Particle uptake and translocation across epithelial membranes

Journal of Anatomy

Volumn 189, Issue 3, 1996, Pages 487-490

  Thomas, N W ^b   Jenkins, P G ^c   Howard, K A ^a   Smith, M W ^d   Lavelle, E C ^a   Holland, J ^a   Davis, S S ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^c Proteus Molecular Design Ltd   (United Kingdom)

^d ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

Drug and vaccine delivery; Gastrointestinal tract

Indexed keywords

ANTIGEN; VACCINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; BIODEGRADATION; CONFERENCE PAPER; DIGESTION; DRUG DELIVERY SYSTEM; HUMORAL IMMUNITY; INTESTINE ABSORPTION; INTESTINE EPITHELIUM; LIPID TRANSPORT; MEMBRANE TRANSPORT; NONHUMAN; ORAL DRUG ADMINISTRATION; PARTICULATE MATTER; PRIORITY JOURNAL; PROTEIN TRANSPORT; RAT; VACCINATION;

ADMINISTRATION, ORAL; ANIMALS; ANTIBODY FORMATION; ANTIGENS; CELL MEMBRANE; EPITHELIUM; INTESTINAL ABSORPTION; MICROSPHERES; PEYER'S PATCHES; VERTEBRATES;

EID: 0030474006     PISSN: 00218782     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (17)

1. ALPAR, HO, FIELD WN, HAYES K, LEWIS DA (1989) A possible use of orally administered microspheres in the treatment of inflammation. Journal of Pharmacy and Pharmacology 41, 50-52.
2. CHALLACOMBE SJ, RAHMAN D, JEFFERY H, DAVIS SS, O'HAGAN DT (1992) Enhanced secretory IgA and systemic IgG antibody responses after oral immunisation with biodegradable microparticles containing antigen. Immunology 76, 164-168.
3. ELDRIDGE JH, GILLEY RM, STAAS JK, MOLDOVEANU Z, MEULBROEK JA, TICE TR (1989) Biodegradable microspheres : vaccine delivery systems for oral immunisation. Current Topics in Microbial Immunology 146, 59-66.
4. HOWARD KA, THOMAS NW, JENKINS PG, DAVIS SS, O'HAGAN DT (1994) The absorption of microparticles into Peyer's patches of the rabbit and rat. Pharmaceutical Science Communications 4. 207-216.
5. HUSSAIN N, JANI PU, FLORENCE AT (1994) Intestinal uptake of lectin-conjugated microspheres. Proceedings of the International Symposium on the Controlled Release of Bioactive Materials 21, 29-30.
6. JANI PU, HALBERT GW, LANGRIDGE J, FLORENCE AT (1990) Nanoparticle uptake by the rat gastrointestinal mucosa : quantitation and particle size dependency. Journal of Pharmacy and Pharmacology 42, 821-826.
7. JANI PU, FLORENCE AT, MCCARTHY DE (1992) Further histological evidence of the gastrointestinal absorption of polystyrene nanospheres in the rat. International Journal of Pharmaceutics 84, 245-252.
8. JENKINS PG, HOWARD KA, BLACKBALL NW, THOMAS NW, DAVIS SS, O'HAGAN DT (1994) The quantitation of the absorption of microparticles into the intestinal lymph of Wistar rats. International Journal of Pharmaceutics 102, 261-266.
9. KREUTER J (1991) Peroral administration of nanoparticles Advanced Drug Delivery Reviews 7, 71-86.
10. LAVELLE EC, SHARIF S, THOMAS NW, HOLLAND J, DAVIS SS (1995) The importance of gastrointestinal uptake of particles in the design of oral delivery systems. Advanced Drug Delivery Reviews 18, 5-22.
11. 14C]poly(DL-lactide co-glycolide) nanoparticles after intravenous and oral administration to mice. International Journal of Pharmaceutics 106, 201-211.
12. MCKAY DM, PERDUE MH (1993) Intestinal epithelial function : the case for immunophysiological regulation. Cells and mediators (first of two parts). Digestive Diseases and Sciences 38, 1377-1387.
13. O'HAGAN DT (1994) Microparticles as Oral Vaccines. Novel Delivery Systems for Oral Vaccines, pp. 175-205. Boca Raton, FL : CRC Press.
14. OWEN RL, ERMAK TH (1990) Structural specialisations for antigen uptake and processing in the digestive tract. Springer Seminar, Immunopathology 12, 139-152.
15. PAPPO J, ERMAK TH, STEGER HJ (1991) Monoclonal antibody-directed targeting of fluorescent polystyrene microspheres to Peyer's patch M cells. Immunology 73, 277-280.
16. SMITH MW, THOMAS NW, JENKINS PG, MILLER NGA, CREMASCHI D, PORTA C (1995) Selective transport of microparticles across Peyer's patch follicle-associated M cells from mice and rats. Experimental Physiology 80, 735-743.
17. WALKER WA (1982) Mechanisms of antigen handling by the gut. Clinical Immunology and Allergy 2, 15-40.