Mechanism of corneal permeation of L-Valyl ester of acyclovir: Targeting the oligopeptide transporter on the rabbit cornea

Pharmaceutical Research

Volumn 19, Issue 8, 2002, Pages 1194-1202

  Anand, Banmeet S ^a   Mitra, Ashim K ^a  

^a UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

Author keywords

lactam antibiotics; ACE inhibitors; Acyclovir; Corneal permeability; Glycylproline; Glycylsarcosine; Oligopeptide transporter; Valacyclovir

Indexed keywords

ACICLOVIR; ACICLOVIR DERIVATIVE; BETA LACTAM ANTIBIOTIC; CAPTOPRIL; CARRIER PROTEIN; CEFALEXIN; CEFAZOLIN; DIPEPTIDE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL; ENZYME; ESTER DERIVATIVE; GLYCYLSARCOSINE; OLIGOPEPTIDE; PRODRUG; VALINE;

ANIMAL TISSUE; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; CORNEA EPITHELIUM; CORNEA PERMEABILITY; DRUG BIOAVAILABILITY; DRUG HYDROLYSIS; DRUG PENETRATION; DRUG PROTEIN BINDING; DRUG TARGETING; DRUG TRANSPORT; ENERGY; MALE; NONHUMAN; PH; PRIORITY JOURNAL; RABBIT;

ACYCLOVIR; ANIMALS; CARRIER PROTEINS; CORNEA; DRUG DELIVERY SYSTEMS; ESTERS; HYDROGEN-ION CONCENTRATION; MALE; OLIGOPEPTIDES; PERMEABILITY; RABBITS; VALINE;

EID: 0036689265     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1019806411610     Document Type: Article

References (36)

1. Acyclovir. A review of its pharmacodynamic properties and therapeutic efficacy
2. Acyclovir in the treatment of herpetic stromal disease
3. Effect of acylation on the ocular disposition of acyclovir. II: Corneal permeability and anti-HSV 1 activity of 2′-esters in rabbit epithelial keratitis
4. Pharmacokinetics of the acyclovir pro-drug valaciclovir after escalating single- and multiple-dose administration to normal volunteers
5. Comparative pharmacokinetics of two prodrugs of zidovudine in rabbits: Enhanced levels of zidovudine in brain tissue
6. Amino acid ester prodrugs of Acyclovir
7. Cellular uptake mechanism of amino acid ester prodrugs in Caco-2/hPEPT1 cells over-expressing a human peptide transporter
8. Direct evidence for peptide transporter (PepT1)-mediated uptake of a nonpeptide prodrug, valacyclovir
9. Transport of L-valine-acyclovir via the oligopeptide transporter in the human intestinal cell line Caco-2
10. Characterization of an oligopeptide transporter in renal lysosomes
11. Cloning and characterization of a rat H+/peptide cotransporter mediating absorption of beta-lactam antibiotics in the intestine and kidney
12. Membrane transporters
13. Carrier-mediated intestinal transport of drugs
14. Drug transport and targeting. Intestinal transport
15. Transporter-mediated permeation of drugs across the blood-brain barrier
16. Ocular disposition of acyclovir analogs: Aqueous stability, ocular tissue hydrolysis and transport characteristics
17. Molecular evidence for the existence of dipeptide transporters in rabbit cornea and conjunctiva
18. Interactions of a nonpeptidic drug, valacyclovir, with the human intestinal peptide transporter (hPEPT1) expressed in a mammalian cell line
19. Effect of mono and di acylation on the ocular disposition of ganciclovir: Physicochemical properties, ocular bioreversion and antiviral activity of short chain ester prodrugs
20. Transport of acyclovir ester prodrugs through rabbit cornea and SIRC-rabbit corneal epithelial cell line
21. Rapid determination of valaciclovir and acyclovir in human biological fluids by high-performance liquid chromatography using isocratic elution
22. The predominant contribution of oligopeptide transporter PepT1 to intestinal absorption of beta-lactam antibiotics in the rat small intestine
23. Recognition of beta-lactam antibiotics by rat peptide transporters, PEPT1 and PEPT2, in LLC-PK1 cells
24. Transport of valganciclovir, a ganciclovir prodrug, via peptide transporters PEPT1 and PEPT2
25. Differential recognition of beta-lactam antibiotics by intestinal and renal peptide transporters, PEPT1 and PEPT2
26. Effect of acylation on the ocular disposition of acyclovir. I: Synthesis, physicochemical properties, and antiviral activity of 2′-esters
27. Mechanism of acyclovir uptake in rat jejunum
28. Acyclovir transport by the human placenta
29. Physiological and pharmacological implications of peptide transporters, PEPT1 and PEPT2
30. Human intestinal H+/peptide cotransporter. Cloning, functional expression, and chromosomal localization
31. The influence of luminal pH on transport of neutral and charged dipeptides by rat small intestine, in vitro
32. Effect of ionization on the variable uptake of valacyclovir via the human intestinal peptide transporter (hPepT1) in CHO cells
33. Determination of acid surface pH in vivo in rat proximal jejunum
34. How peptides cross biological membranes