-
1
-
-
58149398623
-
Translation of the Philadelphia chromosome into therapy for CML
-
Druker B.J. Translation of the Philadelphia chromosome into therapy for CML. Blood 112 (2008) 4808-4817
-
(2008)
Blood
, vol.112
, pp. 4808-4817
-
-
Druker, B.J.1
-
2
-
-
64249120430
-
The discovery of anti-angiogenic molecules: a historical review
-
Rabatti D. The discovery of anti-angiogenic molecules: a historical review. Curr Pharm Des 15 (2009) 345-352
-
(2009)
Curr Pharm Des
, vol.15
, pp. 345-352
-
-
Rabatti, D.1
-
3
-
-
47149084688
-
Epidermal growth factor receptor monoclonal antibodies for the treatment of metastatic colorectal cancer
-
Jean G.W., and Shah S.R. Epidermal growth factor receptor monoclonal antibodies for the treatment of metastatic colorectal cancer. Pharmacotherapy 28 (2008) 742-754
-
(2008)
Pharmacotherapy
, vol.28
, pp. 742-754
-
-
Jean, G.W.1
Shah, S.R.2
-
4
-
-
33847642135
-
Glycotargeting to improve cellular delivery efficiency of nucleic acids
-
Yan H., and Tram K. Glycotargeting to improve cellular delivery efficiency of nucleic acids. Glycoconj J 24 (2007) 107-123
-
(2007)
Glycoconj J
, vol.24
, pp. 107-123
-
-
Yan, H.1
Tram, K.2
-
6
-
-
53449088574
-
The neovasculature homing motif NGR: more than meets the eye
-
Corti A., Curnis F., Arap W., and Pasqualini R. The neovasculature homing motif NGR: more than meets the eye. Blood 112 (2008) 2628-2635
-
(2008)
Blood
, vol.112
, pp. 2628-2635
-
-
Corti, A.1
Curnis, F.2
Arap, W.3
Pasqualini, R.4
-
7
-
-
35748963560
-
Tumor targeting with RGD peptide ligand - design of new molecular conjugates for imaging and therapy of cancer
-
Garanger E., Boturyn D., and Dumy P. Tumor targeting with RGD peptide ligand - design of new molecular conjugates for imaging and therapy of cancer. Anticancer Agents Med Chem 7 (2007) 552-558
-
(2007)
Anticancer Agents Med Chem
, vol.7
, pp. 552-558
-
-
Garanger, E.1
Boturyn, D.2
Dumy, P.3
-
8
-
-
40949127319
-
Therapeutic nanoparticles for drug delivery in cancer
-
Cho K., Wang X., Nie S., Chen Z., and Shin D. Therapeutic nanoparticles for drug delivery in cancer. Clin Cancer Res 14 (2008) 1310-1316
-
(2008)
Clin Cancer Res
, vol.14
, pp. 1310-1316
-
-
Cho, K.1
Wang, X.2
Nie, S.3
Chen, Z.4
Shin, D.5
-
9
-
-
45349101921
-
Vitamin B12-mediated transport: a potential tool for tumor targeting of anti-neoplastic drugs and imaging agents
-
Gupta Y., Kohli D.V., and Jain S.K. Vitamin B12-mediated transport: a potential tool for tumor targeting of anti-neoplastic drugs and imaging agents. Crit Rev Ther Drug Carrier Syst 25 (2008) 347-379
-
(2008)
Crit Rev Ther Drug Carrier Syst
, vol.25
, pp. 347-379
-
-
Gupta, Y.1
Kohli, D.V.2
Jain, S.K.3
-
10
-
-
38949215454
-
Discovery and development of folic-acid based receptor targeting for imaging and therapy of cancer and inflammatory disease
-
This review highlights the discovery and development of folate-targeted imaging and therapeutic agents for cancer and inflammatory diseases.
-
Low P.S., Henne W.A., and Doorneweerd D.D. Discovery and development of folic-acid based receptor targeting for imaging and therapy of cancer and inflammatory disease. Acc Chem Res 41 (2008) 120-129. This review highlights the discovery and development of folate-targeted imaging and therapeutic agents for cancer and inflammatory diseases.
-
(2008)
Acc Chem Res
, vol.41
, pp. 120-129
-
-
Low, P.S.1
Henne, W.A.2
Doorneweerd, D.D.3
-
12
-
-
41449098351
-
Targeted drug delivery via folate receptor
-
Zhao X., Li H., and Lee R.J. Targeted drug delivery via folate receptor. Expert Opin Drug Deliv 5 (2008) 309-319
-
(2008)
Expert Opin Drug Deliv
, vol.5
, pp. 309-319
-
-
Zhao, X.1
Li, H.2
Lee, R.J.3
-
13
-
-
0026652116
-
The biological chemistry of folate receptor
-
Antony A.C. The biological chemistry of folate receptor. Blood 79 (1992) 2807-2820
-
(1992)
Blood
, vol.79
, pp. 2807-2820
-
-
Antony, A.C.1
-
14
-
-
33947424386
-
Human reduced folate carrier translation of basic biology to cancer etiology and therapy
-
Matherly L.H., Hou Z., and Deng Y. Human reduced folate carrier translation of basic biology to cancer etiology and therapy. Cancer Metastasis Rev 26 (2007) 111-128
-
(2007)
Cancer Metastasis Rev
, vol.26
, pp. 111-128
-
-
Matherly, L.H.1
Hou, Z.2
Deng, Y.3
-
15
-
-
63249102414
-
A role for the proton-coupled folate transporter (PCFT-SLC46A1) in folate receptor-mediated endocytosis
-
Zhao R., Min S.H., Wang Y., Campanella E., Low P.S., and Goldman I.D. A role for the proton-coupled folate transporter (PCFT-SLC46A1) in folate receptor-mediated endocytosis. J Boil Chem 284 (2009) 4267-4274
-
(2009)
J Boil Chem
, vol.284
, pp. 4267-4274
-
-
Zhao, R.1
Min, S.H.2
Wang, Y.3
Campanella, E.4
Low, P.S.5
Goldman, I.D.6
-
16
-
-
1942503303
-
Distribution, functionality and gene reglation of folate receptor isoforms: Implications in targeted therapy
-
Elnakat H., and Ratnam M. Distribution, functionality and gene reglation of folate receptor isoforms: Implications in targeted therapy. Adv Drug Deliv Rev 56 (2004) 1067-1084
-
(2004)
Adv Drug Deliv Rev
, vol.56
, pp. 1067-1084
-
-
Elnakat, H.1
Ratnam, M.2
-
17
-
-
0026752798
-
Distribution of the folate receptor GP38 in normal and malignant cell lines and tissues
-
Weitman S.D., Lark R.H., Coney L.R., Fort D.W., Frasca V., Zurawski Jr. V.R., and Kamen B.A. Distribution of the folate receptor GP38 in normal and malignant cell lines and tissues. Cancer Res 52 (1992) 3396-3401
-
(1992)
Cancer Res
, vol.52
, pp. 3396-3401
-
-
Weitman, S.D.1
Lark, R.H.2
Coney, L.R.3
Fort, D.W.4
Frasca, V.5
Zurawski Jr., V.R.6
Kamen, B.A.7
-
18
-
-
0026476410
-
Cellular localization of the folate receptor: potential role in drug toxicity and folate homeostasis
-
Weitman S.D., Weinberg A.G., Coney L.R., Zurawski V.R., Jennings D.S., and Kamen B.A. Cellular localization of the folate receptor: potential role in drug toxicity and folate homeostasis. Cancer Res 52 (1992) 6708-6711
-
(1992)
Cancer Res
, vol.52
, pp. 6708-6711
-
-
Weitman, S.D.1
Weinberg, A.G.2
Coney, L.R.3
Zurawski, V.R.4
Jennings, D.S.5
Kamen, B.A.6
-
19
-
-
0034617083
-
Expression and differential polarization of the reduced-folate transporte-1 and the folate receptor alpha in mammalian retinal pigment epithelium
-
Chancy C.D., Kekuda R., Huang W., Prassad P.D., Kuhnel J.M., Sirotnak F.M., Roon P., Ganapathy V., and Smith S.B. Expression and differential polarization of the reduced-folate transporte-1 and the folate receptor alpha in mammalian retinal pigment epithelium. J Biol Chem 275 (2000) 20676-20684
-
(2000)
J Biol Chem
, vol.275
, pp. 20676-20684
-
-
Chancy, C.D.1
Kekuda, R.2
Huang, W.3
Prassad, P.D.4
Kuhnel, J.M.5
Sirotnak, F.M.6
Roon, P.7
Ganapathy, V.8
Smith, S.B.9
-
20
-
-
14644392093
-
Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay
-
This paper contains the most up-to-date data on FR expression in human cancers.
-
Parker N., Turk M.J., Westrick E., Lewis J.D., Low P.S., and Leamon C.P. Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay. Anal Biochem 15 (2005) 284-293. This paper contains the most up-to-date data on FR expression in human cancers.
-
(2005)
Anal Biochem
, vol.15
, pp. 284-293
-
-
Parker, N.1
Turk, M.J.2
Westrick, E.3
Lewis, J.D.4
Low, P.S.5
Leamon, C.P.6
-
21
-
-
0028301752
-
Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines, physiological and clinical implications
-
Ross R.F., Chaudhuri P.K., and Ratnam M. Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines, physiological and clinical implications. Cancer 73 (1994) 2432-2443
-
(1994)
Cancer
, vol.73
, pp. 2432-2443
-
-
Ross, R.F.1
Chaudhuri, P.K.2
Ratnam, M.3
-
22
-
-
0035134253
-
The alpha folate receptor is highly activated in malignant pleural mesothelipma
-
Bueno R., Appasani K., Mercer H., Laster S., and Sugarbaker D. The alpha folate receptor is highly activated in malignant pleural mesothelipma. J Thorac Cardiovasc Surg 121 (2001) 225-233
-
(2001)
J Thorac Cardiovasc Surg
, vol.121
, pp. 225-233
-
-
Bueno, R.1
Appasani, K.2
Mercer, H.3
Laster, S.4
Sugarbaker, D.5
-
23
-
-
0033509413
-
Selective expression of folate receptor beta and its possible role in methotrexate transport in synovial macrophages from patients with rheumatoid arthritis
-
Nakashima-Matsushita A., Homma T., Yu S., Matsuda T., Sunahara N., Nakamura T., Tsukano M., Ratnam M., and Matsuyama T. Selective expression of folate receptor beta and its possible role in methotrexate transport in synovial macrophages from patients with rheumatoid arthritis. Arthritis Rheum 42 (1999) 1609-1616
-
(1999)
Arthritis Rheum
, vol.42
, pp. 1609-1616
-
-
Nakashima-Matsushita, A.1
Homma, T.2
Yu, S.3
Matsuda, T.4
Sunahara, N.5
Nakamura, T.6
Tsukano, M.7
Ratnam, M.8
Matsuyama, T.9
-
24
-
-
58249094867
-
Folate receptor beta as a potential delivery route for novel folate antagonist to macrophage in the synovial tissue of rheumatoid arthritis patients
-
Van der Heijden J.W., Oerlemans R., Dijkmans B.A., Qi H., van der Laken C.J., Lems W.F., Jackman A.L., Kraan Mc, Tak P.P., Ratnum M., et al. Folate receptor beta as a potential delivery route for novel folate antagonist to macrophage in the synovial tissue of rheumatoid arthritis patients. Arthritis Rheum 60 (2009) 12-21
-
(2009)
Arthritis Rheum
, vol.60
, pp. 12-21
-
-
Van der Heijden, J.W.1
Oerlemans, R.2
Dijkmans, B.A.3
Qi, H.4
van der Laken, C.J.5
Lems, W.F.6
Jackman, A.L.7
Kraan Mc8
Tak, P.P.9
Ratnum, M.10
-
25
-
-
58849142161
-
A functional folate receptor is induced during macrophage activation and can be used to target drugs to activated macrophages
-
This paper defines in detail the properties of activated macrophages that express FR-β. It also demonstrates that no other hematopoietic cell expresses FR. Finally, it demonstrates for the first time that rheumatoid arthritic joints can be identified with folate-targeted imaging agents.
-
Xia W., Hilgenbrink A.R., Matteson E.L., Lockwood M.B., Cheng J.X., and Low P.S. A functional folate receptor is induced during macrophage activation and can be used to target drugs to activated macrophages. Blood 113 (2009) 438-446. This paper defines in detail the properties of activated macrophages that express FR-β. It also demonstrates that no other hematopoietic cell expresses FR. Finally, it demonstrates for the first time that rheumatoid arthritic joints can be identified with folate-targeted imaging agents.
-
(2009)
Blood
, vol.113
, pp. 438-446
-
-
Xia, W.1
Hilgenbrink, A.R.2
Matteson, E.L.3
Lockwood, M.B.4
Cheng, J.X.5
Low, P.S.6
-
26
-
-
34447643405
-
Control of immune responses by antigen-specific regulatory T cells expressing the folate receptor
-
Yamaguchi T., Hirota K., Nagahama K., Ohkawa K., Takahashi T., Nomura T., and Sakaguchi S. Control of immune responses by antigen-specific regulatory T cells expressing the folate receptor. Immunity 27 (2007) 145-159
-
(2007)
Immunity
, vol.27
, pp. 145-159
-
-
Yamaguchi, T.1
Hirota, K.2
Nagahama, K.3
Ohkawa, K.4
Takahashi, T.5
Nomura, T.6
Sakaguchi, S.7
-
27
-
-
0034722715
-
Identification of two putative novel folate receptor genes in humans and mouse
-
Spiegelstine O., Eudy J.D., and Finnell R.H. Identification of two putative novel folate receptor genes in humans and mouse. Gene 258 (2000) 117-125
-
(2000)
Gene
, vol.258
, pp. 117-125
-
-
Spiegelstine, O.1
Eudy, J.D.2
Finnell, R.H.3
-
28
-
-
27944455140
-
Folate receptor-mediated drug targeting: from therapeutics to diagnostics
-
Hilgenbrink A.R., and Low P.S. Folate receptor-mediated drug targeting: from therapeutics to diagnostics. J Pharm Sci 94 (2005) 2135-2146
-
(2005)
J Pharm Sci
, vol.94
, pp. 2135-2146
-
-
Hilgenbrink, A.R.1
Low, P.S.2
-
29
-
-
0032981308
-
Pathogenesis of joint damage in rheumatoid arthritis
-
Bresnihan B. Pathogenesis of joint damage in rheumatoid arthritis. J Rheumatol 26 (1999) 717-719
-
(1999)
J Rheumatol
, vol.26
, pp. 717-719
-
-
Bresnihan, B.1
-
30
-
-
0142072318
-
Increased apoptotic neutrophils and macrophages and impaired macrophage phagocytic clearance of apoptotic neutrophils in systemic lupus erythematosus
-
Ren Y., Tang J., Mok M.Y., Chan A.W., Wu A., and Lau C.S. Increased apoptotic neutrophils and macrophages and impaired macrophage phagocytic clearance of apoptotic neutrophils in systemic lupus erythematosus. Arthritis Rheum 48 (2003) 2888-2897
-
(2003)
Arthritis Rheum
, vol.48
, pp. 2888-2897
-
-
Ren, Y.1
Tang, J.2
Mok, M.Y.3
Chan, A.W.4
Wu, A.5
Lau, C.S.6
-
32
-
-
34247869755
-
Statins attenuate ischemia-reperfusion injury by inducing heme oxygenase-1 in infiltrating macrophages
-
Gueler F., Park J.K., Rong S., Kirsch T., Lindschau C., Zheng W., Elger M., Fiebeler A., Fliser D., Luft F.C., et al. Statins attenuate ischemia-reperfusion injury by inducing heme oxygenase-1 in infiltrating macrophages. Am J Pathol 170 (2007) 1192-1199
-
(2007)
Am J Pathol
, vol.170
, pp. 1192-1199
-
-
Gueler, F.1
Park, J.K.2
Rong, S.3
Kirsch, T.4
Lindschau, C.5
Zheng, W.6
Elger, M.7
Fiebeler, A.8
Fliser, D.9
Luft, F.C.10
-
33
-
-
3242726883
-
Uptake and trafficking of fluorescent conjugates of folic acid in intact kidney determined using intravital two-photon microscopy
-
Sandoval R.M., Kennedy M.D., Low P.S., and Molitoris B.A. Uptake and trafficking of fluorescent conjugates of folic acid in intact kidney determined using intravital two-photon microscopy. Am J Physiol Cell Physiol 287 (2004) C517-C526
-
(2004)
Am J Physiol Cell Physiol
, vol.287
-
-
Sandoval, R.M.1
Kennedy, M.D.2
Low, P.S.3
Molitoris, B.A.4
-
34
-
-
33749034747
-
Synthesis and biological evaluation of EC140: a novel folate-targeted vinka alkaloid conjugate
-
Leamon C.P., Reddy J.A., Vlahov I.R., Kleindl P.J., Vetzel M., and Westrick E. Synthesis and biological evaluation of EC140: a novel folate-targeted vinka alkaloid conjugate. Bioconjugate Chem 17 (2006) 1226-1232
-
(2006)
Bioconjugate Chem
, vol.17
, pp. 1226-1232
-
-
Leamon, C.P.1
Reddy, J.A.2
Vlahov, I.R.3
Kleindl, P.J.4
Vetzel, M.5
Westrick, E.6
-
35
-
-
34447128803
-
Folate receptor-specific antitumor activity of EC131, a flate-maytansinoid conjugate
-
Reddy J.A., Westrick E., Santhapuram H.R.K., Howard S.J., Miller M.L., Vetzel M., Vlahov I., Chari R.V.J., Goldmacher V.S., and Leamon C.P. Folate receptor-specific antitumor activity of EC131, a flate-maytansinoid conjugate. Cancer Res 67 (2007) 6376-6382
-
(2007)
Cancer Res
, vol.67
, pp. 6376-6382
-
-
Reddy, J.A.1
Westrick, E.2
Santhapuram, H.R.K.3
Howard, S.J.4
Miller, M.L.5
Vetzel, M.6
Vlahov, I.7
Chari, R.V.J.8
Goldmacher, V.S.9
Leamon, C.P.10
-
36
-
-
34249321972
-
Preclinical evaluation of EC145, a folate-vinca alkaloid conjugate
-
This article documents the use of a folate-desacetylvinblastine conjugate to selectively eliminate FR+ tumors from live mice without causing collateral damaged to normal tissues.
-
Reddy J.A., Dorton R., Westrick E., Dawson A., Smith T., Xu L.C., Vetzel M., Kleindl P., Vlahov I.R., and Leamon C.P. Preclinical evaluation of EC145, a folate-vinca alkaloid conjugate. Cancer Res 67 (2007) 4434-4442. This article documents the use of a folate-desacetylvinblastine conjugate to selectively eliminate FR+ tumors from live mice without causing collateral damaged to normal tissues.
-
(2007)
Cancer Res
, vol.67
, pp. 4434-4442
-
-
Reddy, J.A.1
Dorton, R.2
Westrick, E.3
Dawson, A.4
Smith, T.5
Xu, L.C.6
Vetzel, M.7
Kleindl, P.8
Vlahov, I.R.9
Leamon, C.P.10
-
37
-
-
34447131647
-
Comparative preclinical activity of the folate-targeted vica alkaloid conjugates EC140 and EC145
-
Leamon C.P., Reddy J.A., Vlahov I.R., Westrick E., Parker N., Nicoson J.S., and Vetzel M. Comparative preclinical activity of the folate-targeted vica alkaloid conjugates EC140 and EC145. Int J Cancer 121 (2007) 1585-1592
-
(2007)
Int J Cancer
, vol.121
, pp. 1585-1592
-
-
Leamon, C.P.1
Reddy, J.A.2
Vlahov, I.R.3
Westrick, E.4
Parker, N.5
Nicoson, J.S.6
Vetzel, M.7
-
38
-
-
35548957255
-
Preclinical antitumor activity of a novel folate-targeted dual drug conjugate
-
Leamon C.P., Reddy J.A., Vlahov I.R., Westrick E., Dawson A., Dorton R., Vetzel M., Santhapuram H.K., and Wang Y. Preclinical antitumor activity of a novel folate-targeted dual drug conjugate. Mol Pharm 4 (2007) 659-667
-
(2007)
Mol Pharm
, vol.4
, pp. 659-667
-
-
Leamon, C.P.1
Reddy, J.A.2
Vlahov, I.R.3
Westrick, E.4
Dawson, A.5
Dorton, R.6
Vetzel, M.7
Santhapuram, H.K.8
Wang, Y.9
-
39
-
-
57149087269
-
Folate targeting enables durable and specific antitumor responses from a therapeutically null tubulysin B analogue
-
Leamon C.P., Reddy J.A., Vetzel M., Dorton R., Westrick E., Parker N., Wang Y., and Vlahov I. Folate targeting enables durable and specific antitumor responses from a therapeutically null tubulysin B analogue. Cancer Res 68 (2008) 9839-9844
-
(2008)
Cancer Res
, vol.68
, pp. 9839-9844
-
-
Leamon, C.P.1
Reddy, J.A.2
Vetzel, M.3
Dorton, R.4
Westrick, E.5
Parker, N.6
Wang, Y.7
Vlahov, I.8
-
40
-
-
0025951931
-
Delovery of macromolecules into living cells: a method that exploits folate receptor endocytosis
-
Leamon C.P., and Low P.S. Delovery of macromolecules into living cells: a method that exploits folate receptor endocytosis. Proc Natl Acad Sci U S A 88 (1991) 5572-5576
-
(1991)
Proc Natl Acad Sci U S A
, vol.88
, pp. 5572-5576
-
-
Leamon, C.P.1
Low, P.S.2
-
41
-
-
1942439032
-
Antifolates targeted specifically to the folate receptor
-
Jackman A.L., Theti D.S., and Gibbs D.D. Antifolates targeted specifically to the folate receptor. Adv Drug Deliv 56 (2004) 1111-1125
-
(2004)
Adv Drug Deliv
, vol.56
, pp. 1111-1125
-
-
Jackman, A.L.1
Theti, D.S.2
Gibbs, D.D.3
-
42
-
-
0027436790
-
Endocytosis of folate-protein conjugates: ultrastructural localization in KB cells
-
Turek J.J., Leamon C.P., and Low P.S. Endocytosis of folate-protein conjugates: ultrastructural localization in KB cells. J Cell Sci 106 (1993) 423-430
-
(1993)
J Cell Sci
, vol.106
, pp. 423-430
-
-
Turek, J.J.1
Leamon, C.P.2
Low, P.S.3
-
43
-
-
33748792549
-
Evaluation of disulfide reduction during receptor-mediated endocytosis by FRET imaging
-
This reference characterizes the itinerary of folate-drug conjugates following FR-mediated endocytosis and defines the intracellular compartment where the disulfide bond linking folate to its attached drug is cleaved. It also demonstrates that folate is sorted into a different endosome from the attached drug, and that folate and FR are recycled back to the plasma membrane while the released drug is retained inside the cell.
-
Yang J., Chen H., Vlahov I.R., Cheng J.-X., and Low P.S. Evaluation of disulfide reduction during receptor-mediated endocytosis by FRET imaging. Proc Natl Am Soc 103 (2006) 13878-13977. This reference characterizes the itinerary of folate-drug conjugates following FR-mediated endocytosis and defines the intracellular compartment where the disulfide bond linking folate to its attached drug is cleaved. It also demonstrates that folate is sorted into a different endosome from the attached drug, and that folate and FR are recycled back to the plasma membrane while the released drug is retained inside the cell.
-
(2006)
Proc Natl Am Soc
, vol.103
, pp. 13878-13977
-
-
Yang, J.1
Chen, H.2
Vlahov, I.R.3
Cheng, J.-X.4
Low, P.S.5
-
44
-
-
0035794533
-
GPI anchoring leads to sphingolopid-dependent retention of endocytosed in the recycling endosomal compartment
-
Chatterjee S., Smith E.R., Hanada K., Stevens V.L., and Mayer S. GPI anchoring leads to sphingolopid-dependent retention of endocytosed in the recycling endosomal compartment. EMBO J 20 (2001) 1583-1593
-
(2001)
EMBO J
, vol.20
, pp. 1583-1593
-
-
Chatterjee, S.1
Smith, E.R.2
Hanada, K.3
Stevens, V.L.4
Mayer, S.5
-
45
-
-
9444279605
-
Ligand biding and kinetics of folate receptor recycycling in vivo: impact on receptor-mediated drug delivery
-
Paulos C.M., Reddy J.A., Leamon C.P., Turk M.J., and Low P.S. Ligand biding and kinetics of folate receptor recycycling in vivo: impact on receptor-mediated drug delivery. Mol Pharmacol 66 (2004) 1406-1414
-
(2004)
Mol Pharmacol
, vol.66
, pp. 1406-1414
-
-
Paulos, C.M.1
Reddy, J.A.2
Leamon, C.P.3
Turk, M.J.4
Low, P.S.5
-
46
-
-
34247249415
-
Characterization of the pH of folate receptor-containing endosomes and the rate of hydrolysis of internalized acid-labile folate-drug conjugates
-
Yang J., Chen H., Vlahov I.R., Cheng J.X., and Low P.S. Characterization of the pH of folate receptor-containing endosomes and the rate of hydrolysis of internalized acid-labile folate-drug conjugates. J Pharmacol Exp Ther 321 (2007) 462-468
-
(2007)
J Pharmacol Exp Ther
, vol.321
, pp. 462-468
-
-
Yang, J.1
Chen, H.2
Vlahov, I.R.3
Cheng, J.X.4
Low, P.S.5
-
47
-
-
0030600223
-
Measurement of endosome pH following folate-mediated endocytosis
-
Lee R.J., Wang S., and Low P.S. Measurement of endosome pH following folate-mediated endocytosis. Biochem Biophys Acta 1312 (1996) 237-242
-
(1996)
Biochem Biophys Acta
, vol.1312
, pp. 237-242
-
-
Lee, R.J.1
Wang, S.2
Low, P.S.3
-
48
-
-
0038621645
-
111In-DTPA-folate as a receptor-targeted diagnostic agent for ovarian cancer: initial clinical results
-
111In-DTPA-folate as a receptor-targeted diagnostic agent for ovarian cancer: initial clinical results. J Nucl Med 44 (2003) 700-707
-
(2003)
J Nucl Med
, vol.44
, pp. 700-707
-
-
Siegel, B.A.1
Dehdashti, F.2
Mutch, D.G.3
Podoloff, D.A.4
Wendt, R.5
Sutton, G.P.6
Burt, R.W.7
Ellis, P.R.8
Mathais, C.J.9
Green, M.A.10
-
49
-
-
0036862058
-
Synthesis and biological evaluation of EC20: a new folate-derived 99mTc-based radiopharmaceutical
-
Leamon C.P., Parker M.A., Vlahov I.R., Xu L.C., Reddy J.A., Vetzel M., and Douglas N. Synthesis and biological evaluation of EC20: a new folate-derived 99mTc-based radiopharmaceutical. Bioconjugate Chem 13 (2002) 1200-1210
-
(2002)
Bioconjugate Chem
, vol.13
, pp. 1200-1210
-
-
Leamon, C.P.1
Parker, M.A.2
Vlahov, I.R.3
Xu, L.C.4
Reddy, J.A.5
Vetzel, M.6
Douglas, N.7
-
51
-
-
0031658693
-
Indium-111-DTPA-dlate as a potential folate-receptor-targeted radiopharmacetical
-
Mathias C.J., Wang S., Waters D.J., Turek J.J., Low P.S., and Green M.A. Indium-111-DTPA-dlate as a potential folate-receptor-targeted radiopharmacetical. J Nucl Med 39 (1998) 1579-1585
-
(1998)
J Nucl Med
, vol.39
, pp. 1579-1585
-
-
Mathias, C.J.1
Wang, S.2
Waters, D.J.3
Turek, J.J.4
Low, P.S.5
Green, M.A.6
-
52
-
-
44849127008
-
Exploratory study of 99mTc-EC20 imaging for identifying patients with folate receptor-positive solid tumors
-
Fisher R.E., Siegel B.A., Edell S.L., Oyesiku N.M., Morgenstern D.E., Messmann R.A., and Amato R.J. Exploratory study of 99mTc-EC20 imaging for identifying patients with folate receptor-positive solid tumors. J Nucl Med 49 (2008) 899-906
-
(2008)
J Nucl Med
, vol.49
, pp. 899-906
-
-
Fisher, R.E.1
Siegel, B.A.2
Edell, S.L.3
Oyesiku, N.M.4
Morgenstern, D.E.5
Messmann, R.A.6
Amato, R.J.7
-
53
-
-
0036219732
-
Folate targeting of haptens to cancer cell surfaces mediated immunotherapy of syngenic murine tumors
-
This paper describes a novel tumor targeted immunotherapy that marks a cancer cells with so many foreign haptens that it becomes highly recognized by the immune system.
-
Lu Y., and Low P.S. Folate targeting of haptens to cancer cell surfaces mediated immunotherapy of syngenic murine tumors. Cancer Immunol Immunother 51 (2002) 153-162. This paper describes a novel tumor targeted immunotherapy that marks a cancer cells with so many foreign haptens that it becomes highly recognized by the immune system.
-
(2002)
Cancer Immunol Immunother
, vol.51
, pp. 153-162
-
-
Lu, Y.1
Low, P.S.2
-
54
-
-
23244454577
-
Folate receptor-targeted immunotherapy: induction of humoral and cellular immunity against hapten-decorated cancer cells
-
Lu Y., Sega E., and Low P.S. Folate receptor-targeted immunotherapy: induction of humoral and cellular immunity against hapten-decorated cancer cells. Int J Cancer 116 (2005) 710-719
-
(2005)
Int J Cancer
, vol.116
, pp. 710-719
-
-
Lu, Y.1
Sega, E.2
Low, P.S.3
-
55
-
-
33747349484
-
Design and regioselective synthesis of a new generation of targeted chemotherapeutics. Part I: EC145, a folic acid conjugate of desacetylvinblastine monohydrazide
-
Vlahov I.R., Santhapuram H.K., Kleindl P.J., Howard S.J., Stanford K.M., and Leamon C.P. Design and regioselective synthesis of a new generation of targeted chemotherapeutics. Part I: EC145, a folic acid conjugate of desacetylvinblastine monohydrazide. Bioorg Med Chem Lett 16 (2006) 5093-5096
-
(2006)
Bioorg Med Chem Lett
, vol.16
, pp. 5093-5096
-
-
Vlahov, I.R.1
Santhapuram, H.K.2
Kleindl, P.J.3
Howard, S.J.4
Stanford, K.M.5
Leamon, C.P.6
|