MCT1-mediated transport of L-lactic acid at the inner blood-retinal barrier: A possible route for delivery of monocarboxylic acid drugs to the retina

Pharmaceutical Research

Volumn 18, Issue 12, 2001, Pages 1669-1676

  K i, Hosoya ^a,b   Kondo, T ^c   Tomi, M ^a,b   Takanaga, H ^b,c   Ohtsuki, S ^b,c   Terasaki, T ^b,c  

^a UNIVERSITY OF TOYAMA   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c TOHOKU UNIVERSITY   (Japan)

Author keywords

Inner blood retinal barrier; L lactic acid transport; MCT1; Retinal capillary endothelial cell line

Indexed keywords

CARBOXYLIC ACID; LACTIC ACID; MEMBRANE PROTEIN; SALICYLIC ACID; VALPROIC ACID;

ACTIVE TRANSPORT; ANIMAL CELL; ANIMAL TISSUE; ANION EXCHANGE; ARTICLE; BLOOD RETINA BARRIER; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG TRANSPORT; DRUG UPTAKE; ENDOTHELIUM CELL; MALE; MEMBRANE TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTON SODIUM EXCHANGE; RAT; RETINA CAPILLARY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TEMPERATURE DEPENDENCE;

ANIMALS; BIOLOGICAL TRANSPORT; BLOOD-RETINAL BARRIER; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; HYDROGEN-ION CONCENTRATION; LACTIC ACID; MALE; MODELS, BIOLOGICAL; MONOCARBOXYLIC ACID TRANSPORTERS; ORGANIC CHEMICALS; RATS; RATS, WISTAR; RETINAL VESSELS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SYMPORTERS;

EID: 0035662969     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1013310210710     Document Type: Article

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