Peptide prodrugs: Improved oral absorption of lopinavir, a HIV protease inhibitor

International Journal of Pharmaceutics

Volumn 359, Issue 1-2, 2008, Pages 7-14

  Agarwal, Sheetal ^a   Boddu, S H S ^a   Jain, Ritesh ^a   Samanta, Swapan ^a   Pal, Dhananjay ^a   Mitra, Ashim K ^a  

^a UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

Author keywords

GVL; Lopinavir; LVR; Peptide; Prodrug; VL; VVL

Indexed keywords

AMINO ACID; CYTOCHROME P450 3A4; ESTER; LOPINAVIR; LOPINAVIR PLUS RITONAVIR; MULTIDRUG RESISTANCE PROTEIN 2; PRODRUG; PROTEINASE INHIBITOR;

ANIMAL CELL; AQUEOUS SOLUTION; ARTICLE; CELL LINE; CELL STRAIN CACO 2; DRUG ABSORPTION; DRUG METABOLISM; DRUG PENETRATION; DRUG SOLUBILITY; DRUG TRANSPORT; ENZYME STABILITY; HOMOGENATE; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MASS SPECTROMETER; MICROSOME; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL TRANSPORT; CACO-2 CELLS; CELL LINE; CYTOCHROME P-450 CYP3A; DIPEPTIDES; DOGS; DRUG DELIVERY SYSTEMS; ENZYME STABILITY; HIV PROTEASE INHIBITORS; HUMANS; MEMBRANE TRANSPORT PROTEINS; MICROSOMES, LIVER; PRODRUGS; PYRIMIDINONES; RATS; SOLUBILITY;

EID: 44749093484     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2008.03.031     Document Type: Article

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