Characterization of a clonal human colon adenocarcinoma line intrinsically resistant to doxorubicin

British Journal of Cancer

Volumn 76, Issue 1, 1997, Pages 67-76

  Dolfini, E ^a   Dasdia, T ^a   Arancia, G ^b   Molinari, A ^b   Calcabrini, A ^b   Scheper, R J ^c   Flens, M J ^c   Gariboldi, M B ^a   Monti, E ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Colon adenocarcinoma; Intrinsic drug resistance, doxorubicin; Lung resistance related protein; Multidrug resistance associated protein

Indexed keywords

CAMPTOTHECIN; DOXORUBICIN; ETOPOSIDE; GLUTATHIONE; GLYCOPROTEIN P; MELPHALAN; PROTEIN KINASE C; VINCRISTINE;

ARTICLE; CANCER CELL CULTURE; CELL CLONE; COLON ADENOCARCINOMA; CONFOCAL MICROSCOPY; CONTROLLED STUDY; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0030950351     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1997.338     Document Type: Article

References (38)

1. Ahmad S and Glazer RI (1991) Expression of the antisense cDNA for protein kinase C alpha attenuates resistance in doxorubicin-resistunt MCF-7 breast carcinoma cells. Mol Phamacol 43: 858-862
2. Alley MC, Scudiero DA, Monks A, Hursey ML, Czerwinski MJ, Fine DL, Abbott BJ, Mayo JG, Shoemaker RH and Boyd MR (1988) Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay. Cancer Res 48: 589-601
3. Beck WT, Cirtain MC, Danks MK, Felsted RL, Sala AR, Wolverton JS, Suttle DP and Trent JM (1987) Pharmacological, molecular and cytogenetic analysis of 'atypical' multidrug-resistam human leukemic cells. Cancer Res 47: 5455-5460
4. Blobe GC, Sachs CW, Khan WA, Fahbro D, Stabel S, Wetsel WC, Obeid LM, Fine RL and Hannun YA (1993) Selective regulation of expression of protein kinase C (PKC) isoenzymes in multidrug-resistant MCF-7 cells. J Biol Chem 268: 658-664
5. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye-binding. Anal Biochem 72: 248-254
6. Chaudhary PM and Roninson IB (1992) Activation of MDR1 (P-glycoprotein) gene expression in human cells by protein kinase C agonists. Oncol Res 4: 281-290
7. Cianfriglia M, Willingham MC, Tombesi M, Scagliotti V. Frasca G and Chersi A (1994) P-glycoprotein epitope mapping. I. Identification of a linear human-specific epitope in the fourth loop of the P-glycoprotein extracellular domain by MM.4.17 murine monoclonal antibody to human multidrug-resistant cells. Int J Cancer 56: 153-160
8. Cole SPC, Bhardwaj G, Gerlach JH, Mackie JE, Grant CE, Almquist KC, Stewart AJ, Kurz EU, Duncan AMV and Deeley RG (1992) Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 258: 1650-1654
9. Conforti G, Codegoni AM, Scanziani E, Dolfini E, Dasdia T, Calza M, Caniatti M and Broggini M (1995) Different vimentin expression in two clones derived from a human colocarcinoma cell line (LoVo) showing different sensitivity to doxorubicin. Br J Cancer 71: 505-511
10. Davies R, Budworth J, Riley J, Snowden R, Gescher A and Gant TW (1996) Regulation of P-glycoprotein 1 and 2 gene expression and protein activity in two MCF-7/DOX cell line subclones. Br J Cancer 73: 307-315
11. Dong Z, Ward NE, Fan D, Gupta K and O'Brian CA (1992) In vitro model for intrinsic drug resistance: effects of protein kinase C activators on the chemosensitivity of cultured human colon cancer cells. Mol Pharmacol 39: 563-569
12. Dolfini E, Dasdia T, Perletti G, Romagnoni M and Piccinini F (1993) Analysis of calcium-dependent protein kinase-C isoenzymes in intrinsically resistant cloned lines of LoVo cells. Reversal of resistance by kinase inhibitor I-(5-isoquinolinylsulfonyl)2-methylpiperazine. Anticancer Res 13: 1123-1128
13. Drew L, Groome N, Hallam TJ, Ware JR and Rumsby MG (1994) Changes in protein kinase C subspecies protein expression and activity in a series of multidrug-resistant human KB carcinoma cell lines. Oncol Res 6: 429-439
14. Eijdems EW, Zaman GJ, de Haas M, Versantvoort CH, Flens MJ, Scheper RJ, Kanist E, Borst P and Baas F (1995) Altered MRP is associated with multidrug resistance and reduced drug accumulation in human SW-1573 cells. Br J Cancer 72: 298-306
15. Fine RL, Patel J and Chabner BA (1988) Phorbol ester induce multidrug resistance in breast cancer cells. Proc Natl Acad Sci USA 85: 582-586
16. Flens MJ, Izquierdo MA, Scheffer GL, Schroeijers AB, Fritz JM, Meijer CJLM, Scheper RJ and Zaman GJR (1994) Immunochemical detection of MRP in human multidrug-resistant tumor cells by monoclonal antibodies. Cancer Res 54: 4557-4563
17. Gekeler V, Boer R, Ise W, Schachtele C and Beck J (1995) The specific bisindolylmaleimide PKC-inhibitor GF 109203X efficiently modulates MRP-associated multiple drug resistance. Biochem Biophys Res Commun 206: 119-126
18. Gollapudi S, Patel K, Jain V and Gupta S (1992) Protein kinase C isoforms in multidrug resistant P388/ADR cells: a possible role in daunorubicin transport. Cancer Lett 62: 69-75
19. Gottesman MM and Pastan I (1993) Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu Rev Biochem 62: 385-427
20. Grandi M, Geroni C and Giuliani GC (1986) Isolation and characterization of a human colon adenocarcinoma cell line resistant to doxorubicin. Br J Cancer 54: 515-518
21. Grant CE, Valdimarsson G, Hipfner DR, Almquist KC, Cole SPC and Deeley RG (1994) Overexpression of multidrug resistance-associated protein increases resistance to natural product drugs. Cancer Res 54: 357-361
22. Habig WH, Pabst MJ and Jakoby WB (1974) Glutathione S-transferases. J Biol Chem 249: 7130-7139
23. Izquierdo MA, Scheffer GL, Flens MJ, Schroeijers AB, van der Valk P and Scheper RJ (1996) Major vault protein LRP related multidrug resistance. Eur J Cancer 32A: 979-984
24. Krishnamachary N and Center MS (1993) The MRP gene associated with a non-P-glycoprotein multidrug resistance encodes a 190-kDa membrane bound glycoprotein. Cancer Res 53: 3658-3661
25. Ma L. Krishnamachary N and Center MS (1995) Phosphorylation of the multidrug resistance-associated protein gene encoded protein P190. Biochemistry 34: 3338-3343
26. Marquardt D and Center MS (1992) Drug transport mechanisms in HL60 cells isolated for resistance to adriamycin: evidence for nuclear drug accumulation and redistribution in resistant cells. Cancer Res 52: 3157-3163
27. O'Brian CA, Fan D, Ward NE, Seid C and Fidler IJ (1989) Level of protein kinase activity correlates directly with resistance to adriamycin in murine fibrosarcoma cells. FEBS Lett 246: 78-82
28. Paglia DE and Valentine WN (1967) Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 70: 158-169
29. Rome L, Kedersha N and Chugani D (1991) Unlocking vaults: organelles in search of a function. Trends Cell Biol 1: 47-50
30. Scheffer GL, Wijngaard PLJ, Flens MJ, Izquierdo MA, Slovak ML, Pinedo HM, Meijer CJLM. Clevers HC and Scheper RJ (1995) The drug resistance-related protein LRP is the human major vault protein. Nature Med 1: 578-582
31. Scheper RJ, Bulte JW, Brakkee JG, Dalton WS, Quak JJ, van der School E, Balm AJ, Meijer CJLM, Broxterman HJ, Kuiper CM, Lankelma J and Pinedo HM (1988) Monoclonal antibody JSB-I detects a highly conserved epitope on the P-glycoprotein associated with multidrug-resistance. Int J Cancer 42: 389-394
32. Scheper RJ, Broxterman HJ, Scheffer GL, Kaaijk P, Dalton WS, van Heijnongen THM, van Kalken CK, Slovak ML, de Vries EGE, van der Valk P. Meijer CJLM and Pinedo HM (1993) Overexpression of a Mr 110,000 vesicular protein in non-P-glycoprotein-mediated multidrug resistance. Cancer Res 53: 1475-1479
33. Schneider E, Horton JK, Yang C-H, Nakagawa M and Cowan KH (1994) Multidrug resistance-associated protein gene overexpression and reduced drug sensitivity of topoisomerase II in a human breast carcinoma MCF7 cell line selected for etoposide resistance. Cancer Res 54: 152-158
34. Smith PK, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, Provenzano MD, Fujimoto EK, Goeke NM, Olson BJ and Klenk DC (1985) Measurement of protein using bicinchoninic acid. Anal Biochem 150: 76-85
35. Tietze F (1969) Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal Biochem 27: 502-522
36. Versantvoort CHM, Broxterman HJ, Bagrij T, Scheper RJ and Twentyman PR (1995) Regulation by glutathione of drug transport in multidrug-resistant lung tumor cell lines overexpressing multidrug resistance associated protein. Br J Cancer 72: 82-89
37. Yu G, Ahmad S, Aquino A, Fairchild CR, Trepel JB, Ohno S, Suzuki K, Tsuruo T, Cowan KH and Glazer RI (1991) Transfection with protein kinase Cα confers increased multidrug resistance to MCF-7 cells expressing P-glycoprotein. Cancer Comms 3: 181-189
38. Zaman GJ, Flens MJ, van Leusden MR, de Haas M, Mülder HS, Lankelma J, Pinedo HM, Scheper RJ, Baas F, Broxterman HJ and Borst P (1994) Role of glutathione in the export of compounds from cells by the multidrug resistance-associated protein. Proc Natl Acad Sci USA 91: 8822-8826