Pharmacokinetics of amino acid ester prodrugs of acyclovir after oral administration: Interaction with the transporters on Caco-2 cells

International Journal of Pharmaceutics

Volumn 362, Issue 1-2, 2008, Pages 93-101

  Katragadda, Suresh ^a   Jain, Ritesh ^a   Kwatra, Deep ^a   Hariharan, Sudharshan ^a   Mitra, Ashim K ^a  

^a UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

Author keywords

Acyclovir; Amino acid prodrugs; Caco 2; Oral bioavailability; Transporters

Indexed keywords

ACICLOVIR; ALANINE ACYCLOVIR; AMINO ACID TRANSPORTER; GAMMA GLUTAMATE ACYCLOVIR; ISOLEUCINE ACYCLOVIR; PRODRUG; SERINE ACYCLOVIR; UNCLASSIFIED DRUG; VALACICLOVIR;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG ABSORPTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG STABILITY; HUMAN; HUMAN CELL; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; RAT;

ACYCLOVIR; ADMINISTRATION, ORAL; AMINO ACID TRANSPORT SYSTEMS; AMINO ACIDS; ANIMALS; BIOLOGICAL AVAILABILITY; BIOLOGICAL TRANSPORT, ACTIVE; CACO-2 CELLS; CARRIER PROTEINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG CARRIERS; ESTERS; HUMANS; MALE; MEMBRANE TRANSPORT PROTEINS; PRODRUGS; RATS; RATS, SPRAGUE-DAWLEY; SUBSTRATE SPECIFICITY; TANDEM MASS SPECTROMETRY; TISSUE DISTRIBUTION;

EID: 50249124852     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2008.06.018     Document Type: Article

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