Folate receptor targeted delivery of liposomal daunorubicin into tumor cells

Anticancer Research

Volumn 22, Issue 4, 2002, Pages 2131-2135

  Ni, Sandy ^a   Stephenson, Stacy M ^a   Lee, Robert J ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

Daunorubicin; Drug delivery; Drug targeting; Folate receptor; Liposomes; Tumor

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; AMMONIUM SULFATE; CYTOTOXIC AGENT; DAUNORUBICIN; FOLATE RECEPTOR; FOLIC ACID; LIPOSOME; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL CELL; ARTICLE; CELLULAR DISTRIBUTION; CHO CELL; DISEASE MODEL; DOSE TIME EFFECT RELATION; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG RETENTION; DRUG TARGETING; DRUG UPTAKE; FLOW CYTOMETRY; FLUOROMETRY; GENE AMPLIFICATION; HUMAN; HUMAN CELL; MOUTH CARCINOMA; NONHUMAN; PRIORITY JOURNAL; TARGET CELL DESTRUCTION;

ANTIBIOTICS, ANTINEOPLASTIC; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; DAUNORUBICIN; DRUG CARRIERS; FOLIC ACID; HUMANS; KB CELLS; KINETICS; LIPOSOMES; RECEPTORS, CELL SURFACE; TUMOR CELLS, CULTURED;

EID: 0036336471     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Distribution of the folate receptor GP38 in normal and malignant cell lines and tissue
2. Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines: Physiologic and clinical implications
3. Expression of folate receptor type α in relation to cell type, maligancy, and differentiation in ovary, uterus, and cervix
4. Folate-mediated targeting of therapeutic and imaging agents to cancers
5. Folate receptor type P is a neutrophilic lineage marker and is differentially expressed in myeloid leukemia
6. Selective expression of folate receptor P and its possible role in methotrexate transport in synovial macrophages from patients with rheumatoid arthritis
7. Adult acute myeloid leukemia: Update on treatment
8. Differentiation-independent retinoid induction of folate receptor type P, a potential tumor target in myeloid leukemia
9. Folate-mediated targeting of anti-neoplastic drugs, imaging agents, and nucleic acids to cancer cells
10. Conjugates of folates and anti T-cell receptor antibodies specifically target folate-receptor-positive tumor cells for lysis
11. Pharmacology of liposomal daunorubicin and its use in Kaposi's sarcoma
12. Phase I/II clinical and pharmacokinetic evaluation of liposomal daunorubicin
13. Liposomal doxorubicin
14. Liposome-encapsulated daunorubicin for PGP-related multidrug resistance
15. Liposome encapsulated caunorubicin doubles anthracycline toxicity in cell lines showing a non-PGP related multidrug resistance
16. In vitro cellular accumulation and cytotoxicity of liposomal and conventional formulations of daunorubicin and doxorubicin in resistant K562 cells
17. Folate-mediated tumor cell targeting of liposome-entrapped doxorubicin in vitro
18. Nuclear delivery of doxorubicin via folate-targeted liposomes with bypass of multidrug-resistance efflux pump
19. Influence of vesicle size, lipid composition, and drug-to-lipid ratio on the biological activity of liposomal doxorubicin in mice
20. Transmembrane ammonium sulfate gradients in liposomes produce efficient and stable entrapment of amphipathic weak bases
21. Receptor-specific delivery of liposomes via folate-PEG-Chol