A systems biology perspective on Nrf2-mediated antioxidant response

Toxicology and Applied Pharmacology

Volumn 244, Issue 1, 2010, Pages 84-97

  Zhang, Qiang ^a   Pi, Jingbo ^a   Woods, Courtney G ^a   Andersen, Melvin E ^a  

^a HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

Author keywords

Antioxidant; Feedback; Feedforward; Keap1; Loop gain; Nrf2; Oxidative stress; Redox homeostasis; ROS; Ultrasensitive motif

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; BETA CAROTENE; CATECHIN; CURCUMIN; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE (NADP); IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ISOTHIOCYANIC ACID; KELCH LIKE ECH ASSOCIATED PROTEIN 1; MITOGEN ACTIVATED PROTEIN KINASE P38; PENTOSE PHOSPHATE; REACTIVE OXYGEN METABOLITE; RESVERATROL; THIOREDOXIN REDUCTASE; TRANSCRIPTION FACTOR MAF; TRANSCRIPTION FACTOR NRF2; UBIQUITIN PROTEIN LIGASE E3;

ANTIOXIDANT ACTIVITY; ANTIOXIDANT RESPONSIVE ELEMENT; AUTOREGULATION; FEEDBACK SYSTEM; HORMESIS; HUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN STABILITY; REVIEW; SIGNAL TRANSDUCTION; SYSTEMS BIOLOGY; TRANSDUCER;

ANIMALS; ANTIOXIDANTS; HOMEOSTASIS; HUMANS; NF-E2-RELATED FACTOR 2; OXIDATION-REDUCTION; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SYSTEMS BIOLOGY;

EID: 77649272110     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.08.018     Document Type: Review

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