vol.126 , pp. 3245-3250
    • Lakshmanan, M.1    Goncalves, E.2    Lessly, G.3    Foti, D.4    Robbins, J.5
  • 103
    • 0028986069 scopus 로고
    • Transport of gabapentin, a gamma-amino acid drug, by system I alpha-amino acid transporters: A comparative study in astrocytes, synaptosomes, and CHO cells
    • Su T.Z., Lunney E., Campbell G.,Oxender D.L. - Transport of gabapentin, a gamma-amino acid drug, by system I alpha-amino acid transporters: a comparative study in astrocytes, synaptosomes, and CHO cells. - J Neurochem, 64, 2125-2131, 1995.
    • (1995) J Neurochem , vol.64 , pp. 2125-2131
    • Su, T.Z.1    Lunney, E.2    Campbell, G.3    Oxender, D.L.4
  • 104
    • 62649129250 scopus 로고    scopus 로고
    • Detection and regulation of cationic amino acid transporters in healthy and diseased ocular surface
    • Jager K., Bonisch U., Risch M., Worlitzsch D.,Paulsen F. - Detection and regulation of cationic amino acid transporters in healthy and diseased ocular surface. - Invest Ophthalmol Vis Sci, 50, 1112-1121, 2009.
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 1112-1121
    • Jager, K.1    Bonisch, U.2    Risch, M.3    Worlitzsch, D.4    Paulsen, F.5
  • 106
    • 31344475734 scopus 로고    scopus 로고
    • Cellular distribution of glutamate transporters in the gastrointestinal tract of mice. An immunohistochemical and in situ hybridization approach
    • DOI 10.2220/biomedres.26.271
    • Iwanaga T, Goto M., Watanabe M. - Cellular distribution of glutamate transporters in the gastrointestinal tract of mice: an immunohistochemical and in situ hybridization approach. - Biomed Res, 26, 271-278, 2005. (Pubitemid 43137334)
    • (2006) Biomedical Research , vol.26 , Issue.6 , pp. 271-278
    • Iwanaga, T.1    Goto, M.2    Watanabe, M.3
  • 107
    • 31544435477 scopus 로고    scopus 로고
    • +-dependent neutral amino acid transporter, ASCT1, in rabbit corneal epithelial cell culture and rabbit cornea
    • DOI 10.1080/02713680500306439, PII K338H6P17087J878
    • +-dependent neutral amino acid transporter, ASCT1, in rabbit corneal epithelial cell culture and rabbit cornea. - Curr Eye Res, 30, 989-1002, 2005. (Pubitemid 43154693)
    • (2005) Current Eye Research , vol.30 , Issue.11 , pp. 989-1002
    • Katragadda, S.1    Talluri, R.S.2    Pal, D.3    Mitra, A.K.4
  • 108
    • 0027734068 scopus 로고
    • Review of research leading to new anti-herpesvirus agents in clinical development: Valaciclovir hydrochloride (256U, the L-valyl ester of acyclovir) and 882C, a specific agent for varicella zoster virus
    • Purifoy D.J., Beauchamp L.M., De Miranda P., Ertl P., Lacey S., Roberts G., Rahim S.G., Darby G., Krenitsky TA.,Powell K.L. - Review of research leading to new anti-herpesvirus agents in clinical development: valaciclovir hydrochloride (256U, the L-valyl ester of acyclovir) and 882C, a specific agent for varicella zoster virus. - J Med Virol, Suppl 1, 139-145, 1993.
    • (1993) J Med Virol , Issue.SUPPL. 1 , pp. 139-145
    • Purifoy, D.J.1    Beauchamp, L.M.2    De Miranda, P.3    Ertl, P.4    Lacey, S.5    Roberts, G.6    Rahim, S.G.7    Darby, G.8    Krenitsky, T.A.9    Powell, K.L.10
  • 111
    • 0031662109 scopus 로고    scopus 로고
    • 5′-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter
    • Han H., De Vrueh R.L., Rhie J.K., Covitz K.M., Smith P.L., Lee C.P., Oh D.M., Sadee W.,Amidon G.L. - 5′-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter. - Pharm Res, 15, 1154-1159, 1998.
    • (1998) Pharm Res , vol.15 , pp. 1154-1159
    • Han, H.1    De Vrueh, R.L.2    Rhie, J.K.3    Covitz, K.M.4    Smith, P.L.5    Lee, C.P.6    Oh, D.M.7    Sadee, W.8    Amidon, G.L.9
  • 112
    • 1842789741 scopus 로고    scopus 로고
    • +)-independent large neutral amino acid transporter (LAT2) on ARPE-19 cells
    • +)-independent large neutral amino acid transporter (LAT2) on ARPE-19 cells. - Int J Pharm, 275, 189-200, 2004.
    • (2004) Int J Pharm , vol.275 , pp. 189-200
    • Gandhi, M.D.1    Pal, D.2    Mitra, A.K.3
  • 115
    • 42949091493 scopus 로고    scopus 로고
    • Characterization and astrocytic modulation of system L transporters in brain microvasculature endothelial cells
    • Omidi Y., Barar J., Ahmadian S., Heidari H.R.,Gumbleton M. - Characterization and astrocytic modulation of system L transporters in brain microvasculature endothelial cells. - Cell Biochem Funct, 26, 381-391, 2008.
    • (2008) Cell Biochem Funct , vol.26 , pp. 381-391
    • Omidi, Y.1    Barar, J.2    Ahmadian, S.3    Heidari, H.R.4    Gumbleton, M.5
  • 117
    • 0033853560 scopus 로고    scopus 로고
    • Enhancement of transport of D-melphalan analogue by conjugation with L-glutamate across bovine brain microvessel endothelial cell monolayers
    • Sakaeda T., Siahaan T.J., Audus K.L., Stella V.J. - Enhancement of transport of D-melphalan analogue by conjugation with L-glutamate across bovine brain microvessel endothelial cell monolayers. - J Drug Target, 8, 195-204, 2000. (Pubitemid 30609587)
    • (2000) Journal of Drug Targeting , vol.8 , Issue.3 , pp. 195-204
    • Sakaeda, T.1    Siahaan, T.J.2    Audus, K.L.3    Stella, V.J.4
  • 119
    • 0035042563 scopus 로고    scopus 로고
    • Chemical stability, enzymatic hydrolysis, and nasal uptake of amino acid ester prodrugs of acyclovir
    • DOI 10.1002/1520-6017(200105)90:5<617::AID-JPS1018>3.0.CO;2-5
    • Yang C., Gao H.,Mitra A.K. - Chemical stability, enzymatic hydrolysis, and nasal uptake of amino acid ester prodrugs of acyclovir. - J Pharm Sci, 90, 617-624, 2001. (Pubitemid 32378383)
    • (2001) Journal of Pharmaceutical Sciences , vol.90 , Issue.5 , pp. 617-624
    • Yang, C.1    Gao, H.2    Mitra, A.K.3
  • 120
    • 0033569442 scopus 로고    scopus 로고
    • The proton-linked monocarboxylate transporter (MCT) family: Structure, function and regulation
    • Halestrap A.P.,Price N.T. - The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. - Biochem J, 343, Pt 2, 281-299, 1999.
    • (1999) Biochem J , vol.343 , Issue.PART 2 , pp. 281-299
    • Halestrap, A.P.1    Price, N.T.2
  • 121
    • 0035662969 scopus 로고    scopus 로고
    • MCT1-mediated transport of L-lactic acid at the inner blood-retinal barrier: A possible route for delivery of monocarboxylic acid drugs to the retina
    • DOI 10.1023/A:1013310210710
    • Hosoya K., Kondo T., Tomi M., Takanaga H., Ohtsuki S., Terasaki T. - MCT1-mediated transport of L-lactic acid at the inner blood-retinal barrier: a possible route for delivery of monocarboxylic acid drugs to the retina. - Pharm Res, 18, 1669-1676, 2001. (Pubitemid 34020421)
    • (2001) Pharmaceutical Research , vol.18 , Issue.12 , pp. 1669-1676
    • K-i, H.1    Kondo, T.2    Tomi, M.3    Takanaga, H.4    Ohtsuki, S.5    Terasaki, T.6
  • 122
    • 2942612987 scopus 로고    scopus 로고
    • Membrane transporter/receptor-targeted prodrug design: Strategies for human and veterinary drug development
    • DOI 10.1016/j.addr.2004.02.006, PII S0169409X04000699, Veterinary Drug Delivery: Part VI
    • Majumdar S., Duwuri S., Mitra A.K. - Membrane transporter/receptor- targeted prodrug design: strategies for human and veterinary drug development. - Adv Drug Deliv Rev, 56, 1437-1452, 2004. (Pubitemid 38748825)
    • (2004) Advanced Drug Delivery Reviews , vol.56 , Issue.10 , pp. 1437-1452
    • Majumdar, S.1    Duvvuri, S.2    Mitra, A.K.3
  • 123
    • 59149090614 scopus 로고    scopus 로고
    • Monocarboxylate transporters: Past, present, and future
    • Merezhinskaya N., Fishbein W.N. -Monocarboxylate transporters: past, present, and future. - Histol Histopathol, 24, 243-264, 2009.
    • (2009) Histol Histopathol , vol.24 , pp. 243-264
    • Merezhinskaya, N.1    Fishbein, W.N.2
  • 125
    • 48749086146 scopus 로고    scopus 로고
    • The SLC16 monocaboxylate transporter family
    • Meredith D., Christian H.C. - The SLC16 monocaboxylate transporter family. - Xenobiotica, 38, 1072-1106, 2008.
    • (2008) Xenobiotica , vol.38 , pp. 1072-1106
    • Meredith, D.1    Christian, H.C.2
  • 128
    • 0037377965 scopus 로고    scopus 로고
    • Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells
    • Philp N.J., Wang D., Yoon H.,Hjelmeland L.M. - Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells. - Invest Ophthalmol Vis Sci, 44, 1716-1721, 2003.
    • (2003) Invest Ophthalmol Vis Sci , vol.44 , pp. 1716-1721
    • Philp, N.J.1    Wang, D.2    Yoon, H.3    Hjelmeland, L.M.4
  • 130
    • 58649097285 scopus 로고    scopus 로고
    • Cell and molecular aspects of human intestinal biotin absorption
    • Said H.M. - Cell and molecular aspects of human intestinal biotin absorption. - J Nutr, 139, 158-162, 2009.
    • (2009) J Nutr , vol.139 , pp. 158-162
    • Said, H.M.1
  • 133
    • 33750074733 scopus 로고    scopus 로고
    • Biotin uptake by rabbit corneal epithelial cells: Role of sodium-dependent multivitamin transporter (SMVT)
    • Janoria K.G., Hariharan S., Paturi D., Pal D.,Mitra A.K. - Biotin uptake by rabbit corneal epithelial cells: role of sodium-dependent multivitamin transporter (SMVT). - Curr Eye Res, 31, 797-809, 2006.
    • (2006) Curr Eye Res , vol.31 , pp. 797-809
    • Janoria, K.G.1    Hariharan, S.2    Paturi, D.3    Pal, D.4    Mitra, A.K.5
  • 134
    • 33645031361 scopus 로고    scopus 로고
    • Biotin uptake and cellular translocation in human derived retinoblastoma cell line (Y-79): A role of hSMVT system
    • Kansara V., Luo S., Balasubrahmanyam B., Pal D., Mitra A.K. - Biotin uptake and cellular translocation in human derived retinoblastoma cell line (Y-79): a role of hSMVT system. - Int J Pharm, 312, 43-52, 2006.
    • (2006) Int J Pharm , vol.312 , pp. 43-52
    • Kansara, V.1    Luo, S.2    Balasubrahmanyam, B.3    Pal, D.4    Mitra, A.K.5
  • 135
    • 0034868135 scopus 로고    scopus 로고
    • Targeting the sodium-dependent multivitamin transporter (SMVT) for improving the oral absorption properties of a retro-inverso Tat nonapeptide
    • Ramanathan S., Pooyan S., Stein S., Prasad P.D., Wang J., Leibowitz M.J., Ganapathy V.,Sinko P.J. - Targeting the sodium-dependent multivitamin transporter (SMVT) for improving the oral absorption properties of a retro-inverso Tat nonapeptide. - Pharm Res, 18, 950-956, 2001.
    • (2001) Pharm Res , vol.18 , pp. 950-956
    • Ramanathan, S.1    Pooyan, S.2    Stein, S.3    Prasad, P.D.4    Wang, J.5    Leibowitz, M.J.6    Ganapathy, V.7    Sinko, P.J.8
  • 136
    • 0035856813 scopus 로고    scopus 로고
    • Targeted PEG-based bioconjugates enhance the cellular uptake and transport of a HIV-1 TAT nonapeptide
    • DOI 10.1016/S0168-3659(01)00474-6, PII S0168365901004746
    • Ramanathan S., Qiu B., Pooyan S., Zhang G., Stein S., Leibowitz M.J., Sinko P.J. - Targeted PEG-based bioconjugates enhance the cellular uptake and transport of a HIV-1 TAT nonapeptide. - J Control Release, 77, 199-212, 2001. (Pubitemid 33145472)
    • (2001) Journal of Controlled Release , vol.77 , Issue.3 , pp. 199-212
    • Ramanathan, S.1    Qiu, B.2    Pooyan, S.3    Zhang, G.4    Stein, S.5    Leibowitz, M.J.6    Sinko, P.J.7
  • 137
    • 0036354863 scopus 로고    scopus 로고
    • Enhancing the anticancer efficacy of camptothecin using biotinylated polyethylene glycol conjugates in sensitive and multidrug-resistant human ovarian carcinoma cells
    • Minko T., Paranjpe RV, Qiu B., Lalloo A., Won R., Stein S.,Sinko P.J. - Enhancing the anticancer efficacy of camptothecin using biotinylated polyethylene glycol) conjugates in sensitive and multidrug-resistant human ovarian carcinoma cells. - Cancer Chemother Pharmacol, 50, 143-150, 2002.
    • (2002) Cancer Chemother Pharmacol , vol.50 , pp. 143-150
    • Minko, T.1    Paranjpe, R.V.2    Qiu, B.3    Lalloo, A.4    Won, R.5    Stein, S.6    Sinko, P.J.7
  • 138
    • 33745795950 scopus 로고    scopus 로고
    • Functional characterization of sodium-dependent multivitamin transporter in MDCK-MDR1 cells and its utilization as a target for drug delivery
    • Luo S., Kansara V.S., Zhu X., Mandava N.K., Pal D.,Mitra A.K. - Functional characterization of sodium-dependent multivitamin transporter in MDCK-MDR1 cells and its utilization as a target for drug delivery. - Mol Pharm, 3, 329-339, 2006.
    • (2006) Mol Pharm , vol.3 , pp. 329-339
    • Luo, S.1    Kansara, V.S.2    Zhu, X.3    Mandava, N.K.4    Pal, D.5    Mitra, A.K.6
  • 139
    • 70350335365 scopus 로고    scopus 로고
    • Receptor mediated gene delivery by folate conjugated N-trimethyl chitosan in vitro
    • Zheng Y., Cai Z., Song X., Yu B., Bi Y., Chen Q., Zhao D., Xu J., Hou S. - Receptor mediated gene delivery by folate conjugated N-trimethyl chitosan in vitro. - Int J Pharm, 382, 262-269, 2009.
    • (2009) Int J Pharm , vol.382 , pp. 262-269
    • Zheng, Y.1    Cai, Z.2    Song, X.3    Yu, B.4    Bi, Y.5    Chen, Q.6    Zhao, D.7    Xu, J.8    Hou, S.9
  • 140
    • 77950623295 scopus 로고    scopus 로고
    • Preparation and characterization of folate-poly(ethylene glycol)-grafted-trimethylchitosan for intracellular transport of protein through folate receptor-mediated endocytosis
    • Zheng Y., Song X., Darby M., Liang Y., He L., Cai Z., Chen Q., Bi Y., Yang X., Xu J., Li Y., Sun Y.,Hou S. - Preparation and characterization of folate-poly(ethylene glycol)-grafted-trimethylchitosan for intracellular transport of protein through folate receptor-mediated endocytosis. - J Biotechnol, 2009.
    • (2009) J Biotechnol
    • Zheng, Y.1    Song, X.2    Darby, M.3    Liang, Y.4    He, L.5    Cai, Z.6    Chen, Q.7    Bi, Y.8    Yang, X.9    Xu, J.10    Li, Y.11    Sun, Y.12    Hou, S.13
  • 141
    • 65949114852 scopus 로고    scopus 로고
    • Tumor cell targeting using folate-conjugated fluorescent quantum dots and receptor-mediated endocytosis
    • Song E.Q., Zhang Z.L., Luo Q.Y., Lu W., Shi Y.B.,Pang D.W. - Tumor cell targeting using folate-conjugated fluorescent quantum dots and receptor-mediated endocytosis. - Clin Chem, 55, 955-963, 2009.
    • (2009) Clin Chem , vol.55 , pp. 955-963
    • Song, E.Q.1    Zhang, Z.L.2    Luo, Q.Y.3    Lu, W.4    Shi, Y.B.5    Pang, D.W.6
  • 142
    • 67649849650 scopus 로고    scopus 로고
    • Folate-targeted therapeutic and imaging agents for cancer
    • Low P.S.,Kularatne S.A. - Folate-targeted therapeutic and imaging agents for cancer. - Curr Opin Chem Biol, 13, 256-262, 2009.
    • (2009) Curr Opin Chem Biol , vol.13 , pp. 256-262
    • Low, P.S.1    Kularatne, S.A.2
  • 143
    • 0036336471 scopus 로고    scopus 로고
    • Folate receptor targeted delivery of liposomal daunorubicin into tumor cells
    • Ni S., Stephenson S.M.,Lee R.J. - Folate receptor targeted delivery of liposomal daunorubicin into tumor cells. - Anticancer Res, 22, 2131-2135, 2002.
    • (2002) Anticancer Res , vol.22 , pp. 2131-2135
    • Ni, S.1    Stephenson, S.M.2    Lee, R.J.3
  • 144
    • 0142072936 scopus 로고    scopus 로고
    • Novel shielded transferrin-polyethylene glycol-polyethylenimine/DNA complexes for systemic tumor-targeted gene transfer
    • DOI 10.1021/bc0256087
    • Kursa M., Walker G.F., Roessler V., Ogris M., Roedl W., Kircheis R., Wagner E. - Novel shielded transferrin-polyethylene glycolpolyethylenimine/DNA complexes for systemic tumor-targeted gene transfer. - Bioconjug Chem, 14, 222-231, 2003. (Pubitemid 36169036)
    • (2003) Bioconjugate Chemistry , vol.14 , Issue.1 , pp. 222-231
    • Kursa, M.1    Walker, G.F.2    Roessler, V.3    Ogris, M.4    Roedl, W.5    Kircheis, R.6    Wagner, E.7
  • 145
    • 0038812123 scopus 로고    scopus 로고
    • Systemic tumor-targeted gene delivery by anti-transferrin receptor scFv-immunoliposomes
    • Xu L., Huang C.C., Huang W., Tang W.H., Rait A., Yin Y.Z., Cruz I., Xiang L.M., Pirollo K.F.,Chang E.H. - Systemic tumor-targeted gene delivery by anti-transferrin receptor scFv-immunoliposomes. - Mol Cancer Ther, 1, 337-346, 2002.
    • (2002) Mol Cancer Ther , vol.1 , pp. 337-346
    • Xu, L.1    Huang, C.C.2    Huang, W.3    Tang, W.H.4    Rait, A.5    Yin, Y.Z.6    Cruz, I.7    Xiang, L.M.8
  • 146
    • 0029334731 scopus 로고
    • Vitamin B12 mediated oral delivery systems for granulocyte-colony stimulating factor and erythropoietin
    • Russell-Jones G.J., Westwood S.W.,Habberfield A.D. - Vitamin B12 mediated oral delivery systems for granulocyte-colony stimulating factor and erythropoietin. - Bioconjug Chem, 6, 459-465, 1995.
    • (1995) Bioconjug Chem , vol.6 , pp. 459-465
    • Russell-Jones, G.J.1    Westwood, S.W.2    Habberfield, A.D.3
  • 147
  • 148
    • 55049110160 scopus 로고    scopus 로고
    • Targeted delivery of macromolecular drugs: Asialoglycoprotein receptor (ASGPR) expression by selected hepatoma cell lines used in antiviral drug development
    • Li Y, Huang G., Diakur J.,Wiebe L.I. - Targeted delivery of macromolecular drugs: asialoglycoprotein receptor (ASGPR) expression by selected hepatoma cell lines used in antiviral drug development. - Curr Drug Deliv, 5, 299-302, 2008.
    • (2008) Curr Drug Deliv , vol.5 , pp. 299-302
    • Li, Y.1    Huang, G.2    Diakur, J.3    Wiebe, L.I.4
  • 149
    • 27144475378 scopus 로고    scopus 로고
    • Interaction with blood components plays a crucial role in asialoglycoprotein receptor-mediated in vivo gene transfer by galactosylated lipoplex
    • DOI 10.1124/jpet.105.089516
    • Fumoto S., Kawakami S., Shigeta K., Higuchi Y., Yamashita F.,Hashida M. - Interaction with blood components plays a crucial role in asialoglycoprotein receptor-mediated in vivo gene transfer by galactosylated lipoplex. - J Pharmacol Exp Ther, 315, 484-493, 2005. (Pubitemid 41500711)
    • (2005) Journal of Pharmacology and Experimental Therapeutics , vol.315 , Issue.2 , pp. 484-493
    • Fumoto, S.1    Kawakami, S.2    Shigeta, K.3    Higuchi, Y.4    Yamashita, F.5    Hashida, M.6


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