Transport of Octreotide and Evaluation of Mechanism of Opening the Paracellular Tight Junctions using Superporous Hydrogel Polymers in Caco-2 Cell Monolayers

Journal of Pharmaceutical Sciences

Volumn 93, Issue 3, 2004, Pages 743-752

  Dorkoosh, Farid A ^a,b   Broekhuizen, Corine A N ^a   Borchard, Gerrit ^a   Rafiee Tehrani, Morteza ^a   Verhoef, J Coos ^a   Junginger, Hans E ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b NV ORGANON   (Netherlands)

Author keywords

Caco 2 cells; Hydrogels; Paracellular transport; Peptides; Polymers; Proteins; Tight junction

Indexed keywords

CHITOSAN DERIVATIVE; N,N,N TRIMETHYLCHITOSAN CHLORIDE; OCTREOTIDE; PENETRATION ENHANCING AGENT; POLYMER; UNCLASSIFIED DRUG;

ARTICLE; CELL VIABILITY; COMPOSITE MATERIAL; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG MECHANISM; DRUG SCREENING; DRUG TRANSPORT; ELECTRIC RESISTANCE; HUMAN; HUMAN CELL; HYDROGEL; INCUBATION TIME; INTRACELLULAR TRANSPORT; MONOLAYER CULTURE; POLYMERIZATION; POROSITY; PRESSURE MEASUREMENT; PROTEIN ANALYSIS; PROTEIN EXPRESSION; STAINING; STRUCTURE ANALYSIS; SUPERPOROUS HYDROGEL; TIGHT JUNCTION; TRANSEPITHELIAL ELECTRICAL RESISTANCE;

EID: 1542619707     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10570     Document Type: Article

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