Dose-dependent transitions in Nrf2-mediated adaptive response and related stress responses to hypochlorous acid in mouse macrophages

Toxicology and Applied Pharmacology

Volumn 238, Issue 1, 2009, Pages 27-36

  Woods, Courtney G ^a,b   Fu, Jingqi ^a,c   Xue, Peng ^a,c   Hou, Yongyong ^a,c   Pluta, Linda J ^a   Yang, Longlong ^a   Zhang, Qiang ^a   Thomas, Russell S ^a   Andersen, Melvin E ^a   Pi, Jingbo ^a  

^a HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

^b EXXONMOBIL UPSTREAM RESEARCH COMPANY   (United States)

^c CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Antioxidant response element; AP 1; Genomic profiling; Hypochlorous acid; NF B; Nrf2; Oxidative stress

Indexed keywords

CHEMOKINE; CHLORINE; DNA; HEAT SHOCK PROTEIN; HYPOCHLOROUS ACID; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; TRANSCRIPTION FACTOR FRA 1; TRANSCRIPTION FACTOR NRF2;

ADAPTIVE RESPONSE; ANIMAL CELL; ARTICLE; CHROMATIN STRUCTURE; CONTROLLED STUDY; DNA DAMAGE; DNA MICROARRAY; DOSE RESPONSE; FRA1 GENE; GADD45 GENE; GENE CLUSTER; GENE EXPRESSION REGULATION; MACROPHAGE; MOUSE; NONHUMAN; ONCOGENE C FOS; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PHAGOCYTE; PROTEIN PROTEIN INTERACTION; RESPIRATORY BURST; STRESS; UBIQUITINATION;

ANIMALS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENOME; HYPOCHLOROUS ACID; IMMUNITY, INNATE; MACROPHAGES; MICE; MICROARRAY ANALYSIS; NF-E2-RELATED FACTOR 2; OXIDANTS; OXIDATIVE STRESS; UBIQUITINATION;

EID: 67349214659     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.04.007     Document Type: Article

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