Presence of a threshold for promoting effects of phenobarbital on diethylnitrosamine-induced hepatic foci in the rat

Carcinogenesis

Volumn 19, Issue 8, 1998, Pages 1475-1480

  Kitano, Mitsuaki ^a   Ichihara, Toshio ^a   Matsuda, Tsutomu ^a   Wanibuchi, Hideki ^a   Tamano, Seiko ^b   Hagiwara, Akihiro ^b   Imaoka, Susumu ^a   Funae, Yoshihiko ^a   Shirai, Tomoyuki ^b   Fukushima, Shoji ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DIETHYLNITROSAMINE; GLUTATHIONE TRANSFERASE; PHENOBARBITAL; TRANSFORMING GROWTH FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOASSAY; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LIVER CARCINOGENESIS; MALE; NONHUMAN; PARTIAL HEPATECTOMY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; CARCINOGENS; CYTOCHROME P-450 ENZYME SYSTEM; DIETHYLNITROSAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE TRANSFERASE; HEPATECTOMY; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MALE; ORGAN SIZE; PHENOBARBITAL; RATS; RATS, INBRED F344; TRANSFORMING GROWTH FACTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA;

EID: 0031659796     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/19.8.1475     Document Type: Article

References (43)

1. Butterworth,B.E. (1990) Consideration of both genotoxic and nongenotoxic mechanisms in predicting carcinogenesis potential. Mutat. Res., 239, 117-132.
2. Peraino,C., Fry,R.J.M. and Staffeldt,E. (1971) Reduction and enhancement by phenobarbital of hepatocarcinogenesis induced in the rat by 2-acetylaminofluorene. Cancer Res., 31, 1506-1512.
3. Pitot,H.C. (1990) Altered hepatic foci: their role in murine hepatocarcinogenesis. Annu. Rev. Pharmacol. Toxicol., 30, 465-500.
4. Butterworth,B.E. and Goldsworthy,T.L. (1991) The role of cell proliferation in multi-stage carcinogenesis. Proc. Soc. Exp. Biol. Med., 198, 683-687.
5. Peraino,C., Michael,R.J. and Staffeldt,E. (1973) Enhancement of spontaneous hepatic tumorigenesis in C3H mice by dietary phenobarbital. J. Natl Cancer Inst., 51, 1349-1350.
6. Feldman,D., Swarm,R.L. and Becker,J. (1981) Ultrastructural study of rat liver neoplasms after long-term treatment with phenobarbital. Cancer Res., 41, 2151-2162.
7. Butler,W.H. (1978) Long-term effects of phenobarbitone-Na on male Fischer rats. Br. J. Cancer, 37, 418-423.
8. Evans,J.G., Collins,M.A., Savage,S.A., Lake,B.G. and Butler,W.H. (1986) The histology and development of hepatic nodules in C3H/He mice following chronic administration of phenobarbitone. Carcinogenesis, 7, 627-631.
9. Ward,J.M. and Henneman,J.R. (1990) Naturally-occurring age-dependent glutathione S-transferase pi immunoreactive hepatocytes in aging female F344 rat liver as potential promotable targets for non-genotoxic carcinogens. Cancer Lett., 52, 187-195.
10. Schulte-Herman,R., Timmermann-Trosiener,I. and Schuppler,J. (1983) Promotion of spontaneous preneoplastic cells in rat liver as a possible explanation of tumor production by nonmutagenic compounds. Cancer Res., 43, 839-844.
11. Kolaja,K.L., Stevenson,D.E., Walborg,E.F. and Klaunig,J.E. (1996) Dose dependence of phenobarbital promotion of preneoplastic hepatic lesions in F344 rats and B6C3F1 mice: effects on DNA synthesis and apoptosis. Carcinogenesis, 17, 947-954.
12. Goldsworthy,T., Campell,H.A. and Pitot,H.C. (1984) The natural history and dose-response characteristics of enzyme-altered foci in rat liver following phenobarbital and diethylnitrosamine administration. Carcinogenesis, 5, 67-71.
13. Kitagawa,T., Hino,O., Nomura,K. and Sugano,H. (1984) Dose-response studies on promoting and anticarcinogenic effects of phenobarbital and DDT in the rat hepatocarcinogenesis. Carcinogenesis. 5, 1653-1656.
14. Preussmann,R. (1980) The problem of thresholds in chemical carcinogenesis - some views on theoretical and practical aspects. Cancer Res. Clin. Oncol., 97, 1-14.
15. Tomatis,L. et al. (1997) Avoided and avoidable risk of cancer. Carcinogenesis, 18, 97-105.
16. Narita,T., Watanabe,R. and Kitagawa,T. (1980) Mechanisms of inhibition by simultaneously administered phenobarbital of 3′-methyl-4-(dimethylamino)azobenzene-induced hepatocarcinogenesis in the rat. Gann, 71, 755-758.
17. Pitot,H.C., Goldsworthy,T.L., Moran,S., Kennan,W., Glauert,H.P., Maronpot,R.R. and Campbell,H.A. (1987) A method to quantitate the relative initiating and promoting potencies of hepatocarcinogenic agents in their dose-response relationships to altered hepatic foci. Carcinogenesis, 8, 1491-1499.
18. Maekawa,A., Onodera,H., Ogasawara,H., Matsushima,Y., Mitsumori,K. and Hayashi,Y. (1992) Threshold dose dependence in phenobarbital promotion of rat hepatocarcinogenesis initiated by diethylnitrosamine. Carcinogenesis, 13, 501-503.
19. Ito,N., Hasegawa,R., Imaida,K., Hirose,M., Shirai,T., Tamano,S. and Hagiwara,A. (1997) Medium-term rat liver bioassay for rapid detection of hepatocarcinogenic substances. J. Toxicol. Pathol., 10, 1-11.
20. Ito,N. et al. (1988) Enhancing effect of various hepatocarcinogens on induction of preneoplastic glutathione S-transferase placental form positive foci in rats - an approach for a new medium-term bioassay system. Carcinogenesis, 9, 387-394.
21. Ogiso,T., Tatematsu,M., Tamano,S., Hasegawa,R. and Ito,N. (1990) Correlation between medium-term liver bioassay system data and results of long-term testing in rats. Carcinogenesis, 11, 561-566.
22. Hasegawa,R. and Ito,N. (1992) Liver medium-term bioassay in rats for screening of carcinogens and modifying factors in hepatocarcinogenesis. Fd Chem. Toxicol., 30, 979-992.
23. Hagiwara,A., Matsuda,T., Tamano,S., Kitano,M., Imaoka,S., Funae,Y., Takesada,Y., Shirai,T. and Fukushima,S. (1996) Dose-related increases in quantitative values for altered hepatocytic foci and cytochrome P-450 levels in the livers of rats exposed to phenobarbital in a medium-term bioassay. Cancer Lett., 110, 155-162.
24. Hsu,S.M., Raine,L. and Fanger,H. (1981) Use of avidine-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J. Histochem. Cytochem., 29, 577-580.
25. Imaida,K., Tatematsu,M., Kato,T., Tsuda,H. and Ito,N. (1989) Advantages and limitations of stereological estimation of placental glutathione S-transferase-positive rat liver cell foci by computerized three-dimensional reconstruction. Jpn. J. Cancer Res., 80, 326-330.
26. Kato,T., Imaida,K., Ogawa,K., Hasegawa,R., Shirai,T. and Tatematsu,M. (1993) Three-dimensional analysis of giutathione S-transferase placental form-positive lesion development in early stages of rat hepatocarcinogenesis. Jpn. J. Cancer Res., 84, 1252-1257.
27. Watanabe,T., Katsura,Y. and Yoshitake,A. (1994) IPAP: image processor for analytical pathology. J. Toxicol Pathol., 7, 353-361.
28. Matsuda,T., Imaoka,S., Funae,Y, Otori,K. and Fukushima,S. (1995) Induction of CYP isoenzymes in various organs of rats by 3-methylcholanthrene or β-naphthoflavone. Cancer Lett., 97, 137-143.
29. Omura,T. and Sato,R. (1964) The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. J. Biol. Chem., 239, 137-143.
30. Lowry,O.H., Rosebrough,N.J., Farr,A.L. and Randall,R.J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem., 193, 265-275.
31. Laemmli,U.K. (1970) Cleavage of structural proteins during the assembly of the head of bactenophage T4. Nature, 227, 680-685.
32. Deguchi,J., Kawabata,T. Kondo,A. and Okada,S. (1993) Transforming growth factor-ex expression of renal proximal tubules in Wistar rats treated with ferric and aluminum nitrilotriacetate. Jpn. J. Cancer Res., 84, 649-655.
33. Atlas,I., Mendelsohn,J., Baselga,J., Fair,W.R., Masui,H. and Kumar,R. (1992) Growth regulation of human renal carcinoma cells: role of transforming growth factor α. Cancer Res., 52, 3335-3339.
34. Orton,T.C., Doughty,S.E., Kalinowski,A.E., Lord,P.G. and Wadsworth,P.F. (1996) Expression of growth factors and growth factor receptors in the liver of C57BL/10J mice following administration of phenobarbitone. Carcinogenesis, 17, 973-981.
35. Kaufmann,W.K., Zhang,Y. and Kaufmann,D.G. (1992) Association between expression of transforming growth factor-alpha and progression of hepatocellular foci to neoplasms. Carcinogenesis, 13, 1481-1483.
36. Jirtle,R.L. and Meyer,S.A. (1991) Liver tumor promotion: effect of phenobarbital on EGF and protein kinase C signal transduction and transforming growth factor-β1 expression. Digest. Dis. Sci., 36, 659-668.
37. Jirtle,R.L., Hankins,G.R., Reisenbichler,H. and Boyer,I.J. (1994) Regulation of mannose 6-phosphate/insulin-like growth factor-II receptors and transforming growth factor beta during liver tumor promotion with phenobarbital. Carcinogenesis, 15, 1473-1478.
38. Braun,L., Mead,J.E., Panzica,M., Bell,G.I. and Faust,N. (1988) Transforming growth factor beta mRNA increases during liver regeneration: a possible paracrine mechanism of growth regulation. Proc. Natl Acad. Sci. USA, 85, 1539-1543.
39. Mansbach,J.M., Mills.J.J., Boyer,I.J. Souza,A.T.D., Hankins,G.R. and Jirle,R.L. (1996) Phenobarbital selectively promotes initiated cells with reduced TGFβ receptor levels. Carcinogenesis, 17, 171-174.
40. Nims,R.W., Devor,D.E., Henneman,J.R. and Lubet,R.A. (1987) Induction of alkoxyresorufin O-dealkylases, epoxide hydrolase, and liver weight gain: correlation with liver tumor-promoting potential in a series of barbiturates. Carcinogenesis, 8, 67-71.
41. Rice,J.M., Diwan,B.A., Hu,H., Ward,J.M., Nims,R.W. and Lubet,R.A. (1994) Enhancement of hepatocarcinogenesis and induction of specific cytochrome P-450-dependent monooxygenase activities by the barbiturates allobarbital, aprobarbital, pentobarbital, secobarbital and 5-phenyl-and 5-ethyl-barbituric acid. Carcinogenesis. 15. 395-402.
42. Farber,E. and Sarma,D.S.R. (1987) Biology of disease. Hepatocarcinogenesis: a dynamic cellular perspective. Hepatic Carcinogen., 56, 4-22.
43. Hanigan,M.H. and Pitot,H.C. (1985) Growth of carcinogen-altered rat hepatocytes in the liver of syngeneic recipients promoted with phenobarbital. Cancer Res., 45, 6063-6070.